Molecular mechanism of HIV-1 resistance to 3′-azido-2′, 3′-dideoxyguanosine

Antiviral Research

Volumn 101, Issue 1, 2014, Pages 62-67

  Meteer, Jeffrey D ^a   Schinazi, Raymond F ^b,c   Mellors, John W ^a   Sluis Cremer, Nicolas ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c ATLANTA VA MEDICAL CENTER   (United States)

Author keywords

3 dideoxyguanosine; 3 Azido 2 ; Discrimination; Excision; HIV 1; Resistance; Reverse transcriptase

Indexed keywords

3' AZIDO 2',3' DIDEOXYGUANOSINE; NUCLEOTIDE; RIBONUCLEASE H; RNA DIRECTED DNA POLYMERASE; ZIDOVUDINE; DNA POLYMERASE; 2',3' DIDEOXYNUCLEOSIDE DERIVATIVE; 3'-AZIDO-2',3'-DIDEOXYGUANOSINE; ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; MUTANT PROTEIN; POL PROTEIN; REVERSE TRANSCRIPTASE, HUMAN IMMUNODEFICIENCY VIRUS 1;

ANTIVIRAL ACTIVITY; ANTIVIRAL RESISTANCE; ARTICLE; BINDING AFFINITY; DRUG MECHANISM; ENZYME ACTIVITY; GENE MUTATION; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; IN VITRO STUDY; NONHUMAN; PRIORITY JOURNAL; CONTROLLED STUDY; DNA RNA HYBRIDIZATION; RNA CLEAVAGE; STEADY STATE; VIRUS MUTANT; VIRUS RESISTANCE; DRUG EFFECT; GENETIC SELECTION; GENETICS; HUMAN; KINETICS; METABOLISM; MISSENSE MUTATION;

HUMAN IMMUNODEFICIENCY VIRUS 1;

3′-AZIDO-2′,3′-DIDEOXYGUANOSINE; 3′-AZIDO-DDG; 3′-AZIDO-DDG-MONOPHOSPHATE; 3′-AZIDO-DDG-TRIPHOSPHATE; 3′-AZIDO-DDGMP; 3′-AZIDO-DDGTP; 50% INHIBITORY CONCENTRATION; AZT; DIPHOSPHATE; DISCRIMINATION; DP; EXCISION; HIV-1; IC(50); MONOPHOSPHATE; MP; NRTI; NRTIS; NUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITORS; NUCLEOSIDE RT INHIBITOR; RESISTANCE; REVERSE TRANSCRIPTASE; RIBONUCLEASE H; RNASE H; RT; T/P; TEMPLATE/PRIMER; TP; TRIPHOSPHATE; WILD-TYPE; WT; ZIDOVUDINE;

ANTI-HIV AGENTS; DIDEOXYNUCLEOSIDES; DRUG RESISTANCE, VIRAL; HIV REVERSE TRANSCRIPTASE; HIV-1; HUMANS; KINETICS; MUTANT PROTEINS; MUTATION, MISSENSE; POL GENE PRODUCTS, HUMAN IMMUNODEFICIENCY VIRUS; SELECTION, GENETIC;

MLCS; MLOWN;

EID: 84888146170     PISSN: 01663542     EISSN: 18729096     Source Type: Journal    
DOI: 10.1016/j.antiviral.2013.10.017     Document Type: Article

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