메뉴 건너뛰기




Volumn 34, Issue 6, 2013, Pages 4033-4057

Candidate epitopes for measurement of hCG and related molecules: The second ISOBM TD-7 workshop

Author keywords

Antibody standardization; Epitope standardization; hCG IRR; hCG variants measurement; International standards for hCG

Indexed keywords

CHORIONIC GONADOTROPIN ANTIBODY; CHORIONIC GONADOTROPIN BETA SUBUNIT; CHORIONIC GONADOTROPIN DERIVATIVE; EPITOPE; HCG BETA CF; HCG BETA N; HCG N; UNCLASSIFIED DRUG;

EID: 84888349473     PISSN: 10104283     EISSN: 14230380     Source Type: Journal    
DOI: 10.1007/s13277-013-0994-6     Document Type: Article
Times cited : (29)

References (72)
  • 1
    • 0036124932 scopus 로고    scopus 로고
    • The isobm td-7 workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis:assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives
    • Berger P, Sturgeon C, Bidart JM, Paus E, Gerth R, Niang M, et al. The isobm td-7 workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis:assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives. Tumor Biol. 2002;23:1-38.
    • (2002) Tumor Biol , vol.23 , pp. 1-38
    • Berger, P.1    Sturgeon, C.2    Bidart, J.M.3    Paus, E.4    Gerth, R.5    Niang, M.6
  • 2
    • 3042600899 scopus 로고    scopus 로고
    • Human chorionic gonadotropin in cancer
    • 15234236 10.1016/j.clinbiochem.2004.05.008 1:CAS:528:DC%2BD2cXltl2gtb8%3D
    • Stenman UH, Alfthan H, Hotakainen K. Human chorionic gonadotropin in cancer. Clin Biochem. 2004;37:549-61.
    • (2004) Clin Biochem , vol.37 , pp. 549-561
    • Stenman, U.H.1    Alfthan, H.2    Hotakainen, K.3
  • 4
    • 0020888557 scopus 로고
    • The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone
    • 6319099 10.1089/dna.1983.2.281 1:CAS:528:DyaL2cXotVKjtw%3D%3D
    • Talmadge K, Boorstein WR, Fiddes JC. The human genome contains seven genes for the beta-subunit of chorionic gonadotropin but only one gene for the beta-subunit of luteinizing hormone. DNA. 1983;2:281-9.
    • (1983) DNA , vol.2 , pp. 281-289
    • Talmadge, K.1    Boorstein, W.R.2    Fiddes, J.C.3
  • 5
    • 0019166519 scopus 로고
    • The cdna for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3′-untranslated region
    • 6774259 10.1038/286684a0 1:CAS:528:DyaL3MXhtFOnsw%3D%3D
    • Fiddes JC, Goodman HM. The cdna for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3′-untranslated region. Nature. 1980;286:684-7.
    • (1980) Nature , vol.286 , pp. 684-687
    • Fiddes, J.C.1    Goodman, H.M.2
  • 6
    • 68149169590 scopus 로고    scopus 로고
    • Differences in recognition of the 1st who international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin
    • 19541864 10.1373/clinchem.2009.124578 1:CAS:528:DC%2BD1MXptleis7o%3D
    • Sturgeon CM, Berger P, Bidart JM, Birken S, Burns C, Norman RJ, et al. Differences in recognition of the 1st who international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin. Clin Chem. 2009;55:1484-91.
    • (2009) Clin Chem , vol.55 , pp. 1484-1491
    • Sturgeon, C.M.1    Berger, P.2    Bidart, J.M.3    Birken, S.4    Burns, C.5    Norman, R.J.6
  • 7
    • 0018667990 scopus 로고
    • Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin
    • 481597 10.1038/281351a0 1:CAS:528:DyaL3cXntFagtg%3D%3D
    • Fiddes JC, Goodman HM. Isolation, cloning and sequence analysis of the cDNA for the alpha-subunit of human chorionic gonadotropin. Nature. 1979;281:351-6.
    • (1979) Nature , vol.281 , pp. 351-356
    • Fiddes, J.C.1    Goodman, H.M.2
  • 9
    • 0037232959 scopus 로고    scopus 로고
    • Preparation and characterization of new who reference reagents for human chorionic gonadotropin and metabolites
    • 12507971 10.1373/49.1.144 1:CAS:528:DC%2BD3sXktFGmug%3D%3D
    • Birken S, Berger P, Bidart JM, Weber M, Bristow A, Norman R, et al. Preparation and characterization of new who reference reagents for human chorionic gonadotropin and metabolites. Clin Chem. 2003;49:144-54.
    • (2003) Clin Chem , vol.49 , pp. 144-154
    • Birken, S.1    Berger, P.2    Bidart, J.M.3    Weber, M.4    Bristow, A.5    Norman, R.6
  • 10
    • 36348986740 scopus 로고    scopus 로고
    • Nonassembled human chorionic gonadotropin subunits and {alpha}{alpha}-homodimers use fast-track processing in the secretory pathway in contrast to {alpha}{beta}-heterodimers
    • 17761764 10.1210/en.2007-0789 1:CAS:528:DC%2BD2sXhsVers7%2FJ
    • Merz WE, Krause JM, Roig J, Singh V, Berger P. Nonassembled human chorionic gonadotropin subunits and {alpha}{alpha}-homodimers use fast-track processing in the secretory pathway in contrast to {alpha}{beta}-heterodimers. Endocrinology. 2007;148:5831-41.
