Leishmania requires Rab7-mediated degradation of endocytosed hemoglobin for their growth

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 10, 2008, Pages 3980-3985

  Patel, Nitin ^a   Singh, Sudha B ^a   Basu, Sandip K ^a   Mukhopadhyay, Amitabha ^a  

^a NATIONAL INSTITUTE OF IMMUNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

HEMIN; HEMOGLOBIN; RAB7 PROTEIN; MUTANT PROTEIN; RAB PROTEIN;

ARTICLE; ENDOCYTOSIS; INTERNALIZATION; LEISHMANIA DONOVANI; LYSOSOME; MOLECULAR CLONING; NONHUMAN; NUCLEOTIDE SEQUENCE; PARASITE DEVELOPMENT; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; PROTEIN TRANSPORT; AMINO ACID SEQUENCE; ANIMAL; CELL COMPARTMENTALIZATION; CHEMISTRY; CYTOLOGY; GROWTH, DEVELOPMENT AND AGING; METABOLISM; MOLECULAR GENETICS; PROTEIN PROCESSING; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY;

LEISHMANIA DONOVANI;

AMINO ACID SEQUENCE; ANIMALS; CELL COMPARTMENTATION; CLONING, MOLECULAR; ENDOCYTOSIS; HEMOGLOBINS; LEISHMANIA DONOVANI; LYSOSOMES; MOLECULAR SEQUENCE DATA; MUTANT PROTEINS; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RAB GTP-BINDING PROTEINS; SEQUENCE ALIGNMENT; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 41649104344     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800404105     Document Type: Article

References (41)

