Health-promoting properties of artichoke in preventing cardiovascular disease by its lipidic and glycemic-reducing action

Monaldi Archives for Chest Disease - Cardiac Series

Volumn 80, Issue 1, 2013, Pages 17-26

  Rondanelli, Mariangela ^a   Monteferrario, Francesca ^a   Perna, Simone ^a   Faliva, Milena Anna ^a   Opizzi, Annalisa ^a  

^a UNIVERSITY OF PAVIA   (Italy)

Author keywords

Artichoke; Caffeic acid derivatives; Cholesterol; Cynara scolimus; Flavonoids; Glycemia

Indexed keywords

ACRYLIC ACID; AMINO ACID; CAFFEIC ACID; CAFFEIC ACID DERIVATIVE; CALCIUM; CAROTENOID; CHLOROGENIC ACID; CLOFIBRATE; CYNARA SCOLYMUS EXTRACT; CYNARINE; ESSENTIAL OIL; FLAVONOID; INULIN; LACTONE; LUTEOLIN; OXIDOREDUCTASE; PEROXIDASE; POLYACETYLENE; POLYSACCHARIDE; POLYUNSATURATED FATTY ACID; PROTEINASE; QUINIC ACID; SESQUITERPENE LACTONE; STEARIC ACID DERIVATIVE; SUGAR; TRIACYLGLYCEROL; ASCORBINASE; ASPARAGINE; CITRIC ACID; CYNARASE; HYDROXYMETHACRYLIC ACID; LACTIC ACID; LINOLEIC ACID; MAGNESIUM; MALIC ACID; OLEIC ACID; PALMITIC ACID; PLANT MEDICINAL PRODUCT; POTASSIUM; STEARIC ACID; SUCCINIC ACID; TERPENOID; UNCLASSIFIED DRUG; UNINDEXED DRUG; UNSATURATED FATTY ACID;

ABDOMINAL PAIN; ALTERNATIVE MEDICINE; ANTIINFLAMMATORY ACTIVITY; ANTIOXIDANT ACTIVITY; ARTICHOKE; CARDIOVASCULAR DISEASE; CLINICAL PRACTICE; CONSTIPATION; DIARRHEA; DIURETIC ACTIVITY; DYSPEPSIA; FLATULENCE; FRUIT; GALLBLADDER; GLYCEMIC CONTROL; HEALTH CARE PERSONNEL; HEALTH PROMOTION; HUMAN; HUNGER; HYPERCHOLESTEROLEMIA; HYPERLIPIDEMIA; HYPERTRIGLYCERIDEMIA; IRRITABLE COLON; LIPID METABOLISM; LIVER FAILURE; LIVER TOXICITY; MEDICAL RESEARCH; METABOLIC DISORDER; NAUSEA; NONHUMAN; NUTRITION; PLANT LEAF; REVIEW; SIDE EFFECT; THERAPY EFFECT; VOCATIONAL EDUCATION; WEAKNESS; AWARENESS; CHOLERECTIC ACTIVITY; DRUG ACTIVITY; DRUG EFFICACY; HEART PROTECTION; LIVER PROTECTING ACTIVITY; PATIENT EDUCATION; PHYTOCHEMISTRY; TREATMENT INDICATION;

EID: 84887943519     PISSN: 11220643     EISSN: None     Source Type: Journal    
DOI: 10.4081/monaldi.2013.87     Document Type: Review

References (76)

