Ghrelin and NUCB2/nesfatin-1 are expressed in the same gastric cell and differentially correlated with body mass index in obese subjects

Histochemistry and Cell Biology

Volumn 139, Issue 6, 2013, Pages 909-918

  Stengel, Andreas ^a   Hofmann, Tobias ^a   Goebel Stengel, Miriam ^a   Lembke, Vanessa ^a   Ahnis, Anne ^a   Elbelt, Ulf ^a   Lambrecht, Nils W G ^b   Ordemann, Jürgen ^a   Klapp, Burghard F ^a   Kobelt, Peter ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^b VA LONG BEACH HEALTHCARE SYSTEM   (United States)

Author keywords

Bariatric surgery; GOAT; Hormone; Nesfatin 1; Stomach; X A like cell

Indexed keywords

ACYLTRANSFERASE; BRAIN PROTEIN; GHRELIN; GHRELIN O ACYLTRANSFERASE; NESFATIN 1; UNCLASSIFIED DRUG;

ADULT; ARTICLE; BODY MASS; BODY WEIGHT; CELL DIFFERENTIATION; CELL TYPE; CLINICAL ARTICLE; COMORBIDITY; FEMALE; GASTRECTOMY; HUMAN; HUMAN CELL; IMMUNOCOMPETENT CELL; IMMUNOREACTIVITY; INTESTINE CELL; MALE; OBESITY; PHENOTYPE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; PROTEIN SECRETION; WEIGHT GAIN;

ACYLTRANSFERASES; ADAPTATION, PHYSIOLOGICAL; ADULT; AGED; BLOTTING, WESTERN; BODY MASS INDEX; CALCIUM-BINDING PROTEINS; DNA-BINDING PROTEINS; FEMALE; GASTRIC MUCOSA; GHRELIN; HUMANS; MALE; MIDDLE AGED; NERVE TISSUE PROTEINS; OBESITY, MORBID;

RATTUS;

EID: 84878251292     PISSN: 09486143     EISSN: 1432119X     Source Type: Journal    
DOI: 10.1007/s00418-013-1087-8     Document Type: Article

References (26)

