-
1
-
-
0025736936
-
Scientific concepts, value, and significance of chemical carcinogenesis studies
-
Huff J.E., Haseman J.K., Rall D.P. Scientific concepts, value, and significance of chemical carcinogenesis studies. Annu. Rev. Pharmacol. Toxicol. 1991, 31:621-625.
-
(1991)
Annu. Rev. Pharmacol. Toxicol.
, vol.31
, pp. 621-625
-
-
Huff, J.E.1
Haseman, J.K.2
Rall, D.P.3
-
2
-
-
0002702420
-
Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans
-
Marcel Dekker, Inc., New York, K.T. Kitchin (Ed.)
-
Huff J. Value, validity, and historical development of carcinogenesis studies for predicting and confirming carcinogenic risks to humans. Carcinogenicity. Testing, Predicting, and Interpreting Chemical Effects 1999, 21-123. Marcel Dekker, Inc., New York. K.T. Kitchin (Ed.).
-
(1999)
Carcinogenicity. Testing, Predicting, and Interpreting Chemical Effects
, pp. 21-123
-
-
Huff, J.1
-
3
-
-
0033403543
-
Long-term chemical carcinogenesis bioassays predict human cancer hazards, issues, controversies, and uncertainties
-
Huff J. Long-term chemical carcinogenesis bioassays predict human cancer hazards, issues, controversies, and uncertainties. Ann. N.Y. Acad. Sci. 1999, 895:56-79.
-
(1999)
Ann. N.Y. Acad. Sci.
, vol.895
, pp. 56-79
-
-
Huff, J.1
-
4
-
-
0024590377
-
Toward a quantitative comparative toxicology of organic compounds
-
Hansch C., Kim D., Leo A.J., Novellino E., Silipo C., Vittoria A. Toward a quantitative comparative toxicology of organic compounds. Crit. Rev. Toxicol. 1989, 19:185-226.
-
(1989)
Crit. Rev. Toxicol.
, vol.19
, pp. 185-226
-
-
Hansch, C.1
Kim, D.2
Leo, A.J.3
Novellino, E.4
Silipo, C.5
Vittoria, A.6
-
5
-
-
85047684589
-
Using chemical categories to fill data gaps in hazard assessment
-
Van Leeuwen K., Schultz T.W., Henry T., Diderich B., Veith G.D. Using chemical categories to fill data gaps in hazard assessment. SAR QSAR Environ. Res. 2009, 20:207-220.
-
(2009)
SAR QSAR Environ. Res.
, vol.20
, pp. 207-220
-
-
Van Leeuwen, K.1
Schultz, T.W.2
Henry, T.3
Diderich, B.4
Veith, G.D.5
-
6
-
-
85073142597
-
The role of QSAR methodology in the regulatory assessment of chemicals
-
Springer, Heidelberg, T. Puzyn, J. Leszczynski, M.T.D. Cronin (Eds.)
-
Worth A.P. The role of QSAR methodology in the regulatory assessment of chemicals. Recent Advances in QSAR Studies: Methods and Applications 2010, 367-382. Springer, Heidelberg. T. Puzyn, J. Leszczynski, M.T.D. Cronin (Eds.).
-
(2010)
Recent Advances in QSAR Studies: Methods and Applications
, pp. 367-382
-
-
Worth, A.P.1
-
7
-
-
33847767499
-
The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens
-
Benigni R., Netzeva T.I., Benfenati E., Bossa C., Franke R., Helma C., Hulzebos E., Marchant C.A., Richard A.M., Woo Y.T., Yang C. The expanding role of predictive toxicology: an update on the (Q)SAR models for mutagens and carcinogens. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 2007, 25:53-97.
-
(2007)
J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.
