Epidemiology, symptoms, and treatment characteristics of hyponatremic psychiatric inpatients

Journal of Clinical Psychopharmacology

Volumn 33, Issue 6, 2013, Pages 799-805

  Lange Asschenfeldt, Christian ^a   Kojda, Georg ^b   Cordes, Joachim ^a   Hellen, Florence ^a   Gillmann, Andreas ^a   Grohmann, Renate ^c   Supprian, Tillmann ^a  

^a Departments of Psychiatry and Psychotherapy   (Germany)

^b Department of Orthopedic Surgery   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

hyponatremia; prevalence; psychiatric inpatients,drug treatment; SIADH

Indexed keywords

AMITRIPTYLINE; CARBAMAZEPINE; CLOMIPRAMINE; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DOXEPIN; MAPROTILINE; NORTRIPTYLINE; OXCARBAZEPINE; SEROTONIN UPTAKE INHIBITOR; SODIUM; THIAZIDE DIURETIC AGENT; TRAZODONE; TRIMIPRAMINE; VENLAFAXINE;

ADULT; AGED; ARTICLE; CONFUSION; DEMENTIA; DISEASE SEVERITY; DRUG EXPOSURE; DRUG SAFETY; DYSPEPSIA; FEMALE; FLUID INTAKE; FOLLOW UP; GAIT DISORDER; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; MAJOR CLINICAL STUDY; MALE; MENTAL PATIENT; MOOD DISORDER; POLYDIPSIA; POLYPHARMACY; POPULATION SIZE; PRESCRIPTION; PREVALENCE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; RISK FACTOR; SCHIZOPHRENIA; SEDATION; SERUM OSMOLARITY; SEX DIFFERENCE; SODIUM BLOOD LEVEL; SYMPTOM; TREATMENT DURATION; URINE OSMOLALITY; WEIGHT GAIN;

ADULT; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS; ANTIPSYCHOTIC AGENTS; FEMALE; HOSPITALS, UNIVERSITY; HUMANS; HYPONATREMIA; INAPPROPRIATE ADH SYNDROME; INPATIENTS; MALE; MENTAL DISORDERS; MIDDLE AGED; RETROSPECTIVE STUDIES; RISK FACTORS; SEVERITY OF ILLNESS INDEX; YOUNG ADULT;

EID: 84888132519     PISSN: 02710749     EISSN: 1533712X     Source Type: Journal    
DOI: 10.1097/JCP.0b013e3182a4736f     Document Type: Article

References (54)

