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Volumn 5, Issue 1, 2012, Pages 85-92

The Loss of Homeostasis in Hemostasis: New Approaches in Treating and Understanding Acute Disseminated Intravascular Coagulation in Critically Ill Patients

Author keywords

Coagulation; Cytokines; DIC; Fibrinolytic enzymes and inhibitors

Indexed keywords

ANTITHROMBIN III; CD14 ANTIGEN; DROTRECOGIN; HEPARIN; INTERLEUKIN 6; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN MD 2; RECOMBINANT ANTITHROMBIN III; RECOMBINANT TISSUE FACTOR PATHWAY INHIBITOR; STRESS ACTIVATED PROTEIN KINASE 1; THROMBOPLASTIN; TOLL LIKE RECEPTOR 4; TUMOR NECROSIS FACTOR ALPHA;

EID: 84857644310     PISSN: 17528054     EISSN: 17528062     Source Type: Journal    
DOI: 10.1111/j.1752-8062.2011.00351.x     Document Type: Review
Times cited : (24)

References (92)
  • 1
    • 0033590515 scopus 로고    scopus 로고
    • Treating patients with severe sepsis
    • Wheeler AP, Bernard GR. Treating patients with severe sepsis. NEJM. 1999; 340: 207-214.
    • (1999) NEJM , vol.340 , pp. 207-214
    • Wheeler, A.P.1    Bernard, G.R.2
  • 2
    • 33748260015 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation
    • Levi M, Cate H ten. Disseminated intravascular coagulation. NEJM. 1999; 341: 586-592.
    • (1999) NEJM , vol.341 , pp. 586-592
    • Levi, M.1    Cate, H.2
  • 3
    • 34548214668 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation
    • Levi M. Disseminated intravascular coagulation. Crit Core Med. 2007; 35: 2191-2195.
    • (2007) Crit Core Med , vol.35 , pp. 2191-2195
    • Levi, M.1
  • 4
    • 0035216041 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in acute leukemia
    • Barbui T, Falanga A. Disseminated intravascular coagulation in acute leukemia. Semin Throm Haemost. 2001; 27: 593-604.
    • (2001) Semin Throm Haemost , vol.27 , pp. 593-604
    • Barbui, T.1    Falanga, A.2
  • 5
    • 61649083524 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation in cancer patients
    • Levi M. Disseminated intravascular coagulation in cancer patients. Best Pract Res Clin Haema-to. 2009; 22: 129-136.
    • (2009) Best Pract Res Clin Haema-to , vol.22 , pp. 129-136
    • Levi, M.1
  • 6
    • 69549124116 scopus 로고    scopus 로고
    • Cancer-associated thrombosis
    • Sood, SL. Cancer-associated thrombosis. Curr Opin Hematol. 2009; 16: 378-385.
    • (2009) Curr Opin Hematol , vol.16 , pp. 378-385
    • Sood, S.L.1
  • 7
    • 54049083511 scopus 로고    scopus 로고
    • The coagulant response in sepsis
    • Levi M. The coagulant response in sepsis. Clin Chest Med. 2008; 29: 627-642.
    • (2008) Clin Chest Med , vol.29 , pp. 627-642
    • Levi, M.1
  • 8
    • 34548680947 scopus 로고    scopus 로고
    • Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia
    • Ogura H, Gando S, Iba T, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, Mayumi T, Murata A, Ikeda T, et al. Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. SIRS-associated coagulopathy and organ dysfunction in critically ill patients with thrombocytopenia. Shock. 2007; 4: 411-417.
    • (2007) Shock , vol.4 , pp. 411-417
    • Ogura, H.1    Gando, S.2    Iba, T.3    Eguchi, Y.4    Ohtomo, Y.5    Okamoto, K.6    Koseki, K.7    Mayumi, T.8    Murata, A.9    T, I.10
  • 10
    • 1842547895 scopus 로고    scopus 로고
    • Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation
    • Dhainaut JF, Yan SB, Joyce DE, Pettila V, Basson B, Brandt JT, Sundin DP. Treatment effects of drotrecogin alfa (activated) in patients with severe sepsis with or without overt disseminated intravascular coagulation. J Thromb Haemost. 2004; 2: 1924-1933.
    • (2004) J Thromb Haemost , vol.2 , pp. 1924-1933
    • Dhainaut, J.F.1    Yan, S.B.2    Joyce, D.E.3    Pettila, V.4    Basson, B.5    Brandt, J.T.6    Sundin, D.P.7
  • 11
    • 57349112998 scopus 로고    scopus 로고
    • Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria. Comparison between sepsis and trauma
    • Kushimoto S, Gando S, Saitoh D, Ogura H, Mayumi T, Koseki K, Iba T, Ueyama M, Eguchi Y, Otomo Y, et al. Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. Clinical course and outcome of disseminated intravascular coagulation diagnosed by Japanese Association for Acute Medicine criteria. Comparison between sepsis and trauma. Thromb Haemost. 2008; 100: 1099-1105.
