Smart drugs: Green shuttle or real drug?

International Journal of Legal Medicine

Volumn 127, Issue 6, 2013, Pages 1109-1123

  Cornara, L ^a   Borghesi, B ^a   Canali, C ^a   Andrenacci, M ^a   Basso, M ^a   Federici, S ^b   Labra, M ^b  

^a UNIVERSITY OF GENOA   (Italy)

^b UNIVERSITY OF MILANO BICOCCA   (Italy)

Author keywords

Cannabinoids; DNA barcoding; GC MS analysis; Micromorphology; SEM EDS; Smart drugs

Indexed keywords

CANNABINOID; DESIGNER DRUG; MITRAGYNINE; PLANT DNA; RAUWOLFIA ALKALOID; RBCL PROTEIN, PLASTID; RIBULOSEBISPHOSPHATE CARBOXYLASE; SPACER DNA; STREET DRUG;

ANATOMY AND HISTOLOGY; CHEMISTRY; COMPARATIVE STUDY; GENETICS; HERBAL MEDICINE; HUMAN; ITALY; MASS FRAGMENTOGRAPHY; PLANT; SCANNING ELECTRON MICROSCOPY; SPECTROMETRY;

CANNABINOIDS; DESIGNER DRUGS; DNA, INTERGENIC; DNA, PLANT; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; HERBAL MEDICINE; HUMANS; ITALY; MICROSCOPY, ELECTRON, SCANNING; PLANTS; RIBULOSE-BISPHOSPHATE CARBOXYLASE; SECOLOGANIN TRYPTAMINE ALKALOIDS; SPECTROMETRY, X-RAY EMISSION; STREET DRUGS;

MLCS; MLOWN;

EID: 84888134772     PISSN: 09379827     EISSN: 14371596     Source Type: Journal    
DOI: 10.1007/s00414-013-0893-9     Document Type: Article

References (49)