, vol.25
, pp. 53-97
-
-
Benigni, R.1
Netzeva, T.I.2
Benfenati, E.3
Bossa, C.4
Franke, R.5
Helma, C.6
Hulzebos, E.7
Marchant, C.A.8
Richard, A.M.9
Woo, Y.T.10
Yang, C.11
-
8
-
-
70350170830
-
Existing approaches incorporating replacement, reduction and refinement of animal testing: applicability in food and feed risk assessment
-
EFSA
-
EFSA Existing approaches incorporating replacement, reduction and refinement of animal testing: applicability in food and feed risk assessment. EFSA J. 2009, 1052:1-57.
-
(2009)
EFSA J.
, vol.1052
, pp. 1-57
-
-
-
9
-
-
72449195675
-
Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities - report from an ECVAM workshop
-
Pfuhler S., Kirkland D.J., Kasper P., Hayashi M., Vanparys P., Carmichael P., Dertinger S.D., Easton D., Elhajouji A., Krul C., Rothfuss A., Schoening G., Smith A., Speit G., Thomas C., van Benthem J., Corvi R. Reduction of use of animals in regulatory genotoxicity testing: Identification and implementation opportunities - report from an ECVAM workshop. Mutat. Res. 2011, 680:31-42.
-
(2011)
Mutat. Res.
, vol.680
, pp. 31-42
-
-
Pfuhler, S.1
Kirkland, D.J.2
Kasper, P.3
Hayashi, M.4
Vanparys, P.5
Carmichael, P.6
Dertinger, S.D.7
Easton, D.8
Elhajouji, A.9
Krul, C.10
Rothfuss, A.11
Schoening, G.12
Smith, A.13
Speit, G.14
Thomas, C.15
van Benthem, J.16
Corvi, R.17
-
10
-
-
67649660033
-
Testing for carcinogens: shift from animals to automation gathers steam - slowly
-
Schmidt C. Testing for carcinogens: shift from animals to automation gathers steam - slowly. J. Natl. Cancer Inst. 2009, 101:910-912.
-
(2009)
J. Natl. Cancer Inst.
, vol.101
, pp. 910-912
-
-
Schmidt, C.1
-
11
-
-
84888009075
-
ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009). A Report Prepared in the Framework of Directive 2003/15/EC (7th Amendment to the Cosmetics Directive). EUR 24413 EN
-
Publications Office of the European Union, Luxenbourg, ISSN 1018-5593
-
Zunag V., Barroso J., Bremer S., Casati S., Ceridono M., Coecke S., Corvi R., Eskes C., Kinsner A., Pellizzer C., Prieto P., Worth A., Kreysa J. ECVAM Technical Report on the Status of Alternative Methods for Cosmetics Testing (2008-2009). A Report Prepared in the Framework of Directive 2003/15/EC (7th Amendment to the Cosmetics Directive). EUR 24413 EN. EUR - Scientific and Technical Research Series 2010, Publications Office of the European Union, Luxenbourg, ISSN 1018-5593.
-
(2010)
EUR - Scientific and Technical Research Series
-
-
Zunag, V.1
Barroso, J.2
Bremer, S.3
Casati, S.4
Ceridono, M.5
Coecke, S.6
Corvi, R.7
Eskes, C.8
Kinsner, A.9
Pellizzer, C.10
Prieto, P.11
Worth, A.12
Kreysa, J.13
-
12
-
-
0032465960
-
Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises, and performance
-
Zeiger E. Identification of rodent carcinogens and noncarcinogens using genetic toxicity tests: premises, promises, and performance. Regulat. Pharmacol. Toxicol. 1998, 28:85-95.
-
(1998)
Regulat. Pharmacol. Toxicol.
, vol.28
, pp. 85-95
-
-
Zeiger, E.1
-
13
-
-
84858843662
-
Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?
-
Benigni R. Alternatives to the carcinogenicity bioassay for toxicity prediction: are we there yet?. Exp. Opin. Drug Metab. Toxicol. 2012, 8:1-11.
-
(2012)
Exp. Opin. Drug Metab. Toxicol.
