Serum thrombomodulin as a newly identified biomarker for postoperative lung injury: A prospective observational study

Tohoku Journal of Experimental Medicine

Volumn 228, Issue 2, 2012, Pages 135-141

  Maeda, Sumiko ^a,b   Takahashi, Satomi ^a   Sato, Masami ^a  

^a Miyagi Cancer Center   (Japan)

^b TOHOKU UNIVERSITY HOSPITAL   (Japan)

Author keywords

Endothelium; Lung injury; Lung resection; Pulmonary capillary vessels; Thrombomodulin

Indexed keywords

BIOLOGICAL MARKER; CARBOHYDRATE ANTIGEN; PROTEIN KL 6; THROMBOMODULIN; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LOBECTOMY; LUNG FIBROSIS; LUNG INJURY; LUNG RESECTION; LUNG VOLUME; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL STUDY; OXYGENATION; POSTOPERATIVE COMPLICATION; POSTOPERATIVE PERIOD; PREOPERATIVE PERIOD; PROSPECTIVE STUDY; PROTEIN BLOOD LEVEL; THORACOTOMY;

BIOLOGICAL MARKERS; HUMANS; LUNG INJURY; LUNG NEOPLASMS; MUCIN-1; PNEUMONECTOMY; POSTOPERATIVE COMPLICATIONS; PROSPECTIVE STUDIES; THROMBOMODULIN;

EID: 84867869375     PISSN: 00408727     EISSN: 13493329     Source Type: Journal    
DOI: 10.1620/tjem.228.135     Document Type: Article

References (31)