1. Ariyasu H, Takaya K, Tagami T, Ogawa Y, Hosoda K, Akamizu T, Suda M, Koh T, Natsui K, Toyooka S, Shirakami G, Usui T, Shimatsu A, Doi K, Hosoda H, Kojima M, Kangawa K, Nakao K (2001) Stomach is a major source of circulating ghrelin, and feeding state determines plasma ghrelin-like immunoreactivity levels in humans. J Clin Endocrinol Metab 86:4753-4758
2. Atsuchi K, Asakawa A, Ushikai M, Ataka K, Tsai M, Koyama K, Sato Y, Kato I, Fujimiya M, Inui A (2010) Centrally administered nesfatin-1 inhibits feeding behaviour and gastroduodenal motility in mice. NeuroReport 21:1008-1011
3. Caminos JE, Nogueiras R, Blanco M, Seoane LM, Bravo S, Alvarez CV, Garcia-Caballero T, Casanueva FF, Dieguez C (2003) Cellular distribution and regulation of ghrelin messenger ribonucleic acid in the rat pituitary gland. Endocrinology 144:5089-5097
4. Eldar S, Heneghan HM, Brethauer SA, Schauer PR (2011) Bariatric surgery for treatment of obesity. Intern J Obes 35(Suppl 3):S16-S21
5. Fischer T, Doll C, Jacobs S, Kolodziej A, Stumm R, Schulz S (2008) Reassessment of sst2 somatostatin receptor expression in human normal and neoplastic tissues using the novel rabbit monoclonal antibody UMB-1. J Clin Endocrinol Metab 93:4519-4524
6. Foo K, Brismar H, Broberger C (2008) Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 156:563-579
7. Garcia-Galiano D, Navarro VM, Roa J, Ruiz-Pino F, Sanchez-Garrido MA, Pineda R, Castellano JM, Romero M, Aguilar E, Gaytan F, Dieguez C, Pinilla L, Tena-Sempere M (2010) The anorexigenic neuropeptide, nesfatin-1, is indispensable for normal puberty onset in the female rat. J Neurosci 30:7783-7792
8. Goebel M, Stengel A, Wang L, Lambrecht NW, Taché Y (2009) Nesfatin-1 immunoreactivity in rat brain and spinal cord autonomic nuclei. Neurosci Lett 452:241-246
9. Gonzalez R, Kerbel B, Chun A, Unniappan S (2010) Molecular, cellular and physiological evidences for the anorexigenic actions of nesfatin-1 in goldfish. PLoS One 5:e15201
10. Gutierrez JA, Solenberg PJ, Perkins DR, Willency JA, Knierman MD, Jin Z, Witcher DR, Luo S, Onyia JE, Hale JE (2008) Ghrelin octanoylation mediated by an orphan lipid transferase. Proc Natl Acad Sci USA 105:6320-6325
11. Janas-Kozik M, Krupka-Matuszczyk I, Malinowska-Kolodziej I, Lewin-Kowalik J (2007) Total ghrelin plasma level in patients with the restrictive type of anorexia nervosa. Regul Pept 140:43-46
12. Katsuki A, Urakawa H, Gabazza EC, Murashima S, Nakatani K, Togashi K, Yano Y, Adachi Y, Sumida Y (2004) Circulating levels of active ghrelin is associated with abdominal adiposity, hyperinsulinemia and insulin resistance in patients with type 2 diabetes mellitus. Eur J Endocrinol Eur Feder Endocr Soc 151:573-577
13. le Roux CW, Patterson M, Vincent RP, Hunt C, Ghatei MA, Bloom SR (2005) Postprandial plasma ghrelin is suppressed proportional to meal calorie content in normal-weight but not obese subjects. J Clin Endocrinol Metab 90:1068-1071
14. Maejima Y, Sedbazar U, Suyama S, Kohno D, Onaka T, Takano E, Yoshida N, Koike M, Uchiyama Y, Fujiwara K, Yashiro T, Horvath TL, Dietrich MO, Tanaka S, Dezaki K, Oh IS, Hashimoto K, Shimizu H, Nakata M, Mori M, Yada T (2009) Nesfatin-1-regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 10:355-365
15. Merali Z, Cayer C, Kent P, Anisman H (2008) Nesfatin-1 increases anxiety- and fear-related behaviors in the rat. Psychopharmacology 201:115-123
16. Ogiso K, Asakawa A, Amitani H, Nakahara T, Ushikai M, Haruta I, Koyama KI, Amitani M, Harada T, Yasuhara D, Inui A (2011) Plasma nesfatin-1 concentrations in restricting-type anorexia nervosa. Peptides 32:150-153
17. Oh-I S, Shimizu H, Satoh T, Okada S, Adachi S, Inoue K, Eguchi H, Yamamoto M, Imaki T, Hashimoto K, Tsuchiya T, Monden T, Horiguchi K, Yamada M, Mori M (2006) Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 443:709-712
18. Ramanjaneya M, Chen J, Brown JE, Tripathi G, Hallschmid M, Patel S, Kern W, Hillhouse EW, Lehnert H, Tan BK, Randeva HS (2010) Identification of nesfatin-1 in human and murine adipose tissue: a novel depot-specific adipokine with increased levels in obesity. Endocrinology 151:3169-3180
19. Stengel A, Goebel M, Wang L, Rivier J, Kobelt P, Monnikes H, Lambrecht NW, Taché Y (2009a) Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology 150:4911-4919
20. Stengel A, Goebel M, Yakubov I, Wang L, Witcher D, Coskun T, Taché Y, Sachs G, Lambrecht NW (2009b) Identification and characterization of nesfatin-1 immunoreactivity in endocrine cell types of the rat gastric oxyntic mucosa. Endocrinology 150:232-238
21. Stengel A, Goebel M, Wang L, Taché Y, Sachs G, Lambrecht NW (2010) Differential distribution of ghrelin-O-acyltransferase (GOAT) immunoreactive cells in the mouse and rat gastric oxyntic mucosa. Biochem Biophys Res Commun 392:67-71
22. Stengel A, Goebel M, Taché Y (2011) Nesfatin-1: a novel inhibitory regulator of food intake and body weight. Obes Rev 12:261-271
23. Tschöp M, Smiley DL, Heiman ML (2000) Ghrelin induces adiposity in rodents. Nature 407:908-913
24. Wren AM, Seal LJ, Cohen MA, Brynes AE, Frost GS, Murphy KG, Dhillo WS, Ghatei MA, Bloom SR (2001) Ghrelin enhances appetite and increases food intake in humans. J Clin Endocrinol Metab 86:5992
25. Yang J, Brown MS, Liang G, Grishin NV, Goldstein JL (2008) Identification of the acyltransferase that octanoylates ghrelin, an appetite-stimulating peptide hormone. Cell 132:387-396
26. Yosten GL, Samson WK (2010) The anorexigenic and hypertensive effects of nesfatin-1 are reversed by pretreatment with an oxytocin receptor antagonist. Am J Physiol Regul Integr Comp Physiol 298:R1642-R1647