Mechanical Stimulation Releases Nucleotides That Activate P2Y1 Receptors to Trigger Neural Reflex Chloride Secretion in Guinea Pig Distal Colon

Journal of Comparative Neurology

Volumn 469, Issue 1, 2004, Pages 1-15

  Cooke, Helen J ^a   Xue, Jianjing ^a   Yu, Jun Ge ^a   Wunderlich, Jacqueline ^a   Wang, Y Z ^a   Guzman, Jorge ^a   Javed, Najma ^b   Christofi, Fievos L ^a,c  

^a OHIO STATE UNIVERSITY   (United States)

^b BALL STATE UNIVERSITY   (United States)

^c THE OHIO STATE UNIVERSITY COLLEGE OF MEDICINE   (United States)

Author keywords

5 adenosine triphosphate; Chloride secretion; Enteric nervous system; Mechanotransduction; Mucosal reflex; Nucleotides; P2X,P2Y1,P2Y2,P2Y4,P2Y6,P2Y12, or P1 receptors; P2Y antisera; Submucous plexus

Indexed keywords

2 METHYLTHIOADENOSINE DIPHOSPHATE; 2 METHYLTHIOADENOSINE TRIPHOSPHATE; 2' DEOXY N 6 METHYLADENOSINE 3',5' DIPHOSPHATE DIAMMONIUM DERIVATIVE; 6 N,N DIETHYL BETA,GAMMA DIBROMOMETHYLENE D ATP; 6-N,N-DIETHYL-BETA,GAMMA-DIBROMOMETHYLENE-D-ATP; ADENOSINE A1 RECEPTOR; ADENOSINE A1 RECEPTOR ANTAGONIST; ADENOSINE DIPHOSPHATE; ADENOSINE TRIPHOSPHATE; ALPHA,BETA METHYLENEADENOSINE TRIPHOSPHATE; APYRASE; BETA,GAMMA DIBROMOMETHYLENE 6 N,N DIETHYLADENOSINE TRIPHOSPHATE; CHLORIDE; DRUG DERIVATIVE; MESSENGER RNA; NUCLEOTIDASE; NUCLEOTIDE DERIVATIVE; PIROXICAM; PURINE NUCLEOTIDE; PURINE P2 RECEPTOR; PURINE P2X1 RECEPTOR AGONIST; PURINE P2X3 RECEPTOR AGONIST; PURINE P2Y1 RECEPTOR; PURINE P2Y12 RECEPTOR; PURINE P2Y2 RECEPTOR; PURINE P2Y4 RECEPTOR; PURINE P2Y6 RECEPTOR; PURINERGIC RECEPTOR BLOCKING AGENT; PURINERGIC RECEPTOR STIMULATING AGENT; PYRIDOXAL PHOSPHATE 6 AZOPHENYL 2',4' DISULFONIC ACID; SURAMIN; TETRODOTOXIN; UNCLASSIFIED DRUG; UNINDEXED DRUG; URIDINE DIPHOSPHATE; URIDINE TRIPHOSPHATE;

ANIMAL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRUSH BORDER; CHLORIDE TRANSPORT; CHOLINERGIC SYSTEM; COLON; CONTROLLED STUDY; DESCENDING COLON; DOSE RESPONSE; DRUG EFFECT; DRUG POTENCY; DRUG POTENTIATION; GUINEA PIG; IMMUNOREACTIVITY; IN VITRO STUDY; INTESTINE MUCOSA; MALE; MECHANICAL STIMULATION; METABOLISM; METHODOLOGY; MUSCLE SPINDLE AFFERENT NERVE; NERVE FIBER; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; PROTEIN EXPRESSION; REFLEX; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SHORT CIRCUIT CURRENT; STIMULATION; SUBMUCOSA; VARICOSIS;

ADENOSINE TRIPHOSPHATE; ANIMALS; CHLORIDES; COLON; DOSE-RESPONSE RELATIONSHIP, DRUG; GUINEA PIGS; INTESTINAL MUCOSA; MALE; PHYSICAL STIMULATION; PURINE NUCLEOTIDES; RECEPTORS, PURINERGIC P2; REFLEX; TETRODOTOXIN;

EID: 0346156104     PISSN: 00219967     EISSN: None     Source Type: Journal    
DOI: 10.1002/cne.10960     Document Type: Article

References (47)

