Glutamate acid decarboxylase 1 promotes metastasis of human oral cancer by β-catenin translocation and MMP7 activation

BMC Cancer

Volumn 13, Issue , 2013, Pages

  Kimura, Ryota ^a   Kasamatsu, Atsushi ^a,b   Koyama, Tomoyoshi ^a   Fukumoto, Chonji ^a   Kouzu, Yukinao ^a   Higo, Morihiro ^a   Endo Sakamoto, Yosuke ^b   Ogawara, Katsunori ^b   Shiiba, Masashi ^a   Tanzawa, Hideki ^a,b   Uzawa, Katsuhiro ^a,b  

^a CHIBA UNIVERSITY   (Japan)

^b CHIBA UNIVERSITY HOSPITAL   (Japan)

Author keywords

catenin; 3 mercaptopropionic acid; Glutamate acid decarboxylase 1; Matrix metalloproteinase 7; Metastasis; Oral squamous cell carcinoma

Indexed keywords

3 MERCAPTOPROPIONIC ACID; BETA CATENIN; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 1; MATRILYSIN; MESSENGER RNA; UNCLASSIFIED DRUG;

ADULT; AGED; ARTICLE; CARCINOMA CELL; CELL INVASION; CELL MIGRATION; CELL NUCLEUS; CELL PROLIFERATION; CONTROLLED STUDY; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; GAD1 GENE; GENE EXPRESSION; GENE SILENCING; GENE TRANSLOCATION; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOBLOTTING; KERATINOCYTE; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; METASTASIS; MIDDLE AGED; MOUTH SQUAMOUS CELL CARCINOMA; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; QUANTITATIVE ANALYSIS; REAL TIME POLYMERASE CHAIN REACTION; REGULATORY MECHANISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR INVASION; UPREGULATION; VERY ELDERLY;

3-MERCAPTOPROPIONIC ACID; ADULT; AGED; AGED, 80 AND OVER; BETA CATENIN; CARCINOMA, SQUAMOUS CELL; CELL LINE, TUMOR; CELL MOVEMENT; CELL NUCLEUS; CELL PROLIFERATION; ENZYME ACTIVATION; GLUTAMATE DECARBOXYLASE; HUMANS; MATRIX METALLOPROTEINASE 7; MIDDLE AGED; MOUTH NEOPLASMS; NEOPLASM INVASIVENESS; PROTEIN TRANSPORT;

EID: 84887919121     PISSN: None     EISSN: 14712407     Source Type: Journal    
DOI: 10.1186/1471-2407-13-555     Document Type: Article

References (50)

