Deficiency of volume-regulated ClC-3 chloride channel attenuates cerebrovascular remodelling in DOCA-salt hypertension

Cardiovascular Research

Volumn 100, Issue 1, 2013, Pages 134-142

  Zheng, Ling Yun ^a,b   Li, Lei ^a   Ma, Ming Ming ^a   Liu, Yun ^a   Wang, Guan Lei ^a   Tang, Yong Bo ^a   Zhou, Jia Guo ^a   Lv, Xiao Fei ^a   Du, Yan Hua ^a   Guan, Yong Yuan ^a  

^a SUN YAT SEN UNIVERSITY   (China)

^b GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cerebrovascular remodelling; Clc 3; Hypertension; MMP; TGF b1

Indexed keywords

CHLORIDE CHANNEL; CLC 3 CHLORIDE CHANNEL; FIBRONECTIN; GELATINASE A; INTERSTITIAL COLLAGENASE; PROPRANOLOL; SERINE; SMAD3 PROTEIN; TISSUE INHIBITOR OF METALLOPROTEINASE 2; TRANSFORMING GROWTH FACTOR BETA1; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL WALL THICKNESS; ARTICLE; BASILAR ARTERY; BODY WEIGHT; CEREBROVASCULAR REMODELLING; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ELECTRON MICROSCOPY; EXTRACELLULAR MATRIX; GENE OVEREXPRESSION; HYPERTENSION; IMMUNOFLUORESCENCE; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TISSUE REGENERATION;

CEREBROVASCULAR REMODELLING; CLC-3; HYPERTENSION; MMP; TGF-Β1;

ANIMALS; BASILAR ARTERY; BLOOD PRESSURE; BODY WEIGHT; CHLORIDE CHANNELS; DESOXYCORTICOSTERONE ACETATE; FIBRONECTINS; HYPERTENSION; MATRIX METALLOPROTEINASE 2; MATRIX METALLOPROTEINASE 9; MICE; MICE, INBRED C57BL; PHOSPHORYLATION; SMAD3 PROTEIN; TRANSFORMING GROWTH FACTOR BETA1;

EID: 84887919396     PISSN: 00086363     EISSN: 17553245     Source Type: Journal    
DOI: 10.1093/cvr/cvt156     Document Type: Article

References (43)

