Analysis of human choriogonadotropin core 2 o-glycan isoforms

Molecular and Cellular Endocrinology

Volumn 204, Issue 1-2, 2003, Pages 21-30

  Birken, S ^a   Yershova, Oksana ^a   Myers, Rebecca V ^b   Bernard, Michael P ^b   Moyle, William ^b  

^a BB1608 ^*  (United States)

^b Robert Wood Johnson   (United States)

Author keywords

Glycoprotein hormone; hCG; Immunoassay; Isoforms; o Glycans

Indexed keywords

CHORIONIC GONADOTROPIN; EPITOPE; GLYCAN; ISOPROTEIN; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY B 152; MONOCLONAL ANTIBODY CTP 104; SERINE; UNCLASSIFIED DRUG;

ALPHA CHAIN; ANIMAL CELL; ANTIBODY AFFINITY; ANTIBODY COMBINING SITE; ANTIGEN BINDING; ARTICLE; BETA CHAIN; BINDING ASSAY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; ENZYME ACTIVITY; HORMONE BINDING; HUMAN; IMMUNOASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; QUANTITATIVE ANALYSIS;

EID: 0038445994     PISSN: 03037207     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0303-7207(03)00153-9     Document Type: Article

References (39)

1. Amano J., Nishimura R., Mochizuki M., Kobata A. Comparative study of the mucin-type sugar chains of human chorionic gonadotropin present in the urine of patients with trophoblastic diseases and healthy pregnant women. J. Biol. Chem. 263:1988;1157-1165.
2. Bahado-Singh R., Oz U., Shahabi S., Omrani A., Mahoney M., Cole L. Urine hyperglycosylated hCG plus ultrasound biometry for detection of down syndrome in the second trimester in a high-risk population. Obstet. Gynecol. 95:2000;889-894.
3. Bahado-Singh R.O., Oz U., Shahabi S., Mahoney M.J., Baumgarten A., Cole L.A. Comparison of urinary hyperglycosylated human chorionic gonadotropin concentration with the serum triple screen for down syndrome detection in high-risk pregnancies. Am. J. Obstet. Gynecol. 183:2000;1114-1118.
4. Birken S., Chen Y., Gawinowicz M.A., Agosto G.M., Canfield R.E., Hartree A.S. Structure and significance of human luteinizing hormone-beta core fragment purified from human pituitary extracts. Endocrinology. 133:1993;985-989.
5. Birken S., Kovalevskaya G., O'Connor J. Metabolism of hCG and hLH to multiple urinary forms. Mol. Cell. Endocrinol. 125:1996;121-131.
6. Birken S., Maydelman Y., Gawinowicz M.A., Pound A., Liu Y., Hartree A.S. Isolation and characterization of human pituitary chorionic gonadotropin. Endocrinology. 137:1996;1402-1411.
7. Birken S., Krichevsky A., O'Connor J., Schlatterer J., Cole L., Kardana A., Canfield R. Development and characterization of antibodies to a nicked and hyperglycosylated form of hCG from a choriocarcinoma patient: generation of antibodies that differentiate between pregnancy hCG and choriocarcinoma hCG. Endocrine. 10:1999;137-144.
8. Birken S., Kovalevskaya G., O'Connor J. Immunochemical measurement of early pregnancy isoforms of hCG. Potential applications to fertility research, prenatal diagnosis, and cancer. Arch. Med. Res. 32:2001;635-643.
9. Birken S., Gawinowicz M.A., Maydelman Y., Milgrom Y. Metabolism of gonadotropins: comparisons of the primary structures of the human pituitary and urinary LHbeta cores and the chimpanzee CGbeta core demonstrate universality of core production. J. Endocrinol. 171:2001;131-141.
10. Birken S., Berger P., Bidart J.-M., Weber M., Bristow A., Norman R., Sturgeon C., Stenman U.-H. Preparation and characterization of new WHO reference reagents for human chorionic gonadotropin (hCG) and metabolites. Clin. Chem. 49:2003;144-154.
11. Brockhausen I. Biosynthesis and functions of O-glycans and regulation of mucin antigen expression in cancer. Biochem. Soc. Trans. 25:1997;871-874.
12. Brockhausen I. Pathways of O-glycan biosynthesis in cancer cells. Biochim. Biophys. Acta. 1473:1999;67-95.
13. Burnett A.F. Gestational trophoblastic disease. Burnett A.F. Clinical Obstetrics and Gynecology. 2001;382-387 Blackwell Science, Los Angeles.
14. Campbell R.K., Dean-Emig D.M., Moyle W.R. Conversion of human choriogonadotropin into a follitropin by protein engineering. Proc. Natl. Acad. Sci. USA. 88:1991;760-764.
15. Cole L.A., Butler S. Detection of hCG in trophoblastic disease. The USA hCG reference service experience. J. Reprod. Med. 47:2002;433-444.
16. Cole L.A., Birken S., Perini F. The structures of the serine-linked sugar chains on human chorionic gonadotropin. Biochem. Biophys. Res. Commun. 126:1985;333-339.
17. Cole L.A. The O-linked oligosaccharide structures are striking different on pregnancy and choriocarcinoma hCG. J. Clin. Endocrinol. Metab. 65:1987;811-813.