    • (2007) Endocrinology , vol.148 , pp. 5831-5841
    • Merz, W.E.1    Krause, J.M.2    Roig, J.3    Singh, V.4    Berger, P.5
  • 11
    • 33751383272 scopus 로고    scopus 로고
    • Site-specific glycan analysis of human chorionic gonadotropin beta-subunit from malignancies and pregnancy by liquid chromatography- electrospray mass spectrometry
    • 16880503 10.1093/glycob/cwl034 1:CAS:528:DC%2BD28Xht1yksb7E
    • Valmu L, Alfthan H, Hotakainen K, Birken S, Stenman UH. Site-specific glycan analysis of human chorionic gonadotropin beta-subunit from malignancies and pregnancy by liquid chromatography-electrospray mass spectrometry. Glycobiology. 2006;16:1207-18.
    • (2006) Glycobiology , vol.16 , pp. 1207-1218
    • Valmu, L.1    Alfthan, H.2    Hotakainen, K.3    Birken, S.4    Stenman, U.H.5
  • 12
    • 33745961481 scopus 로고    scopus 로고
    • Glycosylation patterns of human chorionic gonadotropin revealed by liquid chromatography-mass spectrometry and bioinformatics
    • 16817158 10.1002/elps.200600022 1:CAS:528:DC%2BD28XnslCntrc%3D
    • Toll H, Berger P, Hofmann A, Hildebrandt A, Oberacher H, Lenhof HP, et al. Glycosylation patterns of human chorionic gonadotropin revealed by liquid chromatography-mass spectrometry and bioinformatics. Electrophoresis. 2006;27:2734-46.
    • (2006) Electrophoresis , vol.27 , pp. 2734-2746
    • Toll, H.1    Berger, P.2    Hofmann, A.3    Hildebrandt, A.4    Oberacher, H.5    Lenhof, H.P.6
  • 13
    • 0028302016 scopus 로고
    • A change in the isoforms of human chorionic gonadotropin occurs around the 13th week of gestation
    • 7515388 10.1210/jc.78.6.1419 1:CAS:528:DyaK2cXksFSgsrs%3D
    • Wide L, Lee JY, Rasmussen C. A change in the isoforms of human chorionic gonadotropin occurs around the 13th week of gestation. J Clin Endocrinol Metab. 1994;78:1419-23.
    • (1994) J Clin Endocrinol Metab , vol.78 , pp. 1419-1423
    • Wide, L.1    Lee, J.Y.2    Rasmussen, C.3
  • 14
    • 0031155522 scopus 로고    scopus 로고
    • Analysis of chorionic gonadotrophin secreted by cultured human blastocysts
    • 9239741 10.1093/molehr/3.6.517 1:CAS:528:DyaK2sXkslOltr4%3D
    • Lopata A, Oliva K, Stanton PG, Robertson DM. Analysis of chorionic gonadotrophin secreted by cultured human blastocysts. Mol Hum Reprod. 1997;3:517-21.
    • (1997) Mol Hum Reprod , vol.3 , pp. 517-521
    • Lopata, A.1    Oliva, K.2    Stanton, P.G.3    Robertson, D.M.4
  • 15
    • 18344364663 scopus 로고    scopus 로고
    • Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: Preliminary characterization of the hyperglycosylated hCG epitope
    • 11874698 10.1677/joe.0.1720497 1:CAS:528:DC%2BD38XisVShtr0%3D
    • Kovalevskaya G, Birken S, Kakuma T, Ozaki N, Sauer M, Lindheim S, et al. Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope. J Endocrinol. 2002;172:497-506.
    • (2002) J Endocrinol , vol.172 , pp. 497-506
    • Kovalevskaya, G.1    Birken, S.2    Kakuma, T.3    Ozaki, N.4    Sauer, M.5    Lindheim, S.6
  • 16
    • 0022515656 scopus 로고
    • Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophoblastic tumors
    • 3004921 10.1210/endo-118-4-1558 1:CAS:528:DyaL28XitVSntb8%3D
    • Mann K, Schneider N, Hoermann R. Thyrotropic activity of acidic isoelectric variants of human chorionic gonadotropin from trophoblastic tumors. Endocrinology. 1986;118:1558-66.
    • (1986) Endocrinology , vol.118 , pp. 1558-1566
    • Mann, K.1    Schneider, N.2    Hoermann, R.3
  • 17
    • 0027268251 scopus 로고
    • Variants of human chorionic gonadotropin from pregnant women and tumor patients recognized by monoclonal antibodies
    • 7688376 10.1210/jc.77.2.347 1:STN:280:DyaK3szks1Gntw%3D%3D
    • Berger P, Schwarz S, Spottl G, Wick G, Mann K. Variants of human chorionic gonadotropin from pregnant women and tumor patients recognized by monoclonal antibodies. J Clin Endocrinol Metab. 1993;77:347-51.
    • (1993) J Clin Endocrinol Metab , vol.77 , pp. 347-351
    • Berger, P.1    Schwarz, S.2    Spottl, G.3    Wick, G.4    Mann, K.5
  • 18
    • 0037236685 scopus 로고    scopus 로고
    • Tumor- and pregnancy-derived isoforms of human chorionic gonadotropin: Biological and diagnostic relevance
    • 12637792 10.1159/000069070 1:CAS:528:DC%2BD3sXjs12rs78%3D
    • Lottersberger C, Hoermann R, Mann K, Schwarz S, Berger P. Tumor- and pregnancy-derived isoforms of human chorionic gonadotropin: biological and diagnostic relevance. Horm Res. 2003;59:125-34.
    • (2003) Horm Res , vol.59 , pp. 125-134
    • Lottersberger, C.1    Hoermann, R.2    Mann, K.3    Schwarz, S.4    Berger, P.5
  • 19
    • 0031196046 scopus 로고    scopus 로고
    • Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma
    • 9449027 10.1007/BF02778058 1:CAS:528:DyaK2sXnslems7s%3D
    • Elliott MM, Kardana A, Lustbader JW, Cole LA. Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine. 1997;7:15-32.
