The 'procoagulopathy' of trauma: Too much, too late?

Current Opinion in Critical Care

Volumn 19, Issue 6, 2013, Pages 578-586

  Holley, Anthony D ^a,c   Reade, Michael C ^a,b,c  

^a ROYAL BRISBANE AND WOMEN'S HOSPITAL   (Australia)

^b Army Malaria Research Unit   (Australia)

^c UNIVERSITY OF QUEENSLAND   (Australia)

Author keywords

blood coagulation disorders; disseminated intravascular coagulation; trauma; wounds and injuries

Indexed keywords

ACTIVATED PROTEIN C; ANTIFIBRINOLYTIC AGENT; ANTITHROMBIN III; BLOOD CLOTTING FACTOR 5; BLOOD CLOTTING FACTOR 8; CYTOKINE; ENDOTHELIAL LEUKOCYTE ADHESION MOLECULE 1; HEPARIN; LOW MOLECULAR WEIGHT HEPARIN; PADGEM PROTEIN; PHOSPHOLIPID; PLASMINOGEN ACTIVATOR INHIBITOR 1; THROMBIN; THROMBOMODULIN; THROMBOPLASTIN; TISSUE FACTOR PATHWAY INHIBITOR; TISSUE PLASMINOGEN ACTIVATOR; TRANEXAMIC ACID;

BLOOD CLOTTING DISORDER; COMPRESSION STOCKING; DEEP VEIN THROMBOSIS; DISSEMINATED INTRAVASCULAR CLOTTING; HUMAN; INFLAMMATION; INJURY; LUNG EMBOLISM; MEMBRANE MICROPARTICLE; PROPHYLAXIS; PROTEIN EXPRESSION; REVIEW; RISK ASSESSMENT; THROMBOEMBOLISM; VISCOELASTICITY;

COAGULANTS; CRITICAL CARE; DISSEMINATED INTRAVASCULAR COAGULATION; FEMALE; HUMANS; MALE; PATIENT SELECTION; RISK ASSESSMENT; THROMBOEMBOLISM; TRAUMA SEVERITY INDICES; WOUNDS AND INJURIES;

EID: 84888152252     PISSN: 10705295     EISSN: 15317072     Source Type: Journal    
DOI: 10.1097/MCC.0000000000000032     Document Type: Review

References (73)

