Human visceral leishmaniasis is not associated with expansion or accumulation of Foxp3+ CD4 cells in blood or spleen

Parasite Immunology

Volumn 32, Issue 7, 2010, Pages 479-483

  Maurya, R ^a,b   Kumar, R ^a   Prajapati, V K ^a   Manandhar, K D ^a   Sacks, D ^c   Sundar, S ^a   Nylén, Susanne ^a,d  

^a BANARAS HINDU UNIVERSITY   (India)

^b UNIVERSITY OF HYDERABAD   (India)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

^d KAROLINSKA INSTITUTE   (Sweden)

Author keywords

CD4; Foxp3; Leishmania; Spleen; T cells; Visceral leishmaniasis

Indexed keywords

MESSENGER RNA; TRANSCRIPTION FACTOR FOXP3; FORKHEAD TRANSCRIPTION FACTOR; FOXP3 PROTEIN, HUMAN; IL2RA PROTEIN, HUMAN; INTERLEUKIN 2 RECEPTOR ALPHA;

ADULT; ARTICLE; CD25+ T LYMPHOCYTE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; FEMALE; FLOW CYTOMETRY; FLUORESCENCE ACTIVATED CELL SORTING; HUMAN; IMMUNOSUPPRESSIVE TREATMENT; LEISHMANIA; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY T LYMPHOCYTE; SPLEEN; VISCERAL LEISHMANIASIS; BLOOD; CD4+ T LYMPHOCYTE; CELL CULTURE; CHEMISTRY; IMMUNOLOGY;

ADULT; BLOOD; CD4-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; FEMALE; FLOW CYTOMETRY; FORKHEAD TRANSCRIPTION FACTORS; HUMANS; INTERLEUKIN-2 RECEPTOR ALPHA SUBUNIT; LEISHMANIASIS, VISCERAL; MALE; SPLEEN; T-LYMPHOCYTES, REGULATORY;

EID: 77953519663     PISSN: 01419838     EISSN: 13653024     Source Type: Journal    
DOI: 10.1111/j.1365-3024.2010.01219.x     Document Type: Article

References (13)

1. Ghalib H.W., Whittle J.A., Kubin M., et al. IL-12 enhances Th1-type responses in human Leishmania donovani infections. J Immunol 1995 154: 4623 4629.
2. Sacks D.L., Lal S.L., Shrivastava S.N., Blackwell J Neva F.A. An analysis of T cell responsiveness in Indian kala-azar. J Immunol 1987 138: 908 913.
3. Roncador G., Brown P.J, Maestre L., et al. Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level. Eur J Immunol 2005 35: 1681 1691.
4. Belkaid Y., Piccirillo C.A., Mendez S., Shevach E.M Sacks D.L. CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity. Nature 2002 420: 502 507.
5. Rodrigues O.R., Marques C., Soares-Clemente M, Ferronha M.H Santos-Gomes G.M. Identification of regulatory T cells during experimental Leishmania infantum infection. Immunobiology 2009 214: 101 111.
6. Bourreau E., Ronet C., Darsissac E., et al. In leishmaniasis due to Leishmania guyanensis infection, distinct intralesional interleukin-10 and Foxp3 mRNA expression are associated with unresponsiveness to treatment. J Infect Dis 2009 199: 576 579.
7. Campanelli A.P., Roselino A.M., Cavassani K.A., et al. CD4+CD25+ T cells in skin lesions of patients with cutaneous leishmaniasis exhibit phenotypic and functional characteristics of natural regulatory T cells. J Infect Dis 2006 193: 1313 1322.
8. Nylen S., Maurya R., Eidsmo L., Manandhar K.D., Sundar S. Sacks D. Splenic accumulation of IL-10 mRNA in T cells distinct from CD4+CD25+ (Foxp3) regulatory T cells in human visceral leishmaniasis. J Exp Med 2007 204: 805 817.
9. Saha S., Mondal S., Ravindran R., et al. IL-10-and TGF-beta-mediated susceptibility in kala-azar and post-kala-azar dermal leishmaniasis: the significance of amphotericin B in the control of Leishmania donovani infection in India. J Immunol 2007 179: 5592 5603.
10. Walker M.R., Kasprowicz D.J., Gersuk V.H., et al. Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25-T cells. J Clin Invest 2003 112: 1437 1443.
11. Sakaguchi S Powrie F. Emerging challenges in regulatory T cell function and biology. Science 2007 317: 627 629.
12. Anderson C.F., Lira R., Kamhawi S., Belkaid Y., Wynn T.A Sacks D. IL-10 and TGF-beta control the establishment of persistent and transmissible infections produced by Leishmania tropica in C57BL/6 mice. J Immunol 2008 180: 4090 4097.
13. Anderson C.F., Oukka M., Kuchroo V.J Sacks D. CD4(+)CD25(-) Foxp3(-) Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis. J Exp Med 2007 204: 285 297.