Chronic cadmium exposure in vitro induces cancer cell characteristics in human lung cells

Toxicology and Applied Pharmacology

Volumn 273, Issue 2, 2013, Pages 281-288

  Person, Rachel J ^a   Tokar, Erik J ^a   Xu, Yuanyuan ^a   Orihuela, Ruben ^a   Ngalame, Ntube N Olive ^a   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Adaptation; Cadmium; Epithelial to mesenchymal transition; Human lung cells; Lung cancer; Transformation

Indexed keywords

CADMIUM; CYCLIN D1; GELATINASE A; HEME OXYGENASE 1; HYPOXIA INDUCIBLE FACTOR 1ALPHA; K RAS PROTEIN; METALLOTHIONEIN; PROTEIN P16; VIMENTIN;

ARTICLE; CANCER CELL; CELL GROWTH; CELL PROLIFERATION; CELL TRANSFORMATION; CELLULAR SECRETION; COLONY FORMATION; CONTROLLED STUDY; CULTURE MEDIUM; ENVIRONMENTAL EXPOSURE; EPITHELIAL MESENCHYMAL TRANSITION; GENE EXPRESSION; HUMAN; HUMAN CELL; IN VITRO STUDY; LUNG ALVEOLUS CELL; LUNG ALVEOLUS EPITHELIUM; LUNG CARCINOGENESIS; PHENOTYPE; TUMOR GENE; TUMOR INVASION; TUMOR SUPPRESSOR GENE;

4′,6-DIAMIDINO-2-PHENYLINDOLE; 5,5-DIMETHYL-1-PYRROLINE N-OXIDE; ADAPTATION; BOVINE SERUM ALBUMIN; BSA; CADMIUM; CCT-LC; CHRONIC CADMIUM TREATED-LUNG CELLS; DAPI; DMPO; EPITHELIAL-TO-MESENCHYMAL TRANSITION; HEME OXYGENASE-1; HIF-1A; HO-1; HPL; HUMAN LUNG CELLS; HUMAN PERIPHERAL LUNG; HYPOXIA INDUCIBLE FACTOR-1 ALPHA; IMMUNO-SPIN TRAPPING; INT; IST; LC50; LETHAL CONCENTRATION 50; LUCA; LUNG CANCER; MATRIX METALLOPROTEINASE-2; METALLOTHIONEIN-1A; METALLOTHIONEIN-2A; MMP-2; MT-1A; MT-2A; P-IODONITRO-TETRAZOLIUM VIOLET; PBS; PHOSPHATE BUFFERED SALINE; QRT-PCR; QUANTITATIVE REAL TIME REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSFORMATION; ZINC TRANSPORTER; ZIP; ZNT; ZRT/IRT-LIKE PROTEINS;

CADMIUM; CELL TRANSFORMATION, NEOPLASTIC; DNA DAMAGE; HUMANS; LUNG; LUNG NEOPLASMS; OXIDATIVE STRESS; RESPIRATORY MUCOSA; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 84888203089     PISSN: 0041008X     EISSN: 10960333     Source Type: Journal    
DOI: 10.1016/j.taap.2013.06.013     Document Type: Article

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