    • (1997) Endocrine , vol.7 , pp. 15-32
    • Elliott, M.M.1    Kardana, A.2    Lustbader, J.W.3    Cole, L.A.4
  • 20
    • 22844437900 scopus 로고    scopus 로고
    • Specific measurement of o-linked core 2 sugar-containing isoforms of hyperglycosylated human chorionic gonadotropin by antibody b152
    • 15970647 10.1159/000086484 1:CAS:528:DC%2BD2MXmtVSntLs%3D
    • Birken S. Specific measurement of o-linked core 2 sugar-containing isoforms of hyperglycosylated human chorionic gonadotropin by antibody b152. Tumour Biol. 2005;26:131-41.
    • (2005) Tumour Biol , vol.26 , pp. 131-141
    • Birken, S.1
  • 21
    • 0027194130 scopus 로고
    • Immunochemical mapping of hCG and hCG-related molecules
    • 7690983 10.3109/00365519309086913 1:STN:280:DyaK3szptF2gug%3D%3D
    • Bidart JM, Birken S, Berger P, Krichevsky A. Immunochemical mapping of hCG and hCG-related molecules. Scand J Clin Lab Invest Suppl. 1993;216:118-36.
    • (1993) Scand J Clin Lab Invest Suppl , vol.216 , pp. 118-136
    • Bidart, J.M.1    Birken, S.2    Berger, P.3    Krichevsky, A.4
  • 23
    • 0023201168 scopus 로고
    • Immunochemical mapping of a specific domain on human choriogonadotropin using anti-protein and anti-peptide monoclonal antibodies
    • 2445737 1:CAS:528:DyaL2sXlvFWit70%3D
    • Bidart JM, Troalen F, Bohuon CJ, Hennen G, Bellet DH. Immunochemical mapping of a specific domain on human choriogonadotropin using anti-protein and anti-peptide monoclonal antibodies. J Biol Chem. 1987;262:15483-9.
    • (1987) J Biol Chem , vol.262 , pp. 15483-15489
    • Bidart, J.M.1    Troalen, F.2    Bohuon, C.J.3    Hennen, G.4    Bellet, D.H.5
  • 24
    • 0028205097 scopus 로고
    • The molecular basis for epitopes on the free beta-subunit of human chorionic gonadotrophin (hCG), its carboxyl-terminal peptide and the hCG beta-core fragment
    • 7516961 10.1677/joe.0.1410153 1:CAS:528:DyaK2cXktVWhsro%3D
    • Dirnhofer S, Madersbacher S, Bidart JM, Ten Kortenaar PB, Spottl G, Mann K, et al. The molecular basis for epitopes on the free beta-subunit of human chorionic gonadotrophin (hCG), its carboxyl-terminal peptide and the hCG beta-core fragment. J Endocrinol. 1994;141:153-62.
    • (1994) J Endocrinol , vol.141 , pp. 153-162
    • Dirnhofer, S.1    Madersbacher, S.2    Bidart, J.M.3    Ten Kortenaar, P.B.4    Spottl, G.5    Mann, K.6
  • 25
    • 0019844006 scopus 로고
    • Production and characterization of monoclonal antibodies against bovine luteinizing hormone
    • 7319540 10.1016/S0171-2985(81)80047-2 1:CAS:528:DyaL38Xotlyktw%3D%3D
    • Kofler R, Kalchschmid E, Berger P, Wick G. Production and characterization of monoclonal antibodies against bovine luteinizing hormone. Immunobiology. 1981;160:196-207.
    • (1981) Immunobiology , vol.160 , pp. 196-207
    • Kofler, R.1    Kalchschmid, E.2    Berger, P.3    Wick, G.4
  • 26
    • 0020436380 scopus 로고
    • Monoclonal antibodies against human chorionic gonadotropin (hCG): I. Production, specificity, and intramolecular binding sites
    • 6814270 10.1111/j.1600-0897.1982.tb00168.x 1:CAS:528:DyaL38XmtFeqt7w%3D
    • Kofler R, Berger P, Wick G. Monoclonal antibodies against human chorionic gonadotropin (hCG): I. Production, specificity, and intramolecular binding sites. Am J Reprod Immunol. 1982;2:212-6.
    • (1982) Am J Reprod Immunol , vol.2 , pp. 212-216
    • Kofler, R.1    Berger, P.2    Wick, G.3
  • 28
    • 0021961043 scopus 로고
    • Molecular morphology of placental and pituitary hormones: Epitope mapping with monoclonal antibodies
    • 2413635 1:CAS:528:DyaL2MXkvFyrsLw%3D
    • Berger P. molecular morphology of placental and pituitary hormones: epitope mapping with monoclonal antibodies. Wien Klin Wochenschr. 1985;97:573-81.
    • (1985) Wien Klin Wochenschr , vol.97 , pp. 573-581
    • Berger, P.1
  • 29
    • 0023131051 scopus 로고
    • The immune response to a synthetic peptide analogous to the 109-145 beta hCG carboxyl-terminus is directed against two major and two minor regions
    • 2443832 10.1016/0161-5890(87)90175-1 1:CAS:528:DyaL2sXksFOjsbc%3D
    • Bidart JM, Bellet DH, Alberici GF, Van Besien F, Bohuon C. The immune response to a synthetic peptide analogous to the 109-145 beta hCG carboxyl-terminus is directed against two major and two minor regions. Mol Immunol. 1987;24:339-45.
    • (1987) Mol Immunol , vol.24 , pp. 339-345
    • Bidart, J.M.1    Bellet, D.H.2    Alberici, G.F.3    Van Besien, F.4    Bohuon, C.5
  • 30
    • 0023791893 scopus 로고
    • Antigenic features of human follicle stimulating hormone delineated by monoclonal antibodies and construction of an immunoradiomometric assay
    • 2458911 10.1210/endo-123-5-2351 1:CAS:528:DyaL1MXhtVej
    • Berger P, Panmoung W, Khaschabi D, Mayregger B, Wick G. Antigenic features of human follicle stimulating hormone delineated by monoclonal antibodies and construction of an immunoradiomometric assay. Endocrinology. 1988;123:2351-9.