1. Holcomb JB, McMullin NR, Pearse L, et al. Causes of death in U.S. special operations forces in the global war on terrorism: 2001-2004. Ann Surg 2007; 245:986-991 (Pubitemid 46809302)
2. Evans JA, van Wessem KJ, McDougall D, et al. Epidemiology of traumatic deaths: comprehensive population-based assessment. World J Surg 2010; 34:158-163
3. Cohen MJ, Call M, Nelson M, et al. Critical role of activated protein C in early coagulopathy and later organ failure, infection and death in trauma patients. Ann Surg 2012; 255:379-385
4. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury 2007; 38:298-304 (Pubitemid 46328919)
5. Davenport R, Manson J, Death H, et al. Functional definition and characterisation of acute traumatic coagulopathy. Crit Care Med 2011; 39:2652-2658
6. Brown JB, Cohen MJ, Minei JP, et al. Debunking the survival bias myth: characterization of mortality during the initial 24 h for patients requiring massive transfusion. J Trauma Acute Care Surg 2012; 73:358-364
7. Holcomb JB, del Junco DJ, Fox EE, et al. The prospective, observational, multicenter, major trauma transfusion (PROMMTT) study: comparative effectiveness of a time-varying treatment with competing risks. JAMA Surg 2013; 148:127-136
8. Schochl H, Nienaber U, Hofer G, et al. Goal-directed coagulation management of major trauma patients using thromboelastometry (ROTEM)-guided administration of fibrinogen concentrate and prothrombin complex concentrate. Crit Care 2010; 14:R55
9. Shakur H, Roberts I, Bautista R, et al. Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial. Lancet 2010; 376:23-32
10. Paffrath T, Wafaisade A, Lefering R, et al. Venous thromboembolism after severe trauma: incidence, risk factors and outcome. Injury 2010; 41:97-101
11. Brakenridge SC, Henley SS, Kashner TM, et al. Comparing clinical predictors of deep venous thrombosis versus pulmonary embolus after severe injury: a new paradigm for posttraumatic venous thromboembolism? J Trauma Acute Care Surg 2013; 74:1231-1237
12. Velmahos GC, Petrone P, Chan LS, et al. Electrostimulation for the prevention of deep venous thrombosis in patients with major trauma: a prospective randomized study. Surgery 2005; 137:493-498 (Pubitemid 40613026)
13. Geerts WH, Jay RM, Code KI, et al. A comparison of low-dose heparin with low-molecular-weight heparin as prophylaxis against venous thromboembolism after major trauma. N Engl J Med 1996; 335:701-707 (Pubitemid 26287356)
14. Holley AB, Petteys S, Mitchell JD, et al. Thromboprophylaxis and VTE rates in soldiers wounded in operation enduring freedom and operation Iraqi freedom. Chest 2013; 144:966-973
15. Pierce CA, Haut ER, Kardooni S, et al. Surveillance bias and deep vein thrombosis in the national trauma data bank: the more we look, the more we find. J Trauma 2008; 64:932-936 (Pubitemid 351521880)
16. Haut ER, Chang DC, Pierce CA, et al. Predictors of posttraumatic deep vein thrombosis (DVT): hospital practice versus patient factors-an analysis of the National Trauma Data Bank (NTDB). J Trauma 2009; 66:994-999
17. Bahloul M, Chaari A, Dammak H, et al. Posttraumatic pulmonary embolism in the intensive care unit. Ann Thorac Med 2011; 6:199-206
18. Ho KM, Burrell M, Rao S, Baker R. Incidence and risk factors for fatal pulmonary embolism after major trauma: a nested cohort study. Br J Anaesth 2010; 105:596-602
19. Toker S, Hak DJ, Morgan SJ. Deep vein thrombosis prophylaxis in trauma patients. Thrombosis 2011; 2011:505373
20. Sing RF, Camp SM, Heniford BT, et al. Timing of pulmonary emboli after trauma: implications for retrievable vena cava filters. J Trauma 2006; 60:732-734
21. Schultz DJ, Brasel KJ, Washington L, et al. Incidence of asymptomatic pulmonary embolism in moderately to severely injured trauma patients. J Trauma 2004; 56:727-731
22. Barrera LM, Perel P, Ker K, et al. Thromboprophylaxis for trauma patients. Cochrane Database Syst Rev 2013; 3:CD008303
23. Wells PS, Anderson DR, Bormanis J, et al. Value of assessment of pretest probability of deep-vein thrombosis in clinical management. Lancet 1997; 350:1795-1798 (Pubitemid 28036513)
