Regulatory T cells, Cytotoxic T lymphocytes and a TH1 cytokine profile in dogs naturally infected by Leishmania infantum

Research in Veterinary Science

Volumn 95, Issue 3, 2013, Pages 942-949

  Cortese, Laura ^a   Annunziatella, Mariangela ^a   Palatucci, Anna Teresa ^a   Rubino, Valentina ^a   Piantedosi, Diego ^a   Di Loria, Antonio ^b   Ruggiero, Giuseppina ^a   Ciaramella, Paolo ^a   Terrazzano, Giuseppe ^a,c  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b UNIVERSITY MAGNA GRAECIA OF CATANZARO   (Italy)

^c UNIVERSITY OF BASILICATA   (Italy)

Author keywords

Dogs; Flow cytometry; Leishmaniasis; T CD4+; T CD8+; T regulatory cells

Indexed keywords

ANTIBODY TITER; ARTICLE; CD4+ T LYMPHOCYTE; CD8+ T LYMPHOCYTE; CLINICAL FEATURE; COHORT ANALYSIS; CONTROLLED STUDY; CYTOTOXIC T LYMPHOCYTE; DISEASE ASSOCIATION; DOG; FEMALE; FLOW CYTOMETRY; IMMUNE RESPONSE; IMMUNOFLUORESCENCE TEST; IMMUNOPATHOGENESIS; IMMUNOPATHOLOGY; LEISHMANIA INFANTUM; LEISHMANIASIS; MALE; NONHUMAN; REGULATORY T LYMPHOCYTE; T LYMPHOCYTE SUBPOPULATION; TH1 CELL; UPREGULATION;

ANIMALIA; CANIS FAMILIARIS; LEISHMANIA INFANTUM; PROTOZOA;

DOGS; FLOW CYTOMETRY; LEISHMANIASIS; T CD4(+); T CD8(+); T REGULATORY CELLS;

ANIMALS; AVIAN PROTEINS; CD4 LYMPHOCYTE COUNT; CD4-POSITIVE T-LYMPHOCYTES; CD8-POSITIVE T-LYMPHOCYTES; CYTOKINES; DOG DISEASES; DOGS; FEMALE; FLOW CYTOMETRY; FLUORESCENT ANTIBODY TECHNIQUE; INTERFERON-GAMMA; LEISHMANIA INFANTUM; LEISHMANIASIS, VISCERAL; MALE; T-LYMPHOCYTES, CYTOTOXIC; T-LYMPHOCYTES, REGULATORY; TH1 CELLS;

EID: 84888001875     PISSN: 00345288     EISSN: 15322661     Source Type: Journal    
DOI: 10.1016/j.rvsc.2013.08.005     Document Type: Article

References (53)