1. Barajas-Lopez C, Espinosa-Luna R, Gerzanich V. 1994. ATP closes a potassium and opens a cationic conductance through different receptors in neurons of guinea pig submucous plexus. J Pharmacol Exp Ther 268:1397-1402.
2. 2+ by activation of P2 receptors in submucosal neurons in short-term cultures. Eur J Pharmacol 409:243-257.
3. Burnstock G. 2001. Purinergic signaling in gut. In: Abbracchio MP, Williams M, editors. Handbook of experimental pharmacology. Volume 151/II. Purinergic and pyrimidinergic signaling II, cardiovascular, respiratory, immune, metabolic and gastrointestinal tract function. New York: Springer-Verlag. p 141-238.
4. Christofi FL. 2001. Unlocking mysteries of gut sensory transmission: Is adenosine the key? News Physiol Sci 16:201-207.
5. Christofi FL, Cook MA. 1997a. Possible heterogeneity of adenosine receptors present on myenteric nerve endings. J Pharmacol Exp Ther 243:302-309.
6. Christofi FL, Cook MA. 1997b. Purinergic modulation of gastrointestinal function. In: Jacobson KA, Jarvis MF, editors. Purinergic approaches in experimental therapeutics. New York: Wiley-Liss. p 261-282.
7. 2+ signaling in myenteric neurons via P2 purinoceptors. Am J Physiol 272:463-473.
8. Christofi FL, Zhang H, Yu JG, Guzman, J, Xue J, Kim M, Wang Y-Z, Cooke HJ. 2001. Differential gene expression of adenosine A1, A2a, A2b, and A3 receptors in the human enteric nervous system. J Comp Neurol 439:46-64.
9. Cooke HJ, Sidhu M, Fox P, Wang Y-Z, Zimmerman E. 1997a. Substance P as a mediator of colonic secretory reflexes. Am J Physiol 273:G238-G245.
10. Cooke HJ, Sidhu M, Wang Y-Z. 1997b. 5-HT activates neural reflexes regulating secretion in the guinea pig colon. Neurogastroenterol Mot 9:181-186.
11. 1P receptors on submucosal afferents subsequently triggers VIP neurons and chloride secretion in the guinea-pig colon. J Auton Nerv Sys 66:105-110.
12. 1 receptors suppresses secretory reflexes in the guinea pig colon. Am J Physiol Gastrointest Liver Physiol 276:G451-G462.
13. Cooke HJ, Wunderlich J, Christofi FL. 2003. "The force be with you": ATP in gut mechanosensory transduction. NIPS 18:43-49, 2003.
14. - secretion in T84 cells. Am J Physiol 262:C67-C74.
15. Frieling T, Dobreva G, Weber E, Becker K, Ruprecht C, Neulist M, Schemann M. 1999. Different tachykinin receptors mediate chloride secretion in the distal colon through activation of submucosal neurones. Naunyn-Schmiedeberg Arch Pharmacol 359:71-79.
16. Furness JB, Kunz WAA, Clerk N. 1999. Nutrient tasting and signaling mechanisms in the gut. II. The intestine as a sensory organ: neural, endocrine, and immune responses. Am J Physiol Gastrointest Liver Physiol 277:G922-G928.
17. Galligan JJ, Bertrand PP. 1994. ATP mediates fast synaptic potentials in enteric neurons. J Neurosci 14:7563-7571.
18. Glushakov AV, Melishchuk AI, Skok VI. 1996. ATP-induced currents in submucous plexus neurons of the guinea-pig small intestine. Neurophysiology (Moscow) 28:77-85.
19. Grygorczyk R, Hanrahan JW. 1997. CFTR-independent ATP release from epithelial cells triggered by mechanical stimuli. Am J Physiol 272: C1058-C1066.
20. Homolya L, Steinberg TH, Boucher RC. 2000. Cell to cell communication in response to mechanical stress via bilateral release of ATP and UTP in polarized epithelia. J Cell Biol 150:1349-1360.
21. Hu HZ, Ren J, Liu S, Xia Y, Wood JD. 1999. Functional group I metabotropic glutamate receptors in submucous plexus of guinea pig ileum. Br J Pharmacol 128:1631-1635.
22. Hu HZ, Gao N, Lin Z, Gao C, Liu S, Ren J, Zia Y, Wood JDD. 2001. P2X (7) receptors in the enteric nervous system of guinea-pig small intestine. J Comp Neurol 440:299-310.
23. - secretion via afferent neurons and 5-HT4 receptors. Am J Physiol 277:G515-G520.
24. + secretion via a P2Y2 receptor in rat distal colonic mucosa. Pflugers Arch 436:712-716.