24. Gibson NS, Sohne M, Kruip MJ, et al. Further validation and simplification of the Wells clinical decision rule in pulmonary embolism. Thromb Haemost 2008; 99:229-234
25. Young MD, Daniels AH, Evangelista PT, et al. Predicting pulmonary embolus in orthopedic trauma patients using the wells score. Orthopedics 2013; 36:e642-e647
26. Campbell JE, Brummel-Ziedins KE, Butenas S, Mann KG. Cellular regulation of blood coagulation: a model for venous stasis. Blood 2010; 116:6082-6091
27. Knoebl P. Blood coagulation disorders in septic patients. Wien Med Wochenschr 19462010; 160:129-138
28. Hook KM, Abrams CS. The loss of homeostasis in hemostasis: new approaches in treating and understanding acute disseminated intravascular coagulation in critically ill patients. Clin Transl Sci 2012; 5:85-92
29. Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. British Committee for Standards in Haematology. Brit J Haematol 2009; 145:24-33
30. Brohi K, Cohen MJ, Ganter MT, et al. Acute traumatic coagulopathy: initiated by hypoperfusion: modulated through the protein C pathway? Ann Surg 2007; 245:812-818 (Pubitemid 46684113)
31. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma 2008; 65:748-754
32. Gando S, Sawamura A, Hayakawa M. Trauma, shock, and disseminated intravascular coagulation: lessons from the classical literature. Ann Surg 2011; 254:10-19
33. Levi M, Keller TT, van Gorp E, ten Cate H. Infection and inflammation and the coagulation system. Cardiovasc Res 2003; 60:26-39 (Pubitemid 38373473)
34. Cohen MJ, Brohi K, Calfee CS, et al. Early release of high mobility group box nuclear protein 1 after severe trauma in humans: role of injury severity and tissue hypoperfusion. Crit Care 2009; 13:R174
35. Cohen MJ, Carles M, Brohi K, et al. Early release of soluble RAGE after severe trauma in humans. J Trauma 2010; 68:1273-1278
36. Rao LVM, Mackman N. Factor VIIa and tissue factor - from cell biology to animal models. Thromb Res 2010; 125 (Suppl 1):S1-S3
37. Owens AP, Mackman N. Tissue factor and thrombosis: the clot starts here. Thromb Haemost 2010; 104:432-439
38. Manly DA, Boles J, Mackman N. Role of tissue factor in venous thrombosis. Ann Rev Physiol 2011; 73:515-525
39. Kasthuri RS, Glover SL, Boles J, Mackman N. Tissue factor and tissue factor pathway inhibitor as key regulators of global hemostasis: measurement of their levels in coagulation assays. Semin Thromb Hemost 2010; 36:764-771
40. Lupu C, Kruithof EK, Kakkar VV, Lupu F. Acute release of tissue factor pathway inhibitor after in vivo thrombin generation in baboons. Thromb Haemost 1999; 82:1652-1658
41. Tang H, Ivanciu L, Popescu N, et al. Sepsis-induced coagulation in the baboon lung is associated with decreased tissue factor pathway inhibitor. Am J Pathol 2007; 171:1066-1077 (Pubitemid 47441003)
42. Hoke M, Kyrle PA, Minar E, et al. Tissue factor pathway inhibitor and the risk of recurrent venous thromboembolism. Thromb Haemost 2005; 94:787-790 (Pubitemid 41489238)
43. Crawley JT, Zanardelli S, Chion CK, Lane DA. The central role of thrombin in hemostasis. J Thromb Haemost 2007; 5 (Suppl 1):95-101 (Pubitemid 46958822)
44. Harr JN, Moore EE, Wohlauer MV, et al. The acute coagulopathy of trauma is due to impaired initial thrombin generation but not clot formation or clot strength. J Surg Res 2011; 170:319-324
45. van der Poll T, Levi M, Nick JA, Abraham E. Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am J Respir Crit Care Med 2005; 171:1125-1128 (Pubitemid 40663724)
46. Gando S, Kameue T, Matsuda N, et al. Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation. Inflammation 2004; 28:237-244 (Pubitemid 41449424)
47. Maeda S, Takahashi S, Sato M. Serum thrombomodulin as a newly identified biomarker for postoperative lung injury: a prospective observational study. Tohoku J Exp Med 2012; 228:135-141
48. Bone RC. Modulators of coagulation. A critical appraisal of their role in sepsis. Arch Intern Med 1992; 152:1381-1389
49. Cohen JR, Sarfati I, Birnbaum E, et al. The inactivation of antithrombin III by serum elastase in patients with surgical infections. Am Surg 1990; 56:665-667
