Mineralocorticoid receptor activation causes cerebral vessel remodeling and exacerbates the damage caused by cerebral ischemia

Hypertension

Volumn 47, Issue 3 II, 2006, Pages 590-595

  Dorrance, Anne M ^a   Rupp, Nikki C ^a   Nogueira, Edson F ^a  

^a MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

Aldosterone; Cerebral arteries; Cerebral ischemia; Mineralocorticoids; Remodeling

Indexed keywords

DEOXYCORTICOSTERONE ACETATE; MINERALOCORTICOID RECEPTOR; MINERALOCORTICOID RECEPTOR ANTAGONIST; UNCLASSIFIED DRUG; DEOXYCORTICOSTERONE; POTASSIUM;

AGE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIOGRAPHY; BRAIN BLOOD FLOW; BRAIN BLOOD VESSEL; BRAIN ISCHEMIA; CEREBROVASCULAR DISEASE; CONFERENCE PAPER; CONTROLLED STUDY; DOSE TIME EFFECT RELATION; HORMONE RECEPTOR INTERACTION; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; NEPHRECTOMY; NONHUMAN; PRIORITY JOURNAL; RAT; SALT LOADING; STRESS STRAIN RELATIONSHIP; STROKE; SYSTOLIC BLOOD PRESSURE; ANIMAL; ARTICLE; BLOOD; BLOOD VESSEL; BRAIN; BRAIN INFARCTION; DRUG EFFECT; METABOLISM; MICROSCOPY; MIDDLE CEREBRAL ARTERY; PATHOLOGY; PATHOPHYSIOLOGY; VASCULARIZATION; WISTAR RAT;

ANIMALS; BLOOD VESSELS; BRAIN; BRAIN ISCHEMIA; CEREBRAL INFARCTION; DESOXYCORTICOSTERONE; MALE; MICROSCOPY, VIDEO; MIDDLE CEREBRAL ARTERY; POTASSIUM; RATS; RATS, WISTAR; RECEPTORS, MINERALOCORTICOID;

EID: 33644990636     PISSN: 0194911X     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.HYP.0000196945.73586.0d     Document Type: Conference Paper

References (36)

