Magnetic separations in biotechnology

Biotechnology Advances

Volumn 31, Issue 8, 2013, Pages 1374-1385

  Borlido, L ^a   Azevedo, A M ^a   Roque, A C A ^b   Aires Barros, M R ^a  

^a INSTITUTO SUPERIOR TÉCNICO   (Portugal)

^b UNIVERSIDADE NOVA DE LISBOA   (Portugal)

Author keywords

Automation; Magnetic particles; Magnetic separations; Purification; Synthesis

Indexed keywords

BIO SEPARATION; CRUDE SAMPLES; MAGNETIC ADSORBENTS; MAGNETIC PARTICLE; SCALE-UP; SEPARATION PROCESS; SEPARATION TECHNIQUES;

AUTOMATION; BIOTECHNOLOGY; NUCLEIC ACIDS; PURIFICATION; SYNTHESIS (CHEMICAL); VIRUSES;

MAGNETIC SEPARATION;

AUTOMATION; BIOTECHNOLOGY; NUCLEIC ACID; PURIFICATION; SEPARATION;

MAGNETITE NANOPARTICLE; NUCLEIC ACID; PROTEIN;

AUTOMATION; BIOTECHNOLOGY; ISOLATION AND PURIFICATION; MAGNETIC FIELD; MAGNETIC PARTICLES; MAGNETIC SEPARATIONS; PURIFICATION; REVIEW; SYNTHESIS;

AUTOMATION; MAGNETIC PARTICLES; MAGNETIC SEPARATIONS; PURIFICATION; SYNTHESIS;

BIOTECHNOLOGY; MAGNETIC FIELDS; MAGNETITE NANOPARTICLES; NUCLEIC ACIDS; PROTEINS;

EID: 84887995428     PISSN: 07349750     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biotechadv.2013.05.009     Document Type: Review

References (165)

