Risk factors of oxcarbazepine-induced hyponatremia in patients with epilepsy

Clinical Neuropharmacology

Volumn 33, Issue 6, 2010, Pages 293-296

  Lin, Chih Hsiang ^a   Lu, Cheng Hsien ^a   Wang, Fu Jung ^a   Tsai, Meng Han ^a   Chang, Wen Neng ^a   Tsai, Nai Wen ^a   Lai, Shung Lon ^a   Tseng, Yu Lung ^a   Chuang, Yao Chung ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

dosage; epilepsy; hyponatremia; oxcarbazepine; risk factor

Indexed keywords

ANTICONVULSIVE AGENT; OXCARBAZEPINE; SODIUM ION;

ADULT; ANTICONVULSANT THERAPY; ARTICLE; DOSE RESPONSE; DRUG DOSE INCREASE; DRUG INDUCED HEADACHE; EPILEPSY; FEMALE; GAIT DISORDER; HUMAN; HYPONATREMIA; MAJOR CLINICAL STUDY; MALAISE; MALE; PRIORITY JOURNAL; RISK ASSESSMENT; RISK FACTOR; SODIUM BLOOD LEVEL; SOMNOLENCE;

ADULT; ANTICONVULSANTS; CARBAMAZEPINE; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG MONITORING; DRUG THERAPY, COMBINATION; EPILEPSY; FEMALE; HUMANS; HYPONATREMIA; MALE; MEDICAL RECORDS; MIDDLE AGED; RISK FACTORS; SEVERITY OF ILLNESS INDEX; SODIUM; YOUNG ADULT;

EID: 78651288990     PISSN: 03625664     EISSN: None     Source Type: Journal    
DOI: 10.1097/WNF.0b013e3181f80bd4     Document Type: Article

References (21)

1. Hauser WA, Annegers JF, Kurland LT. Prevalence of epilepsy in Rochester, Minnesota: 1940-1980. Epilepsia 1991;32:429-445.
2. McCorry D, Chadwick D, Marson A. Current drug treatment of epilepsy in adults. Lancet Neurol 2004;3:729-735.
3. Kwan P, Brodie MJ. Early identification of refractory epilepsy. N Engl J Med 2000;342:314-319.
4. Greenwood RS. Adverse effects of antiepileptic drugs. Epilepsia 2000;41(suppl 2):S42-S52.
5. LaRoche SM, Helmers SL. The new antiepileptic drugs: scientific review. JAMA 2004;291:605-614.
6. Schmidt D, Arroyo S, Baulac M, et al. Recommendations on the clinical use of oxcarbazepine in the treatment of epilepsy: a consensus view. Acta Neurol Scand 2001;104:167-170.
7. Wellington K, Goa KL. Oxcarbazepine: an update of its efficacy in the management of epilepsy. CNS Drugs 2001;15:137-163.
8. Schachter SC, Vazquez B, Fisher RS, et al. Oxcarbazepine: double-blind, randomized, placebo-control, monotherapy trial for partial seizures. Neurology 1999;52:732-737.
9. Beydoun A, Sachdeo RC, Rosenfeld WE, et al. Oxcarbazepine monotherapy for partial-onset seizures: a multicenter, double-blind, clinical trial. Neurology 2000;54:2245-2251.
10. Barcs G, Walker EB, Elger CE, et al. Oxcarbazepine placebo-controlled, dose-ranging trial in refractory partial epilepsy. Epilepsia 2000;41: 1597-1607.
11. Kutluay E, McCague K, D'Souza J, et al. Safety and tolerability of oxcarbazepine in elderly patients with epilepsy. Epilepsy Behav 2003;4:175-180.
12. Dong X, Leppik IE, White J, et al. Hyponatremia from oxcarbazepine and carbamazepine. Neurology 2005;65:1976-1978.
13. Van Amelsvoort T, Bakshi R, Devaux CB, et al. Hyponatremia associated with carbamazepine and oxcarbazepine therapy: a review. Epilepsia 1994;35:181-188.
14. Friis ML, Kristensen O, Boas J, et al. Therapeutic experiences with 947 epileptic out-patients in oxcarbazepine treatment. Acta Neurol Scand 1993;87:224-227.
15. Nielsen OA, Johannessen AC, Bardrum B. Oxcarbazepine-induced hyponatremia, a cross-sectional study. Epilepsy Res 1988;2:269-271.
16. Pendlebury SC, Moses DK, Eadie MJ. Hyponatraemia during oxcarbazepine therapy. Hum Toxicol 1989;8:337-344.
17. Tormey WP. Mechanisms of carbamazepine-induced antidiuresis. J Neurol Neurosurg Psychiatry 1993;56:567.
18. Sachdeo RC, Wasserstein A, Mesenbrink PJ, et al. Effects of oxcarbazepine on sodium concentration and water handling. Ann Neurol 2002;51:613-620.
19. Patsalos PN, Fröscher W, Pisani F, et al. The importance of drug interactions in epilepsy therapy. Epilepsia 2002;43:365-385.
20. Dogan EA, Usta BE, Bilgen R, et al. Efficacy, tolerability, and side effects of oxcarbazepine monotherapy: a prospective study in adult and elderly patients with newly diagnosed partial epilepsy. Epilepsy Behav 2008;13:156-161.
21. Grikiniene J, Volbekas V, Stakisaitis D. Gender differences of sodium metabolism and hyponatremia as an adverse drug effect. Medicina (Kaunas) 2004;40:935-942.