메뉴 건너뛰기




Volumn 47, Issue 1, 2012, Pages 141-146

Direct screening of herbal blends for new synthetic cannabinoids by MALDI-TOF MS

Author keywords

herbal blend; MALDI TOF; synthetic cannabinoids

Indexed keywords

ACCELERATING VOLTAGES; CANNABINOIDS; DIRECT ANALYSIS; FLIGHT MASS SPECTROMETRY; HERBAL BLEND; HIGH THROUGHPUT; LASER SHOTS; MALDI TOF MS; MALDI-TOF; MASS SPECTRA; MATRIX; MATRIX ASSISTED LASER DESORPTION; PHARMACOLOGICAL ACTIVITY; PRODUCT MONITORING; QUANTITATIVE METHOD; REFERENCE TECHNIQUE; SAMPLE PREPARATION; SYNTHETIC COMPOUNDS;

EID: 84856347201     PISSN: 10765174     EISSN: 10969888     Source Type: Journal    
DOI: 10.1002/jms.2036     Document Type: Review
Times cited : (41)

References (47)
  • 3
    • 79952816579 scopus 로고    scopus 로고
    • European Monitoring Centre for Drugs and Drug Addiction (EMCDDA) Available at
    • European Monitoring Centre for Drugs and Drug Addiction (EMCDDA). Thematic Papers, 2009. Understanding the "Spice" phenomenon. Available at
    • (2009) Thematic Papers, Understanding the "spice" Phenomenon
  • 4
    • 77953912640 scopus 로고    scopus 로고
    • Cannabimimetic Indoles, Pyrroles, and Indenes: Structure-Activity Relathionships and Receptor Interactions
    • P. H. Reggio (Ed.). Humana Press, University of North Carolina at Greensboro, Greensboro, NC, USA. The Receptors.
    • J. W. Huffman,. Cannabimimetic Indoles, Pyrroles, and Indenes: Structure-Activity Relathionships and Receptor Interactions. The Cannabinoid Receptors, P. H. Reggio, (Ed.). Humana Press, University of North Carolina at Greensboro, Greensboro, NC, USA. The Receptors, 2009, 49.
    • (2009) The Cannabinoid Receptors , pp. 49
    • Huffman, J.W.1
  • 5
    • 79955928510 scopus 로고    scopus 로고
    • CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists
    • B. K. Atwood, D. Lee, A. Straiker, T. S. Widlanski, K. Mackie,. CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. Eur. J. Pharmacol. 2011, 659, 139.
    • (2011) Eur. J. Pharmacol. , vol.659 , pp. 139
    • Atwood, B.K.1    Lee, D.2    Straiker, A.3    Widlanski, T.S.4    MacKie, K.5
  • 6
    • 77952664328 scopus 로고    scopus 로고
    • JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist
    • B. K. Atwood, J. Huffman, A. Straiker, K. Mackie,. JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. Br. J. Pharmacol. 2010, 160, 585.
    • (2010) Br. J. Pharmacol. , vol.160 , pp. 585
    • Atwood, B.K.1    Huffman, J.2    Straiker, A.3    MacKie, K.4
  • 7
    • 77954954841 scopus 로고    scopus 로고
    • Spice drugs as a new trend: Mode of action, identification and legislation
    • I. Vardakou, C. Pistos, C. Spiliopoulou,. Spice drugs as a new trend: Mode of action, identification and legislation. Toxicol. Lett. 2010, 197, 157.
    • (2010) Toxicol. Lett. , vol.197 , pp. 157
    • Vardakou, I.1    Pistos, C.2    Spiliopoulou, C.3
  • 10
    • 79251632165 scopus 로고    scopus 로고
    • Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylindoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products
    • N. Uchiyama, M. Kawamura, R. Kikura-Hanajiri, Y. Goda,. Identification and quantitation of two cannabimimetic phenylacetylindoles JWH-251 and JWH-250, and four cannabimimetic naphthoylindoles JWH-081, JWH-015, JWH-200, and JWH-073 as designer drugs in illegal products. Forensic Toxicol. 2011, 29, 25.
    • (2011) Forensic Toxicol. , vol.29 , pp. 25
    • Uchiyama, N.1    Kawamura, M.2    Kikura-Hanajiri, R.3    Goda, Y.4
  • 12
    • 77956782377 scopus 로고    scopus 로고
    • Warning: Legal synthetic cannabinoid-receptor agonists such as jwh-018 may precipitate psychosis in vulnerable individuals
    • S. Every-Palmer,. Warning: legal synthetic cannabinoid-receptor agonists such as jwh-018 may precipitate psychosis in vulnerable individuals. Addiction 2011, 105, 1859.
