Pathways of iron acquisition and utilization in Leishmania

Current Opinion in Microbiology

Volumn 16, Issue 6, 2013, Pages 716-721

  Flannery, Andrew R ^a   Renberg, Rebecca L ^a   Andrews, Norma W ^a  

^a University of Maryland   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HEME; IRON; LABCG5 PROTEIN; LFR1 PROTEIN; LHR1 PROTEIN; LIT1 PROTEIN; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; PROTOZOAL PROTEIN; TRANSFERRIN RECEPTOR; UNCLASSIFIED DRUG;

ARABIDOPSIS THALIANA; BIOSYNTHESIS; CELL MEMBRANE; IRON RESPONSIVE ELEMENT; IRON STORAGE; LEISHMANIA; LEISHMANIA CHAGASI; LEISHMANIA DONOVANI; NONHUMAN; PROMASTIGOTE; REVIEW; UPREGULATION;

TRYPANOSOMATIDAE;

HOMEOSTASIS; IRON; LEISHMANIA; METABOLIC NETWORKS AND PATHWAYS;

EID: 84888130905     PISSN: 13695274     EISSN: 18790364     Source Type: Journal    
DOI: 10.1016/j.mib.2013.07.018     Document Type: Review

References (43)

1. Alvar J., et al. Leishmaniasis worldwide and global estimates of its incidence. PLoS ONE 2012, 7:e35671.
2. McCall L-I., Zhang W-W., Matlashewski G. Determinants for the development of visceral leishmaniasis disease. PLoS Pathog 2013, 9:e1003053.
3. Kaye P., Scott P. Leishmaniasis: complexity at the host-pathogen interface. Nat Rev Microbiol 2011, 9:604-615.
4. Antoine J.C., et al. The biogenesis and properties of the parasitophorous vacuoles that harbour Leishmania in murine macrophages. Trends Microbiol 1998, 6:392-401.
5. Andrews N.C. Iron homeostasis: insights from genetics and animal models. Nat Rev Genet 2000, 1:208-217.
6. Andrews N.C. The iron transporter DMT1. Int J Biochem Cell Biol 1999, 31:991-994.
7. Borges V.M., Vannier-Santos M.A., de Souza W. Subverted transferrin trafficking in Leishmania-infected macrophages. Parasitol Res 1998, 84:811-822.
8. Voyiatzaki C.S., Soteriadou K.P. Identification and isolation of the Leishmania transferrin receptor. J Biol Chem 1992, 267:9112-9117.
9. Wilson M.E., et al. Leishmania chagasi: uptake of iron bound to lactoferrin or transferrin requires an iron reductase. Exp Parasitol 2002, 100:196-207.
10. Morrissey J., Guerinot M.L. Iron uptake and transport in plants: the good, the bad, and the ionome. Chem Rev 2009, 109:4553-4567.
11. Flannery A.R., et al. LFR1 ferric iron reductase of Leishmania amazonensis is essential for the generation of infective parasite forms. J Biol Chem 2011, 286:23266-23279.
12. Jacques I., Andrews N.W., Huynh C. Functional characterization of LIT1, the Leishmania amazonensis ferrous iron transporter. Mol Biochem Parasitol 2010, 170:28-36.
13. Huynh C., Andrews N.W. Iron acquisition within host cells and the pathogenicity of Leishmania. Cell Microbiol 2008, 10:293-300.
14. Huynh C., Sacks D.L., Andrews N.W. A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. J Exp Med 2006, 203:2363-2375.
15. Mittra B., et al. Iron uptake controls the generation of Leishmania infective forms through regulation of ROS levels. J Exp Med 2013, 210:401-416.
16. Theil E.C. Iron, ferritin, and nutrition. Annu Rev Nutr 2004, 24:327-343.
17. Böttger L.H., et al. Atypical iron storage in marine brown algae: a multidisciplinary study of iron transport and storage in Ectocarpus siliculosus. J Exp Bot 2012, 63:5763-5772.
18. Adamec J., et al. Iron-dependent self-assembly of recombinant yeast frataxin: implications for Friedreich ataxia. Am J Hum Gen 2000, 67:549-562.
19. Severance S., Hamza I. Trafficking of heme and porphyrins in metazoa. Chem Rev 2009, 109:4596-4616.