, vol.8
, pp. 1-11
-
-
Benigni, R.1
-
14
-
-
62749084516
-
Toxicity testing in the 21st century: implications for human health risk assessment
-
Kavlock R.J., Austin C.P., Tice R.R. Toxicity testing in the 21st century: implications for human health risk assessment. Risk Anal. 2009, 29:485-487.
-
(2009)
Risk Anal.
, vol.29
, pp. 485-487
-
-
Kavlock, R.J.1
Austin, C.P.2
Tice, R.R.3
-
15
-
-
78249267226
-
Exploring in vitro/in vivo correlations: lessons learned from analyzing phase i results of U.S.EPA's ToxCast Project
-
Benigni R., Bossa C., Giuliani A., Tcheremenskaia O. Exploring in vitro/in vivo correlations: lessons learned from analyzing phase i results of U.S.EPA's ToxCast Project. J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev. 2010, 28:272-286.
-
(2010)
J. Environ. Sci. Health C Environ. Carcinog. Ecotoxicol. Rev.
, vol.28
, pp. 272-286
-
-
Benigni, R.1
Bossa, C.2
Giuliani, A.3
Tcheremenskaia, O.4
-
16
-
-
84884582909
-
Evaluation of the toxicity forecasting capability of EPA's ToxCast Phase I data: can ToxCast in vitro assays predict carcinogenicity?
-
Benigni R. Evaluation of the toxicity forecasting capability of EPA's ToxCast Phase I data: can ToxCast in vitro assays predict carcinogenicity?. J. Toxicol. Environ. Health C 2013, 31(3):201-212.
-
(2013)
J. Toxicol. Environ. Health C
, vol.31
, Issue.3
, pp. 201-212
-
-
Benigni, R.1
-
17
-
-
79955402142
-
Alternative strategies for carcinogenicity assessment: an efficient and simplified approach based on in vitro mutagenicity and cell transformation assays
-
Benigni R., Bossa C. Alternative strategies for carcinogenicity assessment: an efficient and simplified approach based on in vitro mutagenicity and cell transformation assays. Mutagenesis 2011, 26:455-460.
-
(2011)
Mutagenesis
, vol.26
, pp. 455-460
-
-
Benigni, R.1
Bossa, C.2
-
18
-
-
84871807809
-
In vitro cell transformation assays for an integrated, alternative assessment of carcinogenicity: a data-based analysis
-
Benigni R., Bossa C., Tcheremenskaia O. In vitro cell transformation assays for an integrated, alternative assessment of carcinogenicity: a data-based analysis. Mutagenesis 2013, 28:107-116.
-
(2013)
Mutagenesis
, vol.28
, pp. 107-116
-
-
Benigni, R.1
Bossa, C.2
Tcheremenskaia, O.3
-
19
-
-
0029041571
-
Non-genotoxic mechanisms of carcinogenesis: studies of cell transformation and gap junctional intercellular communication
-
Yamasaki H. Non-genotoxic mechanisms of carcinogenesis: studies of cell transformation and gap junctional intercellular communication. Toxicol. Lett. 1995, 77:55-61.
-
(1995)
Toxicol. Lett.
, vol.77
, pp. 55-61
-
-
Yamasaki, H.1
-
20
-
-
77954749634
-
Research on early-stage carcinogenesis: are we approaching paradigm instability?
-
Baker S.G., Cappuccio A., Potter J.D. Research on early-stage carcinogenesis: are we approaching paradigm instability?. J. Clin. Oncol. 2010, 28:3215-3218.
-
(2010)
J. Clin. Oncol.
, vol.28
, pp. 3215-3218
-
-
Baker, S.G.1
Cappuccio, A.2
Potter, J.D.3
-
21
-
-
59849102430
-
Detailed Review Paper on Cell Transformation Assays for Detection of Chemical Carcinogens. (31)
-
OECD, OECD, Paris
-
OECD Detailed Review Paper on Cell Transformation Assays for Detection of Chemical Carcinogens. (31). OECD Series on Testing and Assessment 2007, OECD, Paris.
