Evidence for anti-cancer properties of blueberries: A mini-review

Anti-Cancer Agents in Medicinal Chemistry

Volumn 13, Issue 8, 2013, Pages 1142-1148

  Johnson, Sarah A ^a   Arjmandi, Bahram H ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

Author keywords

Antioxidant; Cancer prevention; Carcinogenesis; Chemoprevention; DNA damage; Functional food; Inflammation; Oxidative stress; Polyphenol; Pterostilbene; Tumorigenesis; Vaccinium

Indexed keywords

ANTIOXIDANT; BETA CATENIN; BLUEBERRY EXTRACT; CAFFEIC ACID; CATECHIN; CHLOROGENIC ACID; CYCLIN D1; ELLAGIC ACID; EPICATECHIN; ESTRADIOL; FERULIC ACID; GALLIC ACID; GAMMA INTERFERON; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; INTERLEUKIN 13; KAEMPFEROL; KI 67 ANTIGEN; MALONALDEHYDE; MITOGEN ACTIVATED PROTEIN KINASE P38; MYRICETIN; PLANT MEDICINAL PRODUCT; PTEROSTILBENE; QUERCETIN; THROMBOSPONDIN 2; UNCLASSIFIED DRUG; WNT PROTEIN;

ABERRANT CRYPT FOCUS; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; BLUEBERRY; BREAST CANCER; CANCER INHIBITION; CELL PROLIFERATION; DNA DAMAGE; DRUG ABSORPTION; DRUG DOSE REDUCTION; DRUG METABOLISM; ENDOTHELIAL CELL NEOPLASM; ESOPHAGUS CANCER; HEMANGIOENDOTHELIOMA; HUMAN; LIVER METASTASIS; LYMPH NODE METASTASIS; NEOPLASM; NONHUMAN; OXIDATIVE STRESS; RASPBERRY; STRAWBERRY;

ANIMALS; ANTICARCINOGENIC AGENTS; ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; BLUEBERRY PLANT; BREAST NEOPLASMS; DNA DAMAGE; FEMALE; FRUIT; GASTROINTESTINAL NEOPLASMS; HEMANGIOENDOTHELIOMA; HUMANS; PHENOLS; PHYTOTHERAPY; PLANT EXTRACTS;

EID: 84888265954     PISSN: 18715206     EISSN: 18755992     Source Type: Journal    
DOI: 10.2174/18715206113139990137     Document Type: Article

References (53)