1. Grieve M. A Modern Herbal Vol 1. New York, NY: Dover Publications, 1971.
2. Ernst E. The artichoke a welfare plant with history and future prospects. Naturamed 1995; 10: 30-35.
3. Ward A. The Grocer's Encyclopedia - 1911. New York, NY: Cornell University Library, 2009.
4. Rocchietta S. Pharmaceutic e therapeutic history of the artichoke from antiquity to our time. Minerva Med 1959; 50: 612-618.
5. American Botanical Council and Boston. The Complete German Commission E Monographs: Therapeutic Guide to Herbal Medicines. Austin TX: Blumenthal M, Busse WR, Goldberg A, 1998.
6. Blumenthal M, Goldberg A, Brinkmann J. (Eds.). Herbal Medicine: Expanded Commission E Monographs. Boston MA Integrative Medicine Communications, 2000.
7. th Ed., BHMA Publications; 1996.
8. th Ed., Collection Afssaps, 2005.
9. th Ed., ISS, Roma, 2002.
10. th Ed., EDQM, Bruxelles, 2004.
11. nd Ed., 2003; 118-125.
12. Bradley P. British Herbal Compendium: A Handbook of Scientific Information of Widely Used Plant Drugs. Bournemouth: British Herbal Medicine Association, 2006.
13. nd edition. Silver Spring (MD): American Herbal Products Association; 2000.
14. Brinker F. Herb Contraindications and Drug Interactions. Sandy: Eclectic Medical Publications, 2001.
15. Barnes J, Anderson LA, Phillipson JD. Herbal Medicines. A guide for health-care professionals. London: Pharmaceutical Press, 2002.
16. Sofi F, Abbate R, Gensini GF, Casini A. Which diet for an effective cardiovascular prevention? Monaldi Arch Chest Dis 2012; 78: 60-65.
17. Thompson Coon JS, Ernst E. Herbs for serum cholesterol reduction: a systematic view. J Fam Pract 2003; 52: 468-478.
18. Fratianni F, Tucci M, De Palma M, Pepe R, Nazzaro F. Polyphenolic composition in different parts of some cultivars of globe artichoke (Cynara Scolymus L.). Food Chem 2007; 104: 1282-1286.
19. Wang M, Simon JE, Aviles IF, He K, Zheng QY, Tadmor Y. Analysis of antioxidative phenolic compounds in artichoke (Cynara scolymus L.). J Agric Food Chem 2003; 51: 601-608.
20. Mulinacci N, Prucher D, Peruzzi M, Romani A, Pinelli P, Giaccherini C et al. Commercial and laboratory extracts from artichoke leaves: estimation of caffeoyl esters and flavonoidic compounds content. J Pharm Biomed Anal 2004; 34: 349-357.
21. Chabrol E, Charonnat R, Maximin M, Waitz R. Cholagog action of Cynara scolymus. C R Soc Biol 1931; 108: 1020-1022.
22. Panizzi L, Scarpati ML. Sugli acidi 1,4- e 1,5-dicaffeilchinici. Gazzetta Chimica Italiana. XCV: 1965; 71-82.
23. Slanina J, Táborská E, Bochořáková H, Slaninova I, Humpa O, Robinson W et al. New and facile method of preparation of the anti-HIV-1 agent, 1,3-dicaffeoylquinic acid. Tetrahedron Lett 2001; 42: 3383-3385.
24. Scarpati ML, Esposito P. Isomerizzazione per trans-esterificazione degli acidi 3-,4-e 5-monocaffeilchinici e dei loro metil-esteri. Annali di chimica 1964; 51-55.
25. Bombardelli E, Gabetta B, Martinelli EM. Gas-liquid chromatographic and mass spectrometric investigation on Cynara scolymus extracts. Fitoterapia 1977; 48: 143-152.
26. Nichiforesco E. Variation of caffeic acid type o dihydroxyphenolic derivatives of the artichoke (Cynara scolymus L.) during its period of vegetation. Ann Pharm Fr 1966; 24: 451-456.
27. Fleming T. PDR for Herbal Medicines. Montvale, NJ: Medical Economics Company, 2000.
28. Hammouda FM, Seif el-Nasr MM, Shahat AA. Flavonoids of Cynara scolymus L. cultivated in Egypt. Plant Foods Hum Nutr 1993; 44: 163-169.
29. Nétien G, Roulier A. Standardization of artichoke leaves and of artichoke-based galenicals. Bull Trav Soc Pharm Lyon 1967; 11: 121-133.
30. Constantinescu DG, Platon F, Pavel M. Ingredients of leaves of Romanian acclimatized Cynara scolymus. Pharmazie 1967; 22: 176-178.
31. Hinou J, Harvala C, Philianos S. Polyphenolic substances of Cynara scolymus L. leaves. Ann Pharm Fr 1989; 47: 95-98.