1. Alam, N., Park, B.J., Wilton, A., Seshan, V.E., Bains, M.S., Downey, R.J., Flores, R.M., Rizk, N., Rusch, V.W. & Amar, D. (2007) Incidence and risk factors for lung injury after lung cancer resection. Ann. Thorac. Surg., 84, 1085-1091.
2. Bernard, G.R., Artigas, A., Brigham, K.L., Carlet, J., Falke, K., Hudson, L., Lamy, M., Legall, J.R., Morris, A. & Spragg, R. (1994) The American-European Consensus Conference on ARDS. Definitions, mechanisms, relevant outcomes, and clinical trial coordination. Am. J. Respir. Crit. Care Med., 149, 818-824.
3. Boehme, M.W., Galle, P. & Stremmel, W. (2002) Kinetics of thrombomodulin release and endothelial cell injury by neutrophil-derived proteases and oxygen radicals. Immunology, 107, 340-349.
4. Chida, M., Ono, S., Hoshikawa, Y. & Kondo, T. (2008) Subclinical idiopathic pulmonary fibrosis is also a risk factor of postoperative acute respiratory distress syndrome following thoracic surgery. Eur. J. Cardiothorac. Surg., 34, 878-881.
5. Colice, G.L., Shafazand, S., Griffin, J.P., Keenan, R. & Bolliger, C.T. (2007) Physiologic evaluation of the patient with lung cancer being considered for resectional surgery: ACCP evidenced-based clinical practice guidelines (2nd edition). Chest, 132, 161S-177S.
6. Collard, H.R., Calfee, C.S., Wolters, P.J., Song, J.W., Hong, S.B., Brady, S., Ishizaka, A., Jones, K.D., King, T.E. Jr., Matthay, M.A. & Kim, D.S. (2010) Plasma biomarker profiles in acute exacerbation of idiopathic pulmonary fibrosis. Am. J. Physiol. Lung Cell. Mol. Physiol., 299, L3-L7.
7. Cone, J.B., Ferrer, T.J., Wallace, B.H., Wang, J. & Hauer-Jensen, M. (2003) Alterations in endothelial thrombomodulin expression in zymosan-induced lung injury. J. Trauma, 54, 731-736.
8. Dulu, A., Pastores, S.M., Park, B., Riedel, E., Rusch, V. & Halpern, N.A. (2006) Prevalence and mortality of acute lung injury and ARDS after lung resection. Chest, 130, 73-78.
9. Esmon, C.T. & Owen, W.G. (1981) Identification of an endothelial cell cofactor for thrombin-catalyzed activation of protein C. Proc. Natl. Acad. Sci. USA, 78, 2249-2252.
10. Ford, V.A., Stringer, C. & Kennel, S.J. (1992) Thrombomodulin is preferentially expressed in Balb/c lung microvessels. J. Biol. Chem., 267, 5446-5450.
11. Gando, S., Kameue, T., Matsuda, N., Sawamura, A., Hayakawa, M. & Kato, H. (2004) Systemic inflammation and disseminated intravascular coagulation in early stage of ALI and ARDS: role of neutrophil and endothelial activation. Inflammation, 28, 237-244.
12. Hack, C.E. & Zeerleder, S. (2001) The endothelium in sepsis: source of and a target for inflammation. Crit. Care Med., 29, S21-S27.
13. Ishii, H., Uchiyama, H. & Kazama, M. (1991) Soluble thrombomodulin antigen in conditioned medium is increased by damage of endothelial cells. Thromb. Haemost., 65, 618-623.
14. Kohno, N., Kyoizumi, S., Awaya, Y., Fukuhara, H., Yamakido, M. & Akiyama, M. (1989) New serum indicator of interstitial pneumonitis activity. Sialylated carbohydrate antigen KL-6. Chest, 96, 68-73.
15. Maeda, S., Suzuki, S., Suzuki, T., Endo, M., Moriya, T., Chida, M., Kondo, T. & Sasano, H. (2002) Analysis of intrapulmonary vessels and epithelial-endothelial interactions in the human developing lung. Lab. Invest., 82, 293-301.
16. Miyazaki, Y., Inoue, T., Kyi, M., Sawada, M., Miyake, S. & Yoshizawa, Y. (1998) Effects of a neutrophil elastase inhibitor (ONO-5046) on acute pulmonary injury induced by tumor necrosis factor alpha (TNFalpha) and activated neutrophils in isolated perfused rabbit lungs. Am. J. Respir. Crit. Care Med., 157, 89-94.
17. Ohdama, S., Takano, S., Miyake, S., Kubota, T., Sato, K. & Aoki, N. (1994) Plasma thrombomodulin as a marker of vascular injuries in collagen vascular diseases. Am. J. Clin. Pathol., 101, 109-113.
18. Reid, P.T., Donnelly, S.C., MacGregor, I.R., Grant, I.S., Cameron, E., Walker, W., Merrick, M.V. & Haslett, C. (2000) Pulmonary endothelial permeability and circulating neutrophil-endothelial markers in patients undergoing esophagogastrectomy. Crit. Care Med., 28, 3161-3165.
19. Ruffini, E., Parola, A., Papalia, E., Filosso, P.L., Mancuso, M., Oliaro, A., Actis-Dato, G. & Maggi, G. (2001) Frequency and mortality of acute lung injury and acute respiratory distress syndrome after pulmonary resection for bronchogenic carcinoma. Eur. J. Cardiothorac. Surg., 20, 30-36.
20. Saito, H., Minamiya, Y., Nanjo, H., Ito, M., Ono, T., Motoyama, S., Hashimoto, M. & Ogawa, J. (2011) Pathological finding of subclinical interstitial pneumonia as a predictor of postoperative acute respiratory distress syndrome after pulmonary resection. Eur. J. Cardiothorac. Surg., 39, 190-194.
21. Sakata, R., Fujii, Y. & Kuwano, H. (2010) Thoracic and cardiovascular surgery in Japan during 2008: annual report by The Japanese Association for Thoracic Surgery. Gen. Thorac. Cardiovasc. Surg., 58, 356-383.
22. Sakuma, T., Takahashi, K., Ohya, N., Usuda, K. & Handa, M. (1999) Serum KL-6, a novel mucin-like glycoprotein, as an indicator of interstitial pneumonitis following lobectomy. Surg. Today, 29, 121-128.
23. Sawada, K., Yamamoto, H., Matsumoto, K., Yago, H., Suehiro, S., Tahara, C., Ishii, H., Kazama, M. & Abe, T. (1992) Changes in thrombomodulin level in plasma of endotoxin-infused rabbits. Thromb. Res., 65, 199-209.
24. Takano, S., Kimura, S., Ohdama, S. & Aoki, N. (1990) Plasma thrombomodulin in health and diseases. Blood, 76, 2024-2029.
25. Tanaka, A., Ishii, H., Hiraishi, S., Kazama, M. & Maezawa, H. (1991) Increased thrombomodulin values in plasma of diabetic men with microangiopathy. Clin. Chem., 37, 269-272.
26. Tang, S.S., Redmond, K., Griffiths, M., Ladas, G., Goldstraw, P. & Dusmet, M. (2008) The mortality from acute respiratory distress syndrome after pulmonary resection is reducing: a 10-year single institutional experience. Eur. J. Cardiothorac. Surg., 34, 898-902.
27. Terada, Y., Eguchi, Y., Nosaka, S., Toba, T., Nakamura, T. & Shimizu, Y. (2003) Capillary endothelial thrombomodulin expression and fibrin deposition in rats with continuous and bolus lipopolysaccharide administration. Lab. Invest., 83, 1165-1173.
28. van der Poll, T., Levi, M., Nick, J. A. & Abraham, E. (2005) Activated protein C inhibits local coagulation after intrapulmonary delivery of endotoxin in humans. Am. J. Respir. Crit. Care Med., 171, 1125-1128.
29. Wada, H., Minamikawa, K., Wakita, Y., Nakase, T., Kaneko, T., Ohiwa, M., Tamaki, S., Deguchi, K., Shirakawa, S., Hayashi, T. & Suzuki, K. (1993) Increased vascular endothelial cell markers in patients with disseminated intravascular coagulation. Am. J. Hematol., 44, 85-88.
30. Ware, L.B., Fang, X. & Matthay, M.A. (2003) Protein C and thrombomodulin in human acute lung injury. Am. J. Physiol. Lung Cell. Mol. Physiol., 285, L514-L521.
31. Watanabe, S., Asamura, H., Suzuki, K. & Tsuchiya, R. (2004) Recent results of postoperative mortality for surgical resections in lung cancer. Ann. Thorac. Surg., 78, 999-1002.