    • (2008) Thromb Haemost , vol.100 , pp. 1099-1105
    • Kushimoto, S.1    Gando, S.2    Saitoh, D.3    Ogura, H.4    Mayumi, T.5    Koseki, K.6    Iba, T.7    Ueyama, M.8    Eguchi, Y.9
  • 12
    • 0028040319 scopus 로고
    • Gram positive organisms and sepsis
    • Bone RC. Gram positive organisms and sepsis. Arch Intern Med. 1994; 154: 26-34.
    • (1994) Arch Intern Med , vol.154 , pp. 26-34
    • Bone, R.C.1
  • 14
    • 0032695450 scopus 로고    scopus 로고
    • Collagen receptor signaling in platelets and megakaryocytes
    • Watson SP. Collagen receptor signaling in platelets and megakaryocytes. Thromb Haemost. 1999; 82:365-376.
    • (1999) Thromb Haemost , vol.82 , pp. 365-376
    • Watson, S.P.1
  • 15
    • 29244474586 scopus 로고    scopus 로고
    • Platelets in sepsis
    • Levi M. Platelets in sepsis. Hematology. 2005; 10(Suppl. 1): 129-131.
    • (2005) Hematology , vol.10 , Issue.SUPPL. 1 , pp. 129-131
    • Levi, M.1
  • 17
    • 50449098285 scopus 로고    scopus 로고
    • Mechanisms of thrombus formation
    • Furie B, Furie BC. Mechanisms of thrombus formation. NEJM. 2008; 359: 938-949.
    • (2008) NEJM , vol.359 , pp. 938-949
    • Furie, B.1    Furie, B.C.2
  • 19
    • 0025166114 scopus 로고
    • CD14 a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein
    • Wright SD, Ramos RA, Tobias PS, Ulevitch RJ, Mathison JC. CD14 a receptor for complexes of lipopolysaccharide (LPS) and LPS binding protein. Science. 1990; 249: 1431-1433.
    • (1990) Science , vol.249 , pp. 1431-1433
    • Wright, S.D.1    Ramos, R.A.2    Tobias, P.S.3    Ulevitch, R.J.4    Mathison, J.C.5
  • 20
    • 44849113635 scopus 로고    scopus 로고
    • Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes(macrophages
    • Luyendyk JP, Schabbauer GA, Tencati M, Holscher T, Pawlinski R, Mackman N. Genetic analysis of the role of the PI3K-Akt pathway in lipopolysaccharide-induced cytokine and tissue factor gene expression in monocytes(macrophages. J Immunol. 2008; 180: 4218-4226.
    • (2008) J Immunol , vol.180 , pp. 4218-4226
    • Luyendyk, J.P.1    Schabbauer, G.A.2    Tencati, M.3    Holscher, T.4    Pawlinski, R.5    Mackman, N.6
  • 21
    • 77956533379 scopus 로고    scopus 로고
    • Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure
    • Popescu NI, Lupu C, Lupu F. Extracellular protein disulfide isomerase regulates coagulation on endothelial cells through modulation of phosphatidylserine exposure. Blood. 2010; 116: 993-1001.
    • (2010) Blood , vol.116 , pp. 993-1001
    • Popescu, N.I.1    Lupu, C.2    Lupu, F.3
  • 22
    • 18044385747 scopus 로고    scopus 로고
    • The tissue factor pathway in disseminated intravascular coagulation
    • Osterud B and Bjorklid E. The tissue factor pathway in disseminated intravascular coagulation. Semin Thromb Hemost. 2001; 27: 605-617.
    • (2001) Semin Thromb Hemost , vol.27 , pp. 605-617
    • Osterud, B.1    Bjorklid, E.2
  • 23
    • 0024386731 scopus 로고
    • Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis
    • Drake TA, Morrissey JH, Edgington TS. Selective cellular expression of tissue factor in human tissues. Implications for disorders of hemostasis and thrombosis. Am J Pathol. 1989; 134: 1087-1097.
    • (1989) Am J Pathol , vol.134 , pp. 1087-1097
    • Drake, T.A.1    Morrissey, J.H.2    Edgington, T.S.3
  • 28
    • 0034924586 scopus 로고    scopus 로고
    • Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation
    • Levi M, de Jonge E, van der Poll T. Rationale for restoration of physiological anticoagulant pathways in patients with sepsis and disseminated intravascular coagulation. Crit Care Med. 2001; 29(Suppl): S90-S94.
    • (2001) Crit Care Med , vol.29 , Issue.SUPPL.