1. Desjeux P (2004) Leishmaniasis: Current situation and new perspectives. Comp Immun Microbiol Infect Dis 27:305-318.
2. Berman JD (1997) Human Leishmaniasis: clinical, diagnostic, and chemotherapeutic developments in the last 10 years. Clin Infect Dis 24:648-703.
3. Sah JF, et al. (2002) Genetic rescue of Leishmania deficiency in porphyrin biosynthesis creates mutants suitable for analysis of cellular events in uroporphyria and for photodynamic therapy. J Biol Chem 277:14902-14909.
4. Chang KP, Trager W (1974) Nutritional significance of symbiotic bacteria in two species of hemoflagellates. Science 183:531-532.
5. Kelly JX, et al. (2003) Anti-Leishmanial drug development: exploitation of parasite heme dependency. Mol Biochem Parasitol 126:43-49.
6. Sengupta S, et al. (1999) Hb endocytosis in Leishmania is mediated through a 46-kDa protein located in the flagellar pocket. J Biol Chem 274:2758-2765.
7. Krishnamurthy G, et al. (2005) Hemoglobin receptor in Leishmania is a hexokinase located in the flagellar pocket. J Biol Chem 280:5884-5891.
8. Zerial M, McBride H (2001) Rab proteins as membrane organizers. Nature Rev Mol Cell Biol 2:107-117.
9. Goosshans BL, Ortiz D Novick P (2006) Rabs and their effectors: achieving specificity in membrane traffic. Proc Natl Acad Sci USA 103:11821-11827.
10. Gorvel JP, Chavrier P, Zerial M, Gruenberg J (1991) rab5 controls early endosome fusion in vitro. Cell 64:915-925.
11. Mukhopadhyay A, Barbieri AM, Funato K, Roberts R, Stahl PD (1997a) Sequential actions of rab5 and rab7 regulate endocytosis in the Xenopus oocytes. J Cell Biol 136:1227-1237.
12. Feng Y, Press B, Wandinger-Ness A (1995) Rab7: An important regulator of late endocytic membrane traffic. J Cell Biol 131:1435-1452.
13. Mukhopadhyay A, Funato F, Stahl PD (1997b) Rab7 regulates transport from early to late endocytic compartments in Xenopus oocytes. J Biol Chem 272:13055-13059.
14. McConville MJ, Mullin KA, Ilgoutz SC, Teasdale RD (2002) Secretory pathway of Trypanosomatid parasites. Microbiol Mol Biol Rev 66:122-154.
15. Field MC, Carrington M (2004) Intracellular membrane transport systems in Trypanosoma brucei. Traffic 5:905-913.
16. Overath P, Engstler M (2004) Endocytosis, membrane recycling and sorting of GPI-anchored proteins: Trypanosoma brucei as a model system. Mol Microbiol 53:735-744.
17. Morgan GW, Hall BS, Denny PW, Carrington M, Field MC (2002) The kinetoplastida endocytic apparatus. Part I: A dynamic system for nutrition and evasion of host defences. Trends in Parasitol 18:491-496.
18. Pal A, Hall BS, Nesbeth DN, Field HI, Field MC (2002) Differential endocytic functions of Trypanosoma brucei Rab5 isoforms reveal a glycophosphatidylinositol-specific endosomal pathway. J Biol Chem 277:9529-9539.
19. Robibaro B, et al. (2002) Toxoplasma gondii Rab5 enhances cholesterol acquisition from host cells. Cell Microbiol 4:139-152.
20. Temesvari L, Rodriguez-Paris J, Bush J, Steck TL, Cardelli J (1994) Characterization of lysosomal membrane proteins of Dictyostelium discioideum: A complex population of acidic integral membrane glycoprotein, rab GTP binding proteins and vacuolar ATPase subunits. J Biol Chem 269:25719-25727.
21. Quevillon E, et al. (2003) The Plasmodium falciparum family of Rab GTPases. Gene 306:13-25.
22. Singh SB, et al. (2003) Rab5-mediated endosome-endosome fusion regulates hemoglobin endocytosis in Leishmania donovani. EMBO J 22:5712-5722.
23. Stenmark H, Olkkonen VM (2001) The Rab GTPase family. Genome Biol 2:3007.1-3007.7.
24. Press B, Feng Y, Hoflack B, Wandinger-Ness A (1998) Mutant Rab7 causes the accumulation of cathepsin D, cation-independent mannose 6-phosphate receptor in an early endocytic compartment. J Cell Biol 140:1075-1089.
25. Denny PW, et al. (2002) Leishmania RAB7: characterization of terminal endocytic stages in an intracellular parasites. Mol Biochem Parasitol 123:105-113.
26. Araripe JR, et al. (2004) Trypanosoma cruzi: TcRab7 protein is localized at the Golgi apparatus in epimastigotes. Biochem Biophys Res Commun 321:397-402.
27. Tisdale EJ, Bourne JR, Khosravi-Far R, Der CJ, Balch WE (1992) GTP-binding mutants of rabl and rab2 are potent inhibitors of vesicular transport from the endoplasmic reticulum to the Golgi complex. J Cell Biol 119:749-761.
28. Riederer MA, Soldati T, Shapiro AD, Lin J, Pfeffer SR (1994) Lysosome biogenesis requires Rab9 function and receptor recycling from endosomes to the trans-Golgi network. J Cell Biol 125:573-582.
29. Stenmark H, et al. (1994) Inhibition of rab5 GTPase activity stimulates membrane fusion in endocytosis. EMBO J 13:1287-1296.
30. Li G, Stahl PD (1993) Structure-function relationship of the small GTPase rab5. J Biol Chem 268:24475-24480.
31. Nuoffer C, Davidson HW, Matteson J, Meinkoth J, Balch WE (1994) AGDP-bound of rabl inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J Cell Biol 125:225-237.
32. Knutson MD, Oukka M, Koss LM, Aydemir F, Wessling-Resnick M (2005) Iron release from macrophages after erythrophagocytosis is up-regulated by ferroportin 1 overexpression and down-regulated by hepcidin. Proc Natl Acad Sci USA 102:1324-1328.
33. Kamhawi S (2006) Phlebotomine sand flies and Leishmania parasites: Friends or foes? Trends Parasitol 22:439-445.
34. Wilson ME, Vorhies RW, Anderson KA, Britgan BE (1994) Acquisition of iron from transferrin and lactoferrin by the protozoan Leishmania chagasi. Infect Immun 62:3262-3269.
35. Gholamhosseinian A, Vassef A (1988) Superiority of hemoglobin to hemin for cultivation of Leishmania tropica promastigotes in serum-free media. J Protozool 35:446-449.
36. Mukherjee K, et al. (2000) Live Salmonella recruits NSF on phagosomal membrane and promotes fusion with early endosomes. J Cell Biol 148:741-753.
37. Roy JC (1932) Cultivation of various Leishmania parasites in solid medium. Ind J Med Res 20:355-367.
38. Ha DS, Schwarz JK, Turco SJ, Beverley SM (1996) Use of the green fluorescent protein as a marker in transfected Leishmania. Mol Biochem Parasitol 77:57-64.
39. Hashim S, Mukherjee K, Raje M, Basu SK, Mukhopadhyay A (2000) Live Salmonella modulate expression of rab proteins to persist in a specialised compartment and escape transport to lysosomes. J Biol Chem 275:16281-16288.
40. Bhattacharya M, et al. (2006) IL-6 and IL-12 specifically regulate the expression of Rab5 and Rab7 via distinct signaling pathways. EMBO J 25:2878-2888.
41. Abraham R, et al. (1995) Modulation of immunogenicity and antigenicity of proteins by maleylation to target scavenger receptors on macrophages. J Immunol 154:1-8.