Antinociceptive curcuminoid, KMS4034, effects on inflammatory and neuropathic pain likely via modulating TRPV1 in mice

British Journal of Anaesthesia

Volumn 111, Issue 4, 2013, Pages 667-672

  Lee, J Y ^a   Shin, T J ^a   Choi, J M ^a   Seo, K S ^a   Kim, H J ^a   Yoon, T G ^b   Lee, Y S ^c   Han, H ^c   Chung, H J ^d   Oh, Y ^e   Jung, S J ^e   Shin, K J ^f  

^a Seoul National University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c Korea University   (South Korea)

^d Korea Institute of Science and Technology   (South Korea)

^e Hanyang University   (South Korea)

^f The Catholic University of Korea   (South Korea)

Author keywords

Calcitonin gene related peptide; Curcuminoid synthesis; Inflammatory; Neuropathic; Nociceptive; Pain; TRPV1 receptor

Indexed keywords

ANTINOCICEPTIVE AGENT; CALCITONIN GENE RELATED PEPTIDE; CAPSAICIN; CURCUMIN; FORMALDEHYDE; KMS 4034; UNCLASSIFIED DRUG; VANILLOID RECEPTOR 1;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; CELL STRAIN HEK293; CHANNEL GATING; CHRONIC CONSTRICTION INJURY; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG METABOLISM; DRUG SCREENING; DRUG STABILITY; EXPERIMENTAL LIGATION; FORMALIN TEST; HEAT TRANSFER; HOT PLATE TEST; IMMUNOHISTOCHEMISTRY; INFLAMMATORY PAIN; KIDNEY CLEARANCE; LUMBAR SPINE; MALE; MAXIMUM PLASMA CONCENTRATION; MOUSE; NEUROPATHIC PAIN; NONHUMAN; PAIN ASSESSMENT; PAIN THRESHOLD; PLASMA CONCENTRATION-TIME CURVE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPINAL CORD DORSAL HORN; TREATMENT OUTCOME;

EID: 84888245239     PISSN: 00070912     EISSN: 14716771     Source Type: Journal    
DOI: 10.1093/bja/aet176     Document Type: Article

References (39)