1. Heistad DD, Baumbach GL. Cerebral vascular changes during chronic hypertension: good guys and bad guys. J Hypertens 1992; 10(suppl.):S71-S75.
2. Ward MR, Pasterkamp G, Yeung A.C., Borst C. Arterial remodeling. Mechanisms and clinical implications. Circulation 2000; 102: 1186-1191.
3. Pasterkamp G, Galis ZS, de Kleijn DP. Expansive arterial remodeling: location, location, location. Arterioscler Thromb Vasc Biol 2004; 24: 650-665.
4. Lang F, Foller M, Lang K.S., Lang PA, Ritter M, Gulbins E et al. Ion channels in cell proliferation and apoptotic cell death. J Membr Biol 2005; 205: 147-157.
5. Tang YB, Zhou JG, Guan YY. Volume-regulated chloride channels and cerebral vascular remodelling. Clin Exp Pharmacol Physiol 2010; 37: 238-242.
6. Duan D, Winter C, Cowley S., Hume JR, Horowitz B. Molecular identification of a volume-regulated chloride channel. Nature 1997; 390: 417-421.
7. Xiong D, Heyman NS, Airey J, Zhang M., Singer CA, Rawat S et al. Cardiac-specific, indu-cible clc-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice. J Mol Cell Cardiol 2010; 48: 211-219.
8. 2 concentration through volume-regulated clc-3 chloride channels in a10 vascular smooth muscle cells. J Biol Chem 2005; 280: 7301-7308.
9. Guan YY, Wang GL, Zhou JG. The ClC-3 Cl-channel in cell volume regulation, proliferation and apoptosis in vascular smooth muscle cells. Trends Pharmacol Sci 2006; 27: 290-296.
10. Wang GL, Wang XR, Lin M.J., He H., Lan XJ, Guan YY. Deficiency in ClC-3 chloride channels prevents rat aortic smooth muscle cell proliferation. Circ Res 2002; 91:E28-E32.
11. Qian Y, Du YH, Tang Y.B., Lv XF, Liu J, Zhou JG et al. ClC-3 chloride channel prevents apoptosis induced by hydrogen peroxide in basilar artery smooth muscle cells through mitochondria dependent pathway. Apoptosis 2011; 16: 468-477.
12. Shi XL, Wang GL, Zhang Z, Liu Y.J., Chen JH, Zhou JG et al. Alterationofvolume-regulated chloride movement in rat cerebrovascular smooth muscle cells during hypertension. Hypertension 2007; 49: 1371-1377.
13. Liu YJ, Wang XG, Tang Y.B., Chen JH, Lv XF, Zhou JG et al. Simvastatin ameliorates rat cerebrovascular remodeling during hypertension via inhibition of volume-regulated chloride channel. Hypertension 2010; 56: 445-452.
14. Dickerson LW, Bonthius DJ, Schutte B.C., Yang B., Barna TJ, Bailey MC et al. Altered gabaergic function accompanies hippocampal degeneration in mice lacking clc-3 voltage-gated chloride channels. Brain Res 2002; 958: 227-250.
15. Du YH, Guan YY, Alp N.J., Channon KM, Chen AF. Endothelial-specific GTP cyclohydro-lase I overexpression attenuates blood pressure progression in low renin hypertension. Circulation 2008; 117: 1045-1054.
16. Ergul A, Portik-Dobos V, Giulumian A.D., Molero MM, Fuchs LC. Stress upregulates arterial matrix metalloproteinase expression and activity via endothelin a receptor activation. Am J Physiol Heart Circ Physiol 2003; 285:H2225-H2232.
17. Baumbach GL, Heistad DD. Remodeling of cerebral arterioles in chronic hypertension. Hypertension 1989; 13: 968-972.
18. Heistad DD, Mayhan WG, Coyle P, Baumbach GL. Impaired dilatation of cerebral arter-ioles in chronic hypertension. Blood Vessels 1990; 27: 258-262.
19. Dorrance AM, Rupp NC, Nogueira EF. Mineralocorticoid receptor activation causes cerebral vessel remodeling and exacerbates the damage caused by cerebral ischemia. Hypertension 2006; 47: 590-595.
20. Fujita T, Mu S, Shimosawa T., Ogura S, Wang H, Uetake Y et al. Epigenetic modulation of the renal beta-adrenergic-wnk4 pathway in salt-sensitive hypertension. Nature Med 2011; 17:U573-U592.
21. Baumbach GL, Chillon JM. Effects of an angiotensin-converting enzyme inhibitor and a beta-blocker on cerebral arterioles in rats. Hypertension 1999; 33: 856-861.
22. Hajdu MA, Heistad DD, Baumbach GL. Effectsofantihypertensive therapyon mechanics of cerebral arterioles in rats. Hypertension 1991; 17: 308-316.
23. Nag S. Immunohistochemical localization of extracellular matrix proteins in cerebral vessels in chronic hypertension. J Neuropath Exp Neur 1996; 55: 381-388.
