Desferrioxamine attenuates doxorubicin-induced acute cardiotoxicity through TFG-β/Smad p53 pathway in rat model

Oxidative Medicine and Cellular Longevity

Volumn , Issue , 2012, Pages

  Al Shabanah, Othman A ^a   Aleisa, Abdulaziz M ^a   Hafez, Mohamed M ^a   Al Rejaie, Salim S ^a   Al Yahya, Abdulaziz A ^a   Bakheet, Saleh A ^a   Al Harbi, Mohamed M ^a   Sayed Ahmed, Mohamed M ^a  

^a KING SAUD UNIVERSITY   (Saudi Arabia)

Author keywords

[No Author keywords available]

Indexed keywords

CARDIAC ENZYMES; CARDIOTOXICITY; COMBINED TREATMENT; DESFERRIOXAMINE; DOWN-REGULATION; DOXORUBICIN; FOUR-GROUP; GENES EXPRESSION; INTRAPERITONEALLY; IRON CHELATORS; MRNA EXPRESSION; MRNA EXPRESSION LEVEL; RAT MODEL; REACTIVE OXYGEN SPECIES; SINGLE-DOSE; UP-REGULATION;

CELL DEATH; RATS;

GENE EXPRESSION;

ASPARTATE AMINOTRANSFERASE; COMPLEMENTARY DNA; CREATINE KINASE; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DEFEROXAMINE; DOXORUBICIN; LACTATE DEHYDROGENASE; MESSENGER RNA; PROTEIN MDM2; PROTEIN P53; SMAD PROTEIN; SMAD2 PROTEIN; SMAD4 PROTEIN; SMAD7 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; CARDIOTOXIN; ISOENZYME;

ACUTE TOXICITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CANCER CHEMOTHERAPY; CARDIOTOXICITY; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HEMATOLOGICAL PARAMETERS; MALE; NONHUMAN; RAT; SERUM; SINGLE DRUG DOSE; TREATMENT OUTCOME; ANIMAL; BLOOD; DISEASE MODEL; DRUG EFFECT; GENE EXPRESSION REGULATION; GENETICS; HEART DISEASE; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION; WISTAR RAT;

RATTUS;

ANIMALS; CARDIOTOXINS; DEFEROXAMINE; DISEASE MODELS, ANIMAL; DOXORUBICIN; GENE EXPRESSION REGULATION; HEART DISEASES; ISOENZYMES; MALE; RATS; RATS, WISTAR; SIGNAL TRANSDUCTION; SMAD PROTEINS; TRANSFORMING GROWTH FACTOR BETA; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84861083861     PISSN: 19420900     EISSN: 19420994     Source Type: Journal    
DOI: 10.1155/2012/619185     Document Type: Article

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