Quantification of hypercoagulable state after blunt trauma: Microparticle and thrombin generation are increased relative to injury severity, while standard markers are not

Surgery (United States)

Volumn 151, Issue 6, 2012, Pages 831-836

  Park, Myung S ^a   Owen, Barbara A L ^a   Ballinger, Beth A ^a   Sarr, Michael G ^a   Schiller, Henry J ^a   Zietlow, Scott P ^a   Jenkins, Donald H ^a   Ereth, Mark H ^a   Owen, Whyte G ^a,b   Heit, John A ^a  

^a MAYO CLINIC   (United States)

^b MAYO GRADUATE SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LIPOCORTIN 5; THROMBIN;

ADULT; ARTICLE; BLOOD ANALYSIS; BLUNT TRAUMA; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; FLOW CYTOMETRY; HUMAN; HYPERCOAGULABILITY; INJURY SEVERITY; INTERNATIONAL NORMALIZED RATIO; MALE; PARTIAL THROMBOPLASTIN TIME; PATHOGENESIS; PILOT STUDY; PLATELET MICROPARTICLE; POSTTRAUMATIC COMPLICATION; PRIORITY JOURNAL; PROSPECTIVE STUDY; THROMBOCYTE COUNT; THROMBOCYTE POOR PLASMA;

ADULT; ANNEXIN A5; BIOLOGICAL MARKERS; CASE-CONTROL STUDIES; CELL-DERIVED MICROPARTICLES; COHORT STUDIES; FEMALE; HUMANS; MALE; MIDDLE AGED; PARTIAL THROMBOPLASTIN TIME; PILOT PROJECTS; PROSPECTIVE STUDIES; PROTHROMBIN TIME; RISK FACTORS; THROMBIN; THROMBOPHILIA; THROMBOPLASTIN; TRAUMA SEVERITY INDICES; VENOUS THROMBOEMBOLISM; WOUNDS AND INJURIES;

EID: 84861586092     PISSN: 00396060     EISSN: 15327361     Source Type: Journal    
DOI: 10.1016/j.surg.2011.12.022     Document Type: Article

References (28)

1. K. Brohi, J. Singh, and M. Heron Acute traumatic coagulopathy J Trauma 54 2003 1127 1130
2. C.R. Kauffman, K.M. Dwyer, and J.D. Cews Usefulness of thromboelastography in assessment of trauma patient coagulation J Trauma 42 1997 716 722
3. M.A. Schreiber, J. Differding, and P. Thorborg Hypercoagulability is most prevalent early after injury and in female patients J Trauma 58 2005 475 481
4. W.H. Geerts, K.I. Code, and R.M. Jay A prospective study of venous thromboembolism after major trauma N Engl J Med 331 1994 1601 1606
5. M.S. Park, W.Z. Martini, and M.A. Dubick Thromboelastography as a better indicator of hypercoagulable state after injury than prothrombin time or activated partial thromboplastin time J Trauma 67 2009 266 276
6. K.E. Brummel, S.G. Paradis, and S. Butenas Thrombin functions during tissue factor-induced blood coagulation Blood 100 2002 148 152
7. V. Regnault, H.C. Hemker, and D. Wahl Phenotyping the haemostatic system by thrombography - potential for the estimation of thrombotic risk Thromb Res 114 2004 539 545
8. S. Eichinger, G. Hron, and M. Kollars Prediction of recurrent venous thromboembolism by endogenous thrombin potential and D-dimer Clin Chem 54 2008 2042 2048
9. A. Tripodi, C. Legnani, and G. Palareti More on: high thrombin generation and the risk of recurrent thromboembolism J Thromb Haemost 7 2009 906 907
10. M. Sossdorf, V. Konig, and J. Gummert Correlations between platelet-derived microvesicles and thrombin generation in patients with coronary artery disease Platelets 18 2008 476 477
11. W.H. Geerts, D. Bergquist, and G.F. Pineo Prevention of venous thromboembolism: American College of Chest Physicians Evidence-based Clinical Practice Guideline (8th edition) Chest 133 2008 3815 4535
12. J.A. Macleod, M. Lynn, and M.G. McKenny Early coagulopathy predicts mortality in trauma J Trauma 55 2003 39 44
13. W.Z. Martini Coagulopathy by hypothermia and acidosis: mechanisms of thrombin generation and fibrinogen availability J Trauma 67 2009 202 209
14. C.R. Kaufmann, K.M. Dwyer, and J.D. Crews Usefulness of thrombelastography in assessment of trauma patient coagulation J Trauma 42 1997 716 722
15. D.D. Watts, A. Trask, and K. Soeken Hypothermic coagulopathy in trauma: effect of varying levels of hypothermia on enzyme speed, platelet function, and fibrinolytic activity J Trauma 44 1998 846 854
16. M.E. Cinat, W.C. Wallace, and F. Nastansk Improved survival following massive transfusion in patients who have undergone trauma Arch Surg 134 1998 964 970
17. H.C. Hemker Recollections on thrombin generation J Thromb Haemost 6 2008 219 226
18. H.C. Hemker, R. Al Dieri, and E. De Smedt Thrombin generation, a function test of the haemostatic-thrombotic system Thromb Haemost 96 2006 553 561
19. B.A. Owen, A. Xue, and J.A. Heit Procoagulant activity, but not number, of microparticles increases with age and in individuals after a single venous thromboembolism Thromb Res 127 2011 39 46
20. N.M. Dunbar, and W.L. Chandler Thrombin generation in trauma patients Transfusion 49 2009 2652 2660
21. S. Eichinger, G. Hron, and C. Bialonczyk Overweight, obesity and recurrent venous thromboembolism Arch Intern Med 168 2008 1678 1683
22. C. Cimenti, H. Mangge, and H. Haidl Thrombin generation in severely obese children J Thromb Haemost 4 2006 1834 1836
23. H. Haidl, C. Cimenti, and B. Leschnik Age-dependency of thrombin generation measured by means of calibrated automated thrombography (CAT) Thromb Haemost 95 2006 772 775
24. R.J. Bereckmans, R. Neiuwland, and A.N. Boing Cell-derived microparticles circulate in healthy humans and support low grade thrombin generation Thromb Haemost 85 2001 639 646
25. M. Jayachandran, R.D. Litwiller, and W.G. Owen Characterization of blood borne microparticles as markers of premature coronary calcification in newly menopausal women Am J Physiol Heart Circ Physiol 295 2008 H931 H938
26. R.F. Zwaal, and A.J. Schroit Pathophysiologic implications of membrane phospholipid asymmetry in blood cells Blood 89 1997 1121 1132
27. O. Morel, F. Toti, and B. Hugel Procoagulant microparticles: disrupting the vascular homeostasis equation? Arterioscler Thromb Vasc Biol 26 2006 2594 2604
28. P.G. Barton, E.T. Yin, and S. Wessler Reactions of activated factor X-phosphatide mixtures in vitro and in vivo J Lipid Res 11 1970 87 95