1. Coyle P, Jokelainen PT. Differential outcome to middle cerebral artery occlusion in spontaneously hypertensive rats (SHRSP) and Wistar-Kyoto (WKY) rats. Stroke. 1983;14:605-610.
2. Dorrance AM, Osborn HL, Grekin R, Webb RC. Spironolactone reduces cerebral infarct size and epidermal growth factor receptor mRNA in stroke-prone rats. Am J Physiol. 2001;281:R944-R950.
3. Baumbach GL, Heistad DD. Remodeling of cerebral arterioles in chronic hypertension. Hypertension. 1989;13:968-972.
4. Coyle P, Heistad DD. Blood flow through cerebral and collateral vessels one month after middle cerebral artery occlusion. Stroke. 1987;18:407-411.
5. Haper SL, Bohlen HG. Microvascular adaptation the cerebral cortex of adult spontaneously hypertensive rats. Hypertension. 1984;6:408-419.
6. Brown NJ. Aldosterone and end-organ damage. Curr Opin Nephrol Hypertens. 2005;14:235-241.
7. Rigsby CS, Dorrance AM. Spironolactone increases lumen diameter in the middle cerebral artery of spontaneously hypertensive stroke-prone rats (SHRSP). (Abstract) Hypertension. 2004;44:P110.
8. Millette E, de Champlain J, Lamontagne D. Contribution of endogenous endothelin in the enhanced coronary constriction in DOCA-salt hypertensive rats. J Hypertens. 2003;21:115-123.
9. Pu Q, Touyz RM, Schiffrin EL. Comparison of angiotensin-converting enzyme (ACE), neutral endopeptidase (NEP) and dual ACE/NEP inhibition on blood pressure and resistance arteries of deoxycorticosterone acetate-salt hypertensive rats. J Hypertens. 2002;20:899-907.
10. Takaoka M, Ohkita M, Itoh M, Kobayashi Y, Okamoto H, Matsumura Y. A proteasome inhibitor prevents vascular hypertrophy in deoxycorticosterone acetate-salt hypertensive rats. Clin Exp Pharmacol Physiol. 2001;28:466-468.
11. Kuro T, Okahara A, Nose M, Ikuse T, Matsumura Y. Effects of SA7060, a novel dual inhibitor of neutral endopeptidase and angiotensin-converting enzyme, on deoxycorticosterone acetate-salt-induced hypertension in rats. Biol Pharm Bull. 2000;23:820-825.
12. Longa EZ, Weinstein PR, Carlson S, Cummins R. Reversible middle cerebral artery occlusion without craniectomy in rats. Stroke. 1989;20:84-91.
13. Baumbach GL, Hajdu MA. Mechanics and composition of cerebral arterioles in renal and spontaneously hypertensive rats. Hypertension. 1993; 21:816-826.
14. Heagerty AM, Aalkjaer C, Bund SJ, Korsgaard N, Mulvany MJ. Small artery structure in hypertension. Dual processes of remodeling and growth. Hypertension. 1993;21:391-397.
15. Florrian JA, Dorrance AM, Webb RC, Watts SW. Enhanced contraction to epidermal growth factor is not absolutely dependent on an increase in blood pressure. Am J Physiol. 2001;281:R878-R886.
16. Litchfield WR, Anderson BF, Weiss RJ, Lifton RP, Dluhy RG. Intracranial aneurysm and hemorrhagic stroke in glucocorticoid-remediable aldosteronism. Hypertension. 1998;31:445-450.
17. McMahon GT, Dluhy RG. Glucocorticoid-remediable aldosteronism. Cardiol Rev. 2004;12:44-48.
18. Takeda R, Matsubara T, Miyamori I, Hatakeyama H, Morise T. Vascular complications in patients with aldosterone producing adenoma in Japan: comparative study with essential hypertension. The Research Committee of Disorders of Adrenal Hormones in Japan. J Endocrinol Invest. 1995; 18:370-373.
19. Li JS, Turgeon A, Schiffrin EL. Effect of chronic treatment with two different ET(A) selective endothelin receptor antagonists on blood pressure and small artery structure of deoxycorticosterone acetate (DOCA)-salt hypertensive rats. Am J Hypertens. 1998;11:554-562.
20. Scott-Burden T, Resink TJ, Baur U, Burgin M, Buhler FR. Epidermal growth factor responsiveness in smooth muscle cells from hypertensive and normotensive rats. Hypertension. 1989;13:295-304.
21. Fiebeler A, Haller H. Participation of the mineralocorticoid receptor in cardiac and vascular remodeling. Nephron Physiol. 2003;94:47-50.
22. Min LJ, Mogi M, Li JM, Iwanami J, Iwai M, Horiuchi M. Aldosterone and angiotensin II synergistically induce mitogenic response in vascular smooth muscle cells. Circ Res. 2005;97:434-442.
23. Ishizawa K, Izawa Y, Ito H, Miki C, Miyata K, Fujita Y, Kanematsu Y, Tsuchiya K, Tamaki T, Nishiyama A, Yoshizumi M. Aldosterone stimulates vascular smooth muscle cell proliferation via big mitogen-activated protein kinase 1 activation. Hypertension. 2005;46:1046-1052.
24. Callera GE, Touyz RM, Teixeira SA, Muscara MN, Carvalho MH, Fortes ZB, Nigro D, Schiffrin EL, Tostes RC. ETA receptor blockade decreases vascular superoxide generation in DOCA-salt hypertension. Hypertension. 2003;42:811-817.
25. Iglarz M, Touyz RM, Viel EC, Amiri F, Schiffrin EL. Involvement of oxidative stress in the profibrotic action of aldosterone. Interaction with the renin-angiotension system. Am J Hypertens. 2004;17:597-603.
26. Park JB, Schiffrin EL. Cardiac and vascular fibrosis and hypertrophy in aldosterone-infused rats: role of endothelin-1. Am J Hypertens. 2002;15:164-169.
27. Benetos A, Lacolley P, Safar ME. Prevention of aortic fibrosis by spironolactone in spontaneously hypertensive rats. Arterioscler Thromb Vasc Biol. 1997;17:1152-1156.
28. Lacolley P, Safar ME, Lucet B, Ledudal K, Labat C, Benetos A. Prevention of aortic and cardiac fibrosis by spironolactone in old normotensive rats. J Am Coll Cardiol. 2001;37:662-667.
29. Ganguli M, Tobian L, Sugimoto T. Deleterious effects of high magnesium diets and beneficial effects of high potassium diets in hypertensive stroke prone rats. Magnes Res. 1990;34:255-261.
30. Ishimitsu T, Tobian L, Sugimoto K, Lange JM. High potassium diets reduce macrophage adherence to the vascular wall in stroke-prone spontaneously hypertensive rats. J Vasc Res. 1995;32:406-412.
31. Tobian L, Lange JM, Johnson MA, MacNeil DA, Wilke TJ, Ulm KM, Wold LJ. High-K diets markedly reduce brain hemorrhage and infracts, death rate and mesenteric arteriolar hypertrophy in stroke prone spontaneously hypertensive rats. J Hypertens. 1986;4:S205-S207.
32. Tobian L, Jahner TM, Johnson MA. Cholesterol ester deposition is reduced in rats with hypercholesterolemia and hypertension. Clin Exp Hypertens. 1991;13:1009-1017.
33. Werber AH, Fitch-Burke MC, Harrington DG, Shah J. No rarefaction of cerebral arterioles in hypertensive rats. Can J Physiol Pharmacol. 1990; 68:476-479.
34. Sokolova IA, Manukhina EB, Blinkov SM, Koshelev VB, Pinelis VG, Rodionov IM. Rarefication of the arterioles and capillary network in the brain of rats with different forms of hypertension. Microvasc Res. 1985;30:1-9.
35. Pitt B. Effect of aldosterone blockade in patients with systolic left ventricular dysfunction: implications of the RALES and EPHESUS studies. Mol Cell Endocrinol. 2004;217:53-58.
36. Connell JM, Davies E. The new biology of aldosterone. J Endocrinol. 2005;186:1-20.