1. Adalsteinsson O., Lamotte A., Baddour R.F., Colton C.K., Pollak A., Whitesides G.M. Preparation and magnetic filtration of polyacrylamide gels containing covalently ommobilized proteins and a ferrofluid. J Mol Catal 1979, 6:199-225.
2. Al-Deen F.N., Ho J., Selomulya C., Ma C., Coppel R. Superparamagnetic nanoparticles for effective delivery of malaria DNA vaccine. Langmuir 2011, 27:3703-3712.
3. An X., Su Z., Zeng H. Preparation of highly magnetic chitosan particles and their use for affinity purification of enzymes. J Chem Technol Biotechnol 2003, 78:596-600.
4. Babes L., Denizot B., Tanguy G., Le Jeune J.J., Jallet P. Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study. J Colloid Interface Sci 1999, 212:474-482.
5. Batalha I.L., Hussain A., Roque A.C.A. Gum Arabic coated magnetic nanoparticles with affinity ligands specific for antibodies. J Mol Recognit 2010, 23:462-471.
6. BCCResearch Biologic Therapeutic Drugs: Technologies and Global Markets 2011.
7. Becker J.S., Thomas O.R.T., Franzreb M. Protein separation with magnetic adsorbents in micellar aqueous two-phase systems. Sep Purif Technol 2009, 65:46-53.
8. Bee A., Massart R., Neveu S. Synthesis of very fine maghemite particles. J Magn Magn Mater 1995, 149:6-9.
9. Bimboim H.C., Doly J. A rapid alkaline extraction procedure for screening recombinant plasmid DNA. Nucleic Acids Res 1979, 7:1513-1523.
10. Borlido L., Azevedo A.M., Sousa A.G., Oliveira P.H., Roque A.C.A., Aires-Barros M.R. Fishing human monoclonal antibodies from a CHO cell supernatant with boronic acid magnetic particles. J Chromatogr B 2012, 903:163-170.
11. Borlido L., Moura L., Azevedo A.M., Roque A.C.A., Aires-Barros M.R., Farinha J.P.S. Stimuli-responsive magnetic nanoparticles for monoclonal antibody purification. Biotechnol J 2013, 10.1002/biot.201200329.
12. Braconnot S., Eissa M.M., Elaissari A. Morphology control of magnetic latex particles prepared from oil in water ferrofluid emulsion. Colloid Polym Sci 2013, 291:193-203.
13. Brown G.N. Advances in magnetic particle based bioprocessing 2008, University of Birmingham, [PhD Thesis].
14. Butterworth M.D., Bell S.A., Armes S.P., Simpson A.W. Synthesis and characterization of polypyrrole - magnetite-silica particles. J Colloid Interface Sci 1996, 183:91-99.
15. Butterworth M.D., Illum L., Davis S.S. Preparation of ultrafine silica- and PEG-coated magnetite particles. Colloids Surf A Physicochem Eng Asp 2001, 179:93-102.
16. Can K., Ozmen M., Ersoz M. Immobilization of albumin on aminosilane modified superparamagnetic magnetite nanoparticles and its characterization. Colloids Surf B Biointerfaces 2009, 71:154-159.
17. Cao Y., Bai G., Chen J., Tian W., Wang S., Yang W. Preparation and characterization of magnetic microspheres for the purification of interferon α-2b. J Chromatogr B 2006, 833:236-244.
18. Cao Y., Tian W., Gao S., Yu Y., Yang W., Bai G. Immobilization staphylococcal protein A on magnetic cellulose microspheres for IgG affinity purification. Artif Cells Blood Substit Biotechnol 2007, 35:467-480.
19. Cao Y., Zhang Q., Wang C., Zhu Y., Bai G. Preparation of novel immunomagnetic cellulose microspheres via cellulose binding domain-protein A linkage and its use for the isolation of interferon α-2b. J Chromatogr A 2007, 1149:228-235.
20. Chang W.-S., Shang H., Perera R.M., Lok S.-M., Sedlak D., Kuhn R.J., et al. Rapid detection of dengue virus in serum using magnetic separation and fluorescence detection. Analyst 2008, 133:233-240.
21. Chaplin M.F., Kennedy J.F. Magnetic, immobilised derivatives of Enzymes. Carbohydr Res 1976, 50:267-274.
22. Chen G.D., Alberts C.J., Rodriguez W., Toner M. Concentration and purification of human immunodeficiency virus Type 1 virions by microfluidic separation of superparamagnetic nanoparticles. Anal Chem 2009, 82:723-728.
23. Chen S., Reynolds F., Yu L., Weissleder R., Josephson L. A screening paradigm for the design of improved polymer-coated superparamagnetic iron oxide nanoparticles. J Mater Chem 2009, 19.
24. Cheng C., Wen Y., Xu X., Gu H. Tunable synthesis of carboxyl-functionalized magnetite nanocrystal clusters with uniform size. J Mater Chem 2009, 19.
25. Choesmel V., Anract P., Høifødt H., Thiery J.-P., Blin N. A relevant immunomagnetic assay to detect and characterize epithelial cell adhesion molecule-positive cells in bone marrow from patients with breast carcinoma. Cancer 2004, 101:693-703.