    • (1988) Endocrinology , vol.123 , pp. 2351-2359
    • Berger, P.1    Panmoung, W.2    Khaschabi, D.3    Mayregger, B.4    Wick, G.5
  • 31
    • 0025232722 scopus 로고
    • Monoclonal antibodies against the free subunits of human chorionic gonadotrophin
    • 1695661 10.1677/joe.0.1250301 1:CAS:528:DyaK3cXitFWjtLs%3D
    • Berger P, Klieber R, Panmoung W, Madersbacher S, Wolf H, Wick G. Monoclonal antibodies against the free subunits of human chorionic gonadotrophin. J Endocrinol. 1990;125:301-9.
    • (1990) J Endocrinol , vol.125 , pp. 301-309
    • Berger, P.1    Klieber, R.2    Panmoung, W.3    Madersbacher, S.4    Wolf, H.5    Wick, G.6
  • 32
    • 0021948345 scopus 로고
    • Identification of epitopes associated with hCG and the beta hCG carboxyl terminus by monoclonal antibodies produced against a synthetic peptide
    • 2578049 1:CAS:528:DyaL2MXmtVCgug%3D%3D
    • Bidart JM, Ozturk M, Bellet DH, Jolivet M, Gras-Masse H, Troalen F, et al. Identification of epitopes associated with hCG and the beta hCG carboxyl terminus by monoclonal antibodies produced against a synthetic peptide. J Immunol. 1985;134:457-64.
    • (1985) J Immunol , vol.134 , pp. 457-464
    • Bidart, J.M.1    Ozturk, M.2    Bellet, D.H.3    Jolivet, M.4    Gras-Masse, H.5    Troalen, F.6
  • 33
    • 11144348654 scopus 로고    scopus 로고
    • Establishment, value assignment, and characterization of new who reference reagents for six molecular forms of human chorionic gonadotropin
    • 15514095 10.1373/clinchem.2004.038679 1:CAS:528:DC%2BD2MXlt1ymtw%3D%3D
    • Bristow A, Berger P, Bidart JM, Birken S, Norman R, Stenman UH, et al. Establishment, value assignment, and characterization of new who reference reagents for six molecular forms of human chorionic gonadotropin. Clin Chem. 2005;51:177-82.
    • (2005) Clin Chem , vol.51 , pp. 177-182
    • Bristow, A.1    Berger, P.2    Bidart, J.M.3    Birken, S.4    Norman, R.5    Stenman, U.H.6
  • 34
    • 0027431201 scopus 로고
    • Origin of the isoelectric heterogeneity of monoclonal immunoglobulin h1b4
    • 7904750 10.1023/A:1018912417607 1:CAS:528:DyaK2cXmsVyh
    • Tsai PK, Bruner MW, Irwin JI, Ip CC, Oliver CN, Nelson RW, et al. Origin of the isoelectric heterogeneity of monoclonal immunoglobulin h1b4. Pharm Res. 1993;10:1580-6.
    • (1993) Pharm Res , vol.10 , pp. 1580-1586
    • Tsai, P.K.1    Bruner, M.W.2    Irwin, J.I.3    Ip, C.C.4    Oliver, C.N.5    Nelson, R.W.6
  • 35
    • 0033755938 scopus 로고    scopus 로고
    • Determination of the origin of charge heterogeneity in a murine monoclonal antibody
    • 11087044 10.1023/A:1026461830617 1:CAS:528:DC%2BD3cXnvFWhtbo%3D
    • Perkins M, Theiler R, Lunte S, Jeschke M. Determination of the origin of charge heterogeneity in a murine monoclonal antibody. Pharm Res. 2000;17:1110-7.
    • (2000) Pharm Res , vol.17 , pp. 1110-1117
    • Perkins, M.1    Theiler, R.2    Lunte, S.3    Jeschke, M.4
  • 36
    • 0034429880 scopus 로고    scopus 로고
    • Antibodies and immunoassays
    • 10764605 10.1006/meth.2000.0973 1:CAS:528:DC%2BD3cXisVGitrg%3D
    • Madersbacher S, Berger P. Antibodies and immunoassays. Methods. 2000;21:41-50.
    • (2000) Methods , vol.21 , pp. 41-50
    • Madersbacher, S.1    Berger, P.2
  • 37
    • 0028328686 scopus 로고
    • Free alpha subunit of human chorionic gonadotrophin: Molecular basis of immunologically and biologically active domains
    • 7511152 10.1677/joe.0.1400145 1:CAS:528:DyaK2cXis1Wnu7o%3D
    • Dirnhofer S, Lechner O, Madersbacher S, Klieber R, de Leeuw R, Wick G, et al. Free alpha subunit of human chorionic gonadotrophin: Molecular basis of immunologically and biologically active domains. J Endocrinol. 1994;140:145-54.
    • (1994) J Endocrinol , vol.140 , pp. 145-154
    • Dirnhofer, S.1    Lechner, O.2    Madersbacher, S.3    Klieber, R.4    De Leeuw, R.5    Wick, G.6
  • 38
    • 0022636581 scopus 로고
    • The antigenic surface of human chorionic gonadotropin as mapped by murine monoclonal antibodies
    • 2416550 10.1210/endo-118-1-189 1:CAS:528:DyaL28Xos1KgsA%3D%3D
    • Schwarz S, Berger P, Wick G. The antigenic surface of human chorionic gonadotropin as mapped by murine monoclonal antibodies. Endocrinology. 1986;118:189-97.