-
(2007)
OECD Series on Testing and Assessment
-
-
-
22
-
-
84555177872
-
Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs
-
Creton S., Aardema M.J., Carmichael P., Harvey J.S., Martin F.L., Newbold R.F., O'Donovan M.R., Pant K., Poth A., Sakai A., Sasaki K., Scott A.D., Schechtman L.M., Shen R.R., Tanaka N., Yasaei H. Cell transformation assays for prediction of carcinogenic potential: state of the science and future research needs. Mutagenesis 2012, 62:93-101.
-
(2012)
Mutagenesis
, vol.62
, pp. 93-101
-
-
Creton, S.1
Aardema, M.J.2
Carmichael, P.3
Harvey, J.S.4
Martin, F.L.5
Newbold, R.F.6
O'Donovan, M.R.7
Pant, K.8
Poth, A.9
Sakai, A.10
Sasaki, K.11
Scott, A.D.12
Schechtman, L.M.13
Shen, R.R.14
Tanaka, N.15
Yasaei, H.16
-
23
-
-
84859420968
-
Recommended protocol for the Syrian hamster embryo (SHE) cell transformation assay
-
Maire M.A., Pant K., Phrakonkham P., Poth A., Schwind K.R., Rast C., Bruce S.W., Sly J.E., Bohnenberger S., Kunkelmann T., Schulz M., Vasseur P. Recommended protocol for the Syrian hamster embryo (SHE) cell transformation assay. Mutat. Res. 2012, 744:76-81.
-
(2012)
Mutat. Res.
, vol.744
, pp. 76-81
-
-
Maire, M.A.1
Pant, K.2
Phrakonkham, P.3
Poth, A.4
Schwind, K.R.5
Rast, C.6
Bruce, S.W.7
Sly, J.E.8
Bohnenberger, S.9
Kunkelmann, T.10
Schulz, M.11
Vasseur, P.12
-
24
-
-
0034693731
-
The Ames Salmonella/microsome mutagenicity assay
-
Mortelmans K., Zeiger E. The Ames Salmonella/microsome mutagenicity assay. Mutat. Res. 2000, 455:29-60.
-
(2000)
Mutat. Res.
, vol.455
, pp. 29-60
-
-
Mortelmans, K.1
Zeiger, E.2
-
25
-
-
84859435911
-
OECD Detailed Review Paper (DRP) number 31 on "Cell Transformation Assays for Detection of Chemical Carcinogens": main results and conclusions
-
Vasseur P., Lasne C. OECD Detailed Review Paper (DRP) number 31 on "Cell Transformation Assays for Detection of Chemical Carcinogens": main results and conclusions. Mutat. Res. 2012, 744:8-11.
-
(2012)
Mutat. Res.
, vol.744
, pp. 8-11
-
-
Vasseur, P.1
Lasne, C.2
-
26
-
-
84881644721
-
New perspectives in toxicological information management, and the role of ISSTOX databases on assessing chemical mutagenicity and carcinogenicity
-
Benigni R., Battistelli C.L., Bossa C., Tcheremenskaia O., Crettaz P. New perspectives in toxicological information management, and the role of ISSTOX databases on assessing chemical mutagenicity and carcinogenicity. Mutagenesis 2013, 28:401-419.
-
(2013)
Mutagenesis
, vol.28
, pp. 401-419
-
-
Benigni, R.1
Battistelli, C.L.2
Bossa, C.3
Tcheremenskaia, O.4
Crettaz, P.5
-
27
-
-
0022400101
-
Fundamental structural alerts to potential carcinogenicity or noncarcinogenicity
-
Ashby J. Fundamental structural alerts to potential carcinogenicity or noncarcinogenicity. Environ. Mutagen. 1985, 7:919-921.
-
(1985)
Environ. Mutagen.