26. Claesson E.M., Philipse A.P. Monodisperse magnetizable composite silica spheres with tunable dipolar interactions. Langmuir 2005, 21:9412-9419.
27. Corchero J.L., Villaverde A. Biomedical applications of distally controlled magnetic nanoparticles. Trends Biotechnol 2009, 27:468-476.
28. Cornell R.M., Schwertmann U. The iron oxides: structure, properties, reactions, occurrences and uses 2003, Wiley-VCH. 2nd ed.
29. Corot C., Robert P., Idée J.-M., Port M. Recent advances in iron oxide nanocrystal technology for medical imaging. Adv Drug Deliv Rev 2006, 58:1471-1504.
30. Cristea I.M., Williams R., Chait B.T., Rout M.P. Fluorescent proteins as proteomic probes. Mol Cell Proteomics 2005, 4:1933-1941.
31. Cristea I.M., Carroll J.-W.N., Rout M.P., Rice C.M., Chait B.T., MacDonald M.R. Tracking and elucidating alphavirus-host protein interactions. J Biol Chem 2006, 281:30269-30278.
32. Daou T.J., Pourroy G., Bégin-Colin S., Grenèche J.M., Ulhaq-Bouillet C., Legaré P., et al. Hydrothermal synthesis of monodisperse magnetite nanoparticles. Chem Mater 2006, 18:4399-4404.
33. Dawes C.C., Jewess P.J., Murray D.A. Thiophilic paramagnetic particles as a batch separation medium for the purification of antibodies from various source materials. Anal Biochem 2005, 338:186-191.
34. de Vantery Arrighi C., Lucas H., Chardonnens D., de Agostini A. Removal of spermatozoa with externalized phosphatidylserine from sperm preparation in human assisted medical procreation: effects on viability, motility and mitochondrial membrane potential. Reprod Biol Endocrinol 2009, 7:1.
35. Decun S., Jiaxiu S., Sha L., Qingshu L., Youfeng H., Yuxiao W., et al. Preparation of magnetic particle antibodies for radioimmunoassay and immunoradiometric assay of thyroid related hormones. J Radioanal Nucl Chem 1996, 206:189-200.
36. Deggerdal A.H., Larsen F. Isolation of nucleic acid. Invitrogen Dynal AS 2007.
37. Diettrich O., Mills K., Johnson A.W., Hasilik A., Winchester B.G. Application of magnetic chromatography to the isolation of lysosomes from fibroblasts of patients with lysosomal storage disorders. FEBS Lett 1998, 441:369-372.
38. Ditsch A., Laibinis P.E., Wang D.I.C., Hatton T.A. Controlled clustering and enhanced stability of polymer-coated magnetic nanoparticles. Langmuir 2005, 21:6006-6018.
39. Ditsch A., Lindenmann S., Laibinis P.E., Wang D.I.C., Hatton T.A. High-gradient magnetic separation of magnetic nanoclusters. Ind Eng Chem Res 2005, 44:6824-6836.
40. Ditsch A., Yin J., Laibinis P.E., Wang D.I.C., Hatton T.A. Ion-exchange purification of proteins using magnetic nanoclusters. Biotechnol Prog 2006, 22:1153-1162.
41. Dou J., Zhang Q., Ma M., Gu J. Fast fabrication of epoxy-functionalized magnetic polymer core-shell microspheres using glycidyl methacrylate as monomer via photo-initiated miniemulsion polymerization. J Magn Magn Mater 2012, 324:3078-3082.
42. Dunnill P., Lilly M.D. Purification of enzymes using magnetic bio-affinity materials. Biotechnol Bioeng 1974, 16:987-990.
43. Fauconnier N., Bée A., Roger J., Pons J.N. Synthesis of aqueous magnetic liquids by surface complexation of maghemite nanoparticles. J Mol Liq 1999, 83:233-242.
44. Gao J., Li Z., Russell T., Li Z. Antibody affinity purification using metallic nickel particles. J Chromatogr B 2012, 895-896:89-93.
45. Gellf G., Boudrant J. Enzymes immobilized on a magnetic support: preliminary study of a fluidized bed enzyme reactor. Biochim Biophys Acta (BBA) Enzymol 1974, 334:467-470.
46. Goloverda G., Jackson B., Kidd C., Kolesnichenko V. Synthesis of ultrasmall magnetic iron oxide nanoparticles and study of their colloid and surface chemistry. J Magn Magn Mater 2009, 321:1372-1376.
47. Gomes C.S.G. Advances in high-gradient magnetic fishing for bioprocessing 2006, Technical University of Denmark, [PhD Thesis].
48. Gorchakov R., Garmashova N., Frolova E., Frolov I. Different types of nsP3-containing protein complexes in Sindbis virus-infected cells. J Virol 2008, 82:10088-10101.
49. Gotić M., Jurkin T., Musić S. Factors that may influence the micro-emulsion synthesis of nanosize magnetite particles. Colloid Polym Sci 2007, 285:793-800.