1. Adrogue HJ, Madias NE. Hyponatremia. N Engl J Med. 2000;342:1581-1589.
2. Siegel AJ. Hyponatremia in psychiatric patients: update on evaluation and management. Harv Rev Psychiatry. 2008;16:13-24.
3. Boscoe A, Paramore C, Verbalis JG. Cost of illness of hyponatremia in the United States. Cost Eff Resour Alloc. 2006;4:10.
4. Peri A, Pirozzi N, Parenti G, et al. Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). J Endocrinol Invest. 2010;33:671-682.
5. Gross P, Reimann D, Henschkowski J, et al. Treatment of severe hyponatremia: conventional and novel aspects. J Am Soc Nephrol. 2001;12(suppl 17):S10-S14.
6. Reeves WB, Buchet DG, Andreoli TE. Posterior pituitary and water metabolism. In: Wilson J, Foster D, eds. Williams Textbook of Endocrinology. 341-387. 1998. Philadelphia, PA: WB Saunders; 1998:341-387.
7. Liamis G, Milionis H, Elisaf M. A review of drug-induced hyponatremia. Am J Kidney Dis. 2008;52:144-153.
8. Kumar S, Berl T. Sodium. Lancet. 1998;352:220-228.
9. Ellison DH, Berl T. Clinical practice. The syndrome of inappropriate antidiuresis. N Engl J Med. 2007;356:2064-2072.
10. Douglas I. Hyponatremia: why it matters, how it presents, how we can manage it. Cleve Clin J Med. 2006;73(suppl 3):S4-S12.
11. Liu BA, Mittmann N, Knowles SR, et al. Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: a review of spontaneous reports. CMAJ. 1996;155:519-527.
12. Movig KL, Leufkens HG, Lenderink AW, et al. Association between antidepressant drug use and hyponatraemia: a case-control study. Br J Clin Pharmacol. 2002;53:363-369.
13. Roxanas M, Hibbert E, Field M. Venlafaxine hyponatraemia: incidence, mechanism and management. Aust N Z J Psychiatry. 2007;41:411-418.
14. Cosgray RE, Hanna V, Davidhizar RE, et al. The water-intoxicated patient. Arch Psychiatr Nurs. 1990;4:308-312.
15. Miller WR. Psychogenic factors in the polyuria of schizophrenia. J Nerv Ment Dis. 1936;84:418-421.
16. Asadollahi K, Beeching N, Gill G. Hyponatraemia as a risk factor for hospital mortality. QJM. 2006;99:877-880.
17. de Leon J. PolydipsiaVa study in a long-term psychiatric unit. Eur Arch Psychiatry Clin Neurosci. 2003;253:37-39.
18. Kirby D, Harrigan S, Ames D. Hyponatraemia in elderly psychiatric patients treated with selective serotonin reuptake inhibitors and venlafaxine: a retrospective controlled study in an inpatient unit. Int J Geriatr Psychiatry. 2002;17:231-237.
19. Movig KL, Leufkens HG, Lenderink AW, et al. Serotonergic antidepressants associated with an increased risk for hyponatraemia in the elderly. Eur J Clin Pharmacol. 2002;58:143-148.
20. Bhagat CI, Garcia-Webb P, Fletcher E, et al. Calculated vs measured plasma osmolalities revisited. Clin Chem. 1984;30:1703-1705.
21. Lange-Asschenfeldt C, Grohmann R, Lange-Asschenfeldt B, et al. Cutaneous adverse reactions to psychotropic drugs: data from a multicenter surveillance program. J Clin Psychiatry. 2009;70: 1258-1265.
22. Grohmann R, Engel RR, Ruther E, et al. The AMSP drug safety program: methods and global results. Pharmacopsychiatry. 2004;37(suppl 1):S4-S11.
23. Letmaier M, Painold A, Holl AK, et al. Hyponatraemia during psychopharmacological treatment: results of a drug surveillance programme. Int J Neuropsychopharmacol. 2012;15:739-748.
24. Upadhyay A, Jaber BL, Madias NE. Incidence and prevalence of hyponatremia. Am J Med. 2006;119:S30-S35.
25. Mannesse CK, Vondeling AM, van Marum RJ, et al. Prevalence of hyponatremia on geriatric wards compared to other settings over four decades: a systematic review. Ageing Res Rev. 2012;12:165-173.
26. Turnheim K. When drug therapy gets old: pharmacokinetics and pharmacodynamics in the elderly. Exp Gerontol. 2003;38:843-853.
27. Anpalahan M. Chronic idiopathic hyponatremia in older people due to syndrome of inappropriate antidiuretic hormone secretion (SIADH) possibly related to aging. J Am Geriatr Soc. 2001;49:788-792.
