Effects of dietary apigenin on tumor latency, incidence and multiplicity in a medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene- induced breast cancer model

Nutrition and Cancer

Volumn 65, Issue 8, 2013, Pages 1184-1191

  Mafuvadze, Benford ^a   Cook, Matthew ^a   Xu, Zhang ^a   Besch Williford, Cynthia L ^b   Hyder, Salman M ^a  

^a UNIVERSITY OF MISSOURI   (United States)

^b RADIL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

7,12 DIMETHYLBENZ[A]ANTHRACENE; APIGENIN; MEDROXYPROGESTERONE ACETATE; VASCULOTROPIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; BODY WEIGHT; BREAST CANCER; CANCER GROWTH; CANCER INCIDENCE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; DIET SUPPLEMENTATION; FEMALE; HISTOLOGY; MULTIPLE CANCER; NONHUMAN; PROTEIN EXPRESSION; RAT; TUMOR XENOGRAFT;

ANIMALIA;

9,10-DIMETHYL-1,2-BENZANTHRACENE; ANIMALS; APIGENIN; BREAST NEOPLASMS; DIETARY SUPPLEMENTS; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HORMONE REPLACEMENT THERAPY; MAMMARY NEOPLASMS, EXPERIMENTAL; MEDROXYPROGESTERONE ACETATE; POSTMENOPAUSE; RATS; RATS, SPRAGUE-DAWLEY;

EID: 84888342825     PISSN: 01635581     EISSN: 15327914     Source Type: Journal    
DOI: 10.1080/01635581.2013.833637     Document Type: Article

References (36)