50. Gupta A.K., Gupta M. Cytotoxicity suppression and cellular uptake enhancement of surface modified magnetic nanoparticles. Biomaterials 2005, 26:1565-1573.
51. Halling P.J., Dunnill P. Improved nonporous magnetic supports for immobilized enzymes. Biotechnol Bioeng 1979, 21:393-416.
52. Heebøll-Nielsen A., Dalkiær M., Hubbuch J.J., Thomas O.R.T. Superparamagnetic adsorbents for high-gradient magnetic fishing of lectins out of legume extracts. Biotechnol Bioeng 2004, 87:311-323.
53. Hofmann I., Schnölzer M., Kaufmann I., Franke W.W. Symplekin, a constitutive protein of karyo- and cytoplasmic particles involved in mRNA biogenesis in Xenopus laevisoocytes. Mol Biol Cell 2002, 13:1665-1676.
54. Holschuh K., Schwämmle A. Preparative purification of antibodies with protein A-an alternative to conventional chromatography. J Magn Magn Mater 2005, 293:345-348.
55. Horák D., Lednický F., Petrovský E., Kapička A. Magnetic characteristics of ferrimagnetic microspheres prepared by dispersion polymerization. Macromol Mater Eng 2004, 289:341-348.
56. Horák D., Babič M., Macková H., Beneš M.J. Preparation and properties of magnetic nano- and microsized particles for biological and environmental separations. J Sep Sci 2007, 30:1751-1772.
57. Horisberger M. Immobilization of protein and polysaccharide on magnetic particles: selective binding of microorganisms by concanavalin A-magnetite. Biotechnol Bioeng 1976, 18:1647-1651.
58. Hornig-Do H.-T., Günther G., Bust M., Lehnartz P., Bosio A., Wiesner R.J. Isolation of functional pure mitochondria by superparamagnetic microbeads. Anal Biochem 2009, 389:1-5.
59. Iannone A., Magin R.L., Walczak T., Federico M., Swartz H.M., Tomasi A., et al. Blood clearance of dextran magnetite particles determined by a noninvasive in vivo ESR method. Magn Reson Med 1991, 22:435-442.
60. Iwata A., Satoh K., Murata M., Hikata M., Hayakawa T., Yamaguchi T. Virus concentration using sulfonated magnetic beads to improve sensitivity in nucleic acid amplification tests. Biol Pharm Bull 2003, 26:1065-1069.
61. Jiang W., Wu Y., He B., Zeng X., Lai K., Gu Z. Effect of sodium oleate as a buffer on the synthesis of superparamagnetic magnetite colloids. J Colloid Interface Sci 2010, 347:1-7.
62. Kang S., Choi I., Lee K.-B., Kim Y. Bioconjugation of poly(poly(ethylene glycol) methacrylate)-coated iron oxide magnetic nanoparticles for magnetic capture of target proteins. Macromol Res 2009, 17:259-264.
63. Kim D.K., Mikhaylova M., Wang F.H., Kehr J., Bjelke B., Zhang Y., et al. Starch-coated superparamagnetic nanoparticles as MR contrast agents. Chem Mater 2003, 15:4343-4351.
64. Kuczewski M., Schirmer E., Lain B., Zarbis-Papastoitsis G. A single-use purification process for the production of a monoclonal antibody produced in a PER.C6 human cell line. Biotechnol J 2011, 6:56-65.
65. Kumar C.S.S.R., Mohammad F. Magnetic nanomaterials for hyperthermia-based therapy and controlled drug delivery. Adv Drug Deliv Rev 2011, 63:789-808.
66. Lange B.M.H., Bachi A., Wilm M., Gonzalez C. Hsp90 is a core centrosomal component and is required at different stages of the centrosome cycle in Drosophila and vertebrates. EMBO J 2000, 19:1252-1262.
67. Langer E.S. Biosimilars' Technology Needs. BioPharm Int 2011, 16-19.
68. Lawson E.L., Clifton J.G., Huang F., Li X., Hixson D.C., Josic D. Use of magnetic beads with immobilized monoclonal antibodies for isolation of highly pure plasma membranes. Electrophoresis 2006, 27:2747-2758.
69. Lee J., Isobe T., Senna M. Preparation of ultrafine Fe3O4 particles by precipitation in the presence of PVA at high pH. J Colloid Interface Sci 1996, 177:490-494.
70. Liabakk N.-B., Nustad K., Espevik T. A rapid and sensitive immunoassay for tumor necrosis factor using magnetic monodisperse polymer particles. J Immunol Methods 1990, 134:253-259.
71. Liang S., Wang Y., Yu J., Zhang C., Xia J., Yin D. Surface modified superparamagnetic iron oxide nanoparticles: as a new carrier for bio-magnetically targeted therapy. J Mater Sci Mater Med 2007, 18:2297-2302.
72. Liu X., Guan Y., Ma Z., Liu H. Surface modification and characterization of magnetic polymer nanospheres prepared by miniemulsion polymerization. Langmuir 2004, 20:10278-10282.
73. Liu X., Guan Y., Yang Y., Ma Z., Wu X., Liu H. Preparation of superparamagnetic immunomicrospheres and application for antibody purification. J Appl Polym Sci 2004, 94:2205-2211.
