Cardiac-specific, inducible ClC-3 gene deletion eliminates native volume-sensitive chloride channels and produces myocardial hypertrophy in adult mice

Journal of Molecular and Cellular Cardiology

Volumn 48, Issue 1, 2010, Pages 211-219

  Xiong, Dazhi ^a   Heyman, Nathanael S ^a   Airey, Judith ^a   Zhang, Mi ^a   Singer, Cherie A ^a   Rawat, Shanti ^a   Ye, Linda ^a   Evans, Rebecca ^a   Burkin, Dean J ^a   Tian, Honglin ^a   McCloskey, Diana T ^a   Valencik, Maria ^a   Britton, Fiona C ^a   Duan, Dayue ^a   Hume, Joseph R ^a  

^a UNIVERSITY OF NEVADA SCHOOL OF MEDICINE   (United States)

Author keywords

Atrial myocytes; Cardiac hypertrophy and failure; Cardiac specific inducible ClC 3 knock out mice; Doxycycline; Echocardiography; Regulatory volume decrease (RVD); Volume sensitive outwardly rectifying anion channels (VSOACs); Whole cell patch clamp recordings

Indexed keywords

ANION CHANNEL; CHLORIDE CHANNEL; CHLORIDE CHANNEL 3; CRE RECOMBINASE; DOXYCYCLINE; UNCLASSIFIED DRUG; VOLUME SENSITIVE OUTWARDLY RECTIFYING ANION CHANNEL;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CHLORIDE CURRENT; CONTROLLED STUDY; ECHOCARDIOGRAPHY; EMBRYO; GENE DELETION; GENE EXPRESSION; HEART ATRIUM; HEART ELECTROPHYSIOLOGY; HEART FAILURE; HEART MUSCLE CELL; HEART PROTECTION; HEART VENTRICLE; HEART VENTRICLE HYPERTROPHY; KNOCKOUT MOUSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TRANSGENIC MOUSE; WESTERN BLOTTING;

ANIMALS; BLOTTING, WESTERN; BRAIN; CARDIOMEGALY; CELLS, CULTURED; CHLORIDE CHANNELS; GENE DELETION; HEART; IMMUNOHISTOCHEMISTRY; MICE; MICE, KNOCKOUT; MYOCARDIUM; POLYMERASE CHAIN REACTION;

MAMMALIA; MUS; MUS MUSCULUS;

EID: 73049083160     PISSN: 00222828     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.yjmcc.2009.07.003     Document Type: Article

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