1. American Cancer Society. Cancer Facts & Figures 2012. Atlanta: American Cancer Society; 2012.
2. American Cancer Society. Cancer Facts & Figures 2011. Atlanta: American Cancer Society; 2011.
3. Murphy, S.L.; Xu, J.; Kochanek, K.D. Deaths: Preliminary data for 2010. National vital statistics reports, 2012, 60(4).
4. Mariotto, A.B.; Yabroff, K.R.; Shao, Y.; Feuer, E.J.; Brown, M.L. Projections of the cost of cancer care in the United States: 2010-2020. J. Natl. Cancer Inst., 2011, 103(2), 117-128.
5. Liu, R.H. Health benefits of fruit and vegetables are from additive and synergistic combinations of phytochemicals. The Am. J. Clin. Nutr., 2003, 78(Suppl), 517S-20S.
6. Kris-Etherton, P.M.; Hecker, K.D.; Bonanome, A.; Coval, S.M.; Binkoski, A.E.; Hilpert, K.F.; Griel, A.E.; Etherton, T.D. Bioactive compounds in foods: their role in the prevention of cardiovascular disease and cancer. Am. J. Med., 2002, 113(9B), 71S-88S.
7. Milner, J.A., Functional foods: the US perspective. Am J Clin Nutr, 2000, (71):1654S-9S; discussion 1674S-5S.
8. Seeram, N.P., Berry fruits for cancer prevention: current status and future prospects. J. Agric. Food Chem., 2008, 56(3), 630-5.
9. Stoner, G.D.; Wang, L.S.; Zikri, N.; Chen, T.; Hecht, S.S.; Huang, C.; Sardo, C.; Lechner, J.F. Cancer prevention with freeze-dried berries and berry components. Semin. Cancer Biol., 2007, 17(5), 403-10.
10. Casto, B.C.; Kresty, L.A.; Kraly, C.L.; Pearl, D.K.; Knobloch, T.J.; Schut, H.A.; Stoner, G.D.; Mallery, S.R.; Weghorst, C.M. Chemoprevention of oral cancer by black raspberries. Anticancer Res., 2002, 22(6C), 4005-15.
11. Wang, L.S.; Hecht, S.S.; Carmella, S.G.; Yu, N.; Larue, B.; Henry, C.; McIntyre, C.; Rocha, C.; Lechner, J.F.; Stoner, G.D. Anthocyanins in black raspberries prevent esophageal tumors in rats. Cancer Prev. Res., 2009, 2(1), 84-93.
12. Stoner, G.D.; Wang, L.S.; Seguin, C.; Rocha, C.; Stoner, K.; Chiu, S.; Kinghorn, A.D. Multiple Berry Types Prevent N-nitrosomethylbenzylamine-Induced Esophageal Cancer in Rats. Pharm. Res., 2010, 27(6), 1138-45.
13. Harris, G.K.; Gupta, A.; Nines, R.G.; Kresty, L.A.; Habib, S.G.; Frankel, W.L.; LaPerle, K.; Gallaher, D.D.; Schwartz, S.J.; Stoner, G.D. Effects of lyophilized black raspberries on azoxymethane-induced colon cancer and 8-hydroxy-2'-deoxyguanosine levels in the Fischer 344 rat. Nutr. Cancer, 2001, 40(2), 125-33.
14. Balansky, R.; Ganchev, G.; Iltcheva, M.; Kratchanova, M.; Denev, P.; Kratchanov, C.; Polasa, K.; D'Agostini, F.; Steele, V.E.; De Flora, S. Inhibition of lung tumor development by berry extracts in mice exposed to cigarette smoke. Int. J. Cancer, 2012, 131(9), 1991-7.
15. Duncan, F.J.; Martin, J.R.; Wulff, B.C.; Stoner, G.D.; Tober, K.L.; Oberyszyn, T.M.; Kusewitt, D.F.; Van Buskirk, A.M. Topical treatment with black raspberry extract reduces cutaneous UVB-induced carcinogenesis and inflammation. Cancer Prev. Res., 2009, 2(7), 665-72.
16. Carlton, P.S.; Kresty, L.A.; Stoner, G.D. Failure of dietary lyophilized strawberries to inhibit 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-and benzo[a]pyrene-induced lung tumori-genesis in strain A/J mice. Cancer Lett., 2000, 159(2), 113-7.
17. Ehlenfeldt, M.K.; Prior, R.L. Oxygen Radical Absorbance Capacity (ORAC) and Phenolic and Anthocyanin Concentrations in Fruit and Leaf Tissues of Highbush Blueberry. J. Agric. Food Chem., 2001, 49(5), 2222-7.
18. Kalt, W.; Ryan, D.A.; Duy, J.C.; Prior, R.L.; Ehlenfeldt, M.K.; Vander Kloet, S.P. Interspecific Variation in Anthocyanins, Phenolics, and Antioxidant Capacity among Genotypes of Highbush and Lowbush Blueberries (Vaccinium Section cyanococcus spp.). J. Agric. Food Chem., 2001, 49(10), 4761-7.
19. Sellappan, S.; Akoh, C.C.; Krewer, G. Phenolic compounds and antioxidant capacity of georgia-grown blueberries and blackberries. J. Agric. Food Chem., 2002, 50(8), 2432-8.
