PPADS, a P2X receptor antagonist, as a novel inhibitor of the reverse mode of the Na +/Ca 2+ exchanger in guinea pig airway smooth muscle

European Journal of Pharmacology

Volumn 674, Issue 2-3, 2012, Pages 439-444

  Flores Soto, Edgar ^a   Reyes García, Jorge ^a   Sommer, Bettina ^b   Chavez, Jaime ^b   Barajas López, Carlos ^c   Montaño, Luis M ^a  

^a UNIVERSIDAD NACIONAL AUTÓNOMA DE MÉXICO   (Mexico)

^b INSTITUTO NACIONAL DE ENFERMEDADES RESPIRATORIAS   (Mexico)

^c INSTITUTO POTOSINO DE INVESTIGACIÓN CIENTÍFICA Y TECNOLÓGICA   (Mexico)

Author keywords

Airway smooth muscle; KB R7943; Na + Ca 2+ exchanger; PPADS

Indexed keywords

2 [2 [4 (4 NITROBENZYLOXY)PHENYL]ETHYL]ISOTHIOUREA METHANESULFONATE; 2 [4 (2,5 DIFLUOROBENZYLOXY)PHENOXY] 5 ETHOXYANILINE; BICARBONATE; CALCIUM; CALCIUM CHANNEL L TYPE; LITHIUM CHLORIDE; NIFEDIPINE; POTASSIUM CHLORIDE; PURINERGIC P2X RECEPTOR ANTAGONIST; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SODIUM CALCIUM EXCHANGE PROTEIN; SODIUM CHLORIDE; VOLTAGE DEPENDENT ANION CHANNEL;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BREATHING MUSCLE; CALCIUM CELL LEVEL; CALCIUM TRANSPORT; CELL ISOLATION; CONTROLLED STUDY; CYTOPLASM; DRUG ACTIVITY; DRUG EFFICACY; DRUG POTENCY; GUINEA PIG; HEART MUSCLE CELL; MALE; NONHUMAN; PRIORITY JOURNAL; RELIABILITY; SMOOTH MUSCLE; TRACHEA MUSCLE;

ANIMALS; CALCIUM CHANNEL BLOCKERS; CALCIUM CHANNELS, L-TYPE; GUINEA PIGS; MALE; MUSCLE CELLS; MUSCLE, SMOOTH; PURINERGIC P2X RECEPTOR ANTAGONISTS; PYRIDOXAL PHOSPHATE; RECEPTORS, PURINERGIC P2X; REPRODUCIBILITY OF RESULTS; SODIUM-CALCIUM EXCHANGER; THIOUREA; TRACHEA;

EID: 84855542967     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2011.11.018     Document Type: Article

References (25)

1. 2+by activation of P2 receptors in submucosal neurons in short-term cultures. Eur. J. Pharmacol. 409, 243-257.
2. 2+]i during refilling in bovine airway smooth muscle cells. Arch. Med. Res. 31, 558-563.
3. Berridge, M.J., Bootman, M.D., Roderick, H.L., 2003. Calcium signalling: dynamics, homeostasis and remodelling. Nat. Rev. Mol. Cell Biol. 4, 517-529. (Pubitemid 36773404)
4. 2+ current in canine ventricular cardiomyocytes. Naunyn Schmiedebergs Arch. Pharmacol. 372, 63-70.
5. Blaustein, M.P., Lederer, W.J., 1999. Sodium/calcium exchange: its physiological implications. Physiol. Rev. 79, 763-854. (Pubitemid 29330173)
6. 2+ pump and tyrosine kinase. Am. J. Physiol. Lung Cell. Mol. Physiol. 288, L84-L92.
7. DiPolo, R., Beauge, L., 2006. Sodium/calcium exchanger: influence of metabolic regulation on ion carrier interactions. Physiol. Rev. 86, 155-203.
8. Flores-Soto, E., Carbajal, V., Reyes-Garcia, J., Garcia-Hernandez, L.M., Figueroa, A., Checa, M., Barajas-Lopez, C., Montano, L.M., 2011. In airways ATP refills sarcoplasmic reticulum via P2X smooth muscle receptors and induces contraction through P2Y epithelial receptors. Pflugers Arch. 461, 261-275.
9. Floyd, R., Wray, S., 2007. Calcium transporters and signalling in smooth muscles. Cell Calcium 42, 467-476. (Pubitemid 47264013)
10. 2+ indicators with greatly improved fluorescence properties. J. Biol. Chem. 260, 3440-3450.
11. 2+ concentration increases in cultured rat forebrain neurons. Mol. Pharmacol. 53, 742-749.
12. 2+ exchange inhibitors. J. Pharmacol. Sci. 96, 27-32.
13. 2+ exchanger isoforms by divalent cations and isothiourea derivative. Am. J. Physiol. 275, C423-C430.
14. Kajita, J., Yamaguchi, H., 1993. Calcium mobilization by muscarinic cholinergic stimulation in bovine single airway smooth muscle. Am. J. Physiol. 264, L496-L503. (Pubitemid 23150832)
15. 2+ exchange inhibitor. Ann. N. Y. Acad. Sci. 1099, 529-533.
16. Lambrecht, G., Friebe, T., Grimm, U., Windscheif, U., Bungardt, E., Hildebrandt, C., Baumert, H.G., Spatz-Kumbel, G., Mutschler, E., 1992. PPADS, a novel functionally selective antagonist of P2 purinoceptor-mediated responses. Eur. J. Pharmacol. 217, 217-219.
17. 2+ exchange current in guinea pig ventricular myocytes. J. Cardiovasc. Pharmacol. 40, 106-111.
18. McLaren, G.J., Lambrecht, G., Mutschler, E., Baumert, H.G., Sneddon, P., Kennedy, C., 1994. Investigation of the actions of PPADS, a novel P2x-purinoceptor antagonist, in the guinea-pig isolated vas deferens. Br. J. Pharmacol. 111, 913-917. (Pubitemid 24151684)
19. Mejia-Elizondo, R., Espinosa-Tanguma, R., Saavedra-Alanis, V.M., 2002. Molecular identification of the NCX isoform expressed in tracheal smooth muscle of guinea pig. Ann. N. Y. Acad. Sci. 976, 73-76. (Pubitemid 36126872)
20. 2+ exchange inhibitor on membrane currents in guinea pig ventricular myocytes. Ann. N. Y. Acad. Sci. 1099, 534-539.
21. 2+ exchange molecule: an overview. Ann. N. Y. Acad. Sci. 976, 1-10.
22. 2+ exchanger isoforms NCX1, NCX2, and NCX3 in rat. Am. J. Physiol. 272, C1250-C1261.
23. 2+ store-depleted tracheal smooth muscle. Clin. Exp. Pharmacol. Physiol. 36, 619-625.
24. Tanaka, H., Nishimaru, K., Aikawa, T., Hirayama, W., Tanaka, Y., Shigenobu, K., 2002. Effect of SEA0400, a novel inhibitor of sodium-calcium exchanger, on myocardial ionic currents. Br. J. Pharmacol. 135, 1096-1100. (Pubitemid 34259108)
25. 2+ stores in guinea-pig detrusor smooth muscle. J. Physiol. 538, 357-369.