1. Lindigkeit R, Boehme A, Eiserloh I, Luebbecke M, Wiggermann M, Ernst L, Beuerle T (2009) Spice: a never ending story? Forensic Sci Int 191:58-63
2. Schmidt MM, Sharma A, Schifano F, Feinmann C (2011) "Legal highs" on the net - evaluation of UK-based websites, products and product information. Forensic Sci Int 206:92-97
3. Atwood BK, Lee D, Straiker A, Widlanski TS, Mackie K (2011) CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. Eur J Pharmacol 659:139-45
4. Dresen S, Ferreirós N, Pütz M, Westphal F, Zimmermann R, Auwärter V (2010) Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J Mass Spectrom 45:1186-94
5. Auwärter V, Dresen S, Weinmann W, Müller M, Pütz M, Ferreirós N (2009) 'Spice' and other herbal blends: harmless incense or cannabinoid designer drugs? J Mass Spectrom 44:832-837
6. Vardakou I, Pistos C, Spiliopoulou C (2010) Spice drugs as a new trend: mode of action, identification and legislation. Toxicol Lett 197:157-162
7. www.barcoding.si.edu. Accessed 22 Jun 2012
8. Hebert PDN, Cywinska A, Ball SL, deWaard JR (2003) Biological identifications through DNA barcodes. Proc R Soc Lond B 270:313-321
9. Casiraghi M, Labra M, Ferri E, Galimberti A, De Mattia F (2010) DNA barcoding: a six-question tour to improve users' awareness about the method. Brief Bioinform 11:440-453
10. Fay MF, Bayer C, Alverson WS, de Bruijn AY, Chase MW (1998) Plastid rbcL sequence data indicate a close affinity between Diegodendron and Bixa. Taxon 47:43-50
11. Newmaster SG, Ragupathy S (2009) Testing plant barcoding in a sister species complex of pantropical Acacia (Mimosoideae, Fabaceae). Mol Ecol Resour 9:172-180
12. Larkin MA, Blackshields G, Brown NP, Chenna R, McGettigan PA, McWilliam H, Valentin F, Wallace IM, Wilm A, Lopez R, Thompson JD, Gibson TJ, Higgins DG (2007) Clustal W and Clustal X version 2.0. Bioinformatics 23:2947-2948. doi: 10.1093/bioinformatics/btm404
13. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ (1990) Basic local alignment search tool. J Mol Biol 215:403-410
14. BOLD Identification System (IDS) http://www.boldsystems.org/index.php/ IDS-OpenIdEngine. Accessed 12 Oct 2012
15. Jackson BP, Snowdon DW (1990) Atlas of microscopy of medicinal plants, culinary herbs and spices. CRC, Boca Raton
16. Rahfeld B (2011) Mikroskopischer farbatlas pflanzlicher drogen. Spektrum Akademischer Verlag, Plankstadt
17. Tschirch A, Oesterle O (1900) Anatomischer atlas der pharmakognosie und nahrungsmittelkunde. Leipzig Chr. Herm. Tauchnitz, Bern, Schweiz
18. Schneider A (1902) Powdered vegetable drugs. Calumet, Pittsburgh
19. Kumar S, Taneja R, Sharma A (2006) Pharmacognostic standardization of Turnera aphrodisiaca Ward. J Med Food 9:254-260
20. Buchner R, Weber M (2000 onwards) Descriptions, illustrations, identifications, and information retrieval. PalDat-a palinologicaldatabase: http://www.paldat.org/. Accessed 12 Oct 2012
21. Erdtman G (1952) Pollen morphology and plant taxonomy I. Almqvist & Wiksell, Stockholm
22. Faegri K, Iversen J (1975) Textbook of pollen analysis. Hafner, New York
23. Punt W et al. (1976-2003) The Northwest European pollen flora (NEPF). Vols 1-8. Elsevier, Amsterdam
24. Lersten NR, Horner HT (2011) Unique calcium oxalate "duplex" and "concretion" idioblasts in leaves of tribe Naucleeae (Rubiaceae). Am J Bot 98:1-11
25. Jensen WA (1962) Botanical histochemistry. Freeman, San Francisco
26. Martin PS, Drew CM (1969) Scanning electron photomicrographs of southwestern pollen grains. J Ariz-Nev Acad Sci 5:147-176
27. Martin PS, Drew CM (1970) Additional scanning electron micrographs of southwestern pollen grains. J Ariz-Nev Acad Sci 6:140-161
28. Pathan AK, Bond J, Gaskin RE (2008) Sample preparation for scanning electron microscopy of plant surfaces - horses for courses. Micron 39:1049-1061
29. Solomon AM, King JE, Martin PS, Thomas J (1973) Further scanning electron photomicrographs of southwestern pollen grains. J Ariz-Nev Acad Sci 8:135-157
30. Zafar M, Khan MA, Ahmad M, Sultana S, Qureshi R, Tareen RB (2010) Authentication of misidentified crude herbal drugs marketed in Pakistan. Journal of Medicinal Plants Research 4:1584-1593 Available online at http://www.academicjournals.org/JMPR ISSN 1996-0875
31. Uchiyama N, Kawamura M, Kikura-Hanajiri R, Goda Y (2011) Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylindoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products. Forensic Toxicol 29:25-37
32. Department for Antidrug Policies (DPA) National early warning system (N.E.W.S.). www.allertadroga.it/sapd/login/. Accessed 20 Dec 2012
33. Scientific Working Group for the Analysis of Seized Drugs. http://www.swgdrug.org/ms.htm. Accessed 20 Dec 2012
34. Walker MD, Ahmad SJ (1970) The Mitragyna species of Asia. XVII. The anatomy of the leaves of Mitragyna javanica var. microphylla. Planta Medica 18:55-65
35. Razafimandimbison SG, Bremer B (2002) Phylogeny and classification of Naucleeae s.l. (Rubiaceae) inferred from molecular (ITS, rbcL, and trnT-F) and morphological data. Am J Bot 89:1027-1041
36. Kennedy PD, Collin W (2010) Automated ion trap screening method for the detection of synthetic cannabinoids in commercial herbal incense products. Synthetic cannabinoid screening. https://www.caymanchem.com/app/screen/Static/ restrict/public/path/sampleApplications, CaymanChemicalSyntheticCannabinoidScreening.pdf/filename/ CaymanChemicalSyntheticCannabinoidScreening.pdf. Accessed 22 June 2012
37. Decreto del Presidente della Repubblica 9 ottobre 1990, n. 309 GU n. 62 del 15-3-2006 - Suppl Ordinario n.62
38. United Nations Office on Drugs and Crime (UNODC) (2009) Recommended methods for the identification and analysis of cannabis and cannabis products. United Nations New York. http://www.unodc.org/documents/scientific/ST-NAR-40- Ebook.pdf. Accessed 26 Jan 2012
39. Uchiyama N, Kikura-Hanajiri R, Kawahara N, Goda Y (2009) Identification of a cannabimimetic indole as a designer drug in a herbal product. Forensic Toxicol 27:61-66
40. Dargan PI, Hudson S, Ramsey J, Wood DM (2011) The impact of changes in UK classification of the synthetic cannabinoid receptor agonists in 'Spice'. Int J Drug Policy 22:274-277
41. Gottardo R, Chiarini A, Dal Prà I, Seri C, Rimondo C, Serpelloni G, Armato U, Tagliaro F (2012) Direct screening of herbal blends for new synthetic cannabinoids by MALDI-TOF MS. J Mass Spectrom 47:141-146
42. Uchiyama N, Kikura-Hanajiri R, Ogata J, Goda Y (2010) Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Sci Int 198:31-38
43. Kumar S, Taneja R, Sharma A (2005) The genus Turnera: a review update. Pharm Biol 43:383-391
44. Ministero della Salute. D.L. 16/6/2010 http://www.politicheantidroga.it/ media/336190/d.m.-16-giugno-2010.pdf. Accessed 20 Jun 2011
45. Ministero della Salute. D.L. 11/5/2011 http://www.politicheantidroga.it/ media/446920/d.m%2011%20maggio%2011.pdf. Accessed 8 Jul 2011
46. Schultes RE, Hofmann A, Rätsch C (2001) Plants of the gods. Healing Arts Press, Rochester, Vermont
47. De Mattia F, Bruni I, Galimberti A, Cattaneo F, Casiraghi M, Labra M (2011) A comparative study of different DNA barcoding markers for the identification of some members of Lamiaceae. Food Rev Int 44:693-702
48. De Mattia F, Gentili R, Bruni I, Galimberti A, Sgorbati S, Casiraghi M, Labra M (2012) A multi-marker DNA barcoding approach to save time and resources in vegetation surveys. Bot J Linn Soc 169:518-529
49. Serrano R, da Silva G, Silva O (2010) Application of light and scanning electron microscopy in the identification of herbal medicines. In Méndez-Vilas A, Díaz J (eds) Microscopy: science, technology, applications and education. ©FORMATEX 2010, Badajoz, Spain, pp.182-190