Venlafaxine hyponatraemia: Incidence, mechanism and management

Australian and New Zealand Journal of Psychiatry

Volumn 41, Issue 5, 2007, Pages 411-418

  Roxanas, Milton ^a   Hibbert, Emily ^a   Field, Michael ^b  

^a Department of Microbiology and Infectious Diseases   (Australia)

^b UNIVERSITY OF SYDNEY   (Australia)

Author keywords

Hyponatraemia; Venlafaxine

Indexed keywords

ELECTROLYTE; SODIUM; VASOPRESSIN; VENLAFAXINE;

AGED; ARTICLE; CLINICAL OBSERVATION; CLINICAL TRIAL; COMORBIDITY; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DEPRESSION; DIET RESTRICTION; DRUG DOSE TITRATION; ELDERLY CARE; ELECTROLYTE BLOOD LEVEL; FEMALE; FLUID INTAKE; FOLLOW UP; HIGH RISK PATIENT; HORMONE BLOOD LEVEL; HORMONE INHIBITION; HUMAN; HYPONATREMIA; INAPPROPRIATE VASOPRESSIN SECRETION; MAJOR CLINICAL STUDY; MALE; PATHOPHYSIOLOGY; PATIENT MONITORING; PROSPECTIVE STUDY; SERUM OSMOLALITY; SODIUM BLOOD LEVEL; SODIUM URINE LEVEL; URINE OSMOLALITY;

AGE FACTORS; AGED; AGED, 80 AND OVER; ANTIDEPRESSIVE AGENTS, SECOND-GENERATION; CROSS-SECTIONAL STUDIES; CYCLOHEXANOLS; DEPRESSIVE DISORDER; FEMALE; HUMANS; HYPONATREMIA; INAPPROPRIATE ADH SYNDROME; INCIDENCE; PROSPECTIVE STUDIES; RISK FACTORS; SODIUM;

EID: 34248155810     PISSN: 00048674     EISSN: 14401614     Source Type: Journal    
DOI: 10.1080/00048670701261202     Document Type: Article

References (40)