    • (2011) Addiction , vol.105 , pp. 1859
    • Every-Palmer, S.1
  • 13
    • 77951979345 scopus 로고    scopus 로고
    • The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes
    • H. Müller, W. Sperling, M. Khrmann, H. B. Huttner, J. Kornhuber, J. M. Maler,. The synthetic cannabinoid Spice as a trigger for an acute exacerbation of cannabis induced recurrent psychotic episodes. Schizophr. Res. 2010, 118, 309.
    • (2010) Schizophr. Res. , vol.118 , pp. 309
    • Müller, H.1    Sperling, W.2    Khrmann, M.3    Huttner, H.B.4    Kornhuber, J.5    Maler, J.M.6
  • 14
    • 79960313022 scopus 로고    scopus 로고
    • Synthetic cannabinoid JWH-018 and psychosis: An explorative study
    • S. Every-Palmer,. Synthetic cannabinoid JWH-018 and psychosis: An explorative study. Drug Alcohol Depend. 2011, 117, 152.
    • (2011) Drug Alcohol Depend. , vol.117 , pp. 152
    • Every-Palmer, S.1
  • 15
    • 80052884588 scopus 로고    scopus 로고
    • Psychiatric sequelae of spice, K2, and synthetic cannabinoid receptor agonists
    • D. M. Benford, J. P. Caplan,. Psychiatric sequelae of spice, K2, and synthetic cannabinoid receptor agonists. Psychosomatics 2011, 52, 295.
    • (2011) Psychosomatics , vol.52 , pp. 295
    • Benford, D.M.1    Caplan, J.P.2
  • 17
    • 84856495935 scopus 로고    scopus 로고
    • Effects of synthetic cannabinoids on electroencephalogram power spectra in rats
    • DOI: 10.1016/j.forsciint.2011.05.005.
    • N. Uchiyama, R. Kikura-Hanajiri, N. Matsumoto, Z. L. Huang, Y. Goda, Y. Urade,. Effects of synthetic cannabinoids on electroencephalogram power spectra in rats. Forensic Sci. Int. 2011, DOI: 10.1016/j.forsciint.2011.05.005.
    • (2011) Forensic Sci. Int.
    • Uchiyama, N.1    Kikura-Hanajiri, R.2    Matsumoto, N.3    Huang, Z.L.4    Goda, Y.5    Urade, Y.6
  • 18
    • 84860422185 scopus 로고    scopus 로고
    • Gas and liquid chromatography-mass spectrometry studies on the metabolism of the synthetic phenylacetylindole cannabimimetic JWH-250, the psychoactive component of smoking mixtures
    • DOI: 10.1016/j.jchromb.2011.07.004.
    • A. Grigoryeva, A. Melnik, S. Savchuk, A. Simonov, V. Rozhanets,. Gas and liquid chromatography-mass spectrometry studies on the metabolism of the synthetic phenylacetylindole cannabimimetic JWH-250, the psychoactive component of smoking mixtures. J. Chrom. B, DOI: 10.1016/j.jchromb.2011.07.004.
    • J. Chrom. B
    • Grigoryeva, A.1    Melnik, A.2    Savchuk, S.3    Simonov, A.4    Rozhanets, V.5
  • 19
    • 79960562678 scopus 로고    scopus 로고
    • Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing
    • S. Beuck, I. Möller, A. Thomas, A. Klose, N. Schlörer, W. Schänzer, M. Thevis,. Structure characterisation of urinary metabolites of the cannabimimetic JWH-018 using chemically synthesised reference material for the support of LC-MS/MS-based drug testing. Anal. Bioanal. Chem. 2011, 401, 493.
    • (2011) Anal. Bioanal. Chem. , vol.401 , pp. 493
    • Beuck, S.1    Möller, I.2    Thomas, A.3    Klose, A.4    Schlörer, N.5    Schänzer, W.6    Thevis, M.7
  • 20
    • 80053166693 scopus 로고    scopus 로고
    • Conjugation of Synthetic Cannabinoids, JWH-018 [Naphthalen-1-yl-(1- pentylindol-3-yl)methanone] and JWH-073 [naphthalen-1-yl-(1-butylindol-3-yl) methanone], Metabolites by Human UDP-glucuronosyltransferases
    • DOI: 10.1124/dmd.111.040709.