    • (1986) Endocrinology , vol.118 , pp. 189-197
    • Schwarz, S.1    Berger, P.2    Wick, G.3
  • 39
    • 0032985193 scopus 로고    scopus 로고
    • Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: Generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG
    • 10451222 10.1385/ENDO:10:2:137 1:CAS:528:DyaK1MXktFamtLk%3D
    • Birken S, Krichevsky A, O'Connor J, Schlatterer J, Cole L, Kardana A, et al. Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: Generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG. Endocrine. 1999;10:137-44.
    • (1999) Endocrine , vol.10 , pp. 137-144
    • Birken, S.1    Krichevsky, A.2    O'Connor, J.3    Schlatterer, J.4    Cole, L.5    Kardana, A.6
  • 40
    • 0022467905 scopus 로고
    • Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains)
    • 2417241 10.1073/pnas.83.2.226 1:CAS:528:DyaL28XhtVOmtr8%3D
    • Novotny J, Handschumacher M, Haber E, Bruccoleri RE, Carlson WB, Fanning DW, et al. Antigenic determinants in proteins coincide with surface regions accessible to large probes (antibody domains). Proc Natl Acad Sci USA. 1986;83:226-30.
    • (1986) Proc Natl Acad Sci USA , vol.83 , pp. 226-230
    • Novotny, J.1    Handschumacher, M.2    Haber, E.3    Bruccoleri, R.E.4    Carlson, W.B.5    Fanning, D.W.6
  • 41
    • 0025781576 scopus 로고
    • The antigenic structure of the human glycoprotein hormone alpha-subunit: Iii Solution- and solid-phase mapping using synthetic peptides
    • 2036968 10.1210/endo-128-6-2907 1:CAS:528:DyaK3MXkt1ansr4%3D
    • Charlesworth MC, Bergert ER, Morris JC, McCormick DJ, Ryan RJ. The antigenic structure of the human glycoprotein hormone alpha-subunit: Iii Solution- and solid-phase mapping using synthetic peptides. Endocrinology. 1991;128:2907-15.
    • (1991) Endocrinology , vol.128 , pp. 2907-2915
    • Charlesworth, M.C.1    Bergert, E.R.2    Morris, J.C.3    McCormick, D.J.4    Ryan, R.J.5
  • 42
    • 0030220279 scopus 로고    scopus 로고
    • Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit
    • 8887120 10.1016/0165-0378(96)00978-3 1:CAS:528:DyaK28XmtFWgtrk%3D
    • Jackson AM, Klonisch T, Lapthorn AJ, Berger P, Isaacs NW, Delves PJ, et al. Identification and selective destruction of shared epitopes in human chorionic gonadotropin beta subunit. J Reprod Immunol. 1996;31:21-36.
    • (1996) J Reprod Immunol , vol.31 , pp. 21-36
    • Jackson, A.M.1    Klonisch, T.2    Lapthorn, A.J.3    Berger, P.4    Isaacs, N.W.5    Delves, P.J.6
  • 43
    • 2342562475 scopus 로고    scopus 로고
    • The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin
    • 15072560 10.1677/jme.0.0320571 1:CAS:528:DC%2BD2cXjslKjtL8%3D
    • Charrel-Dennis M, Jackson AM, Lund T, Lapthorn AJ, Berger P, Roitt IM, et al. The major hormone-specific discontinuous epitopes on human chorionic gonadotrophin. J Mol Endocrinol. 2004;32:571-81.
    • (2004) J Mol Endocrinol , vol.32 , pp. 571-581
    • Charrel-Dennis, M.1    Jackson, A.M.2    Lund, T.3    Lapthorn, A.J.4    Berger, P.5    Roitt, I.M.6
  • 44
    • 0027787424 scopus 로고
    • Antibody response against epitopes on hCG mapped by monoclonal antibodies in women immunized with an anti-hCG vaccine and its implications for bioneutralization
    • 7513023 10.1016/0165-0378(93)90052-J 1:CAS:528:DyaK2cXktVWhs7Y%3D
    • Deshmukh US, Pal R, Talwar GP, Gupta SK. Antibody response against epitopes on hCG mapped by monoclonal antibodies in women immunized with an anti-hCG vaccine and its implications for bioneutralization. J Reprod Immunol. 1993;25:103-17.
    • (1993) J Reprod Immunol , vol.25 , pp. 103-117
    • Deshmukh, U.S.1    Pal, R.2    Talwar, G.P.3    Gupta, S.K.4
  • 46
    • 0017998988 scopus 로고
    • A proposal for the nomenclature of antigenic sites in peptides and proteins
    • 83294 10.1016/0161-5890(78)90016-0 1:CAS:528:DyaE1MXksFCgu7s%3D
    • Atassi MZ, Smith JA. A proposal for the nomenclature of antigenic sites in peptides and proteins. Immunochemistry. 1978;15:609-10.
    • (1978) Immunochemistry , vol.15 , pp. 609-610
    • Atassi, M.Z.1    Smith, J.A.2
  • 47
    • 0028773646 scopus 로고
    • Structure of human chorionic gonadotropin at 2.6 a resolution from mad analysis of the selenomethionyl protein
    • 7922031 10.1016/S0969-2126(00)00054-X 1:CAS:528:DyaK2MXlslyjsA%3D%3D
    • Wu H, Lustbader JW, Liu Y, Canfield RE, Hendrickson WA. Structure of human chorionic gonadotropin at 2.6 a resolution from mad analysis of the selenomethionyl protein. Structure. 1994;2:545-58.