74. Liu X., Ma Z., Xing J., Liu H. Preparation and characterization of amino-silane modified superparamagnetic silica nanospheres. J Magn Magn Mater 2004, 270:1-6.
75. Liu Z.L., Yang X.B., Yao K.L., Du G.H., Liu Z.S. Preparation and characterization of magnetic P(St-co-MAA-co-AM) microspheres. J Magn Magn Mater 2006, 302:529-535.
76. Liu H., Xu F., Li L., Wang Y., Qiu H. A novel CoFe2O4/polyacrylate nanocomposite prepared via an in situ polymerization in emulsion system. React Funct Polym 2009, 69:43-47.
77. Lüers G.H., Hartig R., Mohr H., Hausmann M., Fahimi H.D., Cremer C., et al. Immuno-isolation of highly purified peroxisomes using magnetic beads and continuous immunomagnetic sorting. Electrophoresis 1998, 19:1205-1210.
78. Ma Z.Y., Guan Y.P., Liu X.Q., Liu H.Z. Synthesis of magnetic chelator for high-capacity immobilized metal affinity adsorption of protein by cerium initiated graft polymerization. Langmuir 2005, 21:6987-6994.
79. Ma Z., Guan Y., Liu H. Synthesis and characterization of micron-sized monodisperse superparamagnetic polymer particles with amino groups. J Polym Sci A Polym Chem 2005, 43:3433-3439.
80. Ma H.-l., Qi X.-R., Maitani Y., Nagai T. Preparation and characterization of superparamagnetic iron oxide nanoparticles stabilized by alginate. Int J Pharm 2007, 333:177-186.
81. Markillie L.M., Lin C.-T., Adkins J.N., Auberry D.L., Hill E.A., Hooker B.S., et al. Simple protein complex purification and identification method for high-throughput mapping of protein interaction networks. J Proteome Res 2005, 4:268-274.
82. Massart R. Preparation of aqueous magnetic liquids in alkaline and acidic media. IEEE Trans Magn 1981, 17:1247-1248.
83. Matsuno R., Yamamoto K., Otsuka H., Takahara A. Polystyrene- and poly(3-vinylpyridine)-grafted magnetite nanoparticles prepared through surface-initiated nitroxide-mediated radical polymerization. Macromolecules 2004, 37:2203-2209.
84. McKay M.S., Olson E., Hesla M.A., Panyutich A., Ganz T., Perkins S., et al. Immunomagnetic recovery of human neutrophil defensins from the human gingival crevice. Oral Microbiol Immunol 1999, 14:190-193.
85. Melville D., Paul F., Roath S. High gradient magnetic separation of red cells from whole blood. IEEE Trans Magn 1975, 11:1701-1704.
86. Mendenhall G.D., Geng Y., Hwang J. Optimization of long-term stability of magnetic fluids from magnetite and synthetic polyelectrolytes. J Colloid Interface Sci 1996, 184:519-526.
87. Moeser G.D., Roach K.A., Green W.H., Alan Hatton T., Laibinis P.E. High-gradient magnetic separation of coated magnetic nanoparticles. AIChE J 2004, 50:2835-2848.
88. Mohapatra S., Pramanik P. Synthesis and stability of functionalized iron oxide nanoparticles using organophosphorus coupling agents. Colloids Surf A Physicochem Eng Asp 2009, 339:35-42.
89. Mohr M., Dalmis F., Hilgenfeld E., Oelmann E., Zühlsdorf M., Kratz-Albers K., et al. Simultaneous immunomagnetic CD34+ cell selection and B-cell depletion in peripheral blood progenitor cell samples of patients suffering from B-Cell Non-Hodgkin's lymphoma. Clin Cancer Res 2001, 7:51-57.
90. Molday R.S., Mackenzie D. Immunospecific ferromagnetic iron-dextran reagents for the labeling and magnetic separation of cells. J Immunol Methods 1982, 52:353-367.
91. Molday R.S., Yen S.P.S., Rembaum A. Application of magnetic microspheres in labelling and separation of cells. Nature 1977, 268:437-438.
92. Montagne F., Mondain-Monval O., Pichot C., Elaïssari A. Highly magnetic latexes from submicrometer oil in water ferrofluid emulsions. J Polym Sci A Polym Chem 2006, 44:2642-2656.
93. Munro P.A., Dunnill P., Lilly M.D. Nonporous magnetic materials as enzyme supports: studies with immobilized chymotrypsin. Biotechnol Bioeng 1977, 19:101-124.
94. Mura C.V., Becker M.A.I., Orellana A., Wolff D. Immunopurification of Golgi vesicles by magnetic sorting. J Immunol Methods 2002, 260:263-271.
95. Nagao D., Yokoyama M., Yamauchi N., Matsumoto H., Kobayashi Y., Konno M. Synthesis of Highly Monodisperse Particles Composed of a Magnetic Core and Fluorescent Shell. Langmuir 2008, 24:9804-9808.
96. Nargessi R.D. Magnetic isolation and purification of nucleic acids. Cortex Biochem 2005, [US patent no. 6'855'499].