50. Dunbar NM, Chandler WL. Thrombin generation in trauma patients. Transfusion 2009; 49:2652-2660
51. Burnier L, Fontana P, Kwak BR, Angelillo-Scherrer A. Cell-derived microparticles in haemostasis and vascular medicine. Thromb Haemost 2009; 101:439-451
52. Piccin A, Murphy WG, Smith OP. Circulating microparticles: pathophysiology and clinical implications. Blood Rev 2007; 21:157-171 (Pubitemid 46529055)
53. Zwaal RF, Comfurius P, Bevers EM. Scott syndrome, a bleeding disorder caused by defective scrambling of membrane phospholipids. Biochim Biophys Acta 2004; 1636:119-128 (Pubitemid 38780788)
54. Owens AP III, Mackman N. Microparticles in hemostasis and thrombosis. Circ Res 2011; 108:1284-1297
55. Nieuwland R, Berckmans RJ, Rotteveel-Eijkman RC, et al. Cell-derived microparticles generated in patients during cardiopulmonary bypass are highly procoagulant. Circulation 1997; 96:3534-3541 (Pubitemid 27513430)
56. Morel N, Morel O, Petit L, et al. Generation of procoagulant microparticles in cerebrospinal fluid and peripheral blood after traumatic brain injury. J Trauma 2008; 64:698-704 (Pubitemid 351366895)
57. Park MS, Owen BA, Ballinger BA, et al. Quantification of hypercoagulable state after blunt trauma: microparticle and thrombin generation are increased relative to injury severity, while standardmarkers are not. Surgery 2012; 151:831-836
58. Morel O, Jesel L, Freyssinet JM, Toti F. Cellular mechanisms underlying the formation of circulating microparticles. Arterioscler Thromb Vasc Biol 2011; 31:15-26
59. Flaumenhaft R, Mairuhu AT, Italiano JE. Platelet- and megakaryocyte-derived microparticles. Semin Thromb Hemost 2010; 36:881-887
60. Coleman DM, Wakefield TW. Biomarkers for the diagnosis of deep vein thrombosis. Expert Opin Med Diagn 2012; 6:253-257
61. da Luz LT, Nascimento B, Rizoli S. Thrombelastography (TEG(R)): practical considerations on its clinical use in trauma resuscitation. Scand J Trauma Resusc Emerg Med 2013; 21:29
62. Keene DD, Woolleey T, Nordmann G. Rotational thromboelastometry (ROTEM) guided trauma resuscitation. Curr Opin Crit Care 2013; 19
63. Park MS, Martini WZ, Dubick MA, et al. Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time. J Trauma 2009; 67:266-275
64. Piotrowski JJ, Alexander JJ, BrandtCP, et al. Is deep vein thrombosis surveillance warranted in high-risk trauma patients? Am J Surg 1996; 172:210-213 (Pubitemid 26303288)
65. Linkins LA, Bates SM, Lang E, et al. Selective D-dimer testing for diagnosis of a first suspected episode of deep venous thrombosis: a randomized trial. Ann Intern Med 2013; 158:93-100
66. Johna S, Cemaj S, OCallaghan T, Catalano R. Effect of tissue injury on D-Dimer levels: a prospective study in trauma patients. Med Sci Monit 2002; 8:CR5-CR8 (Pubitemid 34136315)
67. Haut ER, Schneider EB, Patel A, et al. Duplex ultrasound screening for deep vein thrombosis in asymptomatic trauma patients: a survey of individual trauma surgeon opinions and current trauma center practices. J Trauma 2011; 70:27-33
68. Falck-Ytter Y, Francis CW, Johanson NA, et al. Prevention of VTE in orthopedic surgery patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest 2012; 141:e278S-e325S.
69. Rogers FB, Cipolle MD, Velmahos G, et al. Practice management guidelines for the prevention of venous thromboembolism in trauma patients: the EAST practice management guidelines work group. J Trauma 2002; 53:142-164 (Pubitemid 34863971)
70. Fred HL. Unsuspected pulmonary thromboemboli: a continuing clinical challenge. Tex Heart Inst J 2013; 40:9-12
71. Menaker J, Stein DM, Scalea TM. Incidence of early pulmonary embolism after injury. J Trauma 2007; 63:620-624
72. Mitchell AM, Jones AE, Tumlin JA, Kline JA. Prospective study of the incidence of contrast-induced nephropathy among patients evaluated for pulmonary embolism by contrast-enhanced computed tomography. Acad Emerg Med 2012; 19:618-625
73. Nathens AB, McMurray MK, Cuschieri J, et al. The practice of venous thromboembolism prophylaxis in the major trauma patient. J Trauma 2007; 62:557-562. (Pubitemid 46568849)