Leishmania donovani depletes labile iron pool to exploit iron uptake capacity of macrophage for its intracellular growth

Cellular Microbiology

Volumn 11, Issue 1, 2009, Pages 83-94

  Das, Nupur Kanti ^a   Biswas, Sudipta ^a   Solanki, Sunil ^a   Mukhopadhyay, Chinmay K ^a  

^a JAWAHARLAL NEHRU UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

CD71 ANTIGEN; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; MESSENGER RNA;

3' UNTRANSLATED REGION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; FEMALE; HOST PARASITE INTERACTION; IRON DEPLETION; IRON RESPONSIVE ELEMENT; IRON TRANSPORT; LEISHMANIA DONOVANI; LEISHMANIASIS; MACROPHAGE FUNCTION; MOUSE; NONHUMAN; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RNA STABILITY; SPLEEN;

3' UNTRANSLATED REGIONS; ANIMALS; FEMALE; IRON; IRON REGULATORY PROTEIN 1; IRON REGULATORY PROTEIN 2; LEISHMANIA DONOVANI; MACROPHAGES; MICE; MICE, INBRED BALB C; PROTEIN BINDING; RECEPTORS, TRANSFERRIN;

LEISHMANIA DONOVANI; MAMMALIA; MUS; PROTOZOA;

EID: 58149291350     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2008.01241.x     Document Type: Article

References (32)