, vol.7
, pp. 919-921
-
-
Ashby, J.1
-
28
-
-
33847068743
-
The role of the european chemicals bureau in promoting the regulatory use of (Q)SAR methods
-
Worth A.P., Bassan A., de Brujin J., Gallegos Saliner A., Netzeva T.I., Pavan M., Patlewicz G., Tsakovska I., Eisenreich S. The role of the european chemicals bureau in promoting the regulatory use of (Q)SAR methods. SAR QSAR Environ. Res. 2007, 18:111-125.
-
(2007)
SAR QSAR Environ. Res.
, vol.18
, pp. 111-125
-
-
Worth, A.P.1
Bassan, A.2
de Brujin, J.3
Gallegos Saliner, A.4
Netzeva, T.I.5
Pavan, M.6
Patlewicz, G.7
Tsakovska, I.8
Eisenreich, S.9
-
29
-
-
79954550877
-
Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology
-
Benigni R., Bossa C. Mechanisms of chemical carcinogenicity and mutagenicity: a review with implications for predictive toxicology. Chem. Rev. 2011, 111:2507-2536.
-
(2011)
Chem. Rev.
, vol.111
, pp. 2507-2536
-
-
Benigni, R.1
Bossa, C.2
-
30
-
-
84877658983
-
Nongenotoxic carcinogenicity of chemicals: mechanisms of action, and early recognition through a new set of structural alerts
-
Benigni R., Bossa C., Tcheremenskaia O. Nongenotoxic carcinogenicity of chemicals: mechanisms of action, and early recognition through a new set of structural alerts. Chem. Rev. 2013, 113:2940-2957.
-
(2013)
Chem. Rev.
, vol.113
, pp. 2940-2957
-
-
Benigni, R.1
Bossa, C.2
Tcheremenskaia, O.3
-
31
-
-
4644356332
-
Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide
-
Sakano K., Oikawa S., Hiraku Y., Kawanishi S. Mechanism of metal-mediated DNA damage induced by a metabolite of carcinogenic acetamide. Chem. Biol. Interact. 2004, 149:52-59.
-
(2004)
Chem. Biol. Interact.
, vol.149
, pp. 52-59
-
-
Sakano, K.1
Oikawa, S.2
Hiraku, Y.3
Kawanishi, S.4
-
32
-
-
0036118827
-
Nickel essentiality, toxicity, and carcinogenicity
-
Denkhaus E., Salnikow K. Nickel essentiality, toxicity, and carcinogenicity. Crit. Rev. Oncol. Hematol. 2002, 42:35-56.
-
(2002)
Crit. Rev. Oncol. Hematol.
, vol.42
, pp. 35-56
-
-
Denkhaus, E.1
Salnikow, K.2
-
33
-
-
75449099070
-
A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: gaps in knowledge and directions for future research
-
Assem F.L., Levy L.S. A review of current toxicological concerns on vanadium pentoxide and other vanadium compounds: gaps in knowledge and directions for future research. J. Toxicol. Environ. Health B Crit. Rev. 2009, 12:289-306.
-
(2009)
J. Toxicol. Environ. Health B Crit. Rev.
, vol.12
, pp. 289-306
-
-
Assem, F.L.1
Levy, L.S.2
-
34
-
-
0017670169
-
Selection of an in vitro carcinogenicity test for derivatives of the carcinogen hexamethylphosphoramide
-
Ashby J., Styles J.A., Anderson D. Selection of an in vitro carcinogenicity test for derivatives of the carcinogen hexamethylphosphoramide. Brit. J. Cancer 1977, 36:564-571.
-
(1977)
Brit. J. Cancer
, vol.36
, pp. 564-571
-
-
Ashby, J.1
Styles, J.A.2
Anderson, D.3
-
35
-
-
71849099454
-
Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach
-
Hernández L.G., van Steeg H., Luijten M., van Benthem J. Mechanisms of non-genotoxic carcinogens and importance of a weight of evidence approach. Mutat. Res. 2009, 682:94-109.