    • Levi, M.1    de Jonge, E.2    van der Poll, T.3
  • 29
    • 0026534242 scopus 로고
    • Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies
    • Fourrier F, Chopin C, Goudemand J, Hendrycx S, Caron C, Rime A, Marey A, Lestavel P. Septic shock, multiple organ failure, and disseminated intravascular coagulation. Compared patterns of antithrombin III, protein C, and protein S deficiencies. Chest. 1992; 101: 816-823.
    • (1992) Chest , vol.101 , pp. 816-823
    • Fourrier, F.1    Chopin, C.2    Goudemand, J.3    Hendrycx, S.4    Caron, C.5    Rime, A.6    Marey, A.7    Lestavel, P.8
  • 30
    • 0029743427 scopus 로고    scopus 로고
    • Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients
    • Mesters RM, Mannucci PM, Coppola R, Keller T, Ostermann H, Kienast J. Factor VIIa and antithrombin III activity during severe sepsis and septic shock in neutropenic patients. Blood. 1996; 88:881-886.
    • (1996) Blood , vol.88 , pp. 881-886
    • Mesters, R.M.1    Mannucci, P.M.2    Coppola, R.3    Keller, T.4    Ostermann, H.5    Kienast, J.6
  • 32
    • 0029855166 scopus 로고    scopus 로고
    • Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis
    • Mesters RM, Florke N, Ostermann H, Kienast J. Increase of plasminogen activator inhibitor levels predicts outcome of leukocytopenic patients with sepsis. Thromb Haemost. 1996; 75: 902-907.
    • (1996) Thromb Haemost , vol.75 , pp. 902-907
    • Mesters, R.M.1    Florke, N.2    Ostermann, H.3    Kienast, J.4
  • 33
    • 77949266039 scopus 로고    scopus 로고
    • Alternatively spliced isoforms of tissue factor pathway inhibitor
    • Maroney SA, Ellery PE, Mast AE. Alternatively spliced isoforms of tissue factor pathway inhibitor. Thromb Res. 2010; 125(Suppl. 1): S52-S56.
    • (2010) Thromb Res , vol.125 , Issue.SUPPL. 1
    • Maroney, S.A.1    Ellery, P.E.2    Mast, A.E.3
  • 34
    • 78149281495 scopus 로고    scopus 로고
    • The role of TFPI in regulation of TF-induced thrombogenicity on the surface of human monocytes
    • Basavaraj MG, Gruber FX, Applebom HI Sovershaev, Osterud B, Peterson LC, Hansen J-B. The role of TFPI in regulation of TF-induced thrombogenicity on the surface of human monocytes. Thromb Res. 2010; 126: 418-425.
    • (2010) Thromb Res , vol.126 , pp. 418-425
    • Basavaraj, M.G.1    Gruber, F.X.2    Applebom, H.S.3    Osterud, B.4    Peterson, L.C.5    Hansen, J.-B.6
  • 36
    • 33646480218 scopus 로고    scopus 로고
    • Inflammation and the activated protein C anticoagulant pathway
    • Esmon CT. Inflammation and the activated protein C anticoagulant pathway. Semin Thromb Hemost. 2006; 32(Suppl. 1): 49-60.
    • (2006) Semin Thromb Hemost , vol.32 , Issue.SUPPL. 1 , pp. 49-60
    • Esmon, C.T.1
  • 37
    • 7044262108 scopus 로고    scopus 로고
    • The impact of the inflammatory response on coagulation
    • Esmon CT. The impact of the inflammatory response on coagulation. Thromb Res. 2004; 114: 321-327.
    • (2004) Thromb Res , vol.114 , pp. 321-327
    • Esmon, C.T.1
  • 39
    • 0038115187 scopus 로고    scopus 로고
    • Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein C deficient mice
    • Levi M, Dorffler-Melly J, Reitsma PH, Buller H, Florquin S, van der Poll T, Carmeliet P. Aggravation of endotoxin-induced disseminated intravascular coagulation and cytokine activation in heterozygous protein C deficient mice. Blood. 2003; 101: 4823-4827.
    • (2003) Blood , vol.101 , pp. 4823-4827
    • Levi, M.1    Dorffler-Melly, J.2    Reitsma, P.H.3    Buller, H.4    S, F.5    van der Poll, T.6    Carmeliet, P.7
  • 40
    • 79952066363 scopus 로고    scopus 로고
    • Activated protein C modulates inflammation, apoptosis, and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes
    • Toltl LJ, Austin RC, Liaw PC. Activated protein C modulates inflammation, apoptosis, and tissue factor procoagulant activity by regulating endoplasmic reticulum calcium depletion in blood monocytes. J Thromb Haemost. 2011; 9: 582-592.
    • (2011) J Thromb Haemost , vol.9 , pp. 582-592
    • Toltl, L.J.1    Austin, R.C.2    Liaw, P.C.3
  • 41
    • 60549086978 scopus 로고    scopus 로고
    • Sepsis, coagulation, and antithrombin: old lessons and new insights
    • Levi M, Schouten M, van der Poll T. Sepsis, coagulation, and antithrombin: old lessons and new insights. Semin Thromb Hemost. 2008; 34: 742-746.
