Purinergic Autocrine Regulation of Mechanosensitivity and Serotonin Release in a Human EC Model: ATP-gated P2X3 Channels in EC are Downregulated in Ulcerative Colitis

Inflammatory Bowel Diseases

Volumn 19, Issue 11, 2013, Pages 2366-2379

  Liñán Rico, Andrómeda ^a   Wunderlich, Jacqueline E ^a   Grants, Iveta S ^a   Frankel, Wendy L ^a   Xue, Jianjing ^b   Williams, Kent C ^a,b   Harzman, Alan E ^a   Enneking, Joshua T ^a   Cooke, Helen J ^a   Christofi, Fievos L ^a  

^a THE OHIO STATE UNIVERSITY WEXNER MEDICAL CENTER   (United States)

^b THE RESEARCH INSTITUTE AT NATIONWIDE CHILDREN S HOSPITAL   (United States)

Author keywords

5 HT release; ATP; ATP gated P2X 3 channels; Mechanosensitivity; Ulcerative colitis

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; 2 METHYL THIO ADENOSINE DIPHOSPHATE; 2' DEOXY 6 N METHYLADENOSINE 3',5' BISPHOSPHATE; ADENOSINE DIPHOSPHATE; MESSENGER RNA; PURINERGIC P2X RECEPTOR; PURINERGIC RECEPTOR; UNCLASSIFIED DRUG;

ARTICLE; CLINICAL ARTICLE; ENTERITIS; EVOKED RESPONSE; HUMAN; IMMUNOREACTIVITY; MECHANICAL STIMULATION; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SEROTONIN RELEASE; ULCERATIVE COLITIS; WESTERN BLOTTING;

ADENOSINE TRIPHOSPHATE; AUTOCRINE COMMUNICATION; CELLS, CULTURED; COLITIS, ULCERATIVE; ENTEROCHROMAFFIN CELLS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; INTESTINAL MUCOSA; MECHANOTRANSDUCTION, CELLULAR; RECEPTORS, PURINERGIC P2X3; SEROTONIN;

EID: 84888270772     PISSN: 10780998     EISSN: 15364844     Source Type: Journal    
DOI: 10.1097/MIB.0b013e31829ecf4d     Document Type: Article

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