1. Alexander J., Brombacher F. T helper1/T helper2 cells and resistance/susceptibility to Leishmania infection: is this paradigm still relevant?. Frontiers in Immunology 2012, 3:1-13.
2. Alexandre-Pires G., Algueró C., Martins C., Rodrigues O.R., da Fonseca I.P., Santos-Gomes G. Canine leishmaniasis. Immunophenotypic profile of leukocytes in different compartments of symptomatic, asymptomatic and treated dogs. Veterinary Immunology and Immunopathology 2010, 137:275-283.
3. Alvar J., Canavate C., Molina R., Moreno J., Nieto J. Canine leishmaniasis. Advances in Parasitology 2004, 57:1-88.
4. Baneth G., Koutinas A.F., Solano-Gallego L., Bourdeau P., Ferrer L. Canine leishmaniosis new concepts and insights on an expanding zoonosis: part one. Trends Parasitology 2008, 24:324-330.
5. Belkaid Y., Tarbell K. Regulatory T Cells in the Control of Host-Microorganism Interactions. Annual Review of Immunology 2009, 27:551-589.
6. Biller B.J., Elmslie R.E., Burnett R.C., Avery A.C., Dow S.W. Use of FoxP3 expression to identify regulatory T cells in healthy dogs and dogs with cancer. Veterinary Immunology and Immunopathology 2007, 116:69-78.
7. Boggiatto P.M., Ramer-Tait A.E., Metz K., Kramer E.E., Gibson-Corley K., Mullin K., Hostetter J.M., Gallup J.M., Jones D.E., Petersen C.A. Immunologic indicators of clinical progression during canine Leishmania infantum infection. Clinical and Vaccine Immunology 2010, 17(2):267-273.
8. Bottero E., Poggi M., Viglione M. Lesioni papulari indotte da Leishmania spp in 8 cani giovani. Veterinaria 2006, 1:33-36.
9. Carillo E., Moreno J. Cytokine profiles in canine visceral leishmaniasis. Veterinary Immunology and Immunopathology 2009, 128:67-70.
10. Chamizo C., Moreno J., Alvar J. Semi-quantitative analysis of citokine expression in asymptomatic canine leishmaniasis. Veterinary Immunology and Immunopathology 2005, 103:67-75.
11. Ciaramella P., Oliva G., De Luna R., Gradoni R., Ambrosio R., Cortese L., Scalone A., Persechino A. A retrospective clinical study of canine leishmaniasis in 150 dogs naturally infected by Leishmania infantum. The Veterinary Record 1997, 22:539-543.
12. Cortese L., Sica M., Piantedosi D., Ruggiero G., Pero M.E., Terrazzano G., Mastellone V., Ciaramella P. Secondary immune-mediated thrombocytopenia in dogs naturally infected by Leishmania infantum. Veterinary Record 2009, 164(25):778-782.
13. Cortese L., Terrazzano G., Piantedosi D., Sica M., Prisco M., Ruggiero G., Ciaramella P. Prevalence of anti-platelet antibodies in dogs naturally co-infected by Leishmania infantum and Ehrlichia canis. The Veterinary Journal 2011, 188:118-121.
14. Costa F.A., Goto H., Saldanha L.C., Silva S.M., Sinhorini I.L., Silva T.C., Guerra J.L. Histopathologic patterns of nephropathy in naturally acquired canine visceral leishmaniasis. Veterinary Pathology 2003, 40:677-684.
15. Coura-Vital W., Marques M.J., Giunchetti R.C., Teixeira-Carvalho A., Moreira N.D., Vitoriano-Souza J., Vieira P.M., Carneiro C.M., Corrêa-Oliveira R., Martins-Filho O.A., Carneiro M., Reis A.B. Humoral and cellular immune response in dogs with inapparent natural Leishmania infantum infection. The Veterinary Journal 2011, 190(2):e43-e47.
16. Curiel T.J., Coukos G., Zou L., Alvarez X., Cheng P., Mottram P., Evdemon-Hogan M., Conejo-Garcia J.R., Zhang L., Burow M., Zhu Y., Wei S., Kryczek I., Daniel B., Gordon A., Myers L., Lackner A., Disis M., Knutson K., Chen L., Zou W. Specific recruitment of regulatory T cells in ovarian carcinoma fosters immune privilege and predicts reduced survival. Nature Medicine 2004, 10:942-949.
17. de Lima V.M.F., Ikeda F.A., Rossi C.N., Feitosa M.M., de Oliveira Vasconcelos R., Nunes C.M., Goto H. Diminished CD4+/CD25+ T cell and increased IFN- levels occur in dogs vaccinated with Leishmune in an endemic area for visceral leishmaniasis. Veterinary Immunology and Immunopathology 2010, 135:296-302.