    • K. C. Chimalakonda, S. M. Bratton, V. H. Le, K. H. Yiew, A. Dineva, C. L. Moran, L. P. James, J. H. Moran, A. Radominska-Pandya,. Conjugation of Synthetic Cannabinoids, JWH-018 [Naphthalen-1-yl-(1-pentylindol-3-yl)methanone] and JWH-073 [naphthalen-1-yl-(1-butylindol-3-yl)methanone], Metabolites by Human UDP-glucuronosyltransferases. Drug Metab. Dispos. 2011, DOI: 10.1124/dmd.111.040709.
    • (2011) Drug Metab. Dispos.
    • Chimalakonda, K.C.1    Bratton, S.M.2    Le, V.H.3    Yiew, K.H.4    Dineva, A.5    Moran, C.L.6    James, L.P.7    Moran, J.H.8    Radominska-Pandya, A.9
  • 22
    • 79960003774 scopus 로고    scopus 로고
    • Phase i Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain in Vitro and in Vivo Cannabinoid 1 Receptor Affinity and Activity
    • L. K. Brents, E. E. Reichard, S. M. Zimmerman, J. H. Moran, W. E. Fantegrossi, P. L. Prather,. Phase I Hydroxylated Metabolites of the K2 Synthetic Cannabinoid JWH-018 Retain In Vitro and In Vivo Cannabinoid 1 Receptor Affinity and Activity. PLoS One 2011, 6, e21917.
    • (2011) PLoS One , vol.6
    • Brents, L.K.1    Reichard, E.E.2    Zimmerman, S.M.3    Moran, J.H.4    Fantegrossi, W.E.5    Prather, P.L.6
  • 24
    • 79952814790 scopus 로고    scopus 로고
    • " Spice" girls: Synthetic cannabinoid intoxication
    • A. B. Schneir, J. Cullen, B. T. Ly,. " Spice" girls: synthetic cannabinoid intoxication. J. Emerg. Med. 2011, 40, 296.
    • (2011) J. Emerg. Med. , vol.40 , pp. 296
    • Schneir, A.B.1    Cullen, J.2    Ly, B.T.3
  • 27
    • 79955468228 scopus 로고    scopus 로고
    • Identification and characterization of JWH-122 used as new ingredient in " Spice-like" herbal incenses
    • L. Ernst, H. M. Schiebel, C. Theuring, R. Lindigkeit, T. Beuerle,. Identification and characterization of JWH-122 used as new ingredient in " Spice-like" herbal incenses. Forensic Sci. Int. 2011, 208, e31.
    • (2011) Forensic Sci. Int. , vol.208
    • Ernst, L.1    Schiebel, H.M.2    Theuring, C.3    Lindigkeit, R.4    Beuerle, T.5
  • 28
    • 79960310498 scopus 로고    scopus 로고
    • Analytical Data for Identification of the Cannabimimetic Phenylacetylindole JWH-203
    • M. Bononi, P. Belgi, F. Tateo,. Analytical Data for Identification of the Cannabimimetic Phenylacetylindole JWH-203. J. Anal. Toxicol. 2011, 35, 360.
    • (2011) J. Anal. Toxicol. , vol.35 , pp. 360
    • Bononi, M.1    Belgi, P.2    Tateo, F.3
  • 29
    • 84855201186 scopus 로고    scopus 로고
    • Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary
    • DOI: 10.1016/j.forsciint.2011.07.011.
    • P. Jankovics, A. Váradi, L. Tölgyesi, S. Lohner, J. Németh-Palotás, J. Balla,. Detection and identification of the new potential synthetic cannabinoids 1-pentyl-3-(2-iodobenzoyl)indole and 1-pentyl-3-(1-adamantoyl)indole in seized bulk powders in Hungary. Forensic Sci. Int., DOI: 10.1016/j.forsciint.2011.07.011.
    • Forensic Sci. Int.
    • Jankovics, P.1    Váradi, A.2    Tölgyesi, L.3    Lohner, S.4    Németh-Palotás, J.5    Balla, J.6
  • 30
    • 79960618509 scopus 로고    scopus 로고
    • Identification and quantitation of two benzoylindoles AM-694 and (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone, and three cannabimimetic naphthoylindoles JWH-210, JWH-122, and JWH-019 as adulterants in illegal products obtained via the Internet
    • J. Nakajima, M. Takahashi, T. Seto, C. Kanai, J. Suzuki, T. Hamano,. Identification and quantitation of two benzoylindoles AM-694 and (4-methoxyphenyl)(1-pentyl-1H-indol-3-yl)methanone, and three cannabimimetic naphthoylindoles JWH-210, JWH-122, and JWH-019 as adulterants in illegal products obtained via the Internet. Forensic Toxicol 2011, 29, 95.