    • (2008) Semin Thromb Hemost , vol.34 , pp. 742-746
    • Levi, M.1    M, S.2    van der Poll, T.3
  • 42
    • 0031950793 scopus 로고    scopus 로고
    • Antithrombin III in animal models of sepsis and organ failure
    • Dickneite G. Antithrombin III in animal models of sepsis and organ failure. Semin Thromb Hemost. 1998; 24: 61-69.
    • (1998) Semin Thromb Hemost , vol.24 , pp. 61-69
    • Dickneite, G.1
  • 44
    • 34447569555 scopus 로고    scopus 로고
    • Clinical review: molecular mechanisms underlying the role of antithrombin in sepsis
    • Wiedermann CJ. Clinical review: molecular mechanisms underlying the role of antithrombin in sepsis. Crit Care. 2006; 10: 209-217.
    • (2006) Crit Care , vol.10 , pp. 209-217
    • Wiedermann, C.J.1
  • 45
    • 0029876674 scopus 로고    scopus 로고
    • Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome
    • Gando S, Kameue T, Nanzaki S, Nakanishi Y. Disseminated intravascular coagulation is a frequent complication of systemic inflammatory response syndrome. Thromb Haemost. 1996; 75: 224-228.
    • (1996) Thromb Haemost , vol.75 , pp. 224-228
    • Gando, S.1    Kameue, T.2    Nanzaki, S.3    Nakanishi, Y.4
  • 46
    • 34250699429 scopus 로고    scopus 로고
    • Effects of anticoagulant strategies on activation of inflammation and coagulation
    • Feistritzer C, Wiedermann CJ. Effects of anticoagulant strategies on activation of inflammation and coagulation. Expert Opin Biol Ther. 2007; 7: 855-870.
    • (2007) Expert Opin Biol Ther , vol.7 , pp. 855-870
    • Feistritzer, C.1    Wiedermann, C.J.2
  • 47
    • 76749106159 scopus 로고    scopus 로고
    • Crosstalk between inflammation and thrombosis
    • Esmon CT. Crosstalk between inflammation and thrombosis. Maturitas. 2008; 61: 122-131.
    • (2008) Maturitas , vol.61 , pp. 122-131
    • Esmon, C.T.1
  • 50
    • 0035217872 scopus 로고    scopus 로고
    • Regulatory role of cytokines in disseminated intravascular coagulation
    • Van der Poll T, De Jonge E, Levi M. Regulatory role of cytokines in disseminated intravascular coagulation. Semin Thromb Hemost. 2001; 27: 639-651.
    • (2001) Semin Thromb Hemost , vol.27 , pp. 639-651
    • Van der Poll, T.1    De Jonge, E.2    Levi, M.3
  • 51
    • 0034090602 scopus 로고    scopus 로고
    • Anti-inflammatory cytokines
    • Opal SM, DePalo VA. Anti-inflammatory cytokines. Chest. 2000; 117: 1162-1172.
    • (2000) Chest , vol.117 , pp. 1162-1172
    • Opal, S.M.1    DePalo, V.A.2
  • 52
    • 33745932547 scopus 로고    scopus 로고
    • Compartmentalization of the inflammatory response in sepsis and SIRS
    • Cavaillon JM, Annane D. Compartmentalization of the inflammatory response in sepsis and SIRS. J Endotoxin Res. 2006; 12: 151-170.
    • (2006) J Endotoxin Res , vol.12 , pp. 151-170
    • Cavaillon, J.M.1    Annane, D.2
  • 53
    • 0024562002 scopus 로고
    • Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects
    • Suffredini AF, Harpel PC, Parrillo JE. Promotion and subsequent inhibition of plasminogen activator after administration of intravenous endotoxin to normal subjects. NEJM. 1989; 320: 1165-1172.
    • (1989) NEJM , vol.320 , pp. 1165-1172
    • Suffredini, A.F.1    Harpel, P.C.2    Parrillo, J.E.3
  • 54
    • 0031059478 scopus 로고    scopus 로고
    • Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest
    • Gando S, Kameue T, Nanzaki S, Nakanishi Y. Massive fibrin formation with consecutive impairment of fibrinolysis in patients with out-of-hospital cardiac arrest. Thromb Haemost. 1997; 77: 278-282.
    • (1997) Thromb Haemost , vol.77 , pp. 278-282
    • Gando, S.1    Kameue, T.2    Nanzaki, S.3    Nakanishi, Y.4
  • 55
    • 0032167429 scopus 로고    scopus 로고
    • Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition
    • Pinsky DJ, Liao H, Lawson CA, Yan SF, Chen J, Carmeliet P, Loskutoff DJ, Stern DM. Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest. 1998; 102:919-928.