-
(2009)
Mutat. Res.
, vol.682
, pp. 94-109
-
-
Hernández, L.G.1
van Steeg, H.2
Luijten, M.3
van Benthem, J.4
-
36
-
-
84974803514
-
Mechanisms of action of chemical carcinogens, and their role in Structure-Activity Relationships (SAR) analysis and risk assessment
-
CRC Press, Boca Raton, R. Benigni (Ed.)
-
Woo Y.T. Mechanisms of action of chemical carcinogens, and their role in Structure-Activity Relationships (SAR) analysis and risk assessment. Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens 2003, 41-80. CRC Press, Boca Raton. R. Benigni (Ed.).
-
(2003)
Quantitative Structure-Activity Relationship (QSAR) Models of Mutagens and Carcinogens
, pp. 41-80
-
-
Woo, Y.T.1
-
37
-
-
0034752076
-
The Syrian Hamster Embryo (SHE) cell transformation assay: review of the methods and results
-
Mauthe R.J., Gibson D.P., Bunch R.T., Custer L. The Syrian Hamster Embryo (SHE) cell transformation assay: review of the methods and results. Toxicol. Pathol. 2001, 29:138-146.
-
(2001)
Toxicol. Pathol.
, vol.29
, pp. 138-146
-
-
Mauthe, R.J.1
Gibson, D.P.2
Bunch, R.T.3
Custer, L.4
-
38
-
-
33845637638
-
Efficient immortalization of primary human cells by p.16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT
-
Haga K., Ohno S., Yugawa T., Narisawa-Saito M., Fujita M., Sakamoto M., Galloway D.A., Kiyono T. Efficient immortalization of primary human cells by p.16INK4a-specific short hairpin RNA or Bmi-1, combined with introduction of hTERT. Cancer Sci. 2007, 98:147-154.
-
(2007)
Cancer Sci.
, vol.98
, pp. 147-154
-
-
Haga, K.1
Ohno, S.2
Yugawa, T.3
Narisawa-Saito, M.4
Fujita, M.5
Sakamoto, M.6
Galloway, D.A.7
Kiyono, T.8
-
39
-
-
0345362948
-
Characterisation of the metabolic capacity of Syrian hamster embryo (SHE) cells
-
Stuard S.B., Kerckaert G.A., Lehman-McKeeman L.D. Characterisation of the metabolic capacity of Syrian hamster embryo (SHE) cells. Toxicol. Sci. 1999, 48:366.
-
(1999)
Toxicol. Sci.
, vol.48
, pp. 366
-
-
Stuard, S.B.1
Kerckaert, G.A.2
Lehman-McKeeman, L.D.3
-
40
-
-
0033163236
-
Epigenetic events during the process of cell transformation induced by carcinogens (review)
-
Nguyen-Ba G., Vasseur P. Epigenetic events during the process of cell transformation induced by carcinogens (review). Oncol. Rep. 1999, 6:925-932.
-
(1999)
Oncol. Rep.
, vol.6
, pp. 925-932
-
-
Nguyen-Ba, G.1
Vasseur, P.2
-
41
-
-
55649116409
-
ACToR - Aggregated Computational Toxicology Resource
-
Judson R., Richard A.M., Dix D., Houck K., Elloumi F., Martin M., Cathey T., Transue T., Spencer R., Wolf M. ACToR - Aggregated Computational Toxicology Resource. Toxicol. Appl. Pharmacol. 2008, 233:7-13.
-
(2008)
Toxicol. Appl. Pharmacol.
, vol.233
, pp. 7-13
-
-
Judson, R.1
Richard, A.M.2
Dix, D.3
Houck, K.4
Elloumi, F.5
Martin, M.6
Cathey, T.7
Transue, T.8
Spencer, R.9
Wolf, M.10
|