Relationship between the chemokine receptor CCR5 and microglia in neurological disorders: Consequences of targeting CCR5 on neuroinflammation, neuronal death and regeneration in a model of epilepsy

CNS and Neurological Disorders - Drug Targets

Volumn 12, Issue 6, 2013, Pages 815-829

  Louboutin, Jean Pierre ^a   Strayer, David S ^a  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

Author keywords

CCR5; Chemokines; Epilepsy; Gene therapy; Microglia; Neuroinflammation; Neurological disorders; RNAi

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CX3CR1; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 1; INTERLEUKIN 10; INTERLEUKIN 6; MACROPHAGE INFLAMMATORY PROTEIN 1ALPHA; MACROPHAGE INFLAMMATORY PROTEIN 1BETA; PROTEIN S100B; RANTES; SMALL INTERFERING RNA; TUMOR NECROSIS FACTOR ALPHA; VASCULAR CELL ADHESION MOLECULE 1;

ALZHEIMER DISEASE; BLOOD BRAIN BARRIER; CELL INFILTRATION; CELL MIGRATION; CELL PROLIFERATION; CEREBROVASCULAR ACCIDENT; DOWN REGULATION; EPILEPSY; GENE EXPRESSION; HIV ASSOCIATED DEMENTIA; HIV ASSOCIATED NEPHROPATHY; HUMAN; INFECTION; LEUKOCYTE; MICROGLIA; MULTIPLE SCLEROSIS; NERVE REGENERATION; NERVOUS SYSTEM INFLAMMATION; NEUROLOGIC DISEASE; NONHUMAN; PROTEIN EXPRESSION; REVIEW; TRAUMATIC BRAIN INJURY; UPREGULATION;

ANIMALS; CELL DEATH; CHEMOKINES; DISEASE MODELS, ANIMAL; DRUG DELIVERY SYSTEMS; EPILEPSY; HUMANS; INFLAMMATION; MICROGLIA; NERVE REGENERATION; NERVOUS SYSTEM DISEASES; NEURONS; RECEPTORS, CCR5;

EID: 84888071011     PISSN: 18715273     EISSN: 19963181     Source Type: Journal    
DOI: 10.2174/18715273113126660173     Document Type: Review

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