    • (1994) Structure , vol.2 , pp. 545-558
    • Wu, H.1    Lustbader, J.W.2    Liu, Y.3    Canfield, R.E.4    Hendrickson, W.A.5
  • 48
    • 0025850719 scopus 로고
    • Number and topography of epitopes of human chorionic gonadotropin (hCG) are shared by desialylated and deglycosylated hCG
    • 1720102 10.1016/0303-7207(91)90140-N 1:CAS:528:DyaK3MXmt1ersrk%3D
    • Schwarz S, Krude H, Klieber R, Dirnhofer S, Lottersberger C, Merz WE, et al. Number and topography of epitopes of human chorionic gonadotropin (hCG) are shared by desialylated and deglycosylated hCG. Mol Cell Endocrinol. 1991;80:33-40.
    • (1991) Mol Cell Endocrinol , vol.80 , pp. 33-40
    • Schwarz, S.1    Krude, H.2    Klieber, R.3    Dirnhofer, S.4    Lottersberger, C.5    Merz, W.E.6
  • 49
    • 0030596016 scopus 로고    scopus 로고
    • Metabolism of hCG and hLH to multiple urinary forms
    • 9027350 10.1016/S0303-7207(96)03942-1 1:CAS:528:DyaK2sXksVSktQ%3D%3D
    • Birken S, Kovalevskaya G, O'Connor J. Metabolism of hCG and hLH to multiple urinary forms. Mol Cell Endocrinol. 1996;125:121-31.
    • (1996) Mol Cell Endocrinol , vol.125 , pp. 121-131
    • Birken, S.1    Kovalevskaya, G.2    O'Connor, J.3
  • 50
    • 0032935044 scopus 로고    scopus 로고
    • Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG
    • 10194533 10.1677/joe.0.1610099 1:CAS:528:DyaK1MXktVekt7Y%3D
    • Kovalevskaya G, Birken S, Kakuma T, O'Connor JF. Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. J Endocrinol. 1999;161:99-106.
    • (1999) J Endocrinol , vol.161 , pp. 99-106
    • Kovalevskaya, G.1    Birken, S.2    Kakuma, T.3    O'Connor, J.F.4
  • 51
    • 0038445994 scopus 로고    scopus 로고
    • Analysis of human choriogonadotropin core 2 o-glycan isoforms
    • 12850278 10.1016/S0303-7207(03)00153-9 1:CAS:528:DC%2BD3sXltF2hurs%3D
    • Birken S, Yershova O, Myers RV, Bernard MP, Moyle W. Analysis of human choriogonadotropin core 2 o-glycan isoforms. Mol Cell Endocrinol. 2003;204:21-30.
    • (2003) Mol Cell Endocrinol , vol.204 , pp. 21-30
    • Birken, S.1    Yershova, O.2    Myers, R.V.3    Bernard, M.P.4    Moyle, W.5
  • 52
    • 2142765292 scopus 로고    scopus 로고
    • Between-method variation in human chorionic gonadotropin test results
    • 15016725 10.1373/clinchem.2003.026989 1:CAS:528:DC%2BD2cXjvVakt7k%3D
    • Cole LA, Sutton JM, Higgins TN, Cembrowski GS. Between-method variation in human chorionic gonadotropin test results. Clin Chem. 2004;50:874-82.
    • (2004) Clin Chem , vol.50 , pp. 874-882
    • Cole, L.A.1    Sutton, J.M.2    Higgins, T.N.3    Cembrowski, G.S.4
  • 53
    • 0023711893 scopus 로고
    • Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine
    • 2454811 10.1210/endo-123-1-572 1:CAS:528:DyaL1cXltVCqtr0%3D
    • Birken S, Armstrong EG, Kolks MA, Cole LA, Agosto GM, Krichevsky A, et al. Structure of the human chorionic gonadotropin beta-subunit fragment from pregnancy urine. Endocrinology. 1988;123:572-83.
    • (1988) Endocrinology , vol.123 , pp. 572-583
    • Birken, S.1    Armstrong, E.G.2    Kolks, M.A.3    Cole, L.A.4    Agosto, G.M.5    Krichevsky, A.6
  • 54
    • 77953395440 scopus 로고    scopus 로고
    • Human chorionic gonadotropin isoforms and their epitopes: Diagnostic utility in pregnancy and cancer
    • 1:CAS:528:DC%2BD1MXotFOhtA%3D%3D
    • Berger P, Sturgeon C. Human chorionic gonadotropin isoforms and their epitopes: diagnostic utility in pregnancy and cancer. Expert OpinMedDiagn. 2008;2:1347-64.
    • (2008) Expert OpinMedDiagn , vol.2 , pp. 1347-1364
    • Berger, P.1    Sturgeon, C.2
  • 55
    • 0027449147 scopus 로고
    • Functional and immunological relevance of the COOH-terminal extension of human chorionic gonadotropin beta: Implications for the who birth control vaccine
    • 7693535 1:CAS:528:DyaK2cXht1Gitrg%3D
    • Dirnhofer S, Klieber R, De Leeuw R, Bidart JM, Merz WE, Wick G, et al. Functional and immunological relevance of the COOH-terminal extension of human chorionic gonadotropin beta: implications for the who birth control vaccine. FASEB J. 1993;7:1381-5.
    • (1993) FASEB J , vol.7 , pp. 1381-1385
    • Dirnhofer, S.1    Klieber, R.2    De Leeuw, R.3    Bidart, J.M.4    Merz, W.E.5    Wick, G.6
  • 56
    • 0028586148 scopus 로고
    • Immunological recognition and clinical significance of nicked human chorionic gonadotropin in testicular cancer
    • 7527309 1:CAS:528:DyaK2MXislKnsbg%3D
    • Hoermann R, Berger P, Spoettl G, Gillesberger F, Kardana A, Cole LA, et al. Immunological recognition and clinical significance of nicked human chorionic gonadotropin in testicular cancer. Clin Chem. 1994;40:2306-12.