20. Moze, S.; Polak, T.; Gasperlin, L.; Koron, D.; Vanzo, A.; Poklar Ulrih, N.; Abram, V. Phenolics in Slovenian bilberries (Vaccinium myrtillus L.) and blueberries (Vaccinium corymbosum L.). J. Agric. Food Chem., 2011, 59(13), 6998-7004.
21. Sellappan, S.; Akoh, C.C.; Krewer, G. Phenolic compounds and antioxidant capacity of Georgia-grown blueberries and blackberries. J. Agric. Food Chem., 2002, 50(8), 2432-8.
22. Prior, R.L.; Cao, G.; Martin, A.; Sofic, E.; McEwen, J.; O'Brien, C.; Lischner, N.; Ehlenfeldt, M.; Kalt, W.; Krewer, G.; Mainland, C.M. Antioxidant capacity as influenced by total phenolic and anthocyanin content, maturity, and variety of vaccinium species. J. Agric. Food Chem., 1998, 46(7), 2686-2693.
23. Manach, C.; Williamson, G.; Morand, C.; Scalbert, A.; Rémésy, C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am. J. Clin. Nutr., 2005, 81(1 Suppl), 230S-242S.
24. Manach, C.; Scalbert, A.; Morand, C.; Rémésy, C.; Jiménez L. Polyphenols: Food sources and bioavailability. Am. J. Clin. Nutr., 2004, 79(5), 727-47.
25. Prior, R.L.; Wu, X. Anthocyanins: structural characteristics that result in unique metabolic patterns and biological activities. Free Radic. Res., 2006, 40(10), 1014-28.
26. Wang, L.S.; Stoner, G.D. Anthocyanins and their role in cancer prevention. Cancer Lett., 2008, 269(2), 281-90.
27. Wolfe, K.L.; Kang, X.; He, X.; Dong, M.; Zhang, Q.; Liu, R.H. Cellular antioxidant activity of common fruits. J. Agric. Food Chem., 2008, 56(18), 8418-8426.
28. Gupta, S.C.; Kim, J.H.; Prasad, S.; Aggarwal, B.B. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev., 2010, 29(3), 405-34.
29. Boivin, D.; Blanchette, M.; Barrette, S.; Moghrabi, A.; Béliveau, R. Inhibition of cancer cell proliferation and suppression of TNF-induced Activation of NF B by edible berry juice. Anticancer Res., 2007, 27(2), 937-48.
30. Xie, C.; Kang, J.; Ferguson, M.E.; Nagarajan, S.; Badger, T.M.; Wu, X. Blueberries reduce pro-inflammatory cytokine TNF-and IL-6 production in mouse macrophages by inhibiting NF B activation and the MAPK pathway. Mol. Nutr. Food Res., 2011, 55(10), 1587-91.
31. Paul, S.; Rimando, A.M.; Lee, H.J.; Ji, Y.; Reddy, B.S.; Suh, N. Anti-inflammatory action of pterostilbene is mediated through the p38 MAPK pathway in colon cancer cells. Cancer Prev. Res., 2009, 2(7). 650-7.
32. Reuter, S.; Gupta, S.C.; Chaturvedi, M.M.; Aggarwal, B.B.Oxidative Stress, inflammation, and cancer: How are they linked? Free Radic. Biol. Med., 2010, 49(11), 1603-16.
33. Wilms, L.C.; Hollman, P.C.; Boots, A.W.; Kleinjans, J.C. Protection by quercetin and quercetin-rich fruit juice against induction of oxidative DNA damage and formation of BPDE-DNA adducts in human lymphocytes. Mutat. Res., 2005, 582(1-2), 155-62.
34. Aiyer, H.S.; Vadhanam, M.V.; Stoyanova, R.; Caprio, G.D.; Clapper, M.L.; Gupta, R.C. Dietary berries and ellagic acid prevent oxidative DNA damage and modulate expression of DNA repair genes. Int. J. Mol. Sci., 2008, 9(3), 327-41.
35. Senevirathne, M.; Kim, S.H.; Jeon YJ. Protective effect of enzymatic hydrolysates from highbush blueberry (Vaccinium corymbosum L.) against hydrogen peroxide-induced oxidative damage in Chinese hamster lung fibroblast cell line. Nutr. Res. Pract., 2010, 4(3), 183-90.
36. Seeram, N.P.; Adams, L.S.; Zhang, Y.; Lee, R.; Sand, D.; Scheuller, H.S.; Heber, D. Blackberry, black raspberry, blueberry, cranberry, red raspberry, and strawberry extracts inhibit growth and stimulate apoptosis of human cancer cells in vitro. J. Agric. Food Chem., 2006, 54(25), 9329-9339.
37. Srivastava, A.; Akoh, C.C.; Fischer, J.; Krewer, G. Effect of anthocyanin fractions from selected cultivars of georgia-grown blueberries on apoptosis and phase II enzymes. J. Agric. Food Chem., 2007, 55(8), 3180-3185.