97. Nedkov I., Merodiiska T., Slavov L., Vandenberghe R.E., Kusano Y., Takada J. Surface oxidation, size and shape of nano-sized magnetite obtained by co-precipitation. J Magn Magn Mater 2006, 300:358-367.
98. Nishio K., Gokon N., Hasegawa M., Ogura Y., Ikeda M., Narimatsu H., et al. Identification of a chemical substructure that is immobilized to ferrite nanoparticles (FP). Colloids Surf B Biointerfaces 2007, 54:249-253.
99. Nishio K., Masaike Y., Ikeda M., Narimatsu H., Gokon N., Tsubouchi S., et al. Development of novel magnetic nano-carriers for high-performance affinity purification. Colloids Surf B Biointerfaces 2008, 64:162-169.
100. Nyiro-Kósa I., Nagy D.C., Pósfai M. Size and shape control of precipitated magnetite nanoparticles. Eur J Mineral 2009, 21:293-302.
101. Odabaşi M., Denizli A. Polyhydroxyethylmethacrylate-based magnetic DNA-affinity beads for anti-DNA antibody removal from systemic lupus erythematosus patient plasma. J Chromatogr B Biomed Sci Appl 2001, 760:137-148.
102. Oh J.K., Park J.M. Iron oxide-based superparamagnetic polymeric nanomaterials: Design, preparation, and biomedical application. Prog Polym Sci 2011, 36:168-189.
103. Otto P. MagneSil™ paramagnetic particles: magnetics for DNA purification. J Assoc Lab Autom 2002, 7:34-37.
104. Özkara S., Akgöl S., Çanak Y., Denizli A. A novel magnetic adsorbent for immunoglobulin-G purification in a magnetically stabilized fluidized bed. Biotechnol Prog 2004, 20:1169-1175.
105. Öztürk N., Emin Günay M., Akgöl S., Denizli A. Silane-modified magnetic beads: application to immunoglobulin G separation. Biotechnol Prog 2007, 23:1149-1156.
106. Parker M.R. The physics of magnetic separation. Contemp Phys 1977, 18:279-306.
107. Perçin I., Karakoç V., Akgöl S., Aksöz E., Denizli A. Poly(hydroxyethyl methacrylate) based magnetic nanoparticles for plasmid DNA purification from Escherichia coli lysate. Mater Sci Eng C 2012, 32:1133-1140.
108. Perrin-Cocon L.A., Marche P.N., Villiers C.L. Purification of intracellular compartments involved in antigen processing: a new method based on magnetic sorting. Biochem J 1999, 338:123-130.
109. Pieters B.R., Williams R.A., Webb C. Magnetic carrier technology. Colloid and Surface Engineering: Applications in the Process Industries 1994, 248-286. Butterworth-Heinemann, Oxford. R.A. Williams (Ed.).
110. Plank C., Zelphati O., Mykhaylyk O. Magnetically enhanced nucleic acid delivery. Ten years of magnetofection-progress and prospects. Adv Drug Deliv Rev 2011, 63:1300-1331.
111. Porter, Robinson, Pickup, Edwards An evaluation of lectin-mediated magnetic bead cell sorting for the targeted separation of enteric bacteria. J Appl Microbiol 1998, 84:722-732.
112. Probst C.E., Zrazhevskiy P., Gao X. Rapid multitarget immunomagnetic separation through programmable DNA linker displacement. J Am Chem Soc 2011, 133:17126-17129.
113. Qian H., Chen M.Q., Lin Z.Y. The effective and specific isolation of antibodies from human serum by using thiophilic paramagnetic polymer beads. Colloids Surf B Biointerfaces 2008, 67:224-229.
114. Qian H., Li C., Zhang Y., Lin Z. Efficient isolation of immunoglobulin G by paramagnetic polymer beads modified with 2-mercapto-4-mythyl-pyrimidine. J Immunol Methods 2009, 343:119-129.
115. Qian H., Lin Z., Xu H., Chen M. The efficient and specific isolation of the antibodies from human serum by thiophilic paramagnetic polymer nanospheres. Biotechnol Prog 2009, 25:376-383.
116. Qian H., Li C., Lin Z., Zhang Y. Using thiophilic magnetic beads in purification of antibodies from human serum. Colloids Surf B Biointerfaces 2010, 75:342-348.
117. Quitadamo I.J., Kostman T.A., Schelling M.E., Franceschi V.R. Magnetic bead purification as a rapid and efficient method for enhanced antibody specificity for plant sample immunoblotting and immunolocalization. Plant Sci 2000, 153:7-14.
118. Rǎcuciu M., Creangǎ D., Airinei A. Citric-acid-coated magnetite nanoparticles for biological applications. Eur Phys J E Soft Matter Biol Phys 2006, 21:117-121.
119. Raghavendra N., Shkriabai N., Graham R., Hess S., Kvaratskhelia M., Wu L. Identification of host proteins associated with HIV-1 preintegration complexes isolated from infected CD4+ cells. Retrovirology 2010, 7:66.
120. Rahimi M., Yousef M., Cheng Y., Meletis E.I., Eberhart R.C., Nguyen K. Formulation and characterization of a covalently coated magnetic nanogel. J Nanosci Nanotechnol 2009, 9:4128-4134.