    • (1994) Clin Chem , vol.40 , pp. 2306-2312
    • Hoermann, R.1    Berger, P.2    Spoettl, G.3    Gillesberger, F.4    Kardana, A.5    Cole, L.A.6
  • 57
    • 78649889996 scopus 로고    scopus 로고
    • Falsely decreased human chorionic gonadotropin (hCG) results due to increased concentrations of the free beta subunit and the beta core fragment in quantitative hCG assays
    • 20930131 10.1373/clinchem.2010.143479 1:CAS:528:DC%2BC3cXhsF2js7zM
    • Grenache DG, Greene DN, Dighe AS, Fantz CR, Hoefner D, McCudden C, et al. Falsely decreased human chorionic gonadotropin (hCG) results due to increased concentrations of the free beta subunit and the beta core fragment in quantitative hCG assays. Clin Chem. 2010;56:1839-44.
    • (2010) Clin Chem , vol.56 , pp. 1839-1844
    • Grenache, D.G.1    Greene, D.N.2    Dighe, A.S.3    Fantz, C.R.4    Hoefner, D.5    McCudden, C.6
  • 58
    • 0025181978 scopus 로고
    • Diagnostic value of free subunits of serum chorionic gonadotropin in testicular cancer
    • 1975400 10.1016/0140-6736(90)93428-R 1:STN:280:DyaK3czmtlSntQ%3D%3D
    • Madersbacher S, Berger P, Mann K, Kuzmists R, Wick G. Diagnostic value of free subunits of serum chorionic gonadotropin in testicular cancer. Lancet. 1990;336:630-1.
    • (1990) Lancet , vol.336 , pp. 630-631
    • Madersbacher, S.1    Berger, P.2    Mann, K.3    Kuzmists, R.4    Wick, G.5
  • 59
    • 55349090621 scopus 로고    scopus 로고
    • Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer
    • 18787014 10.1373/clinchem.2008.108548 1:CAS:528:DC%2BD1cXhtlansr3E
    • Lempiainen A, Stenman UH, Blomqvist C, Hotakainen K. Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer. Clin Chem. 2008;54:1840-3.
    • (2008) Clin Chem , vol.54 , pp. 1840-1843
    • Lempiainen, A.1    Stenman, U.H.2    Blomqvist, C.3    Hotakainen, K.4
  • 60
    • 33750218125 scopus 로고    scopus 로고
    • The classification, functions and clinical use of different isoforms of hCG
    • 16877746 10.1093/humupd/dml029 1:CAS:528:DC%2BD28XhtFeisbzJ
    • Stenman UH, Tiitinen A, Alfthan H, Valmu L. The classification, functions and clinical use of different isoforms of hCG. Hum Reprod Update. 2006;12:769-84.
    • (2006) Hum Reprod Update , vol.12 , pp. 769-784
    • Stenman, U.H.1    Tiitinen, A.2    Alfthan, H.3    Valmu, L.4
  • 61
    • 0026773430 scopus 로고
    • Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms
    • 1377600 1:CAS:528:DyaK38XlsVyhsb4%3D
    • Marcillac I, Troalen F, Bidart JM, Ghillani P, Ribrag V, Escudier B, et al. Free human chorionic gonadotropin beta subunit in gonadal and nongonadal neoplasms. Cancer Res. 1992;52:3901-7.
    • (1992) Cancer Res , vol.52 , pp. 3901-3907
    • Marcillac, I.1    Troalen, F.2    Bidart, J.M.3    Ghillani, P.4    Ribrag, V.5    Escudier, B.6
  • 62
    • 0026675258 scopus 로고
    • Elevation of free beta subunit of human choriogonadotropin and core beta fragment of human choriogonadotropin in the serum and urine of patients with malignant pancreatic and biliary disease
    • 1324787 1:CAS:528:DyaK38XlvV2htLs%3D
    • Alfthan H, Haglund C, Roberts P, Stenman UH. Elevation of free beta subunit of human choriogonadotropin and core beta fragment of human choriogonadotropin in the serum and urine of patients with malignant pancreatic and biliary disease. Cancer Res. 1992;52:4628-33.
    • (1992) Cancer Res , vol.52 , pp. 4628-4633
    • Alfthan, H.1    Haglund, C.2    Roberts, P.3    Stenman, U.H.4
  • 63
    • 0025276253 scopus 로고
    • Pregnancy serum contains the beta-core fragment of human choriogonadotropin
    • 1689741 10.1210/jcem-70-3-783 1:CAS:528:DyaK3cXitFWjt7k%3D
    • Alfthan H, Stenman UH. Pregnancy serum contains the beta-core fragment of human choriogonadotropin. J Clin Endocrinol Metab. 1990;70:783-7.
    • (1990) J Clin Endocrinol Metab , vol.70 , pp. 783-787
    • Alfthan, H.1    Stenman, U.H.2
  • 64
    • 0025314241 scopus 로고
    • Detection of a small molecular species of human chorionic gonadotropin in the urine of patients with carcinoma of the cervix and cervical intraepithelial neoplasia: Comparison with other assays for human chorionic gonadotropin and its fragments
    • 2344970 10.1016/0090-8258(90)90343-J 1:CAS:528:DyaK3cXmtV2is7Y%3D
    • Norman RJ, Buck RH, Aktar B, Mayet N, Moodley J. Detection of a small molecular species of human chorionic gonadotropin in the urine of patients with carcinoma of the cervix and cervical intraepithelial neoplasia: comparison with other assays for human chorionic gonadotropin and its fragments. Gynecol Oncol. 1990;37:254-9.
