Neuron-derived IgG Protects Neurons from Complement-dependent Cytotoxicity

Journal of Histochemistry and Cytochemistry

Volumn 61, Issue 12, 2013, Pages 869-879

  Zhang, Jie ^a   Niu, Na ^a   Li, Bingjie ^b   McNutt, Michael A ^c  

^a WEIFANG MEDICAL UNIVERSITY   (China)

^b UNIVERSITY OF TEXAS   (United States)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

active immunity; CD64; complement; endogenous IgG; neuron

Indexed keywords

BRAIN PROTEIN; CD64 ANTIGEN; COMPLEMENT; FC RECEPTOR; FC RECEPTOR I; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; MESSENGER RNA; NITRIC OXIDE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; ASTROCYTE; BRAIN CELL; BRAIN CORTEX; BRAIN LEVEL; CELL ACTIVATION; COMPLEMENT DEPENDENT CYTOTOXICITY; CONTROLLED STUDY; CYTOPLASM; DENDRITE; IMMUNOGLOBULIN PRODUCTION; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; MALE; MICROGLIA; NERVE CELL; NERVE CELL CULTURE; NERVE CELL NECROSIS; NERVE FIBER; NEUROPROTECTION; NONHUMAN; PERIKARYON; PLASMA CELL; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; RAT;

ACTIVE IMMUNITY; CD64; COMPLEMENT; ENDOGENOUS IGG; NEURON;

ANIMALS; APOPTOSIS; CELL SURVIVAL; CELLS, CULTURED; COMPLEMENT SYSTEM PROTEINS; IMMUNOGLOBULIN G; MALE; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER;

EID: 84888358974     PISSN: 00221554     EISSN: None     Source Type: Journal    
DOI: 10.1369/0022155413504196     Document Type: Article

References (33)