    • (1998) J Clin Invest , vol.102 , pp. 919-928
    • Pinsky, D.J.1    Liao, H.2    Lawson, C.A.3    Yan, S.F.4    Chen, J.5    Carmeliet, P.6    Loskutoff, D.J.7    Stern, D.M.8
  • 56
    • 61849136778 scopus 로고    scopus 로고
    • Guidelines for the diagnosis and management of disseminated intravascular coagulation
    • Levi M, Toh CH, Thachil J, Watson HG. Guidelines for the diagnosis and management of disseminated intravascular coagulation. Br J Haematol. 2009; 145: 24-33.
    • (2009) Br J Haematol , vol.145 , pp. 24-33
    • Levi, M.1    Toh, C.H.2    Thachil, J.3    Watson, H.G.4
  • 57
    • 77957367440 scopus 로고    scopus 로고
    • Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation
    • Kim SY, Kim J-E, Kyung H, Han K-S, Toh CH. Accuracy of platelet counting by automated hematologic analyzers in acute leukemia and disseminated intravascular coagulation: potential effects of platelet activation. Am J Clin Pathol. 2010; 134: 634-647.
    • (2010) Am J Clin Pathol , vol.134 , pp. 634-647
    • Kim, S.Y.1    Kim, J.-E.2    Kyung, H.3    Han, K.-S.4    Toh, C.H.5
  • 58
    • 77949391746 scopus 로고    scopus 로고
    • Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults
    • Park YA, Waldrum MR, Marques MB. Platelet count and prothrombin time help distinguish thrombotic thrombocytopenic purpura-hemolytic uremic syndrome from disseminated intravascular coagulation in adults. Am J Clin Pathol. 2010; 133: 460-465.
    • (2010) Am J Clin Pathol , vol.133 , pp. 460-465
    • Park, Y.A.1    Waldrum, M.R.2    Marques, M.B.3
  • 60
    • 0030743537 scopus 로고    scopus 로고
    • Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor
    • Francois B, Trimoreau F, Vignon P, Fixe P, Praloran V, Gastinne H. Thrombocytopenia in the sepsis syndrome: role of hemophagocytosis and macrophage colony-stimulating factor. Am J Med. 1997; 103: 114-120.
    • (1997) Am J Med , vol.103 , pp. 114-120
    • Francois, B.1    Trimoreau, F.2    Vignon, P.3    Fixe, P.4    Praloran, V.5    Gastinne, H.6
  • 61
    • 0035160476 scopus 로고    scopus 로고
    • Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. On behalf of the Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH)
    • Taylor FB, Jr., Toh CH, Hoots WK, Wada H, Levi M. Towards definition, clinical and laboratory criteria, and a scoring system for disseminated intravascular coagulation. On behalf of the Scientific Subcommittee on Disseminated Intravascular Coagulation (DIC) of the International Society on Thrombosis and Haemostasis (ISTH). Thromb Haemost. 2001; 86: 1327-1330.
    • (2001) Thromb Haemost , vol.86 , pp. 1327-1330
    • Taylor Jr., F.B.1    Toh, C.H.2    Hoots, W.K.3    Wada, H.4    Levi, M.5
  • 62
    • 10644283860 scopus 로고    scopus 로고
    • Prospective Validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation
    • Bakhtiari K, Meijers JC, de Jonge E, Levi M. Prospective Validation of the International Society of Thrombosis and Haemostasis scoring system for disseminated intravascular coagulation. Crit Care Med. 2004; 32: 2416-2421.
    • (2004) Crit Care Med , vol.32 , pp. 2416-2421
    • Bakhtiari, K.1    Meijers, J.C.2    de Jonge, E.3    Levi, M.4
  • 63
    • 34247594942 scopus 로고    scopus 로고
    • The scoring system of the scientific and standardization committee on disseminated intravascular coagulation of the Internal Society of Thrombosis and Haemostasis. A 5-year review
    • On behalf of the SCC on Disseminated Intravascular Coagulation of the ISTH.
    • Toh CH, Hoots WK; On behalf of the SCC on Disseminated Intravascular Coagulation of the ISTH. The scoring system of the scientific and standardization committee on disseminated intravascular coagulation of the Internal Society of Thrombosis and Haemostasis. A 5-year review. J Thromb Haemost. 2007; 5: 604-606.
    • (2007) J Thromb Haemost , vol.5 , pp. 604-606
    • Toh, C.H.1    Hoots, W.K.2
  • 64
    • 33747179285 scopus 로고    scopus 로고
    • International Society of Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients
    • Voves C, Wuillemin WA, Zeerleder S. International Society of Thrombosis and Haemostasis score for overt disseminated intravascular coagulation predicts organ dysfunction and fatality in sepsis patients. Blood Coagul Tibrinolysis. 2006; 17: 445-451.
