Fibroblast-specific expression of AC6 enhances β-adrenergic and prostacyclin signaling and blunts bleomycin-induced pulmonary fibrosis

American Journal of Physiology - Lung Cellular and Molecular Physiology

Volumn 298, Issue 6, 2010, Pages

  Liu, Xiaoqiu ^a   Li, Fengying ^a   Sun, Shu Qiang ^a   Thangavel, Muthusamy ^a   Kaminsky, Joseph ^a   Balazs, Louisa ^a   Ostrom, Rennolds S ^a  

^a UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

cAMP; Lipid rafts

Indexed keywords

ADENYLATE CYCLASE; ADENYLATE CYCLASE 6; BERAPROST; BETA ADRENERGIC RECEPTOR; BLEOMYCIN; BUTAPROST; CATECHOLAMINE; CYCLIC AMP; HISTONE DEACETYLASE 6; ISOPRENALINE; PROSTACYCLIN; PROSTAGLANDIN E2; SODIUM CHLORIDE; UNCLASSIFIED DRUG;

ADRENERGIC SYSTEM; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BETA ADRENERGIC STIMULATION; CELL DIFFERENTIATION; CELL SPECIFICITY; COLLAGEN SYNTHESIS; CONTROLLED STUDY; ENZYME INHIBITION; ENZYME SYNTHESIS; EXTRACELLULAR MATRIX; FEMALE; FIBROGENESIS; FIBROSING ALVEOLITIS; GENE OVEREXPRESSION; HISTOPATHOLOGY; IMMUNOBLOTTING; LIPID RAFT; LUNG FIBROBLAST; LUNG FIBROSIS; LUNG FUNCTION; LUNG STRUCTURE; LYMPHOCYTIC INFILTRATION; MALE; MOUSE; MYOFIBROBLAST; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; RAT; SIGNAL TRANSDUCTION; TRANSGENIC MOUSE;

ADENOSINE-5'-(N-ETHYLCARBOXAMIDE); ADENYLATE CYCLASE; ALPROSTADIL; ANIMALS; BLEOMYCIN; CALCIUM-BINDING PROTEINS; CATECHOLAMINES; COLLAGEN; CYCLIC AMP; EPOPROSTENOL; FIBROBLASTS; FORSKOLIN; ISOPROTERENOL; LUNG; MEMBRANE MICRODOMAINS; MICE; MICE, TRANSGENIC; PULMONARY FIBROSIS; RATS; SIGNAL TRANSDUCTION;

EID: 77952774119     PISSN: 10400605     EISSN: 15221504     Source Type: Journal    
DOI: 10.1152/ajplung.00429.2009     Document Type: Article

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