18. Cole L.A., Omrani A., Cermik D., Singh R.O., Mahoney M.J. Hyperglycosylated hCG, a potential alternative to hCG in down syndrome screening. Prenatal Diagn. 18:1998;926-933.
19. Cole L.A., Shahabi S., Oz U.A., Bahado-Singh R.O., Mahoney M.J. Hyperglycosylated human chorionic gonadotropin (invasive trophoblast antigen) immunoassay: a new basis for gestational down syndrome screening. Clin. Chem. 45:1999;2109-2119.
20. Cole L.A., Shahabi S., Oz U.A., Rinne K.M., Omrani A., Bahado-Singh R.O., Mahoney M.J. Urinary screening tests for fetal down syndrome: II. Hyperglycosylated hCG. Prenatal Diagn. 19:1999;351-359.
21. Cuckle H.S., Shahabi S., Sehmi I.K., Jones R., Cole L.A. Maternal urine hyperglycosylated hCG in pregnancies with down syndrome. Prenatal Diagn. 19:1999;918-920.
22. Elliott M.M., Kardana A., Lustbader J.W., Cole L.A. Carbohydrate and peptide structure of the alpha and beta subunits of human chorionic gonadotropin from normal and aberrant pregnancy and choriocarcinoma. Endocrine. 7:1997;15-32.
23. Fares F.A., Suganuma N., Nishimori K., LaPolt P.S., Hsueh A.J., Boime I. Design of a long-acting follitropin agonist by fusing the C-terminal sequence of the chorionic gonadotropin beta subunit to the follitropin beta subunit. Proc. Natl. Acad. Sci. USA. 89:1992;4304-4308.
24. Fisher R.A., Newlands E.S. Gestational trophoblastic disease. Molecular and genetic studies. J. Reprod. Med. 43:1998;87-97.
25. Hartree A.S. Purification of human pituitary glycoprotein hormones. Methods Enzymol. 37:(Pt B):1975;380-389.
26. Kovalevskaya G., Birken S., Kakuma T., O'Connor J.F. Early pregnancy human chorionic gonadotropin (hCG) isoforms measured by an immunometric assay for choriocarcinoma-like hCG. J. Endocrinol. 161:1999;99-106.
27. Kovalevskaya G., Birken S., Kakuma T., Ozaki N., Sauer M., Lindheim S., Cohen M., Kelly A., Schlatterer J., O'Connor J.F. Differential expression of human chorionic gonadotropin (hCG) glycosylation isoforms in failing and continuing pregnancies: preliminary characterization of the hyperglycosylated hCG epitope. J. Endocrinol. 172:2002;497-506.
28. Kovalevskaya G., Genbacev O., Fisher S.J., Caceres E., O'Connor J.F. Trophoblast origin of hCG isoforms: cytotrophoblasts are the primary source of choriocarcinoma-like hCG. Mol. Cell. Endocrinol. 194:2002;147-155.
29. Krichevsky A., Birken S., O'Connor J., Acevedo H.F., Bikel K., Lustbader J., Hartree A., Canfield R.E. Development, characterization, and application of monoclonal antibodies to the native and synthetic beta COOH-terminal portion of human chorionic gonadotropin (hCG) that distinguish between the native and desialylated forms of hCG. Endocrinology. 134:1994;1139-1145.
30. Liu C., Bowers L.D. Mass spectrometric characterization of the beta-subunit of human chorionic gonadotropin. J. Mass. Spectrom. 32:1997;33-42.
31. Moyle W.R., Matzuk M.M., Campbell R.K., Cogliani E., Dean-Emig D.M., Krichevsky A., Barnett R.W., Boime I. Localization of residues that confer antibody binding specificity using human chorionic gonadotropin/luteinizing hormone beta subunit chimeras and mutants. J. Biol. Chem. 265:1990;8511-8518.
32. Myers R.V., Wang Y., Moyle W.R. The surface of alpha-subunit loop 1 distant from the subunit interface is exposed in the hCG lutropin receptor complex. Biochim. Biophys. Acta. 1475:2000;390-394.
33. O'Connor J.F., Birken S., Lustbader J.W., Krichevsky A., Chen Y., Canfield R.E. Recent advances in the chemistry and immunochemistry of human chorionic gonadotropin: impact on clinical measurements. Endocr. Rev. 15:1994;650-683.
34. Odell W.D., Griffin J. Pulsatile secretion of chorionic gonadotropin during the normal menstrual cycle. J. Clin. Endocrinol. Metab. 69:1989;528-532.
35. Seckl M.J., Newlands E.S. Treatment of gestational trophoblastic disease. Gen. Diagn. Pathol. 143:1997;159-171.
36. Seckl M.J., Fisher R.A., Salerno G., Rees H., Paradinas F.J., Foskett M., Newlands E.S. Choriocarcinoma and partial hydatidiform moles. Lancet. 356:2000;36-39.
37. Spencer K., Talbot J.A., Abushoufa R.A. Maternal serum hyperglycosylated human chorionic gonadotrophin (HhCG) in the first trimester of pregnancies affected by down syndrome, using a sialic acid-specific lectin immunoassay. Prenatal Diagn. 22:2002;656-662.
38. Tsuboi S., Fukuda M. Roles of O-linked oligosaccharides in immune responses. Bioessays. 23:2001;46-53.
39. Wang Y., Bernard M.P., Moyle W.R. Bifunctional hCG analogs adopt different conformations in LH and FSH receptor complexes. Mol. Cell. Endocrinol. 170:2000;67-77.