1. Aloisi F.Immune function of microglia.Glia. 2001;36:165-179.
2. Andoh T,Kuraishi Y.Direct action of immunoglobulin G on primary sensory neurons through Fc gamma receptor I.Faseb J. 2004;18:182-184.
3. Arumugam TV,Tang SC,Lathia JD,Cheng A,Mughal MR,Chigurupati S,Magnus T,Chan SL,Jo DG,Ouyang X,Fairlie DP,Granger DN,Vortmeyer A,Basta M,Mattson MP.Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death.Proc Natl Acad Sci U S A. 2007;104:14104-14109.
4. Basta M,Van Goor F,Luccioli S,Billings EM,Vortmeyer AO,Baranyi L,Szebeni J,Alving CR,Carroll MC,Berkower I,Stojilkovic SS,Metcalfe DD.F(ab)'2-mediated neutralization of C3a and C5a anaphylatoxins: a novel effector function of immunoglobulins.Nat Med. 2003;9:431-438.
5. Bouloukos A,Lekakis J,Michael J,Kalofoutis A.Immunoglobulins in cerebrospinal fluid in various neurologic disorders.Clin Chem. 1980;26:115-116.
6. Caggiano AO,Kraig RP.Prostaglandin E receptor subtypes in cultured rat microglia and their role in reducing lipopolysaccharide-induced interleukin-1beta production.J Neurochem. 1999;72:565-575.
7. Carson MJ,Doose JM,Melchior B,Schmid CD,Ploix CC.CNS immune privilege: hiding in plain sight.Immunol Rev. 2006;213:48-65.
8. Fabian RH.Uptake of plasma IgG by CNS motoneurons: comparison of anti-neuronal and normal IgG.Neurology. 1988;38:1775-1780.
9. Floden AM,Li S,Combs CK.Beta-amyloid-stimulated microglia induce neuron death via synergistic stimulation of tumor necrosis factor alpha and NMDA receptors.J Neurosci. 2005;25:2566-2575.
10. Gao HM,Hong JS,Zhang W,Liu B.Distinct role for microglia in rotenone-induced degeneration of dopaminergic neurons.J Neurosci. 2002;22:782-790.
11. Gerber JS,Mosser DM.Reversing lipopolysaccharide toxicity by ligating the macrophage Fc gamma receptors.J Immunol. 2001;166:6861-6868.
12. Griffioen M,van Egmond EH,Kester MG,Willemze R,Falkenburg JH,Heemskerk MH.Retroviral transfer of human CD20 as a suicide gene for adoptive T-cell therapy.Haematologica. 2009;94:1316-1320.
13. Horstman LL,Jy W,Ahn YS,Maghzi AH,Etemadifar M,Alexander JS,McGee JC,Minagar A.Complement in neurobiology.Front Biosci. 2011;17:2921-2960.
14. Huang J,Sun X,Mao Y,Zhu X,Zhang P,Zhang L,Du J,Qiu X.Expression of immunoglobulin gene with classical V-(D)-J rearrangement in mouse brain neurons.Int J Biochem Cell Biol. 2008;40:1604-1615.
15. Hulse RE,Swenson WG,Kunkler PE,White DM,Kraig RP.Monomeric IgG is neuroprotective via enhancing microglial recycling endocytosis and TNF-alpha.J Neurosci. 2008;28:12199-12211.
16. Kerschensteiner M,Meinl E,Hohlfeld R.Neuro-immune crosstalk in CNS diseases.Neuroscience. 2009;158:1122-1132.
17. Lee G,Zhu M,Ge B,Potzold S.Widespread expressions of immunoglobulin superfamily proteins in cancer cells.Cancer Immunol Immunother. 2012;61:89-99.
18. Li YN,Qin XJ,Kuang F,Wu R,Duan XL,Ju G,Wang BR.Alterations of Fc gamma receptor I and Toll-like receptor 4 mediate the anti-inflammatory actions of microglia and astrocytes after adrenaline-induced blood-brain barrier opening in rats.J Neurosci Res. 2008;86:3556-3565.
19. Maloney EK,McLaughlin JL,Dagdigian NE,Garrett LM,Connors KM,Zhou XM,Blattler WA,Chittenden T,Singh R.An anti-insulin-like growth factor I receptor antibody that is a potent inhibitor of cancer cell proliferation.Cancer Res. 2003;63:5073-5083.
20. Mix E,Goertsches R,Zettl UK.Immunology and neurology.J Neurol. 2007;254:II2-7.
21. Mohamed HA,Mosier DR,Zou LL,Siklos L,Alexianu ME,Engelhardt JI,Beers DR,Le WD,Appel SH.Immunoglobulin Fc gamma receptor promotes immunoglobulin uptake, immunoglobulin-mediated calcium increase, and neurotransmitter release in motor neurons.J Neurosci. Res. 2002;69:110-116.
22. Nakahara J,Tan-Takeuchi K,Seiwa C,Gotoh M,Kaifu T,Ujike A,Inui M,Yagi T,Ogawa M,Aiso S,Takai T,Asou H.Signaling via immunoglobulin Fc receptors induces oligodendrocyte precursor cell differentiation.Dev Cell. 2003;4:841-852.
23. Niu N,Zhang J,Guo Y,Yang C,Gu J.Cystic fibrosis transmembrane conductance regulator expression in human spinal and sympathetic ganglia.Lab Invest. 2009;89:636-644.
24. Niu N,Zhang J,Guo Y,Zhao Y,Korteweg C,Gu J.Expression and distribution of immunoglobulin G and its receptors in the human nervous system.Int J Biochem Cell Biol. 2011a;43:556-563.
25. Niu N,Zhang J,Sun Y,Wang S,Sun Y,Korteweg C,Gao W,Gu J.Expression and distribution of immunoglobulin G and its receptors in an immune privileged site: the eye.Cell Mol Life Sci. 2011b;68:2481-2492.
26. Panaro MA,Cianciulli A.Current opinions and perspectives on the role of immune system in the pathogenesis of Parkinson's disease.Curr Pharm Des. 2012;18:200-208.
27. Qiu X,Zhu X,Zhang L,Mao Y,Zhang J,Hao P,Li G,Lv P,Li Z,Sun X,Wu L,Zheng J,Deng Y,Hou C,Tang P,Zhang S,Zhang Y.Human epithelial cancers secrete immunoglobulin g with unidentified specificity to promote growth and survival of tumor cells.Cancer Res. 2003;63:6488-6495.
28. Reiber H,Ungefehr S,Jacobi C.The intrathecal, polyspecific and oligoclonal immune response in multiple sclerosis.Mult Scler. 1998;4:111-117.
29. Thompson EJ,Riches PG,Kohn J.Antibody synthesis within the central nervous system: comparisons of CSF IgG indices and electrophoresis.J Clin Pathol. 1983;36:312-315.
30. Upender MB,Dunn JA,Wilson SM,Naegele JR.Immunoglobulin molecules are present in early-generated neuronal populations in the rat cerebral cortex and retina.J Comp Neurol. 1997;384:271-282.
31. Wang XJ,Yan ZQ,Lu GQ,Stuart S,Chen SD.Parkinson disease IgG and C5a-induced synergistic dopaminergic neurotoxicity: role of microglia.Neurochem Int. 2007;50:39-50.
32. Woodruff TM,Ager RR,Tenner AJ,Noakes PG,Taylor SM.The role of the complement system and the activation fragment C5a in the central nervous system.Neuromolecular Med. 2010;12:179-192.
33. Zhao X,Singh S,Pardoux C,Zhao J,Hsi ED,Abo A,Korver W.Targeting C-type lectin-like molecule-1 for antibody-mediated immunotherapy in acute myeloid leukemia.Haematologica. 2010;95:71-78.