Hyperglycosylated human chorionic gonadotropin in serum of testicular cancer patients

Clinical Chemistry

Volumn 58, Issue 7, 2012, Pages 1123-1129

  Lempiäinen, Anna ^a,b   Hotakainen, Kristina ^a,b   Blomqvist, Carl ^a   Alfthan, Henrik ^a   Stenman, Ulf Håkan ^a,b  

^a HELSINKI UNIVERSITY CENTRAL HOSPITAL   (Finland)

^b UNIVERSITY OF HELSINKI   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN BETA SUBUNIT;

ARTICLE; BIOASSAY; CANCER PATIENT; CANCER PROGNOSIS; CANCER RELAPSE; CANCER SURVIVAL; DIAGNOSTIC VALUE; FOLLOW UP; GLYCOSYLATION; HUMAN; IMMUNOFLUORESCENCE; MAJOR CLINICAL STUDY; PROGRESSION FREE SURVIVAL; SERUM; SURVIVAL TIME; TESTIS CANCER;

ADOLESCENT; ADULT; AGED; CHORIONIC GONADOTROPIN; CHORIONIC GONADOTROPIN, BETA SUBUNIT, HUMAN; DISEASE-FREE SURVIVAL; FLUOROIMMUNOASSAY; GLYCOSYLATION; HUMANS; MALE; MIDDLE AGED; NEOPLASM RECURRENCE, LOCAL; NEOPLASMS, GERM CELL AND EMBRYONAL; PROGNOSIS; SEMINOMA; SENSITIVITY AND SPECIFICITY; SERUM; TESTICULAR NEOPLASMS; TUMOR MARKERS, BIOLOGICAL; YOUNG ADULT;

EID: 84863602687     PISSN: 00099147     EISSN: 15308561     Source Type: Journal    
DOI: 10.1373/clinchem.2012.183723     Document Type: Article

References (26)