24. Sottile J, Hocking DC. Fibronectin polymerization regulates the composition and stability of extracellular matrix fibrils and cell-matrix adhesions. Mol Biol Cell 2002; 13: 3546-3559.
25. Sottile J, Chiang HY, Korshunov V.A., Serour A., Shi F. Fibronectinis animportant regulator of flow-induced vascular remodeling. Arterioscl Throm Vas 2009; 29:U1074-U1157.
26. Takasaki I, Chobanian AV, Sarzani R, Brecher P. Effect of hypertension on fibronectin expression in the rat aorta. J Biol Chem 1990; 265: 21935-21939.
27. Saouaf R, Takasaki I, Eastman E., Chobanian AV, Brecher P. Fibronectin biosynthesis in the rat aorta in vitro. Changes due to experimental hypertension. J Clin Invest 1991; 88: 1182-1189.
28. Takasaki I, Takizawa T, Sugimoto K., Gotoh E, Shionoiri H, Ishii M. Effects of hypertension and aging on fibronectin expression in aorta of dahl salt-sensitive rats. Am J Physiol 1994; 267:H1523-H1529.
29. Brassard P, Amiri F, Schiffrin EL. Combined angiotensin II type 1 and type 2 receptor blockade on vascular remodeling and matrix metalloproteinases in resistance arteries. Hypertension 2005; 46: 598-606.
30. Visse R, Nagase H. Matrix metalloproteinases and tissue inhibitors of metalloprotei-nases: structure, function, and biochemistry. Circ Res 2003; 92: 827-839.
31. Galis ZS, Khatri JJ. Matrix metalloproteinases in vascular remodeling and atherogenesis - the good, the bad, and the ugly. Circ Res 2002; 90: 251-262.
32. Watts SW, Rondelli C, Thakali K., Li X, Uhal B, Pervaiz MH et al. Morphological and biochemical characterization of remodelinginaorta and vena cavaofdoca-salt hypertensive rats. Am J Physiol Heart Circ Physiol 2007; 292:H2438-H2448.
33. Flamant M, Placier S, Dubroca C., Esposito B, Lopes I, Chatziantoniou C et al. Role of matrix metalloproteinases in early hypertensive vascular remodeling. Hypertension 2007; 50: 212-218.
34. Jackson ZS, Gotlieb AI, Langille BL. Wall tissue remodeling regulates longitudinal tension in arteries. Circ Res 2002; 90: 918-925.
35. Varga J, Chen SJ, Yuan W.H., Lo ST, Trojanowska M. Interaction of smad3 with a proximal smad-binding element of the human alpha 2(i) procollagen gene promoter required for transcriptional activation by tgf-beta. J Cell Physiol 2000; 183: 381-392.
36. Ziyadeh FN, Isono M, Chen S., Hong SW, Iglesias-de la Cruz MC. Smad pathway is activated in the diabetic mouse kidney and smad3 mediates tgf-beta-induced fibronectin in mesangial cells. Biochem Bioph Res Co 2002; 296: 1356-1365.
37. Ruiz-Ortega M., Rodriguez-Vita J, Sanchez-Lopez E, Esteban V, Ruperez M., Egido J. Angio-tensin II activates the smad pathway in vascular smooth muscle cells by a transforming growth factor-beta-independent mechanism. Circulation 2005; 111: 2509-2517.
38. Ooshima A, Sato M, Muragaki Y., Saika S, Roberts AB. Targeted disruption of tgf-beta 1/smad3 signaling protects against renal tubulointerstitial fibrosis induced by unilateral ureteral obstruction. J Clin Invest 2003; 112: 1486-1494.
39. Frangogiannis NG, Bujak M, Ren G., Kweon HJ, Dobaczewski M, Reddy A et al. Essential role of smad3 in infarct healing and in the pathogenesis of cardiac remodeling. Circulation 2007; 116: 2127-2138.
40. Roberts AB, Ashcroft GS, Yang X, Glick A.B., Weinstein M., Letterio JJ et al. Mice lacking smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol 1999; 1: 260-266.
41. Wang Y, Wang DH. Protective effect of TRPV1 against renal fibrosis via inhibition of TGF-b/Smad signaling in DOCA-salt hypertension. Mol Med 2011; 17: 1204-1212.
42. Wang M, Zhao D, Spinetti G., Zhang J, Jiang LQ, Pintus G et al. Matrix metalloproteinase 2 activationoftransforming growth factor-beta1 (tgf-beta1) and tgf-beta1-type ii receptor signaling within the aged arterial wall. Arterioscler Thromb Vasc Biol 2006; 26: 1503-1509.
43. Kent KC, Ryer EJ, Hom R.P., Sakakibara K., Nakayama KI, Nakayama K et al. Pkc delta is necessary for smad3 expression and transforming growth factor beta-induced fibronec-tin synthesis in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol 2006; 26: 780-786.