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Volumn 23, Issue 12, 2013, Pages 587-592

Concealing cellular defects in pluripotent stem cells

Author keywords

Disease modeling; Pluripotent stem cell; Reprogramming

Indexed keywords

CELL AGING; CELL DAMAGE; CELL DIFFERENTIATION; CELL TRANSFORMATION; CYTOARCHITECTURE; EMBRYONIC STEM CELL; EPIGENETICS; HUMAN; NONHUMAN; PHENOTYPE; PLURIPOTENT STEM CELL; PRIORITY JOURNAL; REVIEW; SENESCENCE; SOMATIC CELL; TRINUCLEOTIDE REPEAT;

EID: 84888200046     PISSN: 09628924     EISSN: 18793088     Source Type: Journal    
DOI: 10.1016/j.tcb.2013.07.001     Document Type: Review
Times cited : (16)

References (50)
  • 1
    • 79952899995 scopus 로고    scopus 로고
    • Methods for making induced pluripotent stem cells: reprogramming a la carte
    • Gonzalez F., et al. Methods for making induced pluripotent stem cells: reprogramming a la carte. Nat. Rev. Genet. 2011, 12:231-242.
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 231-242
    • Gonzalez, F.1
  • 2
    • 77956214743 scopus 로고    scopus 로고
    • Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells
    • Urbach A., et al. Differential modeling of fragile X syndrome by human embryonic stem cells and induced pluripotent stem cells. Cell Stem Cell 2010, 6:407-411.
    • (2010) Cell Stem Cell , vol.6 , pp. 407-411
    • Urbach, A.1
  • 3
    • 84865064735 scopus 로고    scopus 로고
    • Signaling defects in iPSC-derived fragile X premutation neurons
    • Liu J., et al. Signaling defects in iPSC-derived fragile X premutation neurons. Hum. Mol. Genet. 2012, 21:3795-3805.
    • (2012) Hum. Mol. Genet. , vol.21 , pp. 3795-3805
    • Liu, J.1
  • 4
    • 80053948646 scopus 로고    scopus 로고
    • Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome
    • Sheridan S.D., et al. Epigenetic characterization of the FMR1 gene and aberrant neurodevelopment in human induced pluripotent stem cell models of fragile X syndrome. PLoS ONE 2011, 6:e26203.
    • (2011) PLoS ONE , vol.6
    • Sheridan, S.D.1
  • 5
    • 84872922075 scopus 로고    scopus 로고
    • Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus
    • Alisch R.S., et al. Genome-wide analysis validates aberrant methylation in fragile X syndrome is specific to the FMR1 locus. BMC Med. Genet. 2013, 14:18.
    • (2013) BMC Med. Genet. , vol.14 , pp. 18
    • Alisch, R.S.1
  • 6
    • 70350380887 scopus 로고    scopus 로고
    • Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells
    • Utikal J., et al. Sox2 is dispensable for the reprogramming of melanocytes and melanoma cells into induced pluripotent stem cells. J. Cell Sci. 2009, 122:3502-3510.
    • (2009) J. Cell Sci. , vol.122 , pp. 3502-3510
    • Utikal, J.1
  • 7
    • 3543073392 scopus 로고    scopus 로고
    • Reprogramming of a melanoma genome by nuclear transplantation
    • Hochedlinger K., et al. Reprogramming of a melanoma genome by nuclear transplantation. Genes Dev. 2004, 18:1875-1885.
    • (2004) Genes Dev. , vol.18 , pp. 1875-1885
    • Hochedlinger, K.1
  • 8
    • 77953250105 scopus 로고    scopus 로고
    • Generation of iPSCs from cultured human malignant cells
    • Carette J.E., et al. Generation of iPSCs from cultured human malignant cells. Blood 2010, 115:4039-4042.
    • (2010) Blood , vol.115 , pp. 4039-4042
    • Carette, J.E.1
  • 9
    • 80051899099 scopus 로고    scopus 로고
    • Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells
    • Choi S.M., et al. Reprogramming of EBV-immortalized B-lymphocyte cell lines into induced pluripotent stem cells. Blood 2011, 118:1801-1805.
    • (2011) Blood , vol.118 , pp. 1801-1805
    • Choi, S.M.1
  • 10
    • 84863505092 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples
    • Kumano K., et al. Generation of induced pluripotent stem cells from primary chronic myelogenous leukemia patient samples. Blood 2012, 119:6234-6242.
    • (2012) Blood , vol.119 , pp. 6234-6242
    • Kumano, K.1
  • 11
    • 84866149023 scopus 로고    scopus 로고
    • Reprogramming to pluripotency can conceal somatic cell chromosomal instability
    • Hamada M., et al. Reprogramming to pluripotency can conceal somatic cell chromosomal instability. PLoS Genet. 2012, 8:e1002913.
    • (2012) PLoS Genet. , vol.8
    • Hamada, M.1