1. Townsend JS, Richardson LC, German RR. Incidence of testicular cancer in the united states, 1999-2004. Am J Mens Health 2010;4:353-60.
2. Mostofi FK, Sesterhenn IA, Davis CJ Jr. Immunopathology of germ cell tumors of the testis. Semin Diagn Pathol 1987;4:320-41. (Pubitemid 18065438)
3. Krege S, Beyer J, Souchon R, Albers P, Albrecht W, Algaba F, et al. European consensus conference on diagnosis and treatment of germ cell cancer: a report of the second meeting of the European Germ Cell Cancer Consensus Group (EGCCCG): part I. Eur Urol 2008;53:478-96.
4. Kovalevskaya G, Birken S, Kakuma T, O'Connor JF. Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. J Endocrinol 1999;161:99-106. (Pubitemid 29170196)
5. Kovalevskaya G, Genbacev O, Fisher SJ, Caceres E, O'Connor JF. Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG. Mol Cell Endocrinol 2002;194:147-55. (Pubitemid 35291929)
6. Cole LA, Khanlian SA, Riley JM, Butler SA. Hyperglycosylated hCG in gestational implantation and in choriocarcinoma and testicular germ cell malignancy tumorigenesis. J Reprod Med 2006;51:919-29. (Pubitemid 44788841)
7. Kelly LS, Birken S, Puett D. Determination of hyperglycosylated human chorionic gonadotropin produced by malignant gestational trophoblastic neoplasias and male germ cell tumors using a lectin-based immunoassay and surface plasmon resonance. Mol Cell Endocrinol 2007;260-262:33-9. (Pubitemid 44792349)
8. Valmu L, Alfthan H, Hotakainen K, Birken S, Stenman UH. Site-specific glycan analysis of human chorionic gonadotropin β-subunit from malignancies and pregnancy by liquid-chromatography-electrospray mass spectrometry. Glycobiology 2006;16:1207-18. (Pubitemid 44811584)
9. Cole LA, Butler SA, Khanlian SA, Giddings A, Muller CY, Seckl MJ, Kohorn EI. Gestational trophoblastic diseases, 2: hyperglycosylated hCG as a reliable marker of active neoplasia. Gynecol Oncol 2006;102:151-9. (Pubitemid 44063585)
10. Elliott MM, Kardana A, Lustbader JW, Cole LA. Carbohydrate and peptide structure of the alpha- and beta-subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine 1997;7:15-32. (Pubitemid 127483081)
11. Cole LA, Dai D, Butler SA, Leslie KK, Kohorn EI. Gestational trophoblastic diseases: 1. Pathophysiology of hyperglycosylated hCG. Gynecol Oncol 2006;102:145-50. (Pubitemid 44041655)
12. Hamada AL, Nakabayashi K, Sato A, Kiyoshi K, Takamatsu Y, Laoag-Fernandez JB, et al. Transfection of antisense chorionic gonadotropin beta gene into choriocarcinoma cells suppresses the cell proliferation and induces apoptosis. J Clin Endocrinol Metab 2005;90:4873-9. (Pubitemid 41159385)
13. Lempiäinen A, Stenman UH, Blomqvist C, Hotakainen K. Free beta-subunit of human chorionic gonadotropin in serum is a diagnostically sensitive marker of seminomatous testicular cancer. Clin Chem 2008;54:1840-3.
14. Sobin L, Wittekind C. UICC:TNM classification of malignant tumors. 6th ed. New York: Wiley-Liss; 2002.
15. Kardana A, Cole LA. The stability of hCG and free beta-subunit in serum samples. Prenat Diagn 1997;17:141-7. (Pubitemid 27092831)
16. Pettersson K, Siitari H, Hemmilä I, Soini E, Lövgren T, Hänninen V, et al. Time-resolved fluoroimmunoassay of human choriogonadotropin. Clin Chem 1983;29:60-4. (Pubitemid 13167621)
17. Stenman UH, Bidart JM, Birken S, Mann K, Nisula B, O'Connor J. Standardization of protein immunoprocedures. Choriogonadotropin (CG). Scand J Clin Lab Invest Suppl 1993;216:42-78. (Pubitemid 23213291)
18. Alfthan H, Haglund C, Dabek J, Stenman UH. Concentrations of human choriogonadotropin, its beta-subunit, and the core fragment of the beta-subunit in serum and urine of men and nonpregnant women. Clin Chem 1992;38:1981-7.
19. Lempiäinen A, Hotakainen K, Blomqvist C, Alfthan H, Stenman UH. Increased human chorionic gonadotropin due to hypogonadism after treatment of a testicular seminoma. Clin Chem 2007;53:1560-1. (Pubitemid 47206362)
20. Birken S, Krichevsky A, O'Connor J, Schlatterer J, Cole L, Kardana A, Canfield R. Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG. Endocrine 1999;10:137-44. (Pubitemid 29295787)
21. Stenman UH, Birken S, Lempiäinen A, Hotakainen K, Alfthan H. Elimination of complement interference in immunoassay of hyperglycosylated human chorionic gonadotropin. Clin Chem 2011;57:1075-7.
22. Birken S, Berger P, Bidart JM, Weber M, Bristow A, Norman R, et al. Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin and metabolites. Clin Chem 2003;49:144-54. (Pubitemid 36078564)
23. Bristow A, Berger P, Bidart JM, Birken S, Norman R, Stenman UH, Sturgeon C. Establishment, value assignment, and characterization of new WHO reference reagents for six molecular forms of human chorionic gonadotropin. Clin Chem 2005;51:177-82. (Pubitemid 40024028)
24. Sturgeon CM, Berger P, Bidart JM, Birken S, Burns C, Norman RJ, Stenman UH. Differences in recognition of the 1st WHO international reference reagents for hCG-related isoforms by diagnostic immunoassays for human chorionic gonadotropin. Clin Chem 2009;55:1484-91.
25. Cole LA, Sutton JM. Selecting an appropriate hCG test for managing gestational trophoblastic disease and cancer. J Reprod Med 2004;49:545-53. (Pubitemid 38944240)
26. Harvey RA, Mitchell HD, Stenman UH, Blankenstein MA, Nustad K, Stieber P, et al. Differences in total human chorionic gonadotropin immunoassay analytical specificity and ability to measure human chorionic gonadotropin in gestational trophoblastic disease and germ cell tumors. J Reprod Med 2010;55:285-95.