121. Rahman M.M., Elaissari A. Temperature and magnetic dual responsive microparticles for DNA separation. Sep Purif Technol 2011, 81:286-294.
122. Rahman M.M., Chehimi M.M., Fessi H., Elaissari A. Highly temperature responsive core-shell magnetic particles: synthesis, characterization and colloidal properties. J Colloid Interface Sci 2011, 360:556-564.
123. Robinson P.J., Dunnill P., Lilly M.D. The properties of magnetic supports in relation to immobilized enzyme reactors. Biotechnol Bioeng 1973, 15:603-606.
124. Roca A.G., Morales M.P., Serna C.J. Synthesis of monodispersed magnetite particles from different organometallic precursors. IEEE Trans Magn 2006, 42:3025-3029.
125. Rodrigo F.-P., Manuel A., Clara M., Ricardo I., Jordi A., Jesús S. Highly magnetic silica-coated iron nanoparticles prepared by the arc-discharge method. Nanotechnology 2006, 17:1188.
126. Rossomando E.F., White L.B., Hadjimichael J. Immunomagnetic separation of tumor necrosis factor α: II. In situ procedure for the human gingival space. J Chromatogr B Biomed Sci Appl 1992, 583:19-26.
127. Rossomando E.F., White L.B., Hadjimichael J., Shafer D. Immunomagnetic separation of tumor necrosis factor α: I. Batch procedure for human temporomandibular fluid. J Chromatogr B Biomed Sci Appl 1992, 583:11-18.
128. Rye P.D., Bovin N.V. Selection of carbohydrate-binding cell phenotypes using oligosaccharide-coated magnetic particles. Glycobiology 1997, 7:179-182.
129. Sabatkova Z., Safarikova M., Safarik I. Magnetic ovalbumin and egg white aggregates as affinity adsorbents for lectins separation. Biochem Eng J 2008, 40:542-545.
130. Šafaříková M., Šafařík I. One-step partial purification of Solanum tuberosum tuber lectin using magnetic chitosan particles. Biotechnol Lett 2000, 22:941-945.
131. Sahoo Y., Pizem H., Fried T., Golodnitsky D., Burstein L., Sukenik C.N., et al. Alkyl phosphonate/phosphate coating on magnetite nanoparticles: a comparison with fatty acids. Langmuir 2001, 17:7907-7911.
132. Sakudo A., Ikuta K. Efficient capture of infectious H5 avian influenza virus utilizing magnetic beads coated with anionic polymer. Biochem Biophys Res Commun 2008, 377:85-88.
133. Sakudo A., Baba K., Tsukamoto M., Sugimoto A., Okada T., Kobayashi T., et al. Anionic polymer, poly(methyl vinyl ether-maleic anhydride)-coated beads-based capture of human influenza A and B virus. Bioorg Med Chem 2009, 17:752-757.
134. Satoh K., Iwata A., Murata M., Hikata M., Hayakawa T., Yamaguchi T. Virus concentration using polyethyleneimine-conjugated magnetic beads for improving the sensitivity of nucleic acid amplification tests. J Virol Methods 2003, 114:11-19.
135. Shan Z., Li C., Zhang X., Oakes K.D., Servos M.R., Wu Q., et al. Temperature-dependent selective purification of plasmid DNA using magnetic nanoparticles in an RNase-free process. Anal Biochem 2011, 412:117-119.
136. Shan Z., Li X., Gao Y., Wang X., Li C., Wu Q. Application of magnetic hydroxyapatite nanoparticles for solid phase extraction of plasmid DNA. Anal Biochem 2012, 425:125-127.
137. Shao D., Xia A., Hu J., Wang C., Yu W. Monodispersed magnetite/silica composite microspheres: preparation and application for plasmid DNA purification. Colloids Surf A Physicochem Eng Asp 2008, 322:61-65.
138. Smetak M., Kimmel B., Birkmann J., Schaefer-Eckart K., Einsele H., Wilhelm M., et al. Clinical-scale single-step CD4+ and CD8+ cell depletion for donor innate lymphocyte infusion (DILI). Bone Marrow Transplant 2007, 41:643-650.
139. Smith C.E., York C.K. Methods of isolating biological target materials using silica magnetic particles 2000, Promega Corporation.
140. Sun Z.-X., Su F.-W., Forsling W., Samskog P.-O. Surface characteristics of magnetite in aqueous suspension. J Colloid Interface Sci 1998, 197:151-159.
141. Sun Y.-K., Ma M., Zhang Y., Gu N. Synthesis of nanometer-size maghemite particles from magnetite. Colloids Surf A Physicochem Eng Asp 2004, 245:15-19.
142. Suzuki M., Kamihira M., Shiraishi T., Takeuchi H., Kobayashi T. Affinity partitioning of protein a using a magnetic aqueous two-phase system. J Ferment Bioeng 1995, 80:78-84.
143. Tchikov V., Schütze S. Chapter Five Immunomagnetic Isolation of Tumor Necrosis Factor Receptosomes. Methods in Enzymology 2008, 101-123. Academic Press. Z.Z.R.A.L. Roya Khosravi-Far, P. Mauro (Eds.).