    • (2006) Blood Coagul Tibrinolysis , vol.17 , pp. 445-451
    • Voves, C.1    Wuillemin, W.A.2    Zeerleder, S.3
  • 65
    • 0042925576 scopus 로고    scopus 로고
    • Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for Overt DIC
    • Wada H, Gabazza EC, Asakura H, Koike K, Okamoto K, Maruyama I, Shiku H, Nobori T. Comparison of diagnostic criteria for disseminated intravascular coagulation (DIC): diagnostic criteria of the International Society of Thrombosis and Hemostasis (ISTH) and of the Japanese Ministry of Health and Welfare for Overt DIC. Am J Hematol. 2003; 74: 17-22.
    • (2003) Am J Hematol , vol.74 , pp. 17-22
    • Wada, H.1    Gabazza, E.C.2    Asakura, H.3    Koike, K.4    Okamoto, K.5    Maruyama, I.6    Shiku, H.7    Nobori, T.8
  • 67
    • 33644589346 scopus 로고    scopus 로고
    • A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria
    • Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group.
    • Gando S, Iba T, Eguchi Y, Ohtomo Y, Okamoto K, Koseki K, Mayumi T, Murata A, Ikeda T, Ishikura H, et al.; Japanese Association for Acute Medicine Disseminated Intravascular Coagulation (JAAM DIC) Study Group. A multicenter, prospective validation of disseminated intravascular coagulation diagnostic criteria for critically ill patients: comparing current criteria. Crit Care Med. 2006; 34: 625-631.
    • (2006) Crit Care Med , vol.34 , pp. 625-631
    • Gando, S.1    Iba, T.2    Eguchi, Y.3    Ohtomo, Y.4    Okamoto, K.5    Koseki, K.6    Mayumi, T.7    Murata, A.8    Ikeda, T.9    Ishikura, H.10
  • 68
    • 76449097783 scopus 로고    scopus 로고
    • Expert consensus for the treatment of disseminated intravascular coagulation in Japan
    • Japanese Society of Thrombosis Hemostasis(DIC subcommittee.
    • Wada H, Asakura H, Okamoto K, Iba T, Uchiyama T, Kawasugi K, Koga S, Mayumi T, Koike K, Gando S, et al.; Japanese Society of Thrombosis Hemostasis(DIC subcommittee. Expert consensus for the treatment of disseminated intravascular coagulation in Japan. Thromb Res. 2010; 125: 6-11.
    • (2010) Thromb Res , vol.125 , pp. 6-11
    • Wada, H.1    Asakura, H.2    Okamoto, K.3    Iba, T.4    Uchiyama, T.5    Kawasugi, K.6    Koga, S.7    Mayumi, T.8    Koike, K.9    Gando, S.10
  • 69
    • 0019961863 scopus 로고
    • Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy
    • Feinstein DI. Diagnosis and management of disseminated intravascular coagulation: the role of heparin therapy. Blood. 1982; 60: 284-287.
    • (1982) Blood , vol.60 , pp. 284-287
    • Feinstein, D.I.1
  • 72
    • 34748837272 scopus 로고    scopus 로고
    • Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review
    • Franchini M, Mantazo F, Salvagno GL, Lippi G. Potential role of recombinant activated factor VII for the treatment of severe bleeding associated with disseminated intravascular coagulation: a systematic review. Blood Coagul Fibrinolysis. 2007; 18: 589-593.
    • (2007) Blood Coagul Fibrinolysis , vol.18 , pp. 589-593
    • Franchini, M.1    Mantazo, F.2    Salvagno, G.L.3    Lippi, G.4
  • 73
    • 0027528798 scopus 로고
    • Anticytokine strategies in the treatment of the systemic inflammatory response syndrome
    • Dinarello CA, Gelfand JA, Wolff SM. Anticytokine strategies in the treatment of the systemic inflammatory response syndrome. JAMA. 1993; 269: 1829-1835.
    • (1993) JAMA , vol.269 , pp. 1829-1835
    • Dinarello, C.A.1    Gelfand, J.A.2    Wolff, S.M.3
  • 74
    • 37549063078 scopus 로고    scopus 로고
    • Cytokines and anti-cytokines as therapeutics-an update
    • Tayal V, Kalra BS. Cytokines and anti-cytokines as therapeutics-an update. Eur J Pharmacol. 2008; 579: 1-12.
    • (2008) Eur J Pharmacol , vol.579 , pp. 1-12
    • Tayal, V.1    Kalra, B.S.2
  • 75
    • 84873076357 scopus 로고    scopus 로고
    • Package insert, Xigris. Eli Lilly and Company, Indianapolis, Indiana, USA. Updated 10/2008. Accessed on 11/08/10 at
    • Package insert, Xigris. Eli Lilly and Company, Indianapolis, Indiana, USA. Updated 10/2008. Accessed on 11/08/10 at.