38. Yi, W.; Fischer, J.; Krewer, G.; Akoh, C.C. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J. Agric. Food Chem., 2005, 53(18), 7320-7329.
39. Pan, M.H.; Chang, Y.H.; Badmaev, V.; Nagabhushanam, K.; Ho, C.T. Pterostilbene induces apoptosis and cell cycle arrest in human gastric carcinoma cells. J. Agric. Food Chem., 2007, 55(19), 7777-7785.
40. Adams, L.S.; Phung, S.; Yee, N.; Seeram, N.P.; Li, L.; Chen, S. Blueberry phytochemicals inhibit growth and metastatic potential of MDA-MB-231 breast cancer cells through modulation of the phosphatidyllinositol 3-kinase pathway. Cancer Res., 2010, 70(9), 3594-3605.
41. Roy, S.; Khanna, S.; Alessio, H.M.; Vider, J.; Bagchi, D.; Bagchi, M.; Sen, C.K. Anti-angiogenic property of edible berries. Free Radic. Res., 2002, 36(9), 1023-1031.
42. Atalay, M.; Gordillo, G.; Roy, S.; Rovin, B.; Bagchi, D.; Bagchi, M.; Sen, C.K. Anti-angiogenic property of edible berry in a model of hemangioma. FEBS Lett., 2003, 544(1-3), 252-257.
43. Aiyer, H.S.; Kichambare, S.; Gupta, R.C. Prevention of oxidative DNA damage by bioactive berry components. Nutr. Cancer, 2008, 60 Suppl 1, 36-42.
44. Wang, L.S.; Hecht, S.; Carmella, S.; Seguin, C.; Rocha, C.; Yu, N.; Stoner, K.; Chiu, S.; Stoner, G. Berry ellagitannins may not be sufficient for prevention of tumors in the rodent esophagus. J. Agric. Food Chem., 2010, 58(7), 3992-3995.
45. Boateng, J.; Verghese, M.; Shackelford, L.; Walker, L.T.; Khatiwada, J.; Ogutu, S.; Williams, D.S.; Jones, J.; Guyton, M.; Asiamah, D.; Henderson, F.; Grant, L.; DeBruce, M.; Johnson, A.; Washington, S.; Chawan, C.B. Selected fruits reduce azoxymethane (AOM)-induced aberrant crypt foci (ACF) in Fisher 344 male rats. Food Chem. Toxicol., 2007, 45(5), 725-732.
46. Suh, N.; Paul, S.; Hao, X.; Simi, B.; Xiao, H.; Rimando, A.M.; Reddy, B.S. Pterostillbene, an active constituent of blueberries, suppresses aberrant crypt foci formation in the azoxymethane-induced colon carcinogenesis model in rats. Clin. Cancer Res., 2007, 13(1), 350-355.
47. Paul, S.; DeCastro, A.J.; Lee, H.J.; Smolarek, A.K.; So, J.Y.; Simi, B.; Wang, C.X.; Zhou, R.; Rimando, A.M.; Suh, N. Dietary intake of pterostillbene, a constituent of blueberries, inhibits the catenin/p65 downstream signaling pathway and colon carcino-genesis in rats. Carcinogenesis, 2010, 31(7), 1272-1278.
48. Simmen, F.A.; Frank, J.A.; Wu, X.; Xiao, R.; Hennings, L.J.; Prior, R.L. Lack of efficacy in nutritional prevention of azoxymethane-initiated cancers of rat small intestine and colon. BMC Gastroenterol., 2009, 9(67).
49. Aiyer, H.S.; Srinivasan, C.; Gupta, R.C. Dietary berries and ellagic acid diminish estrogen-mediated mammary tumorigenesis in ACI rats. Nutr. Cancer, 2008, 60(2), 227-234.
50. Aiyer, H.S.; Gupta, R.C. Berries and ellagic acid prevent estrogen-induced mammary tumorigenesis by modulating enzymes of estrogen metabolism Cancer Prev. Res., 2010, 3(6), 727-737.
51. Adams, L.S.; Kanaya, N.; Phung, S.; Liu, Z.; Chen, S. Whole blueberry powder modulates growth and metastasis of MDA-MB-231 triple negative breast tumors in nude mice. J. Nutr., 2011, 141(10), 1805-1812.
52. Gordillo, G.; Fang, H.; Khanna, S.; Harper, J.; Phillips, G.; Sen, C.K. Oral administration of blueberry inhibits angiogenic tumor growth and enhances surivival of mice with endothelial cell neoplasm. Antioxid. Redox Signal, 2009, 11(1), 47-58.
53. Wilms, L.C.; Boots, A.W.; de Boer, V.C.; Maas, L.M.; Pachen, D.M.; Gottschalk, R.W.; Ketelslegers, H.B.; Godschalk, R.W.; Haenen, G.R.; van Schooten, F.J.; Kleinjans, J.C. Impact of multiple genetic polymorphisms on effects of a 4-week blueberry juice intervention on ex vivo induced lymphocytic DNA damage in human volunteers. Carcinogenesis, 2007, 28(8), 1800-1806.