Acquisition of apoptotic resistance in cadmium-induced malignant transformation: Specific perturbation of JNK signal transduction pathway and associated metallothionein overexpression

Molecular Carcinogenesis

Volumn 45, Issue 8, 2006, Pages 561-571

  Qu, Wei ^a   Fuquay, Richard ^a   Sakurai, Teruaki ^a   Waalkes, Michael P ^a  

^a NATIONAL INSTITUTE OF ENVIRONMENTAL HEALTH SCIENCES   (United States)

Author keywords

Apoptosis; Cadmium; JNK; Malignant transformation; Metallothionein

Indexed keywords

2 [1 (3 AMIDINOTHIOPROPYL) 1H INDOL 3 YL] 3 (1 METHYL 1H INDOL 3 YL)MALEIMIDE; CADMIUM; EPIDERMAL GROWTH FACTOR RECEPTOR; ETOPOSIDE; METALLOTHIONEIN; MITOGEN ACTIVATED PROTEIN KINASE; STRESS ACTIVATED PROTEIN KINASE;

ANIMAL CELL; APOPTOSIS; ARTICLE; CARCINOGENESIS; CELL TRANSFORMATION; DRUG EXPOSURE; DRUG RESISTANCE; ENZYME SPECIFICITY; EPITHELIUM CELL; FLOW CYTOMETRY; GENE OVEREXPRESSION; LIVER PARENCHYMA; MALIGNANT TRANSFORMATION; NONHUMAN; PRIORITY JOURNAL; RAT; SIGNAL TRANSDUCTION;

ANIMALS; APOPTOSIS; CADMIUM; CELL TRANSFORMATION, NEOPLASTIC; CELLS, CULTURED; INDOLES; JNK MITOGEN-ACTIVATED PROTEIN KINASES; LIVER; METALLOTHIONEIN; MITOGEN-ACTIVATED PROTEIN KINASE 8; MITOGEN-ACTIVATED PROTEIN KINASE 9; PHOSPHORYLATION; PROTEIN KINASE INHIBITORS; RATS; SIGNAL TRANSDUCTION; UP-REGULATION;

EID: 33746978180     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.20185     Document Type: Article

References (33)