1. Erlander MG, Tobin AJ. The structural and functional heterogeneity of glutamic acid decarboxylase: a review. Neurochem Res 1991, 16:215-226. 10.1007/BF00966084, 1780024.
2. Young SZ, Bordey A. GABA's control of stem and cancer cell proliferation in adult neural and peripheral niches. Physiology (Bethesda) 2009, 24:171-185. 10.1152/physiol.00002.2009, 2931807, 19509127.
3. Rambrand T, Pociot F, Rønningen KS, Rønningen K, Nerup J, Michelsen BK. Genetic markers for glutamic acid decarboxylase do not predict insulin-dependent diabetes mellitus in pairs of affected siblings. The Danish Study Group of Diabetes in Childhood. Hum Genet 1997, 99:177-185. 10.1007/s004390050334, 9048916.
4. Hijazi J, Bedat-Millet AL, Hannequin D. Stiff-person syndrome and other neurological disorders associated with anti-GAD antibodies. Rev Med Interne 2010, 31:23-28. 10.1016/j.revmed.2009.01.012, 19828214.
5. Condie BG, Bain G, Gottlieb DI, Capecchi MR. Cleft palate in mice with a targeted mutation in the gamma-aminobutyric acid-producing enzyme glutamic acid decarboxylase 67. Proc Natl Acad Sci U S A 1997, 94:11451-11455. 10.1073/pnas.94.21.11451, 23502, 9326630.
6. Li CM, Kim CE, Margolin AA, Guo M, Zhu J, Mason JM, Hensle TW, Murty VV, Grundy PE, Fearon ER, et al. CTNNB1 mutations and overexpression of Wnt/beta-catenin target genes in WT1-mutant Wilms' tumors. Am J Pathol 2004, 165:1943-1953. 10.1016/S0002-9440(10)63246-4, 1618727, 15579438.
7. Schwartz DR, Wu R, Kardia SL, Levin AM, Huang CC, Shedden KA, Kuick R, Misek DE, Hanash SM, Taylor JM, et al. Novel candidate targets of beta-catenin/T-cell factor signaling identified by gene expression profiling of ovarian endometrioid adenocarcinomas. Cancer Res 2003, 63:2913-2922.
8. Orsulic S, Huber O, Aberle H, Arnold S, Kemler R. E-cadherin binding prevents beta-catenin nuclear localization and beta-catenin/LEF-1-mediated transactivation. J Cell Sci 1999, 112(Pt 8):1237-1245.
9. Huang J, Xiao D, Li G, Ma J, Chen P, Yuan W, Hou F, Ge J, Zhong M, Tang Y. EphA2 promotes epithelial-mesenchymal transition through the Wnt/β-catenin pathway in gastric cancer cells. Oncogene 2013, 10:1-11.
10. Howard S, Deroo T, Fujita Y, Itasaki N. A positive role of cadherin in Wnt/β-catenin signalling during epithelial-mesenchymal transition. PLoS One 2011, 6:e23899. 10.1371/journal.pone.0023899, 3166074, 21909376.
11. Li VS, Ng SS, Boersema PJ, Low TY, Karthaus WR, Gerlach JP, Mohammed S, Heck AJ, Maurice MM, Mahmoudi T, et al. Wnt signaling through inhibition of β-catenin degradation in an intact Axin1 complex. Cell 2012, 149:1245-1256. 10.1016/j.cell.2012.05.002, 22682247.
12. Valenta T, Hausmann G, Basler K. The many faces and functions of β-catenin. EMBO J 2013, 31:2714-2736.
13. Ougolkov AV, Yamashita K, Mai M, Minamoto T. Oncogenic beta-catenin and MMP-7 (matrilysin) cosegregate in late-stage clinical colon cancer. Gastroenterology 2002, 122:60-71. 10.1053/gast.2002.30306, 11781281.
14. Pajouh MS, Nagle RB, Breathnach R, Finch JS, Brawer MK, Bowden GT. Expression of metalloproteinase genes in human prostate cancer. J Cancer Res Clin Oncol 1991, 117:144-150. 10.1007/BF01613138, 1848860.
15. Yoshimoto M, Itoh F, Yamamoto H, Hinoda Y, Imai K, Yachi A. Expression of MMP-7 (PUMP-1) mRNA in human colorectal cancers. Int J Cancer 1993, 54:614-618. 10.1002/ijc.2910540415, 8514452.
16. Adachi Y, Itoh F, Yamamoto H, Matsuno K, Arimura Y, Kusano M, Endoh T, Hinoda Y, Oohara M, Hosokawa M, et al. Matrix metalloproteinase matrilysin (MMP-7) participates in the progression of human gastric and esophageal cancers. Int J Oncol 1998, 13:1031-1035.
17. Heppner KJ, Matrisian LM, Jensen RA, Rodgers WH. Expression of most matrix metalloproteinase family members in breast cancer represents a tumor-induced host response. Am J Pathol 1996, 149:273-282. 1865221, 8686751.