  • 77
    • 0002295408 scopus 로고    scopus 로고
    • Recombinant human activated protein C (rhAPC) improves coagulation abnormalities associated with severe sepsis
    • Abstract.
    • Hartman DL, Bernard GR, Helterbrand JD, Yan SB, Fisher CJ. Recombinant human activated protein C (rhAPC) improves coagulation abnormalities associated with severe sepsis. Intensive Care Med. 1998; 24(Suppl. 1): S77. Abstract.
    • (1998) Intensive Care Med , vol.24 , Issue.SUPPL. 1
    • Hartman, D.L.1    Bernard, G.R.2    Helterbrand, J.D.3    Yan, S.B.4    Fisher, C.J.5
  • 78
    • 0037352375 scopus 로고    scopus 로고
    • Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial
    • Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group.
    • Vincent JL, Angus DC, Artigas A, Kalil A, Basson BR, Jamal HH, Johnson 3rd G, Bernard GR, Recombinant Human Activated Protein C Worldwide Evaluation in Severe Sepsis (PROWESS) Study Group. Effects of drotrecogin alfa (activated) on organ dysfunction in the PROWESS trial. Crit Care Med. 2003; 3: 834-840.
    • (2003) Crit Care Med , vol.3 , pp. 834-840
    • Vincent, J.L.1    Angus, D.C.2    Artigas, A.3    Kalil, A.4    Basson, B.R.5    Jamal, H.H.6    Johnson 3rd, G.7    Bernard, G.R.8
  • 79
    • 0037803423 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial
    • Recombinant Human Activated Protein C Worldwide Evaluation in Sepsis (PROWESS) Study Group.
    • Dhainaut JF, Laterre PF, Janes JM, Bernard GR, Artigas A, Bakker J, Riess H, Basson BR, Charpentier J, Utterback BG, et al.; Recombinant Human Activated Protein C Worldwide Evaluation in Sepsis (PROWESS) Study Group. Drotrecogin alfa (activated) in the treatment of severe sepsis patients with multiple-organ dysfunction: data from the PROWESS trial. Intensive Care Med. 2003; 29: 894-903.
    • (2003) Intensive Care Med , vol.29 , pp. 894-903
    • Dhainaut, J.F.1    Laterre, P.F.2    Janes, J.M.3    Bernard, G.R.4    Artigas, A.5    Bakker, J.6    Riess, H.7    Basson, B.R.8    Charpentier, J.9    Utterback, B.G.10
  • 80
    • 25444492831 scopus 로고    scopus 로고
    • Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death
    • Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group.
    • Abraham E, Laterre PF, Garg R, Levy H, Talwar D, Trzaskoma BL, François B, Guy JS, Brückmann M, Rea-Neto A, et al.; Administration of Drotrecogin Alfa (Activated) in Early Stage Severe Sepsis (ADDRESS) Study Group. Drotrecogin alfa (activated) for adults with severe sepsis and a low risk of death. NEJM. 2005; 353: 1332-1341.
    • (2005) NEJM , vol.353 , pp. 1332-1341
    • Abraham, E.1    Laterre, P.F.2    Garg, R.3    Levy, H.4    Talwar, D.5    Trzaskoma, B.L.6    François, B.7    Guy, J.S.8    Brückmann, M.9    Rea-Neto, A.10
  • 81
    • 67949120336 scopus 로고    scopus 로고
    • The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes
    • Martin G, Brunkhorst FM, Janes JM, Reinhart K, Sundin DP, Garnett K, Beale R. The international PROGRESS registry of patients with severe sepsis: drotrecogin alfa (activated) use and patient outcomes. Crit Care. 2009; 13: R103-R116.
    • (2009) Crit Care , vol.13
    • Martin, G.1    Brunkhorst, F.M.2    Janes, J.M.3    Reinhart, K.4    Sundin, D.P.5    Garnett, K.6    Beale, R.7
  • 82
    • 0030974615 scopus 로고    scopus 로고
    • The suprapharmacologic dosing of antithrombin concentrate for Staphylococcus aureus-induced disseminated intravascular coagulation in guinea pigs: substantial reduction in mortality and morbidity
    • Kessler CM, Tang Z, Jacobs HM, Szymanski LM. The suprapharmacologic dosing of antithrombin concentrate for Staphylococcus aureus-induced disseminated intravascular coagulation in guinea pigs: substantial reduction in mortality and morbidity. Blood. 1997; 89: 4393-4401.
    • (1997) Blood , vol.89 , pp. 4393-4401
    • Kessler, C.M.1    Tang, Z.2    Jacobs, H.M.3    Szymanski, L.M.4
  • 83
    • 0034651773 scopus 로고    scopus 로고
    • Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli
    • Minnema MC, Chang AC, Jansen PM, Lubbers YT, Pratt BM, Whittaker BG, Taylor FB, Hack CE, Friedman B. Recombinant human antithrombin III improves survival and attenuates inflammatory responses in baboons lethally challenged with Escherichia coli. Blood. 2000; 95: 1117-1123.