    • (2011) Forensic Toxicol , vol.29 , pp. 95
    • Nakajima, J.1    Takahashi, M.2    Seto, T.3    Kanai, C.4    Suzuki, J.5    Hamano, T.6
  • 32
    • 80051687424 scopus 로고    scopus 로고
    • Detection of synthetic cannabinoids in herbal incense products
    • DOI: 10.1016/j.clinbiochem.2011.06.078.
    • H. J. Penn, L. J. Langman, D. Unold, J. Shields, J. H. Nichols,. Detection of synthetic cannabinoids in herbal incense products. Clin. Biochem. 2011, DOI: 10.1016/j.clinbiochem.2011.06.078.
    • (2011) Clin. Biochem.
    • Penn, H.J.1    Langman, L.J.2    Unold, D.3    Shields, J.4    Nichols, J.H.5
  • 33
    • 84856358393 scopus 로고    scopus 로고
    • Identification of 1-butyl-3-(1-(4-methyl)naphthoyl)indole in a herbal mixture
    • DOI: 10.1016/j.forsciint.2011.03.031.
    • F. Westphal, F. D. Sönnichsen, S. Thiemt,. Identification of 1-butyl-3-(1-(4-methyl)naphthoyl)indole in a herbal mixture. Forensic Sci. Int. 2011, DOI: 10.1016/j.forsciint.2011.03.031.
    • (2011) Forensic Sci. Int.
    • Westphal, F.1    Sönnichsen, F.D.2    Thiemt, S.3
  • 34
    • 79960614744 scopus 로고    scopus 로고
    • The emergence and analysis of synthetic cannabinoids
    • S. Hudson, J. Ramsey,. The emergence and analysis of synthetic cannabinoids. Drug Test. Anal. 2011, 3, 466.
    • (2011) Drug Test. Anal. , vol.3 , pp. 466
    • Hudson, S.1    Ramsey, J.2
  • 35
    • 77955897603 scopus 로고    scopus 로고
    • Use of High-Resolution Accurate Mass Spectrometry to Detect Reported and Previously Unreported Cannabinomimetics in "herbal High" Products
    • S. Hudson, J. Ramsey, L. King, S. Timbers, S. Maynard, P. I. Dargan, D. M. Wood,. Use of High-Resolution Accurate Mass Spectrometry to Detect Reported and Previously Unreported Cannabinomimetics in "Herbal High" Products. J. Anal. Toxicol. 2010, 34, 252.
    • (2010) J. Anal. Toxicol. , vol.34 , pp. 252
    • Hudson, S.1    Ramsey, J.2    King, L.3    Timbers, S.4    Maynard, S.5    Dargan, P.I.6    Wood, D.M.7
  • 36
    • 78650752280 scopus 로고    scopus 로고
    • Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds
    • S. Dresen, N. Ferreiros, M. Putz, F. Westphal, R. Zimmermann, V. Auwarter,. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J. Mass Spectrom. 2010, 45, 1186.
    • (2010) J. Mass Spectrom. , vol.45 , pp. 1186
    • Dresen, S.1    Ferreiros, N.2    Putz, M.3    Westphal, F.4    Zimmermann, R.5    Auwarter, V.6
  • 37
    • 77952291222 scopus 로고    scopus 로고
    • Chemical analysis of synthetic cannabinoids as designer drugs in herbal products
    • N. Uchiyama, R. Kikura-Hanajiri, J. Ogata, Y. Goda,. Chemical analysis of synthetic cannabinoids as designer drugs in herbal products. Forensic Sci. Int. 2010, 198, 31.
    • (2010) Forensic Sci. Int. , vol.198 , pp. 31
    • Uchiyama, N.1    Kikura-Hanajiri, R.2    Ogata, J.3    Goda, Y.4
  • 38
    • 79251633132 scopus 로고    scopus 로고
    • Identification and quantitation of cannabimimetic compound JWH-250 as an adulterant in products obtained via the Internet
    • J. Nakajima, M. Takahashi, T. Seto, J. Suzuki,. Identification and quantitation of cannabimimetic compound JWH-250 as an adulterant in products obtained via the Internet. Forensic Toxicol. 2011, 29, 51.