  • 12
    • 84860319957 scopus 로고    scopus 로고
    • Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells
    • Yang H., et al. Generation of genetically modified mice by oocyte injection of androgenetic haploid embryonic stem cells. Cell 2012, 149:605-617.
    • (2012) Cell , vol.149 , pp. 605-617
    • Yang, H.1
  • 13
    • 80455174608 scopus 로고    scopus 로고
    • Derivation of haploid embryonic stem cells from mouse embryos
    • Leeb M., Wutz A. Derivation of haploid embryonic stem cells from mouse embryos. Nature 2011, 479:131-134.
    • (2011) Nature , vol.479 , pp. 131-134
    • Leeb, M.1    Wutz, A.2
  • 14
    • 82755182211 scopus 로고    scopus 로고
    • Forward and reverse genetics through derivation of haploid mouse embryonic stem cells
    • Elling U., et al. Forward and reverse genetics through derivation of haploid mouse embryonic stem cells. Cell Stem Cell 2011, 9:563-574.
    • (2011) Cell Stem Cell , vol.9 , pp. 563-574
    • Elling, U.1
  • 15
    • 84867673247 scopus 로고    scopus 로고
    • Androgenetic haploid embryonic stem cells produce live transgenic mice
    • Li W., et al. Androgenetic haploid embryonic stem cells produce live transgenic mice. Nature 2012, 490:407-411.
    • (2012) Nature , vol.490 , pp. 407-411
    • Li, W.1
  • 16
    • 80053916211 scopus 로고    scopus 로고
    • Human oocytes reprogram somatic cells to a pluripotent state
    • Noggle S., et al. Human oocytes reprogram somatic cells to a pluripotent state. Nature 2011, 478:70-75.
    • (2011) Nature , vol.478 , pp. 70-75
    • Noggle, S.1
  • 17
    • 77955777216 scopus 로고    scopus 로고
    • Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming
    • Ron-Bigger S., et al. Aberrant epigenetic silencing of tumor suppressor genes is reversed by direct reprogramming. Stem Cells 2010, 28:1349-1354.
    • (2010) Stem Cells , vol.28 , pp. 1349-1354
    • Ron-Bigger, S.1
  • 18
    • 84877574727 scopus 로고    scopus 로고
    • Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming
    • Zhang X., et al. Terminal differentiation and loss of tumorigenicity of human cancers via pluripotency-based reprogramming. Oncogene 2013, 32:2249-2260.
    • (2013) Oncogene , vol.32 , pp. 2249-2260
    • Zhang, X.1
  • 19
    • 79961133928 scopus 로고    scopus 로고
    • Unexpected X chromosome skewing during culture and reprogramming of human somatic cells can be alleviated by exogenous telomerase
    • Pomp O., et al. Unexpected X chromosome skewing during culture and reprogramming of human somatic cells can be alleviated by exogenous telomerase. Cell Stem Cell 2011, 9:156-165.
    • (2011) Cell Stem Cell , vol.9 , pp. 156-165
    • Pomp, O.1
  • 20
    • 78149488365 scopus 로고    scopus 로고
    • A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells
    • Marchetto M.C., et al. A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell 2010, 143:527-539.
    • (2010) Cell , vol.143 , pp. 527-539
    • Marchetto, M.C.1
  • 21
    • 79955602167 scopus 로고    scopus 로고
    • Isolation of MECP2-null Rett syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation
    • Cheung A.Y., et al. Isolation of MECP2-null Rett syndrome patient hiPS cells and isogenic controls through X-chromosome inactivation. Hum. Mol. Genet. 2011, 20:2103-2115.
    • (2011) Hum. Mol. Genet. , vol.20 , pp. 2103-2115
    • Cheung, A.Y.1
  • 22
    • 80053143413 scopus 로고    scopus 로고
    • Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model
    • Ananiev G., et al. Isogenic pairs of wild type and mutant induced pluripotent stem cell (iPSC) lines from Rett syndrome patients as in vitro disease model. PLoS ONE 2011, 6:e25255.
    • (2011) PLoS ONE , vol.6
    • Ananiev, G.1
  • 23
    • 84878641770 scopus 로고    scopus 로고
    • MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons
    • Larimore J., et al. MeCP2 regulates the synaptic expression of a Dysbindin-BLOC-1 network component in mouse brain and human induced pluripotent stem cell-derived neurons. PLoS ONE 2013, 8:e65069.
    • (2013) PLoS ONE , vol.8
    • Larimore, J.1
  • 24
    • 80052155858 scopus 로고    scopus 로고
    • Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome
    • Kim K.Y., et al. Neuronal maturation defect in induced pluripotent stem cells from patients with Rett syndrome. Proc. Natl. Acad. Sci. U.S.A. 2011, 108:14169-14174.
    • (2011) Proc. Natl. Acad. Sci. U.S.A. , vol.108 , pp. 14169-14174
    • Kim, K.Y.1
  • 25
    • 33645524772 scopus 로고    scopus 로고
    • Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation
    • Constantinescu D., et al. Lamin A/C expression is a marker of mouse and human embryonic stem cell differentiation. Stem Cells 2006, 24:177-185.
    • (2006) Stem Cells , vol.24 , pp. 177-185
    • Constantinescu, D.1
  • 26
    • 84864251887 scopus 로고    scopus 로고
    • Navigating the epigenetic landscape of pluripotent stem cells
    • Li M., et al. Navigating the epigenetic landscape of pluripotent stem cells. Nat. Rev. Mol. Cell Biol. 2012, 13:524-535.
    • (2012) Nat. Rev. Mol. Cell Biol. , vol.13 , pp. 524-535
    • Li, M.1
  • 27
    • 79954626173 scopus 로고    scopus 로고
    • Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome
    • Liu G.H., et al. Recapitulation of premature ageing with iPSCs from Hutchinson-Gilford progeria syndrome. Nature 2011, 472:221-225.
    • (2011) Nature , vol.472 , pp. 221-225
    • Liu, G.H.1
  • 28
    • 84872506168 scopus 로고    scopus 로고
    • Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells
    • Siu C.W., et al. Modeling of lamin A/C mutation premature cardiac aging using patient-specific induced pluripotent stem cells. Aging (Albany NY) 2012, 4:803-822.
    • (2012) Aging (Albany NY) , vol.4 , pp. 803-822
    • Siu, C.W.1
  • 29
    • 84877642990 scopus 로고    scopus 로고
    • An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells
    • Xiong Z.M., et al. An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells. Aging (Albany NY) 2013, 5:288-303.
    • (2013) Aging (Albany NY) , vol.5 , pp. 288-303
    • Xiong, Z.M.1
  • 30
    • 78650995671 scopus 로고    scopus 로고
    • A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects
    • Zhang J., et al. A human iPSC model of Hutchinson Gilford progeria reveals vascular smooth muscle and mesenchymal stem cell defects. Cell Stem Cell 2011, 8:31-45.
    • (2011) Cell Stem Cell , vol.8 , pp. 31-45
    • Zhang, J.1
  • 31
    • 84455208122 scopus 로고    scopus 로고
    • Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells
    • Kim Y., et al. Mouse B-type lamins are required for proper organogenesis but not by embryonic stem cells. Science 2011, 334:1706-1710.
    • (2011) Science , vol.334 , pp. 1706-1710
    • Kim, Y.1
  • 32
    • 79952209101 scopus 로고    scopus 로고
    • Mitochondrial rejuvenation after induced pluripotency
    • Suhr S.T., et al. Mitochondrial rejuvenation after induced pluripotency. PLoS ONE 2010, 5:e14095.
    • (2010) PLoS ONE , vol.5
    • Suhr, S.T.1
  • 33
    • 81055124788 scopus 로고    scopus 로고
    • Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations
    • Prigione A., et al. Mitochondrial-associated cell death mechanisms are reset to an embryonic-like state in aged donor-derived iPS cells harboring chromosomal aberrations. PLoS ONE 2011, 6:e27352.
    • (2011) PLoS ONE , vol.6
    • Prigione, A.1
  • 34
    • 80455144472 scopus 로고    scopus 로고
    • Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state
    • Lapasset L., et al. Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state. Genes Dev. 2011, 25:2248-2253.
    • (2011) Genes Dev. , vol.25 , pp. 2248-2253
    • Lapasset, L.1
  • 35
    • 80052100421 scopus 로고    scopus 로고
    • Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C
    • Ho J.C., et al. Generation of induced pluripotent stem cell lines from 3 distinct laminopathies bearing heterogeneous mutations in lamin A/C. Aging (Albany NY) 2011, 3:380-390.
    • (2011) Aging (Albany NY) , vol.3 , pp. 380-390
    • Ho, J.C.1
  • 36
    • 84877642990 scopus 로고    scopus 로고
    • An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells
    • Xiong Z.M., et al. An inhibitory role of progerin in the gene induction network of adipocyte differentiation from iPS cells. Aging (Albany NY) 2013, 5:288-303.
    • (2013) Aging (Albany NY) , vol.5 , pp. 288-303
    • Xiong, Z.M.1
  • 37
    • 79959282291 scopus 로고    scopus 로고
    • Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells
    • Batista L.F., et al. Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Nature 2011, 474:399-402.
    • (2011) Nature , vol.474 , pp. 399-402
    • Batista, L.F.1
  • 38
    • 77949424341 scopus 로고    scopus 로고
    • Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients
    • Agarwal S., et al. Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients. Nature 2010, 464:292-296.
    • (2010) Nature , vol.464 , pp. 292-296
    • Agarwal, S.1
  • 39
    • 58949094552 scopus 로고    scopus 로고
    • Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells
    • Marion R.M., et al. Telomeres acquire embryonic stem cell characteristics in induced pluripotent stem cells. Cell Stem Cell 2009, 4:141-154.
    • (2009) Cell Stem Cell , vol.4 , pp. 141-154
    • Marion, R.M.1
  • 40
    • 84859423676 scopus 로고    scopus 로고
    • Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells
    • Wang F., et al. Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells. Cell Res. 2012, 22:757-768.
    • (2012) Cell Res. , vol.22 , pp. 757-768
    • Wang, F.1
  • 41
    • 84862260147 scopus 로고    scopus 로고
    • Evolution of iPSC disease models
    • Zhang W., et al. Evolution of iPSC disease models. Protein Cell 2012, 3:1-4.
    • (2012) Protein Cell , vol.3 , pp. 1-4
    • Zhang, W.1
  • 42
    • 84869877601 scopus 로고    scopus 로고
    • Progressive degeneration of human neural stem cells caused by pathogenic LRRK2
    • Liu G.H., et al. Progressive degeneration of human neural stem cells caused by pathogenic LRRK2. Nature 2012, 491:603-607.
    • (2012) Nature , vol.491 , pp. 603-607
    • Liu, G.H.1
  • 43
    • 84871936169 scopus 로고    scopus 로고
    • IPSC technology to study human aging and aging-related disorders
    • Liu G.H., et al. iPSC technology to study human aging and aging-related disorders. Curr. Opin. Cell Biol. 2012, 24:765-774.
    • (2012) Curr. Opin. Cell Biol. , vol.24 , pp. 765-774
    • Liu, G.H.1
  • 44
    • 84862929910 scopus 로고    scopus 로고
    • Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells
    • Quarto N., et al. Skeletogenic phenotype of human Marfan embryonic stem cells faithfully phenocopied by patient-specific induced-pluripotent stem cells. Proc. Natl. Acad. Sci. U.S.A. 2012, 109:215-220.
    • (2012) Proc. Natl. Acad. Sci. U.S.A. , vol.109 , pp. 215-220
    • Quarto, N.1
  • 45
    • 79960833952 scopus 로고    scopus 로고
    • Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations
    • Soldner F., et al. Generation of isogenic pluripotent stem cells differing exclusively at two early onset Parkinson point mutations. Cell 2011, 146:318-331.
    • (2011) Cell , vol.146 , pp. 318-331
    • Soldner, F.1
  • 46
    • 79957866291 scopus 로고    scopus 로고
    • Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs
    • Liu G.H., et al. Targeted gene correction of laminopathy-associated LMNA mutations in patient-specific iPSCs. Cell Stem Cell 2011, 8:688-694.
    • (2011) Cell Stem Cell , vol.8 , pp. 688-694
    • Liu, G.H.1
  • 47
    • 84856599259 scopus 로고    scopus 로고
    • Cut and paste: restoring cellular function by gene correction
    • Liu G.H., et al. Cut and paste: restoring cellular function by gene correction. Cell Res. 2012, 22:283-284.
    • (2012) Cell Res. , vol.22 , pp. 283-284
    • Liu, G.H.1
  • 48
    • 84865389143 scopus 로고    scopus 로고
    • Non-viral iPSCs: a safe way for therapy?
    • Zhang W., et al. Non-viral iPSCs: a safe way for therapy?. Protein Cell 2012, 3:241-245.
    • (2012) Protein Cell , vol.3 , pp. 241-245
    • Zhang, W.1
  • 49
    • 84877255434 scopus 로고    scopus 로고
    • Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism
    • Liu W., et al. Reevaluation of the safety of induced pluripotent stem cells: a call from somatic mosaicism. Protein Cell 2013, 4:83-85.
    • (2013) Protein Cell , vol.4 , pp. 83-85
    • Liu, W.1
  • 50
    • 48649091905 scopus 로고    scopus 로고
    • Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency
    • Chamberlain S.J., et al. Polycomb repressive complex 2 is dispensable for maintenance of embryonic stem cell pluripotency. Stem Cells 2008, 26:1496-1505.
    • (2008) Stem Cells , vol.26 , pp. 1496-1505
    • Chamberlain, S.J.1


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