    • (2000) Blood , vol.95 , pp. 1117-1123
    • Minnema, M.C.1    Chang, A.C.2    Jansen, P.M.3    Lubbers, Y.T.4    Pratt, B.M.5    Whittaker, B.G.6    Taylor, F.B.7    Hack, C.E.8    Friedman, B.9
  • 84
    • 0023757465 scopus 로고
    • Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons
    • Taylor FB, Jr., Emerson TEJ, Jordan R, Chang AK, Blick KE. Antithrombin-III prevents the lethal effects of Escherichia coli infusion in baboons. Circ Shock. 1988; 26: 227-235.
    • (1988) Circ Shock , vol.26 , pp. 227-235
    • Taylor Jr., F.B.1    Emerson, T.E.J.2    Jordan, R.3    Chang, A.K.4    Blick, K.E.5
  • 85
    • 0035904368 scopus 로고    scopus 로고
    • Caring for the critically ill patient. High dose antithrombin III in severe sepsis: a randomized controlled trial
    • For the KyberSept Trial Study Group.
    • Warren BL, Eid A, Singer P, Pillay SS, Carl P, Novak I, Chalupa P, Atherstone A, Renzes I, Kubler A, et al.; For the KyberSept Trial Study Group. Caring for the critically ill patient. High dose antithrombin III in severe sepsis: a randomized controlled trial. JAMA. 2001; 286: 1869-1878.
    • (2001) JAMA , vol.286 , pp. 1869-1878
    • Warren, B.L.1    Eid, A.2    Singer, P.3    Pillay, S.S.4    Carl, P.5    Novak, I.6    Chalupa, P.7    Atherstone, A.8    Renzes, I.9    Kubler, A.10
  • 86
    • 33644859949 scopus 로고    scopus 로고
    • Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation
    • Kienast J, Juers M, Wiedermann CJ, et al. Treatment effects of high-dose antithrombin without concomitant heparin in patients with severe sepsis with or without disseminated intravascular coagulation. J Thromb Haemost. 2006; 4: 90-97.
    • (2006) J Thromb Haemost , vol.4 , pp. 90-97
    • Kienast, J.1    Juers, M.2    Wiedermann, C.J.3
  • 87
    • 30344449496 scopus 로고    scopus 로고
    • Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia
    • Leitner JM, Firbas C, Mayr FB, Reiter RA, Steinlechner B, Jilma B. Recombinant human antithrombin inhibits thrombin formation and interleukin 6 release in human endotoxemia. Clin Pharmaco Ther. 2006; 79: 23-34.
    • (2006) Clin Pharmaco Ther , vol.79 , pp. 23-34
    • Leitner, J.M.1    Firbas, C.2    Mayr, F.B.3    Reiter, R.A.4    Steinlechner, B.5    Jilma, B.6
  • 89
    • 0033816376 scopus 로고    scopus 로고
    • Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis
    • Abraham E. Tissue factor inhibition and clinical trial results of tissue factor pathway inhibitor in sepsis. Crit Care Med. 2000; 28(Suppl. 9): S31-S33.
    • (2000) Crit Care Med , vol.28 , Issue.SUPPL. 9
    • Abraham, E.1
  • 91
    • 0038690407 scopus 로고    scopus 로고
    • Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial
    • OPTIMIST Trial Study Group.
    • Abraham E, Reinhart K, Opal S, Demeyer I, Doig C, Rodriguez AL, Beale R, Svoboda P, Laterre PF, Simon S, et al.; OPTIMIST Trial Study Group. Efficacy and safety of tifacogin (recombinant tissue factor pathway inhibitor) in severe sepsis: a randomized controlled trial. JAMA. 2003; 290: 238-247.
    • (2003) JAMA , vol.290 , pp. 238-247
    • Abraham, E.1    Reinhart, K.2    Opal, S.3    Demeyer, I.4    Doig, C.5    Rodriguez, A.L.6    Beale, R.7    Svoboda, P.8    Laterre, P.F.9    Simon, S.10
  • 92
    • 0035829842 scopus 로고    scopus 로고
    • Early goal-directed therapy in the treatment of severe sepsis and septic shock
    • For the Early Goal-Directed Therapy Collaborative Group.
    • Rivers E, Nguyen B, Havstad S, Ressler J, Muzzin A, Knoblich B, Peterson E, Tomlanovich M; For the Early Goal-Directed Therapy Collaborative Group. Early goal-directed therapy in the treatment of severe sepsis and septic shock. NEJM. 2001; 345: 1368-1377.
    • (2001) NEJM , vol.345 , pp. 1368-1377
    • Rivers, E.1    Nguyen, B.2    Havstad, S.3    Ressler, J.4    Muzzin, A.5    Knoblich, B.6    Peterson, E.7    Tomlanovich, M.8


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