1. Luzecky, MH, Burman, KD and Schultz, ER. (1974) The syndrome of inappropriate secretion of antidiuretic hormone associated with amitriptyline administration. South Med J, 67, pp. 495-497.
2. Fabian, TJ, Amico, JA, Kroboth, PD, Mulsant, BH, Reynolds, CF and Pollock, BG. (2003) Paroxetine-induced hyponatremia in the elderly due to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH). J Geriatr Psychiatry Neurol, 16, pp. 160-164.
3. Oslin, DW, Have, TR Ten and Streim, JE (2003) Probing the safety of medications in the frail elderly: Evidence from a randomized clinical trial of sertraline and venlafaxine in depressed nursing home residents [see comment]. J Clin Psychiatry, 64, pp. 875-882.
4. Fabian, TJ, Amico, JA and Kroboth, PD (2004) Paroxetine-induced hyponatremia in older adults: A 12-week prospective study. Arch Intern Med, 164, pp. 327-332.
5. Miller, M., Hecker, MS, Friedlander, DA and Carter, JM. (1996) Apparent idiopathic hyponatremia in an ambulatory geriatric population. J Am Geriatr Soc, 44, pp. 404-408.
6. Miller, MM, Morley, JE and Rubenstein, LZ (1995) Hyponatraemia in a nursing home population. J Am Geriatr Soc, 43, pp. 1410-1413.
7. Pillans, PI and Coulter, DM. (1994) Fluoxetine and hyponatraemia: A potential hazard in the elderly. N Z Med J, 107, pp. 85-86.
8. Strachan, J. and Shepherd, J. (1998) Hyponatraemia associated with the use of selective serotonin re-uptake inhibitors. Aust N Z J Psychiatry, 32, pp. 295-298.
9. Bouman, WP, Trescoli-Serano, C., Johnson, H. and Jones, RG. (1997) Transient hyponatraemia and SIADH associated with citalopram. Pharmaceut J, 259, p. 132.
10. Wilkinson, TJ, Begg, EJ, Winter, AC and Sainsbury, R. (1999) Incidence and risk factors for hyponatraemia following treatment with fluoxetine or paroxetine in elderly people [see comment]. Br J Clin Pharmacol, 47, pp. 211-217.
11. Catalano, MC, Catalano, G., Kanfer, SN, Toner, LC, Stock, SL and Taylor, WD. (2000) The effect of sertraline on routine blood chemistry values. Clin Neuropharmacol, 23, pp. 267-270.
12. Kirby, D., Harrigan, S. and Ames, D. (2002) Hyponatraemia in elderly psychiatric patients treated with selective serotonin reuptake inhibitors and venlafaxine: A retrospective controlled study in an inpatient unit. Int J Geriatr Psychiatry, 17, pp. 231-237.
13. Degner, D., Grohman, R. and Kropp, S. (2004) Severe adverse drug reactions of antidepressants: Results of the German multicenter drug surveillance program AMSP. Pharmacopsychiatry, 37, pp. S39-S45.
14. Wee, R. and Lim, WK. (2004) Selective serotonin re-uptake inhibitors (SSRI's) and hyponatraemia in the elderly. Int J Geriatr Psychiatry, 19, pp. 590-591.
15. Movig, KL, Leufkens, HG, Lenderink, AW and Egberts, AC. (2002) Serotonergic antidepressants associated with an increased risk for hyponatraemia in the elderly. Eur J Clin Pharmacol, 58, pp. 143-148.
16. Liu, BA, Mittmann, N., Knowles, SR and Shear, NH. (1996) Hyponatremia and the syndrome of inappropriate secretion of antidiuretic hormone associated with the use of selective serotonin reuptake inhibitors: A review of spontaneous reports. [erratum appears in Can Med Assoc J 1996 15; 155:1043]. Can Med Assoc J, 155, pp. 519-527.
17. Spigset, O. and Hedenmalm, K. (1997) Hyponatremia in relation to treatment with antidepressants: A survey of reports in the World Health Organization data base for spontaneous reporting of adverse drug reactions. Pharmacotherapy, 17, pp. 348-352.
18. Movig, KL, Leufkens, HG and Lenderink, AW (2002) Association between antidepressant drug use and hyponatraemia: A case-control study. Br J Clin Pharmacol, 53, pp. 363-369.
19. Wijnen, HH, van Schendel, FM, Rikkert, MG Olde, van der Hooft, CS and van Puijenbroek, EP. (2004) [Hyponatraemia during the use of selective serotonin re-uptake inhibitors (SSRIs): Reports from 1992-2002]. Ned Tijdschr Geneesk, 148, pp. 1921-1924.
20. Siegler, EL, Tamres, D., Berlin, JA, Allen-Taylor, L. and Strom, BL. (1995) Risk factors for the development of hyponatremia in psychiatric inpatients. Arch Intern Med, 155, pp. 953-957.
21. Sharma, H. and Pompei, P. (1996) Antidepressant-induced hyponatraemia in the aged. Avoidance and management strategies. Drugs Aging, 8, pp. 430-435.
22. Kovacs, L. and Robertson, GL. (1992) Syndrome of inappropriate antidiuresis. Endocrinol Metab Clin North Am, 21, pp. 859-875.
23. Roxanas, MG. (2003) Mirtazapine-induced hyponatraemia. Med J Aust, 179, pp. 453-454.
24. Sand, PG, Atzinger, AK and Buwe, A. (2002) SNRI and hyponatremia [comment]. Int J Geriatr Psychiatry, 17, pp. 491-492.
25. Maramattom, BV. (2006) Duloxetine-induced syndrome of inappropriate antidiuretic hormone secretion and seizures. Neurology, 66, pp. 773-774.
26. Blass, DM and Pearson, VE. (2000) SIADH with multiple antidepressants in a geriatric patient. J Clin Psychiatry, 61, pp. 448-449.
27. Alderman, CP. (2002) Syndrome of inappropriate antidiuretic hormone secretion secondary to venlafaxine. J Pharm Pract Res, 32, pp. 35-36.
28. Critchlow, S. (1998) Hyponatremia in elderly psychiatric inpatients. Int J Geriatr Psychiatry, 13, pp. 816-818.
29. Meynaar, IA, Peeters, AJ, Mulder, AH and Ottervanger, JP. (1997) Syndrome of inappropriate ADH secretion attributed to the serotonin re-uptake inhibitors, venlafaxine and paroxetine. Neth J Med, 50, pp. 243-245.
30. Gupta, AK and Saravay, SM. (1997) Venlafaxine-induced hyponatremia J Clin Psychopharmacol, 17, pp. 223-225.
31. Bourgeois, JA, Babine, SE and Bahadur, N. (2002) A case of SIADH and hyponatremia associated with citalopram. Psychosomatics, 43, pp. 241-242.
32. Masood, GR, Karki, SD and Patterson, WR. (1998) Hyponatremia with venlafaxine [see comment]. Ann Pharmacother, 32, pp. 49-51.
33. Holmes, CL, Patel, BM, Russell, JA and Walley, KR. (2001) Physiology of vasopressin relevant to management of septic shock [see comment]. Chest, 120, pp. 989-1002.
34. Holliday, SM and Benfield, P. (1995) Venlafaxine. A review of its pharmacology and therapeutic potential in depression. Drugs, 49, pp. 280-294.
35. Anderson, IK, Martin, GR and Ramage, AG. (1992) Central administration of 5-HT activates 5-HT1A receptors to cause sympathoexcitation and 5-HT2/ 5-HT1C receptors to release vasopressin in anaesthetized rats. Br J Pharmacol, 107, pp. 1020-1028.
36. Brownfield, MS, Greathouse, J., Lorens, SA, Armstrong, J., Urban, JH and Van de Kar, LD. (1988) Neuropharmacological characterization of serotoninergic stimulation of vasopressin secretion in conscious rats. Neuroendocrinology, 47, pp. 277-283.
37. Leibowitz, SF, Eidelman, D., Suh, JS, Diaz, S. and Sladek, CD. (1990) Mapping study of noradrenergic stimulation of vasopressin release. Exp Neurol, 110, pp. 298-305.
38. Frolkis, VV, Golovchenko, SF, Medved, VI and Frolkis, RA. (1982) Vasopressin and cardiovascular system in aging. Gerontology, 28, pp. 290-302.
39. Marar, IE and Amico, JA. (1998) Vasopressin, oxytocin, corticotrophin-releasing factor, and sodium responses during fluoxetine administration in the rat. Endocrine, 8, pp. 13-18.
40. Mastorakos, G., Weber, JS, Magiakou, MA, Gunn, H. and Chrousos, GP. (1994) Hypothalamic-pituitary-adrenal axis activation and stimulation of systemic vasopressin secretion by recombinant interleukin-6 in humans: potential implications for the syndrome of inappropriate vasopressin secretion [see comment]. J Clin Endocrinol Metab, 79, pp. 934-939.