    • (2011) Forensic Toxicol. , vol.29 , pp. 51
    • Nakajima, J.1    Takahashi, M.2    Seto, T.3    Suzuki, J.4
  • 39
    • 24344450298 scopus 로고    scopus 로고
    • Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry
    • A.-K. Su, J.-T. Liu, C.-H. Lin,. Rapid drug-screening of clandestine tablets by MALDI-TOF mass spectrometry. Talanta 2005, 67, 718.
    • (2005) Talanta , vol.67 , pp. 718
    • Su, A.-K.1    Liu, J.-T.2    Lin, C.-H.3
  • 40
    • 0036041749 scopus 로고    scopus 로고
    • Small molecule analysis by MALDI mass spectrometry
    • L. H. Cohen, I. G. Arkady,. Small molecule analysis by MALDI mass spectrometry. Anal. Bioanal. Chem. 2002, 373, 571.
    • (2002) Anal. Bioanal. Chem. , vol.373 , pp. 571
    • Cohen, L.H.1    Arkady, I.G.2
  • 41
    • 33947275727 scopus 로고    scopus 로고
    • Surfactant-mediated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules
    • D. C. Grant, R. J. Helleur,. Surfactant-mediated matrix-assisted laser desorption/ionization time-of-flight mass spectrometry of small molecules. Rapid Commun. Mass Spectrom. 2007, 21, 837.
    • (2007) Rapid Commun. Mass Spectrom. , vol.21 , pp. 837
    • Grant, D.C.1    Helleur, R.J.2
  • 42
    • 0036535168 scopus 로고    scopus 로고
    • A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry
    • Z. Guo, Q. Zhang, H. Zou, B. Guo, J. Ni,. A method for the analysis of low-mass molecules by MALDI-TOF mass spectrometry. Anal. Chem. 2002, 74, 1637.
    • (2002) Anal. Chem. , vol.74 , pp. 1637
    • Guo, Z.1    Zhang, Q.2    Zou, H.3    Guo, B.4    Ni, J.5
  • 43
    • 56349116855 scopus 로고    scopus 로고
    • Suppression of matrix related ion using cyclodextrin in MALDI mass spectrometry
    • S. Yamaguchi, T. Fujita, T. Fujino, T. Korenaga,. Suppression of matrix related ion using cyclodextrin in MALDI mass spectrometry. Anal. Sci. 2008, 24, 1497.
    • (2008) Anal. Sci. , vol.24 , pp. 1497
    • Yamaguchi, S.1    Fujita, T.2    Fujino, T.3    Korenaga, T.4
  • 44
    • 0032762429 scopus 로고    scopus 로고
    • Use of meso-tetrakis(pentafluorophenyl)porphyrin as a matrix for low molecular weight alkylphenol ethoxylates in laser desorption/ionization time-of-flight mass spectrometry
    • F. O. Ayorinde, P. Hambright, T. N. Porter, Q. L. Keith,. Use of meso-tetrakis(pentafluorophenyl)porphyrin as a matrix for low molecular weight alkylphenol ethoxylates in laser desorption/ionization time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 1999, 13, 2474.
    • (1999) Rapid Commun. Mass Spectrom. , vol.13 , pp. 2474
    • Ayorinde, F.O.1    Hambright, P.2    Porter, T.N.3    Keith, Q.L.4
  • 45
    • 33746803188 scopus 로고    scopus 로고
    • Qualitative and quantitative analysis of pharmaceutical compounds by MALDI-TOF mass spectrometry
    • J. A. J. Van Kampen, P. C. Burgers, R. de Groot, T. M. Luider,. Qualitative and quantitative analysis of pharmaceutical compounds by MALDI-TOF mass spectrometry. Anal. Chem. 2006, 78, 5403.
    • (2006) Anal. Chem. , vol.78 , pp. 5403
    • Van Kampen, J.A.J.1    Burgers, P.C.2    De Groot, R.3    Luider, T.M.4
  • 46
    • 33846015488 scopus 로고    scopus 로고
    • Matrix-free methods for laser desorption/ionization mass spectrometry
    • D. S. Peterson,. Matrix-free methods for laser desorption/ionization mass spectrometry. Mass Spectrom. Rev. 2007, 26, 19.
    • (2007) Mass Spectrom. Rev. , vol.26 , pp. 19
    • Peterson, D.S.1
  • 47
    • 0000907544 scopus 로고    scopus 로고
    • Maldi-TOF mass spectrometry of synthetic polymers
    • M. W. F. Nielen,. Maldi-TOF mass spectrometry of synthetic polymers. Mass Spectrom. Rev. 1999, 18, 309.
    • (1999) Mass Spectrom. Rev. , vol.18 , pp. 309
    • Nielen, M.W.F.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.