144. Tombácz E., Bica D., Hajdú A., Illés E., Majzik A., Vékás L. Surfactant double layer stabilized magnetic nanofluids for biomedical application. J Phys Condens Matter 2008, 20:204103.
145. Torres Martin de Rosales R., Tavaré R., Glaria A., Varma G., Protti A., Blower P.J. 99mTc-bisphosphonate-iron oxide nanoparticle conjugates for dual-modality biomedical imaging. Bioconjug Chem 2011, 22:455-465.
146. Trexler-Schmidt M., Sze-Khoo S., Cothran A.R., Thai B.Q., Sargis S., Lebreton B., et al. Purification strategies to process 5g/L titers of monoclonal antibodies. BioPharm Int Suppl 2009; March.
147. Uchida E., Kogi M., Oshizawa T., Furuta B., Satoh K., Iwata A., et al. Optimization of the virus concentration method using polyethyleneimine-conjugated magnetic beads and its application to the detection of human hepatitis A, B and C viruses. J Virol Methods 2007, 143:95-103.
148. Ughelstard J., Ellingsen T., Berge A., Helgée B. Magnetic polymer particles and process for the preparation thereof 1983.
149. Van Leemputten E., Horisberger M. Immobilization of enzymes on magnetic particles. Biotechnol Bioeng 1974, 16:385-396.
150. Villanueva A., Cañete M., Roca A.G., Calero M., Veintemillas-Verdaguer S., Serna C.J., et al. The influence of surface functionalization on the enhanced internalization of magnetic nanoparticles in cancer cells. Nanotechnology 2009, 20:115103.
151. Wang X., Gu H., Yang Z. The heating effect of magnetic fluids in an alternating magnetic field. J Magn Magn Mater 2005, 293:334-340.
152. Wang C., Yan J., Cui X., Wang H. Synthesis of raspberry-like monodisperse magnetic hollow hybrid nanospheres by coating polystyrene template with Fe3O4@SiO2 particles. J Colloid Interface Sci 2011, 354:94-99.
153. Williams D., Gold K., Holoman T., Ehrman S., Wilson O. Surface modification of magnetic nanoparticles using gum arabic. J Nanopart Res 2006, 8:749-753.
154. Wittrup A., Zhang S.-H., Svensson K.J., Kucharzewska P., Johansson M.C., Mörgelin M., et al. Magnetic nanoparticle-based isolation of endocytic vesicles reveals a role of the heat shock protein GRP75 in macromolecular delivery. Proc Natl Acad Sci 2010, 107:13342-13347.
155. Wooding A., Kilner M., Lambrick D.B. Studies of the double surfactant layer stabilization of water-based magnetic fluids. J Colloid Interface Sci 1991, 144:236-242.
156. Wotschadlo J., Liebert T., Heinze T., Wagner K., Schnabelrauch M., Dutz S., et al. Magnetic nanoparticles coated with carboxymethylated polysaccharide shells-Interaction with human cells. J Magn Magn Mater 2009, 321:1469-1473.
157. Xu Z.Z., Wang C.C., Yang W.L., Deng Y.H., Fu S.K. Encapsulation of nanosized magnetic iron oxide by polyacrylamide via inverse miniemulsion polymerization. J Magn Magn Mater 2004, 277:136-143.
158. Xu J., Yang H., Fu W., Du K., Sui Y., Chen J., et al. Preparation and magnetic properties of magnetite nanoparticles by sol-gel method. J Magn Magn Mater 2007, 309:307-311.
159. Xu H., Aguilar Z.P., Yang L., Kuang M., Duan H., Xiong Y., et al. Antibody conjugated magnetic iron oxide nanoparticles for cancer cell separation in fresh whole blood. Biomaterials 2011, 32:9758-9765.
160. Yamaura M., Camilo R.L., Sampaio L.C., Macêdo M.A., Nakamura M., Toma H.E. Preparation and characterization of (3-aminopropyl)triethoxysilane-coated magnetite nanoparticles. J Magn Magn Mater 2004, 279:210-217.
161. Yoza B., Arakaki A., Maruyama K., Takeyama H., Matsunaga T. Fully automated DNA extraction from blood using magnetic particles modified with a hyperbranched polyamidoamine dendrimer. J Biosci Bioeng 2003, 95:21-26.
162. Zhang H.-P., Bai S., Xu L., Sun Y. Fabrication of mono-sized magnetic anion exchange beads for plasmid DNA purification. J Chromatogr B 2009, 877:127-133.
163. Zhang Y., Liu J.-Y., Ma S., Zhang Y.-J., Zhao X., Zhang X.-D., et al. Synthesis of PVP-coated ultra-small Fe3O4 nanoparticles as a MRI contrast agent. J Mater Sci Mater Med 2010, 21:1205-1210.
164. Zheng W., Gao F., Gu H. Magnetic polymer nanospheres with high and uniform magnetite content. J Magn Magn Mater 2005, 288:403-410.
165. Zollner T.C.A., Zollner RdL, De Cuyper M., Santana M.H.A. Adsorption of isotype "E" antibodies on affinity magnetoliposomes. J Dispers Sci Technol 2003, 24:615-622.