    • (1990) Gynecol Oncol , vol.37 , pp. 254-259
    • Norman, R.J.1    Buck, R.H.2    Aktar, B.3    Mayet, N.4    Moodley, J.5
  • 65
    • 0023857938 scopus 로고
    • Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its beta-subunit, and beta core fragment in the urine: Application to malignancies
    • 2449279
    • O'Connor JF, Schlatterer JP, Birken S, Krichevsky A, Armstrong EG, McMahon D, et al. Development of highly sensitive immunoassays to measure human chorionic gonadotropin, its beta-subunit, and beta core fragment in the urine: application to malignancies. Cancer Res. 1988;48:1361-6.
    • (1988) Cancer Res , vol.48 , pp. 1361-1366
    • O'Connor, J.F.1    Schlatterer, J.P.2    Birken, S.3    Krichevsky, A.4    Armstrong, E.G.5    McMahon, D.6
  • 66
    • 0022239277 scopus 로고
    • Epitope-selective, monoclonal-antibody-based immunoradiometric assays of predictable specificity for differential measurement of choriogonadotropin and its subunits
    • 2410164 1:CAS:528:DyaL2MXkvFyrsbo%3D
    • Schwarz S, Berger P, Wick G. Epitope-selective, monoclonal-antibody-based immunoradiometric assays of predictable specificity for differential measurement of choriogonadotropin and its subunits. Clin Chem. 1985;31:1322-8.
    • (1985) Clin Chem , vol.31 , pp. 1322-1328
    • Schwarz, S.1    Berger, P.2    Wick, G.3
  • 67
    • 0029842544 scopus 로고    scopus 로고
    • Enhancement in antigen binding by a combination of synergy and antibody capture
    • 8943709 10.1046/j.1365-2567.1996.d01-722.x 1:CAS:528:DyaK28Xmt1Kitbg%3D
    • Klonisch T, Panayotou G, Edwards P, Jackson AM, Berger P, Delves PJ, et al. Enhancement in antigen binding by a combination of synergy and antibody capture. Immunology. 1996;89:165-71.
    • (1996) Immunology , vol.89 , pp. 165-171
    • Klonisch, T.1    Panayotou, G.2    Edwards, P.3    Jackson, A.M.4    Berger, P.5    Delves, P.J.6
  • 68
    • 0023116880 scopus 로고
    • Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin-releasing hormone and sex steroids
    • 3546353 10.1210/jcem-64-4-730 1:CAS:528:DyaL2sXhs12gs70%3D
    • Stenman UH, Alfthan H, Ranta T, Vartiainen E, Jalkanen J, Seppala M. Serum levels of human chorionic gonadotropin in nonpregnant women and men are modulated by gonadotropin-releasing hormone and sex steroids. J Clin Endocrinol Metab. 1987;64:730-6.
    • (1987) J Clin Endocrinol Metab , vol.64 , pp. 730-736
    • Stenman, U.H.1    Alfthan, H.2    Ranta, T.3    Vartiainen, E.4    Jalkanen, J.5    Seppala, M.6
  • 69
    • 0026533499 scopus 로고
    • Free alpha-subunit, free beta-subunit of human chorionic gonadotropin (hCG), and intact hCG in sera of healthy individuals and testicular cancer patients
    • 1372196 1:CAS:528:DyaK38XlvVGisb4%3D
    • Madersbacher S, Klieber R, Mann K, Marth C, Tabarelli M, Wick G, et al. Free alpha-subunit, free beta-subunit of human chorionic gonadotropin (hCG), and intact hCG in sera of healthy individuals and testicular cancer patients. Clin Chem. 1992;38:370-6.
    • (1992) Clin Chem , vol.38 , pp. 370-376
    • Madersbacher, S.1    Klieber, R.2    Mann, K.3    Marth, C.4    Tabarelli, M.5    Wick, G.6
  • 70
    • 84863602687 scopus 로고    scopus 로고
    • Hyperglycosylated human chorionic gonadotropin in serum of testicular cancer patients
    • 22529110 10.1373/clinchem.2012.183723 1:CAS:528:DC%2BC38XhtVegsrvE
    • Lempiainen A, Hotakainen K, Blomqvist C, Alfthan H, Stenman UH. Hyperglycosylated human chorionic gonadotropin in serum of testicular cancer patients. Clin Chem. 2012;58:1123-9.
    • (2012) Clin Chem , vol.58 , pp. 1123-1129
    • Lempiainen, A.1    Hotakainen, K.2    Blomqvist, C.3    Alfthan, H.4    Stenman, U.H.5
  • 71
    • 0029835217 scopus 로고    scopus 로고
    • Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model
    • 8765037 10.1002/eji.1830260834 1:CAS:528:DyaK28XkvVOhsLk%3D
    • Klonisch T, Delves PJ, Berger P, Panayotou G, Lapthorn AJ, Isaacs NW, et al. Relative location of epitopes involved in synergistic antibody binding using human chorionic gonadotropin as a model. Eur J Immunol. 1996;26:1897-905.
    • (1996) Eur J Immunol , vol.26 , pp. 1897-1905
    • Klonisch, T.1    Delves, P.J.2    Berger, P.3    Panayotou, G.4    Lapthorn, A.J.5    Isaacs, N.W.6
  • 72
    • 22444450128 scopus 로고    scopus 로고
    • The human chorionic gonadotropin-beta arginine68 to glutamic acid substitution fixes the conformation of the c-terminal peptide
    • 15718290 10.1210/me.2004-0109 1:CAS:528:DC%2BD2MXlvFSkurs%3D
    • Charrel-Dennis M, Terrazzini N, McBride JD, Kaye P, Martensen PM, Justesen J, et al. The human chorionic gonadotropin-beta arginine68 to glutamic acid substitution fixes the conformation of the c-terminal peptide. Mol Endocrinol. 2005;19:1803-11.
    • (2005) Mol Endocrinol , vol.19 , pp. 1803-1811
    • Charrel-Dennis, M.1    Terrazzini, N.2    McBride, J.D.3    Kaye, P.4    Martensen, P.M.5    Justesen, J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.