18. Ferrer L. Leishmaniasis. XI Current Veterinary Therapy 1992, 266. W.B. Saunders, Philadelphia. R.W. Kirk, J.D. Bonagura (Eds.).
19. Gradoni L., Gramiccia M. Leishmaniosis. OIE Manual of Diagnostic tests and vaccines for terrestrial animals (mammals, birds and bees) 2008, 240-250. Office International des Epizooties, Paris. sixth ed. V. Daniel (Ed.).
20. Guarga J.L., Moreno J., Lucientes J., Gracia M.J., Peribanez M.A., Alvar J., Castillo J.A. Canine leishmaniasis transmission: higher infectivity amongst naturally infected dogs to sand flies is associated with lower proportions of T helper cells. Research Veterinary Science 2000, 69:249-253.
21. Guarga J.L., Moreno J., Lucientes J., Gracia M.J., Peribanez M.A., Castillo J.A. Evaluation of a specific immunochemotherapy for the treatment of canine visceral leishmaniasis. Veterinary Immunology and Immunopathology 2002, 88:13-20.
22. Guerra L.L., Teixeira-Carvalho A., Giunchetti R.C., Martins-Filho O.A., Reis A.B., Correa-Oliveira R. Evaluation of the influence of tissue parasite density on hematological and phenotypic cellular parameters of circulating leukocytes and splenocytes during ongoing canine visceral leishmaniasis. Parasitology Research 2009, 104(3):611-622.
23. Houriuchi Y., Tominaga M., Ichikawa M., Yamashita M., Jikumaru Y., Nariai Y., Nakajima Y., Kuwabara M., Yukawa M. Increase of regulatory T cells in the peripheral blood of dogs with metastatic tumors. Microbiology and Immunology 2009, 53:468-474.
24. + T cells. European Journal of Immunology 2012, 42:69-79.
25. + regulatory CD8 T cells in human peripheral blood. PLoS One 2013, 8:1-10.
26. Huehn J., Hamann A. Homing to suppress: address codes for Treg migration. Trends in Immunology 2005, 26:632-636.
27. Inokuma H., Ohono K., Onischi T., Raoult D., Brouqui P. Detection of ehrlichial infection by PCR in dogs from Yamaguchi and Okinawa Prefectures, Japan. Journal of Veterinary Medical Science 2001, 63:815-817.
28. Kaye P., Scott P. Leishmaniasis: complexity at the host-pathogen interface. Nature Reviews Microbiology 2011, 9(8):604-615.
29. Kharazmi A., Rezai H.R., Fani M., Behforouz N.C. Evidence for the presence of circulating immune complexes in serum and C3b and C3d on red cells of kala-azar patients. Transaction of Royal Society of Tropical Medicine and Hygiene 1982, 76:793-796.
30. Koutinas A.F., Polizopoulou Z.S., Saridomichelakis M.N., Argyriadis D., Fytianou A., Plevraki K.G. Clinical consideration on canine visceral leishmaniasis in Greece: a retrospective study of 158 cases (1989-1996). Journal of American Animal Hospital Association 1999, 35:376-383.
31. Maia C., Campino L. Cytokine and phenotypic cell profiles of Leishmania infantum infection in the dog. Journal of Tropical Medicine 2012, 2012:1-7.
32. Maurya R., Kumar R., Kumar Prajapati V., Das Manandhar K., Sacks D., Sundar S., Nylen S. Human visceral leishmaniasis is not associated with expansion or accumulation of Foxp3+ CD4 cells in blood or spleen. Parasite Immunology 2010, 32(7):479-483.
33. Miller M.J., Safrina O., Parker I., Cahalan M.D. Imaging the single cell dynamics of CD4T Cell activation by dendritic cells in lymph nodes. Journal of Experimental Medicine 2004, 200:847-856.
34. Miranda S., Martorell S., Costa M., Ferrer L., Ramis A. Characterization of circulating lymphocyte subpopulations in canine leishmaniasis throughout treatment with antimonials and allopurinol. Veterinary Parasitology 2007, 144:251-260.
35. Moreno J., Nieto J., Chamizo C., Gonzalez F., Blanco F., Barker D.C., Alvar J. The immune responses in dogs with canine visceral leishmaniasis before and after, chemotherapy. Veterinary Immunology and Immunopathology 1999, 71:181-195.
36. + (Foxp3) regulatory cells in human in human visceral leishmaniasis. TRENDS in Immunology 2007, 28(9):378-384.