1. Andrews, N.C. (2004) Probing the iron pool. Focus on 'Detection of intracellular iron by its regulatory effect'. Am J Physiol Cell Physiol 287: C1537-C1538.
2. Andrews, N.C., and Schmidt, P.J. (2007) Iron homeostasis. Annu Rev Physiol 69: 69-85.
3. Borges, V.M., Vannier-Santos, M.A., and de Souza, W. (1998) Subverted transferrin trafficking in Leishmania - infected macrophages. Parasitol Res 84: 811-822.
4. Braun, V., and Killmann, H. (1999) Bacterial solutions to the iron-supply problem. Trends Biochem Sci 24: 104-109.
5. Chang, K.P. (1980) Human cutaneous lieshmania in a mouse macrophage line: Propagation and isolation of intracellular parasites. Science 209: 1240-1242.
6. Drakesmith, H., Chen, N., Ledermann, H., Screaton, G., Townsend, A., and Xu, X.N. (2005) HIV-1 Nef down-regulates the hemochromatosis protein HFE, manipulating cellular iron homeostasis. Proc Natl Acad Sci USA 102: 11017-11022.
7. Drapier, J.C., and Hibbs, J.B., Jr (1986) Murine cytotoxic activated macrophages inhibit aconitase in tumor cells. Inhibition involves the iron-sulfur prosthetic group and is reversible. J Clin Invest 78: 790-797.
8. Forget, G., Gregory, D.J., Whitcombe, L.A., and Olivier, M. (2006) Role of host protein tyrosine phosphatase SHP-1 in Leishmania donovani -induced inhibition of nitric oxide production. Infect Immun 74: 6272-6279.
9. Ghosh, S., Goswami, S., and Adhya, S. (2003) Role of superoxide dismutase in survival of Leishmania within the macrophage. Biochem J 369: 447-452.
10. Hentze, M.W., and Kuhn, L.C. (1996) Molecular control of vertebrate iron metabolism: MRNA-based regulatory circuits operated by iron, nitric oxide and oxidative stress. Proc Natl Acad Sci USA 93: 8175-8182.
11. Hentze, M.W., Rouault, T.A., Harford, J.B., and Klausner, R.D. (1989) Oxidation-reduction and the molecular mechanism of a regulatory RNA-protein interaction. Science 244: 357-359.
12. Huynh, C., Sacks, D.L., and Andrews, N.W. (2006) A Leishmania amazonensis ZIP family iron transporter is essential for parasite replication within macrophage phagolysosomes. J Exp Med 203: 2363-2375.
13. Ismaeel, A.Y., Garmson, J.C., Molyneux, D.H., and Bates, P.A. (1998) Transformation, development, and transmission of axenically cultured amastigotes of Leishmania mexicana in vitro and in Lutzomyia longipalpis. Am J Trop Med Hyg 59: 421-425.
14. Iwai, K., Klausner, R.D., and Rouault, T.A. (1995) Requirements for iron-regulated degradation of the RNA binding protein, iron regulatory protein 2. EMBO J 14: 5350-5357.
15. Klausner, R.D., Renswoude, J.V., Ashwell, G., Kempf, C., Schechter, A.N., Dean, A., and Bridges, K.R. (1983) Receptor-mediated endocytosis of transferrin in K562 cells. J Biol Chem 258: 4715-4724.
16. Krishnamurthy, G., Vikram, R., Singh, S.B., Patel, N., Agarwal, S., Mukhopadhyay, G., etal. (2005) Hemoglobin receptor in Leishmania is a hexokinase located in the flagellar pocket. J Biol Chem 280: 5884-5891.
17. Leibold, E.A., and Munro, H.N. (1988) Cytoplasmic protein binds in vitro to a highly conserved sequence in the 5′ untranslated region of ferritin heavy- and light-subunit mRNAs. Proc Natl Acad Sci USA 85: 2171-2175.
18. McConville, M.J., de Souza, D., Saunders, E., Likic, V.A., and Naderer, T. (2007) Living in a phagolysosome; metabolism of Leishmania amastigotes. Trends Parasitol 23: 368-375.
19. Marquis, J.F., and Gros, P. (2007) Intracellular Leishmania: Your iron or mine? Trends Microbiol 15: 93-95.
20. Mukhopadhyay, S., Bhattacharyya, S., Majhi, R., De, T., Naskar, K., Majumdar, S., and Roy, S. (2000) Use of an attenuated leishmanial parasite as an immunoprophylactic and immunotherapeutic agent against murine visceral leishmaniasis. Clin Diagn Lab Immunol 7: 233-240.
21. Mulero, V., and Brock, J.H. (1999) Regulation of iron metabolism in murine J774 macrophages: Role of nitric oxide-dependent and - independent pathways following activation with gamma interferon and lipopolysaccharide. Blood 94: 2383-2389.
22. Nairaz, M., Theurl, I., Ludwiczek, S., Theurl, M., Mair, S.M., Fritsche, G., and Weiss, G. (2007) The co-ordinated regulation of iron homeostasis in murine macrophages limits the availability of iron for intracellular Salmonella typhimurium. Cell Microbiol 9: 2126-2140.
23. Paramchuk, W.J., Ismail, S.O., Bhatia, A., and Gedamu, L. (1997) Cloning, characterization and overexpression of two iron superoxide dismutase cDNAs from Leishmania chagasi: Role in pathogenesis. Mol Biochem Parasitol 90: 203-221.
24. Rouault, T.A. (2006) The role of iron regulatory proteins in mammalian iron homeostasis and disease. Nat Chem Biol 2: 406-414.
25. Schaible, U.E., and Kaufmann, S.H.E. (2004) Iron and microbial infection. Nat Rev Microbiol 2: 946-953.
26. Schneider, B.D., and Leibold, E.A. (2003) Effects of iron regulatory protein regulation on iron homeostasis during hypoxia. Blood 102: 3404-3411.
27. Stäubli, A., and Boelsterli, U.A. (1998) The labile iron pool in hepatocytes: Prooxidant-induced increase in free iron precedes oxidative cell injury. Am J Physiol 274: G1031-G1037.
28. Taetle, R., Ralph, S., Smedsrud, S., and Trowbridge, I. (1987) Regulation of transferrin receptor expression in myeloid leukemia cells. Blood 70: 852-859.
29. Theurl, I., Fritsche, G., Ludwiczek, S., Garimorth, K., Bellmann-Weiler, R., and Weiss, G. (2005) The macrophage: A cellular factory at the interphase between iron and immunity for the control of infections. Biometals 18: 359-367.
30. Wigley, P., Berchieri, A., Jr, Page, K.L., Smith, A.L., and Barrow, P.A. (2001) Salmonella enterica serovar Pullorum persists in splenic macrophages and in the reproductive tract during persistent, disease-free carriage in chickens. Infect Immun 69: 7873-7879.
31. Wilson, M.E., Vorhies, R.W., Andersen, K.A., and Britigan, B.E. (1994) Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi. Infect Immun 62: 3262-3269.
32. Wong, I.L., and Chow, L.M. (2006) The role of Leishmania enriettii multidrug resistance protein 1 (LeMDR1) in mediating drug resistance is iron-dependent. Mol Biochem Parasitol 150: 278-287.