25. Khahn BS, Burnstock G, Kennedy C, King BF, North RA, Seguela P, Voigt M, Humphrey PPA. 2001. International Union of Pharmacology. XXIV. Current status of the nomenclature and properties of P2X receptors and their subunits. Pharmacol Rev 53:107-118.
26. Korman LY, Lemp GF, Jackson MJ, Gardner JD. 1982. Mechanism of action of ATP on intestinal epithelial cells. Cyclic AMP-mediated stimulation of active ion transport. Biochim Biophys Acta 721:47-54.
27. Kuwahara A, Bowen S, Wang J, Condon C, Cooke HJ. 1987. Epithelial responses evoked by stimulant of submucosal neurons in guinea pig distal colon. Am J Physiol 252:G667-G674.
28. Lawarowski ER, Boucher RC. 2001. UTP as an extracellular signaling molecule. News Physiol Sci 16:1-5.
29. Lazarowski ER, Homolya L, Boucher RC, Harden TK. 1997. Direct demonstration of mechanically induced release of cellular UTP and its implication for uridine nucleotide receptor activation. Am Soc Biochem Mol Biol 272:24348-24354.
30. i and ion secretion via a basolateral P2Y-receptor in rat distal colonic mucosa. Pflugers Arch 434:77-83.
31. Liu M-T, Kirchgessner AL. 2000. Agonist- and reflex-evoked internalization of metabotropic glutamate receptor 5 in enteric neurons. J Neurosci 20:3200-3205.
32. Lomax AE, Furness JB. 2000. Neurochemical classification of enteric neurons in the guinea-pig distal colon. Cell Tissue Res 302:59-72.
33. McAlroy HL, Collett A, Ahmed S, Ko WH, Baines DL, Wilson SM. 1999. Expression of multiple P2Y receptor subtypes by Caco-2 human colonic adenocarcinoma cells [abstract]. J Physiol 517:97P.
34. McAlroy HL, Ahmed S, Day SM, Baines DL, Wong HY, Yip CY, Ko WH, Wilson SM, Collett A. 2000. Multiple P2Y receptor subtypes in the apical membranes of polarized epithelial cells. Br J Pharmacol 131:1651-1658.
35. Nakamura F, Strittmatter SM. 1996. P2Y1 purinergic receptors in sensory neurons: contribution to touch-induced impulse generation. Proc Natl Acad Sci USA 93:10465-10470.
36. 12 receptor: a novel member of the P2Y family of receptors activated by extracellular nucleotides. Mol Pharm 60:416-420.
37. Ostrom RS, Gregorian C, Insel PA. 2000. Cellular release of and response to ATP as key determinants of the set-point of signal transduction pathways. J Biol Chem 275:11735-11739.
38. Pan H, Gershon MD. 2000. Activation of intrinsic afferent pathways in submucosal ganglia of the guinea pig small intestine. J Neurosci 20:3295-3309.
39. Pintor J, Diaz-Hernandes M, Gualix J, Gomez-Villafuertes R, Hernando F, Miras-Portugal MT. 2000. Diadenosine polyphosphate receptors. From rat and guinea-pig brain to human nervous system. Pharmacol Ther 87:103-115.
40. Ralevic V, Burnstock G. 1998. Receptors for purines and pyrimidines. Pharmacol Rev 50:413-492.
41. Reed DE, Vanner SJ. 2001. Converging and diverging cholinergic inputs from submucosal neurons amplify activity of secretomotor neurons in guinea pig ileal submucosa. Neuroscience 107:685-696.
42. Roman RM, Fitz JG. 1999. Emerging roles of purinergic signaling in gastrointestinal epithelial secretion and hepatobiliary function. Gastroenterology 116:964-979.
43. Sidhu M and Cooke, HJ. 1995. Role for 5-HT and ACh in submucosal reflexes mediating colonic secretion. Am J Physiol 269:G346-G351.
44. Smitham JE, Barrett KE. 2001. Differential effects of apical and basolateral uridine triphosphate on intestinal epithelial chloride secretion. Am J Physiol 280:C1431-C1439.
45. Vigne P, Breittmayer JP, Frelin C. 2000. Diadenosine polyphosphates as antagonists of the endogenous P2Y(1) receptor in rat brain capillary endothelial cells of the BB10 clones. Br J Pharmacol 129:1506-1512.
46. Weber E, Neulist M, Schemann M, Frieling T. 2001. Neural components of distension-evoked secretory responses in the guinea-pig distal colon. J Physiol 536:741-751.
47. + absorption in guinea pig distal colon. Am J Physiol 283: G300-G308.