1. Kariagina A, Xie J, Leipprandt JR, and Haslam SZ: Amphiregulin mediates estrogen, progesterone, and EGFR signaling in the normal rat mammary gland and in hormone-dependent rat mammary cancers. Horm Canc 1, 229-244, 2010.
2. Fernandez-Valdivia R, Mukherjee A, Creighton CJ, Buser AC, DeMayo FJ, et al.: Transcriptional response of the murine mammary gland to acute progesterone exposure. Endocrinology 149, 6236-6250, 2008.
3. Aupperlee MD and Haslam SZ: Differential hormonal regulation and function of progesterone receptor isoforms in normal adult mouse mammary gland. Endocrinology 148, 2290-2300, 2007.
4. Benakanakere I, Besch-Williford C, Schnell J, Brandt S, Ellersieck MR, et al.: Natural and synthetic progestins accelerate 7,12-dimethylbenz[a] anthracene-initiated mammary tumors and increase angiogenesis in Sprague-Dawley rats. Clin Cancer Res 12, 4062-4071, 2006.
5. Benakanakere I, Besch-Williford C, Carroll CE, and Hyder SM: Synthetic progestins differentially promote or prevent 7,12-dimethylbenz(a) anthracene-induced mammary tumors in Sprague-Dawley rats. Cancer Prev Res 3, 1157-1167, 2010.
6. Liang Y, Besch-Williford C, Brekken RA, and Hyder SM: Progestindependent progression of human breast tumor xenografts: a novel model for evaluating anti-tumor therapeutics. Cancer Res 67, 9929-9936, 2007.
7. Lanari C and Molinolo AA: Progesterone receptors-animal models and cell signalling in breast cancer. Diverse activation pathways for the progesterone receptor: possible implications for breast biology and cancer. Breast Cancer Res 4, 240-243, 2002.
8. Giulianelli S, Vaqúe JP, Soldati R, Wargon V, Vanzulli SI, et al.: Estrogen receptor alpha mediates progestin-induced mammary tumor growth by interacting with progesterone receptors at the cyclin D1/MYC promoters. Cancer Res 72, 2416-2427, 2012.
9. Ross RK, Paganini-Hill A, Wan PC, and Pike MC: Effect of hormone replacement therapy on breast cancer risk: estrogen versus estrogen plus progestin. J Natl Cancer Inst 92, 328-332, 2000.
10. Chlebowski RT, Anderson GL, Gass M, Lane DS, Aragaki AK, et al.: Estrogen plus progestin and breast cancer incidence and mortality in postmenopausal women. JAMA 304, 1719-1720, 2010.
11. Narod SA: Hormone replacement therapy and the risk of breast cancer. Nat Rev Clin Oncol 8, 669-676, 2011.
12. Chlebowski RT and Anderson GL: Changing concepts: Menopausal hormone therapy and breast cancer. J Natl Cancer Inst 104, 517-527, 2012.
13. Aggarwal BB and Shishodia S: Molecular targets of dietary agents for prevention and therapy of cancer. Biochem Pharmacol 71, 1397-1421, 2006.
14. Carroll CE, Benakanakere I, Besch-Williford C, Ellersieck MR, and Hyder SM: Curcumin delays development of medroxyprogesterone acetateaccelerated 7,12-dimethybenz(a)anthracene-induced mammary tumors. Menopause 17, 178-184, 2010.
15. Mafuvadze B, Benakanakere I, Ĺopez Ṕerez FR, Besch-Williford C, Ellersieck MR, et al.: Apigenin prevents development of medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumors in Sprague-Dawley rats. Cancer Prev Res 4, 1316-1324, 2011.
16. Mafuvadze B, Liang Y, Besch-Williford C, Zhang X, and Hyder SM: Apigenin induces apoptosis and blocks growth of medroxyprogesterone acetate-dependent BT-474 xenograft tumors. Horm Canc 3, 160-171, 2012.
17. Patel D, Shukla S, and Gupta S: Apigenin and cancer chemoprevention: progress, potential and promise. Int J Oncol 30, 233-245, 2007.
18. Werner M, Chott A, Fabiano A, and Battifora H: Effect of formalin tissue fixation and processing on immunohistochemistry. Am J Surg Pathol 24, 1016-1019, 2000.
19. Mohsin SK, Weiss H, Havighurst T, Clark GM, Berardo M, et al.: Progesterone receptor by immunohistochemistry and clinical outcome in breast cancer: a validation study. Modern Pathol 17, 1545-1554, 2004.
20. Au A, Li B, Wang W, Roy H, Koehler K, and Birt D: Effect of dietary apigenin on colonic ornithine decarboxylase activity, aberrant crypt foci formation, and tumorigenesis in different experimental models. Nutr Cancer 54, 243-251, 2006.
21. Leonardi T, Vanamala J, Taddeo SS, Davidson LA, Murphy ME, et al.: Apigenin and naringenin suppress colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. Exp Bio Med 235, 710-717, 2010.
22. Rimm EB, Katan MB, Ascherio A, Stampfer MJ, andWillett WC: Relation between intake of flavonoids and risk for coronary heart disease in male health professionals. Ann Intern Med 125, 384-389, 1996.
23. Stroheker T, Picard K, Lhuguenot JC, Canivenc-Lavier MC, and Chagnon MC: Steroid activities comparison of natural and food wrap compounds in human breast cancer cell lines. Food Chem Toxicol 42, 887-897, 2004.
24. Kim H, Hall P, Smith M, Kirk M, Prasain JK, et al.: Chemoprevention by grape seed extract and genistein in carcinogen-induced mammary cancer in rats is diet dependent. J Nutr 134, 3445-3452, 2004.
25. Hanske L, Loh G, Sczesny S, BlautM, and Braune A: The bioavailability of apigenin-7-glucoside is influenced by human intestinal microbiota in rats. J Nutr 139, 1095-1102, 2009.
26. Griffiths LA and Smith GE:Metabolism of apigenin and related compounds in the rat. Metabolite formation in vivo and by the intestinal microflora in vitro. Biochem J 128, 901-911, 1972.
27. Lin Y, Shi R, Wang X, and Shen HM: Luteolin, a flavonoid with potential for cancer prevention and therapy. Curr Cancer Drug Targets 8, 634-646, 2008.
28. Cai Y, Luo Q, Sun M, and Corke H: Antioxidant activity and phenolic compounds of 112 traditional Chinese medicinal plants associated with anticancer. Life Sci 74, 2157-2184, 2004.
29. Kampa M, Alexaki VI, Notas G, Nifli AP, Nistikaki A, et al.: Antiproliferative and apoptotic effects of selective phenolic acids on T47D human breast cancer cells: potential mechanisms of action. Breast Cancer Res 6, R63-R74, 2003.
30. Vargo MA, Voss OH, Poustka F, Cardounel AJ, Grotewold E, et al.: Apigenin-induced-apoptosis is mediated by the activation of PKCdelta and caspases in leukemia cells. Biochem Pharmacol 72, 681-692, 2006.
31. Budhraja A, Gao N, Zhang Z, Son YO, Cheng S, et al.: Apigenin induces apoptosis in human leukemia cells and exhibits anti-leukemic activity in vivo. Mol Cancer Ther 11, 132-142, 2012.
32. Gates MA,Tworoger SS, Hecht JL, DeVivo I, Rosner B, et al.:Aprospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int. J. Cancer 121, 2225-2232, 2007.
33. Palmieri D, Halverson DO, Ouatas T, Horak CE, et al.: Medroxyprogesterone acetate elevation ofNM23-H1 receptor-negative breast cancer.JNatl Cancer Inst 97, 632-642, 2005.
34. Houghton PJ, Howes MJ, Lee CC, and Steventon G: Uses and abuses of in vitro tests in ethnopharmacology: visualizing an elephant. J Ethnopharmacol 110, 391-400, 2007.
35. Bansal SS, Kausar H, VadhanamMV, Aqil F, Jeyabalan J, et al.: Curcumin implants, not curcumin diet inhibits estrogen induced-mammary carcinogenesis. Cancer Res (abstr) 71, 2011.
36. Laupattarakasem P, Houghton PJ, Hoult JR, and Itharat A: An evaluation of the activity related to inflammation of four plants used in Thailand to treat arthritis. J Ethnopharmacol 85, 207-215, 2003.