1. IARC. Beryllium, cadmium, mercury, and exposure in the glass manufacturing industry. In: International Agency for Research on Cancer Monographs on the Evaluation of the Carcinogenic Risks to Humans, Vol. 58, IARC, Lyon. 1993.
2. Waalkes MP. Cadmium carcinogenesis. Mutat Res 2003; 533:107-120.
3. National Toxicology Program. Ninth report on carcinogens. Research Triangle Park, NC: National Toxicology Program; 2000.
4. DiPaolo JA, Casto BC. Quantitative studies of in vitro morphological transformation of Syrian hamster cells by inorganic metal salts. Cancer Res 1979;39:1008-1013.
5. Terracio L, Nachtigal M. Oncogenicity of rat prostate cells transformed in vitro with cadmium chloride. Arch Toxicol 1988;61:450-456.
6. Acharvar WE, Diwan BA, Liu J, Quader ST, Webber MM, Waalkes MP. Cadmium-induced malignant transformation of human prostate epithelial cells. Cancer Res 2001;61:455-458.
7. Qu W, Diwan BA, Reece JM, et al. Cadmium-induced malignant transformation in rat liver cells: Role of aberrant oncogene expression and minimal role of oxidative stress. Int J Cancer 2005;114:346-355.
8. Shivapurkar N, Reddy J, Chaudhary PM, Gazdar AF. Apoptosis and lung cancer: A review. J Cell Biochem 2003; 88:885-898.
9. Hanahan D, Weinberg RA. The hallmarks of cancer. Cell 2000;100:57-70.
10. Qu W, Bortner CD, Sakurai T, Hobson MJ, Waalkes MP. Acquisition of apoptotic resistance in arsenic-induced malignant transformation: Role of the JNK signal transduction pathway. Carcinogenesis 2002;23:151-159.
11. Xia Z, Dickens M, Raingeaud J, Davis RJ, Greenberg ME. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 1995;270:1326-1331.
12. Klaassen CD, Liu J, Choudhuri S. Metallothionein: An intracellular protein to protect against cadmium toxicity. Annu Rev Pharmacol Toxicol 1999;39:267-294.
13. Habeebu SS, Liu J, Liu Y, Klaassen CD. Metallothionein-null mice are more susceptible than wild-type mice to chronic CdCl(2)-induced bone injury. Toxicol Sci 2000;56:211-219.
14. Waalkes MP. Cadmium carcinogenesis in review. J Inorg Biochem 2000;79:241-244.
15. Lazo JS, Kuo SM, Woo ES, Pitt BR. The protein thiol metallothionein as an antioxidant and protectant against antineoplastic drugs. Chem Biol Interact. 1998;112:255-262.
16. Wang GW, Klein JB, Kang YJ. Metallothionein inhibits doxorubicin-induced mitochondrial cytochrome c release and caspase-3 activation in cardiomyocytes. J Pharmacol Exp Ther 2001;298:461-468.
17. McAleer MF, Tuan RS. Metallothionein overexpression in human trophoblastic cells protects against cadmium-induced apoptosis. In Vitr Mol Toxicol 2001;14:25-42.
18. Shimoda R, Achanzar WE, Qu W, et al. Metallothionein is a potential negative regulator of apoptosis. Toxicol Sci 2003; 73:294-300.
19. Shimoda R, Nagamine T, Takagi H, Mori M, Waalkes MP. Induction of apoptosis in cells by cadmium: Quantitative negative correlation between basal or induced metallothionein concentration and apoptolic rate. Toxicol Sci 2001;64:208-215.
20. Idoine JB, Elliott JM, Wilson MJ, Weisburger EK. Rat liver cells in culture: Effect of storage, long-term culture, and transformation on some enzyme levels. In Vitro 1976;12:541-553.
21. Zhao CQ, Young MR, Diwan BA, Coogan TP, Waalkes MP. Association of arsenic-induced malignant transformation with DNA hypomethylation and aberrant gene expression. Proc Natl Acad Sci USA 1997;94:10907-10912.
22. Qu W, Kasprzak SK, Kadiiska M, et al. Mechanisms of arsenic-induced cross-tolerance to nickel cytotoxicity, genotoxicity and apoptosis in rat liver epithelial cells. Toxicol Sci 2001;63:189-195.
23. Bradford MM. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem 1976;72:248-254.
24. Waalkes MP, Liu J, Chen H, et al. Estrogen signaling in livers of male mice with hepatocellular carcinoma induced by exposure to arsenic in utero. J Natl Cancer Inst 2004;96:466-474.
25. Beltrnan J, McCormick F, Cook SJ. The selective protein kinase, C inhibitor, Ro-31-8220, inhibits mitogen-activated protein kinase phosphatase-1 (MKP-1) expression, induces c-jun expression, and activates jun N-terminal kinase. J Biol Chem 1996;271:27018-27024.
26. Sandau KB, Callsen D, Brüne B. Protection against nitric oxide-induced apoptosis in rat mesangial cells demands mitogen-activated protein kinasesand reduced glutathione. Mol Pharmacol 1999;56:744-751.
27. Achanzar WE, Webber MM, Waalkes MP. Altered apoptotic gene expression and acquired apoptotic resistance in cadmium-transformed human prostate epithelial cells. Prostate 2002;52:236-244.
28. Hart BA, Potts RJ, Watkin RD. Cadmium adaptation in the lung-A double-edged sword? Toxicology 2001;160:65-70.
29. Vasilevskaya I, O'Dwyer PJ. Role of jun and jun kinase in resistance of cancer cells to therapy. Drug Resist Updat 2003;6:147-156.
30. Koo MS, Kwo YG, Park JH, Choi WJ, Billiar TR, Kim YM. Signaling and function of caspase and c-jun N-terminal kinase in cisplatin-induced apoptosis. Mol Cells 2002;13:194-201.
31. Vivo C, Liu W, Broaddus VC. c-jun N-terminal kinase contributes to apoptotic synergy induced by tumor necrosis factor-related apoptosis-inducing ligand plus DNA damage in chemoresistant, p53 inactive mesothelioma cells. J Biol Chem 2003;278:25461-25467.
32. Kondo Y, Rusnak JM, Hoyt DG, Settineri CE, Pitt BR, Lazo JS. Enhanced apoptosis in metallothionein null cells. Mol Pharmacol 1997;52:195-201.
33. Liu J, Kadiiska MB, Corton JC, et al. Acute cadmium exposure induces stress-related gene expression in wild-type and metallothionein-I/II-null mice. Free Radic Biol Med 2002; 32:525-535.