37. Oliva G., Scalone A., Foglia Manzillo V., Gramiccia M., Pagano A., Di Muccio T., Gradoni L. Incidence and time course of Leishmania infantum infections examined by parasitological, serological and Nested-PCR techniques in a cohort of naïve dogs exposed to three consecutive transmission seasons. Journal of Clinical Microbiology 2006, 44(4):1318-1322.
38. Olsen I., Sollid L.M. Pittfals in determining the cytokine profile of human T cell. Journal of Immunological Methods 2013, 390:106-112.
39. O'Neill K., Guth A., Biller B.J., Elmslie R.E., Dow S.W. Changes in regulatory T cells in dog with cancer and associations with tumor type. Journal Veterinary Internal Medicine 2009, 23:875-881.
40. Ordeix L., Solano-Gallego L., Fondevila D., Ferrer L., Fondati A. Papular dermatitis due to Leishmania spp. infection in dogs with parasite-specific cellular immune responses. Veterinary Dermatology 2005, 16:187-191.
41. Papadogiannakis E.I., Kontos V.I., Tamamidou M., Roumeliotou A. Determination of intracellular cytokines IFN- and IL-4 in canine T lymphocytes by flow cytometry following whole-blood culture. The Canadian Journal of Veterinary Research 2009, 73:137-143.
42. + T cells in the peripheral blood of dogs with leishmaniasis before and after prolonged allopurinol monotherapy. The Veterinary Journal 2010, 186:262-263.
43. Petersen C.A., Barr S.C. Canine leishmaniasis in North America: emerging or newly recognized?. Veterinary Clinical North America Small Animal Practice 2009, 39(6):1065-1074.
44. Reis A.B., Teixeira-Carvalho A., Giunchetti R.C., Guerra L.L., Carvalho M.G., Mayrink W., Genaro O., Correa-Oliveira R., Martins-Filho O.A. Phenotypic features of circulating leucocytes as immunological markers for clinical status and bone marrow parasite density in dogs naturally infected by Leishmania chagasi. Clinical and Experimental Immunology 2006, 146:303-311.
45. Reis A.B., Martins-Filho O.A., Teixeira-Carvalho A., Giunchetti R.C., Carneiro C.M., Mayrink W., Tafuri W.L., Corrêa-Oliveira R. Systemic and compartmentalized immune response in canine visceral leishmaniasis. Veterinary Immunology and Immunopathology 2009, 128:87-95.
46. Rissetto K.C., Rindt H., Selting K.A., Villamil J.A., Henry C.J., Reinero C.R. Cloning and expression of canine CD25 for validation of anti-human CD25 antibody to compare T regulatory lymphocytes in healthy dogs and dogs with osteosarcoma. Veterinary Immunology Immunopathology 2010, 135:137-145.
47. Rodrigues O.R., Marques C., Soares-Clemente M., Ferronha M.H., Santos-Gomes G.M. Identification of regulatory T cells during experimental Leishmania infantum infection. Immunobiology 2009, 214:101-111.
48. + regulatory T cells in immunological tolerance to self and nonself. Nature Immunology 2005, 6:345-352.
49. Solano-Gallego L., Koutinas A., Miró G., Cardoso L., Pennisi M.G., Ferrer L., Bourdeau P., Oliva G., Baneth G. Directions for the diagnosis, clinical staging, treatment and prevention of canine leishmaniosis. Veterinary Parasitology 2009, 165:1-18.
50. Strauss-Ayali D., Baneth G., Jaffe C.L. Splenic immune responses during canine visceral leishmaniasis. Veterinary Research 2007, 38:547-564.
51. Terrazzano G., Sica M., Becchimanzi C., Costantini S., Rotoli B., Zappacosta S., Alfinito F., Ruggiero G. T cells from paroxysmal nocturnal haemoglobinuria (PNH) patients show an altered CD40-dependent pathway. Journal of Leukocyte Biology 2005, 78:27-36.
52. Terrazzano G., Cortese L., Piantedosi D., Zappacosta S., Di Loria A., Santoro D., Ruggiero G., Ciaramella P. Presence of anti-platelet IgM and IgG antibodies in dogs naturally infected by Leishmania infantum. Veterinary Immunology and Immunopathology 2006, 110:331-337.
53. Van Eys G.J., Schoone G.J., Kroon N.C., Ebeling S.B. Sequence analysis of small subunit ribosomal RNA genes and its use for detection and identification of Leishmania parasites. Molecular and Biochemical Parasitology 1992, 51:133-142.