32. Sanchez-Rabaneda F, Jauregui O, Lamuela-Raventos RM, Bastida J, Viladomat F, Codina C. Identification of phenolic compounds in artichoke waste by high-performance liquid chromatography-tandem mass spectrometry. J Chromatogr A 2003; 1008: 57-72.
33. Fraga BM. Natural sesquiterpenoids. Nat Prod Rep 2008; 25: 1180-1209.
34. Schütz K, Persike M, Carle R, Schieber A. Characterization and quantification of anthocyanins in selected artichoke (Cynara scolymus L.) cultivars by HPLC-DAD-ESI-MSn. Anal Bioanal Chem 2006; 384: 1511-1517.
35. Buttery RG, Guadagni DG, Ling LC. Volatile aroma components of cooked artichoke. J Agric Food Chem 1978; 26: 791-793.
36. Granado F, Olmedilla B, Blanco I, Rojas-Hidalgo E. Major fruit and vegetable contributors to the main serum carotenoids in the Spanish diet. Eur J Clin Nutr 1996; 50: 246-250.
37. Choudhary D. Globe artichoke (Cynara scolymus L.) oil: a potential new source of essential polyunsaturated fatty acids. Res Ind 1992; 37: 29-30.
38. Stevens KL, Witt SC, Turner CE. Polyacetylenes in related thistles of the subtribes Centaureinae and Carduinae. Biochem Syst Ecol 1990; 18: 229-232.
39. Bogaert JP, Mortier F, Jouany JM, Pelt JM, Delaveau P. Organic acids, principally acid-alcohols, in Cynara scolymus L. (Compositae). Ann Pharm Fr 1972; 30: 401-408.
40. Lopez-Molina D, Navarro-Martínez MD, Rojas-Melgarejo F, Hiner AN, Chazarra S, Rodriguez-Lopez JN. Molecular properties and prebiotic effect of inulin obtained from artichoke (Cynara scolymus L.). Phytochemistry 2005; 66: 1476-1484.
41. Schütz K, Muks E, Carle R, Schieber A. Separation and quantification of inulin in selected artichoke (Cynara scolymus L.) cultivars and dandelion (Taraxacum officinale WEB. ex WIGG.) roots by high-performance anion exchange chromatography with pulsed amperometric detection. Biomed Chromatogr 2006; 20: 1295-1303.
42. López-Molina D, Hiner ANP, Tudela J, García-Cánovas F, Rodríguez-Lopez JN. Enzymatic removal of phenols from aqueous solution by artichoke (Cynara scolymus L.) extracts. Enzyme Microb Technol 2003; 33: 738-742.
43. Sidrach L, García-Cánovas F, Tudela J, Rodríguez- López JN. Purification of cynarases from artichoke (Cynara scolymus L.): enzymatic properties of cynarase A. Phytochemistry 2005; 66: 41-49.
44. Del Vecchio A. Action of an extract of artichoke (Cynara scolymus) on cholesterol esterase in vitro. Boll Soc Ital Biol Sper 1953; 29: 48-50.
45. Preziosi P, Loscalzo B. Pharmacological properties of 1,4-dicaffeylquinicacid, the active principle of Cynara scolymus. Arch Int Pharmacodyn 1958; 117: 63-80.
46. Preziosi P, Loscalzo B, Marmo E, Miele E. Effects of single or repeated treatment with several anti-cholesterolemic compounds on biliary excretion of cholesterol. Biochem Pharmacol 1960; 5: 251-262.
47. Mancini M, Oriente P, D'Andrea L. Hypocholesterolemic effects of quinic acid 1,4-dicaffein in atherosclerotic patients. In: Garattini S, Paoletti R, eds. Proceedings of the symposium on drugs affecting lipid metabolism. London: Elsevier, 1961: 533-537.
48. Gebhardt R, Fausel M. Antioxidant and hepatoprotective effects of artichoke extracts and constituents in cultured rat hepatocytes. Toxicol In Vitro 1997; 11: 669-672.
49. Wegener T. The status of herbal antilipemic agents. Wien Med Wochenschr 2002; 152: 412-417.
50. Kraft K. Artichoke leaf extracts - Recent findings reflecting effects on lipid metabolism, liver and gastrointestinal tracts. Phytomedicine 1997; 4: 369-378.
51. Wegener T, Fintelmann V. Pharmacological properties and therapeutic profile of artichoke (Cynara scolymus L.). Wien Med Wochenschr 1999; 149: 241-247.
52. Heckers H, Dittmar K, Schmahl FW, Huth K. Inefficiency of cynarin as therapeutic regimen in familial type II hyperlipoproteinaemia. Atherosclerosis 1977; 26: 249-253.
53. Wojcicki J. Effect of 1,5-dicaffeoylquinic acid on ethanol-induced hypertriglyceridemia. Arzneim-Forsch/Drug Res 1976; 26: 2047.