28. Juul KV, Klein BM, Sandstrom R, et al. Gender difference in antidiuretic response to desmopressin. Am J Physiol Renal Physiol. 2011;300:F1116-F1122.
29. Grikiniene J, Volbekas V, Stakisaitis D. Gender differences of sodium metabolism and hyponatremia as an adverse drug effect. Medicina (Kaunas). 2004;40:935-942.
30. Josiassen RC, Filmyer DM, Geboy AG, et al. Impact of hyponatremia on resource utilization in state psychiatric hospitals: a retrospective analysis. J Clin Psychopharmacol. 2012;32:580-582.
31. Bun S, Serby MJ, Friedmann P. Psychotropic medication use, hyponatremia, and falls in an inpatient population: a retrospective study. J Clin Psychopharmacol. 2011;31:395-397.
32. Renneboog B, Musch W, Vandemergel X, et al. Mild chronic hyponatremia is associated with falls, unsteadiness, and attention deficits. Am J Med. 2006;119:71-78.
33. Tolouian R, Alhamad T, Farazmand M, et al. The correlation of hip fracture and hyponatremia in the elderly. J Nephrol. 2012;25:789-793.
34. Decaux G. Is asymptomatic hyponatremia really asymptomatic? Am J Med. 2006;119:S79-S82.
35. Waikar SS, Mount DB, Curhan GC. Mortality after hospitalization with mild, moderate, and severe hyponatremia. Am J Med. 2009;122:857-865.
36. Sajadieh A, Binici Z, Mouridsen MR, et al. Mild hyponatremia carries a poor prognosis in community subjects. Am J Med. 2009;122:679-686.
37. Verbalis JG, Barsony J, Sugimura Y, et al. Hyponatremia-induced osteoporosis. J Bone Miner Res. 2010;25:554-563.
38. Meinders AE, Cejka V, Robertson GL. The antidiuretic action of carbamazepine in man. Clin Sci Mol Med. 1974;47:289-299.
39. Gold PW, Robertson GL, Ballenger JC, et al. Carbamazepine diminishes the sensitivity of the plasma arginine vasopressin response to osmotic stimulation. J Clin Endocrinol Metab. 1983;57:952-957.
40. Van Amelsvoort T, Bakshi R, Devaux CB, et al. Hyponatremia associated with carbamazepine and oxcarbazepine therapy: a review. Epilepsia. 1994;35:181-188.
41. Kuz GM, Manssourian A. Carbamazepine-induced hyponatremia: assessment of risk factors. Ann Pharmacother. 2005;39:1943-1946.
42. Lin CH, Lu CH, Wang FJ, et al. Risk factors of oxcarbazepine-induced hyponatremia in patients with epilepsy. Clin Neuropharmacol. 2010;33:293-296.
43. Dong X, Leppik IE, White J, et al. Hyponatremia from oxcarbazepine and carbamazepine. Neurology. 2005;65:1976-1978.
44. Kis GK, Ocsko T, Galfi M, et al. The effects of orexins on monoaminergic-induced changes in vasopressin level in rat neurohypophyseal cell cultures. Neuropeptides. 2011;45:385-389.
45. Abbott R. Hyponatremia due to antidepressant medications. Ann Emerg Med. 1983;12:708-710.
46. Madhusoodanan S, Bogunovic OJ, Moise D, et al. Hyponatraemia associated with psychotropic medications. A review of the literature and spontaneous reports. Adverse Drug React Toxicol Rev. 2002;21:17-29.
47. Vanpee D, Laloyaux P, Gillet JB. Seizure and hyponatraemia after overdose of trazadone. Am J Emerg Med. 1999;17:430-431.
48. Balestrieri G, Cerudelli B, Ciaccio S, et al. Hyponatraemia and seizure due to overdose of trazodone. BMJ. 1992;304:686.
49. Baughan E, Jawad SS. Effect of overdose of trazodone. BMJ. 1992;304:1114.
50. Meulendijks D, Mannesse CK, Jansen PA, et al. Antipsychotic-induced hyponatraemia: a systematic review of the published evidence. Drug Saf. 2010;33:101-114.
51. Bersani G, Pesaresi L, Orlandi V, et al. Atypical antipsychotics and polydipsia: a cause or a treatment? Hum Psychopharmacol. 2007;22:103-107.
52. Spears NM, Leadbetter RA, Shutty MS Jr. Clozapine treatment in polydipsia and intermittent hyponatremia. J Clin Psychiatry. 1996;57:123-128.
53. Leadbetter RA, Shutty MS Jr. Differential effects of neuroleptic and clozapine on polydipsia and intermittent hyponatremia. J Clin Psychiatry. 1994;55(suppl b):110-113.
54. Jessani M, Montgomery J, Fedde JD, et al. Lack of association between antipsychotics and hyponatremia in chronic schizophrenia. Schizophr Res. 2006;83:307-309.