1. Samuhasaneeto S, Thong-Ngam D, Kulaputana O, Suyasunanont D, laikeawN.Curcumindecreasedoxidativestress, inhibitedNF-kappaB activation, and improved liver pathology in ethanol-induced liver injury in rats. J Biomed Biotechnol 2009; 2009: 981963
2. Pinlaor S, Yongvanit P, PrakobwongS, et al. Curcumin reduces oxidative and nitrative DNA damage through balancing of oxidant-antioxidant status in hamsters infected with Opisthorchis viverrini. Mol Nutr Food Res 2009; 53: 1316-28
3. Srimal RC,DhawanBN.Pharmacologyof diferuloylmethane(curcumin), a non-steroidal anti-inflammatory agent. J Pharm Pharmacol 1973; 25: 447-52
4. Mahady GB, Pendland SL, Yun G, Lu ZZ. Turmeric (Curcuma longa) and curcumin inhibit the growth of Helicobacter pylori, a group 1 carcinogen. Anticancer Res 2002; 22: 4179-81
5. Wang Y, Lu Z,Wu H, Lv F. Studyon the antibiotic activity of microcapsule curcumin against foodborne pathogens. Int J Food Microbiol2009; 136: 71-4
6. Mittal N, Joshi R, Hota D, Chakrabarti A. Evaluation of antihyperalgesic effect of curcumin on formalin-induced orofacial pain in rat. Phytother Res 2008; 23: 507-12
7. SharmaS, Kulkarni SK, Agrewala JN, ChopraK. Curcumin attenuates thermal hyperalgesia in a diabetic mouse model of neuropathic pain. Eur J Pharmacol 2006; 536: 256-61
8. Chainani-Wu N. Safety and anti-inflammatory activity of curcumin: acomponent of tumeric (Curcumalonga). J AlternComplementMed 2003; 9: 161-8
9. Anand P, Kunnumakkara AB, Newman RA, Aggarwal BB. Bioavailability of curcumin: problems and promises. Mol Pharm 2007; 4:807-18
10. Yeon KY, Kim SA, Kim YH, et al. Curcumin produces an antihyperalgesic effect via antagonism of TRPV1. J Dent Res 2010; 89: 170-4
11. Hunskaar S, Hole K. The formalin test in mice: dissociation between inflammatory and non-inflammatory pain. Pain 1987; 30: 103-14
12. Rosland JH, Tjolsen A, Maehle B, Hole K. The formalin test in mice: effect of formalin concentration. Pain 1990; 42: 235-42
13. Hunskaar S, Fasmer OB, Hole K. Formalin test in mice, a useful technique for evaluating mild analgesics. J Neurosci Methods 1985; 14: 69-76
14. Eddy NB, Leimbach D. Synthetic analgesics. 2. ithienylbutenylanddithienylbutylamines. J Pharmacol Exp Ther 1953;107: 385-93
15. Bennett GJ, Xie YK. A peripheral mononeuropathy in rat that produces disorders of pain sensation like those seen in man. Pain 1988; 33: 87-107
16. Lee MJ, Shin TJ, Lee JE, et al. KST5468,anewT-type calcium channel antagonist, has an antinociceptive effect on inflammatory and neuropathic pain models. Pharmacol Biochem Behav 2010; 97: 198-204
17. Lee W-H, Shin TJ, Kim HJ, et al. Intrathecal administration of botulinum neurotoxin type A attenuates formalin-induced nociceptive responses in mice. Anesth Analg 2011; 112: 228-35
18. Yang KY, Lin LC, Tseng TY, Wang SC, Tsai TH. Oral bioavailability of curcumin in rat and the herbal analysis from Curcuma longa by LC-MS/MS. J Chromatogr B Anal Technol Biomed Life Sci 2007; 853: 183-9
19. Lam PM, McDonald J, Lambert DG. Characterization and comparison of recombinant human and rat TRPV1 receptors: effects of exo- and endocannabinoids. Br J Anaesth 2005; 94: 649-56
20. Szallasi A, Blumberg PM. Vanilloid (Capsaicin) receptors and mechanisms. Pharmacol Rev 1999; 51: 159-212
21. Caterina MJ, Schumacher MA, Tominaga M, Rosen TA, Levine JD, Julius D. The capsaicin receptor: a heat-activated ion channel in the pain pathway. Nature 1997; 389: 816-24
22. Tominaga M, Caterina MJ, Malmberg AB, et al. The cloned capsaicin eceptor integrates multiple pain-producing stimuli. Neuron 1998; 21: 531-43eceptor integrates multiple pain-producing stimuli. Neuron 1998; 21: 531-43
23. Jordt SE, Tominaga M, Julius D. Acid potentiation of the capsaicin receptor determined by a key extracellular site. Proc Natl Acad Sci USA 2000; 97: 8134-9
24. Ji R-R, Samad TA, Jin S-X, Schmoll R,Woolf CJ. p38 MAPK activation by NGF in primary sensory neurons after inflammation increases TRPV1 levels and maintains heat hyperalgesia. Neuron 2002; 36: 57-68
25. Hudson LJ, Bevan S,Wotherspoon G, Gentry C, Fox A, Winter J. VR1 protein expression increases in undamaged DRG neurons afterpartial nerve injury. Eur J Neurosci 2001; 13: 2105-14
26. Lambert DG. Capsaicin receptor antagonists: a promising newaddition to the pain clinic. Br J Anaesth 2009; 102: 153-5
27. Nguyen TL,NamYS, Lee SY, KimHC, Jang CG. Effects of capsazepine, a transient receptor potential vanilloid type 1 antagonist, on morphine-induced antinociception, tolerance, and dependence in mice. Br J Anaesth 2010; 105: 668-74
28. Niiyama Y, Kawamata T, Yamamoto J, Furuse S, Namiki A. SB366791, a TRPV1 antagonist, potentiates analgesic effects of systemic morphine in a murine model of bone cancer pain. Br J Anaesth 2009; 102: 251-8
29. Tjolsen A, Berge OG, Hunskaar S, Rosland JH, Hole K. The formalin test: an evaluation of the method. Pain 1992; 51: 5-17
30. VissersKC, Geenen F, Biermans R, Meert TF. Pharmacological correlation between the formalin test and the neuropathic pain behaviorin different species with chronic constriction injury. Pharmacol Biochem Behav 2006; 84: 479-86
31. Bannon AW, Malmberg AB. Models of nociception: hot-plate, tailflick, and formalin tests in rodents. Curr Protoc Neurosci 2007; Ch. 8: Unit 8 9
32. Treede RD, Meyer RA, Raja SN, Campbell JN. Peripheral and central mechanisms of cutaneous hyperalgesia. Prog Neurobiol 1992; 38: 397-421
33. Oku R, Satoh M, Fujii N, Otaka A, Yajima H, Takagi H. Calcitonin gene-related peptide promotes mechanical nociception by potentiating release of substance P from the spinal dorsal horn in rats. Brain Res 1987; 403: 350-4
34. Bird G, Han J, Fu Y, Adwanikar H, Willis W, Neugebauer V. Painrelated synaptic plasticity in spinal dorsal horn neurons: role ofCGRP. Mol Pain 2006; 2: 31
35. Miki K, Fukuoka T, Tokunaga A, Noguchi K. Calcitonin gene-related peptide increase in the rat spinal dorsal horn and dorsal column nucleus following peripheral nerve injury: up-regulation in a subpopulation of primary afferent sensory neurons. Neuroscience 1998; 82: 1243-52
36. Lee SE, Kim JH. Involvement of substance P and calcitonin gene-related peptide in development and maintenance of neuropathic pain from spinal nerve injury model of rat. Neurosci Res 2007; 58: 245-9
37. Fernihough J, Gentry C, Bevan S, Winter J. Regulation of calcitonin gene-related peptide and TRPV1 in a rat model of osteoarthritis. Neurosci Lett 2005; 388: 75-80
38. Murata Y, Masuko S. Peripheral and central distribution of TRPV1,substance P and CGRP of rat corneal neurons. Brain Res 2006;1085: 87-94
39. Brain SD, Grant AD. Vascular actions of calcitonin gene-related peptide and adrenomedullin. Physiol Rev 2004; 84: 903-34