54. Wojcicki J: Effects of 1,5-dicaffeoylquinic acid (cynarin) on cholesterol levels in serum and liver of acute ethanol-treated rats. Drug Alcohol Dep 1978; 3: 143.
55. Englisch W, Beckers C, Unkauf M, Ruepp M, Zinserling V. Efficacy of Artichoke dry extract in patients with hyperlipoproteinemia. Arzneimittelforschung 2000; 50: 260-265.
56. Bundy R, Walker AF, Middleton RW, Wallis C, Simpson HC. Artichoke leaf extract (Cynara scolymus) reduces plasma cholesterol in otherwise healthy hypercholesterolemic adults: a randomized, double blind placebo controlled trial. Phytomedicine. 2008; 15: 668-675.
57. Lupattelli G, Marchesi S, Lombardini R, Roscini AR, Trinca F, Gemelli F et al. Artichoke juice improves endothelial function in hyperlipemia. Life Sci 2004; 76: 775-782.
58. Pittler MH, Thompson CO, Ernst E. Artichoke leaf extract for treating hypercholesterolaemia. Cochrane Database Syst Rev 2002; 3: CD003335.
59. Rondanelli M, Giacosa A, Opizzi A et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr 2013; 64: 7-15.
60. Samochowiec L, Woicicki J, Kadykow M. The influence of 1,5-dicaffeoylquinic acid on serum lipids in the experimentally alcoholized rat. Panminerva Med 1971; 13: 87.
61. Miccadei S, Di Venere D, Cardinali A, Romano F, Durazzo A, Foddai MS et al. Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutr Cancer 2008; 60: 276-283.
62. Arion WJ, Canfield WK, Ramos FC, Schindler PW, Burger HJ, Hemmerle H et al. Chlorogenic acid and hydroxynitrobenzaldehyde: new inhibitors of hepatic glucose 6-phosphatase. Arch Biochem Biophys 1997; 339: 315-322.
63. Matsui T, Ogunwande IA, Abesundara KJ, Matsumoto K. Anti-hyperglycemic potential of natural products. Mini Rev Med Chem 2006; 6: 349-356.
64. Kaur N, Gupta AK. Applications of inulin and oligofructose in health and nutrition. J Biosci 2002; 27: 703-714.
65. Vinik AI. Neuropathy: new concepts in evaluation and treatment. South Med J 2002; 95: 21-23.
66. Nazni P, Poongodi Vijayakumar P, Alagianambi P, Amirthaveni M. Hypoglycemic and hypolipidemic effect of Cynara Scolymus among selected type 2 diabetic individuals. Pak J Nutr 2006; 5: 147-151.
67. Rondanelli M, Giacosa A, Orsini F, Opizzi A, Villani S. Appetite Control and Glycaemia Reduction in Overweight Subjects treated with a Combination of Two Highly Standardized Extracts from Phaseolus vulgaris and Cynara scolymus. Phytother Res 2011 Feb 10. [Epub ahead of print].
68. Gibson GR. Dietary modulation of the human gut microflora using prebiotics. Br J Nutr 1998; 80: 209-212.
69. Maros T, Racz G, Katonai B, Kovacs VV. Effects of Cynara scolymus extracts on the regeneration of rat liver. Arzneimittelforschung 1966; 16: 127-129.
70. Adzet T, Camarasa J, Hernandez JS, Laguna JC. Action of an artichoke extract against CCl4-induced hepatotoxicity in rats. Acta Pharm Jugosl 1987; 37: 183-187.
71. Speroni E, Cervellati R, Govoni P, Guizzardi S, Renzulli C, Guerra MC. Efficacy of different Cynara scolymus preparations on liver complaints. J Ethnopharmacol 2003; 86: 203-211.
72. Matuschowski P. Testing of Cynara scolymus in the isolated perfused rat liver. 43rd Ann Congr Soc Med Plant Res 1996: 3-7.
73. Saénz RT, García GD, De la Puerta VR. Choleretic activity and biliary elimination of lipids and bile acids induced by an artichoke leaf extract in rats. Phytomedicine 2002; 9: 687-693.
74. Kirchhoff R, Beckers C, Kirchhoff GM, Trinczek-Gartner H, Petrowicz O, Reimann HJ. Increase in choleresis by means of artichoke extract. Phytomedicine 1994; 1: 107-115.
75. Held C. Artischocke bei Gallenwegsdyskinesien. Neue Aspekte zur Therapie mit Choleretika. Z Klin Med 1992; 47: 92.
76. Fintelmann V. Therapeutic profile and mechanism of action of artichoke leaf extract: hypolipemic, antioxidant, hepatoprotective and choleretic properties. Phytomed 1996; 1: 50.