20. Tripodi K.E.J., Menendez Bravo S.M., Cricco J.A. Role of heme and heme-proteins in trypanosomatid essential metabolic pathways. Enzyme Res 2011, 2011:873230.
21. Verma S., Mehta A., Shaha C. CYP5122A1, a novel cytochrome P450 is essential for survival of Leishmania donovani. PLoS ONE 2011, 6:e25273.
22. Adak S., Pal S. Ascorbate peroxidase acts as a novel determiner of redox homeostasis in Leishmania. Antioxid Redox Signal 2012, 0:1-9. 10.1089/ars.2012.4745.
23. Hamza I., Dailey H.A. One ring to rule them all: trafficking of heme and heme synthesis intermediates in the metazoans. Biochem Biophys Acta 2012, 1823:1617-1632.
24. Alves J.M.P., et al. Identification and phylogenetic analysis of heme synthesis genes in trypanosomatids and their bacterial endosymbionts. PLoS ONE 2011, 6:e23518.
25. Kořený L., Lukeš J., Oborník M. Evolution of the haem synthetic pathway in kinetoplastid flagellates: an essential pathway that is not essential after all?. Int J Parasitol 2010, 40:149-156.
26. Chang C.S., Chang K.P. Heme requirement and acquisition by extracellular and intracellular stages of Leishmania mexicana amazonensis. Mol Biochem Parasitol 1985, 16:267-276.
27. Krishnamurthy G., et al. Hemoglobin receptor in Leishmania is a hexokinase located in the flagellar pocket. J Biol Chem 2005, 280:5884-5891.
28. Agarwal S., et al. Clathrin-mediated hemoglobin endocytosis is essential for survival of Leishmania. Biochem Biophys Acta 2013, 1833:1065-1077.
29. Campos-Salinas J., et al. A new ATP-binding cassette protein is involved in intracellular haem trafficking in Leishmania. Mol Microbiol 2011, 79:1430-1444.
30. Huynh C., et al. Heme uptake by Leishmania amazonensis is mediated by the transmembrane protein LHR1. PLoS Pathog 2012, 8:e1002795.
31. Sengupta S., et al. Hemoglobin endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket. J Biol Chem 1999, 274:2758-2765.
32. Singh S.B., et al. Rab5-mediated endosome-endosome fusion regulates hemoglobin endocytosis in Leishmania donovani. EMBO J 2003, 22:5712-5722.
33. Patel N., et al. Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth. Proc Natl Acad Sci U S A 2008, 105:3980-3985.
34. Galbraith R.A., McElrath M.J. Heme binding to Leishmania mexicana amazonensis. Mol Biochem Parasitol 1988, 29:47-53.
35. Carvalho S., et al. Heme as a source of iron to Leishmania infantum amastigotes. Acta Trop 2009, 109:131-135.
36. Rajagopal A., et al. Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature 2008, 453:1127-1131.
37. White C., et al. HRG1 is essential for heme transport from the phagolysosome of macrophages during erythrophagocytosis. Cell Metab 2013, 17:261-270.
38. Cupello M.P., et al. The heme uptake process in Trypanosoma cruzi epimastigotes is inhibited by heme analogues and by inhibitors of ABC transporters. Acta Trop 2011, 120:211-218.
39. Anderson C.P., et al. Mammalian iron metabolism and its control by iron regulatory proteins. BBA-Mol Cell Res 2012, 1823:1468-1483.
40. Meehan H.A., Lundberg R.A., Connell G.J. A trypanosomatid protein specifically interacts with a mammalian iron-responsive element. Parasitol Res 2000, 86:109-114.
41. Fast B., et al. Iron-dependent regulation of transferrin receptor expression in Trypanosoma brucei. Biochem J 1999, 342(Pt 3):691.
42. Ganz T. Macrophages and systemic iron homeostasis. J Innate Immun 2012, 4:446-453.
43. Das N.K., et al. Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth. Cell Microbiol 2009, 11:83-94.