18. Samukange V, Yasukawa K, Inouye K. Interaction of 8-anilinonaphthalene 1-sulphonate (ANS) and human matrix metalloproteinase 7 (MMP-7) as examined by MMP-7 activity and ANS fluorescence. J Biochem 2012, 151:533-540. 10.1093/jb/mvs025, 22390874.
19. Chuang HC, Su CY, Huang HY, Huang CC, Chien CY, Du YY, Chuang JH. Active matrix metalloproteinase-7 is associated with invasion in buccal squamous cell carcinoma. Mod Pathol 2008, 21:1444-1450. 10.1038/modpathol.2008.99, 18931651.
20. Endo Y, Uzawa K, Mochida Y, Shiiba M, Bukawa H, Yokoe H, Tanzawa H. Sarcoendoplasmic reticulum Ca(2+) ATPase type 2 downregulated in human oral squamous cell carcinoma. Int J Cancer 2004, 110:225-231. 10.1002/ijc.20118, 15069686.
21. Kasamatsu A, Uzawa K, Nakashima D, Koike H, Shiiba M, Bukawa H, Yokoe H, Tanzawa H. Galectin-9 as a regulator of cellular adhesion in human oral squamous cell carcinoma cell lines. Int J Mol Med 2005, 16:269-273.
22. Iyoda M, Kasamatsu A, Ishigami T, Nakashima D, Endo-Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Epithelial cell transforming sequence 2 in human oral cancer. PLoS One 2010, 5:e14082. 10.1371/journal.pone.0014082, 2993930, 21124766.
23. Kouzu Y, Uzawa K, Koike H, Saito K, Nakashima D, Higo M, Endo Y, Kasamatsu A, Shiiba M, Bukawa H, et al. Overexpression of stathmin in oral squamous-cell carcinoma: correlation with tumour progression and poor prognosis. Br J Cancer 2006, 94:717-723. 2361217, 16495930.
24. Ogoshi K, Kasamatsu A, Iyoda M, Sakuma K, Yamatoji M, Sakamoto Y, Ogawara K, Shiiba M, Tanzawa H, Uzawa K. Dickkopf-1 in human oral cancer. Int J Oncol 2011, 39:329-336.
25. Crick EW, Osorio I, Bhavaraju NC, Linz TH, Lunte CE. An investigation into the pharmacokinetics of 3-mercaptopropionic acid and development of a steady-state chemical seizure model using in vivo microdialysis and electrophysiological monitoring. Epilepsy Res 2007, 74:116-125. 10.1016/j.eplepsyres.2007.02.003, 2474737, 17382519.
26. Netopilová M, Drsata J, Kubová H, Mares P. Differences between immature and adult rats in brain glutamate decarboxylase inhibition by 3-mercaptopropionic acid. Epilepsy Res 1995, 20:179-184. 10.1016/0920-1211(94)00068-8, 7796789.
27. Tunnicliff G. Action of inhibitors on brain glutamate decarboxylase. Int J Biochem 1990, 22:1235-1241. 10.1016/0020-711X(90)90304-L, 2257949.
28. Erdö SL. Postmortem increase of GABA levels in peripheral rat tissues: prevention by 3-mercapto-propionic acid. J Neural Transm 1984, 60:303-314. 10.1007/BF01249102, 6527141.
29. Yamamoto A, Kasamatsu A, Ishige S, Koike K, Saito K, Kouzu Y, Koike H, Sakamoto Y, Ogawara K, Shiiba M, et al. Exocyst complex component Sec8: a presumed component in the progression of human oral squamous-cell carcinoma by secretion of matrix metalloproteinases. J Cancer Res Clin Oncol 2013, 139:533-542. 10.1007/s00432-012-1356-2, 23207790.
30. Ho BY, Wu YM, Chang KJ, Pan TM. Dimerumic acid inhibits SW620 cell invasion by attenuating H2O2-mediated MMP-7 expression via JNK/C-Jun and ERK/C-Fos activation in an AP-1-dependent manner. Int J Biol Sci 2011, 7:869-880. 3149281, 21814482.
31. Snoek-van Beurden PA, Von den Hoff JW. Zymographic techniques for the analysis of matrix metalloproteinases and their inhibitors. Biotechniques 2005, 38:73-83. 10.2144/05381RV01, 15679089.
32. Kim HJ, Park SY, Park OJ, Kim YM. Curcumin suppresses migration and proliferation of Hep3B hepatocarcinoma cells through inhibition of the Wnt signaling pathway. Mol Med Rep 2013, 8:282-286.
33. Kobayashi T, Shimura T, Yajima T, Kubo N, Araki K. Transient gene silencing of galectin-3 suppresses pancreatic cancer cell migration and invasion through degradation of β-catenin. Int J Cancer 2011, 129:2775-2786. 10.1002/ijc.25946, 3833077, 21448903.
34. Zik M, Arazi T, Snedden WA, Fromm H. Two isoforms of glutamate decarboxylase in Arabidopsis are regulated by calcium/calmodulin and differ in organ distribution. Plant Mol Biol 1998, 37:967-975. 10.1023/A:1006047623263, 9700069.
35. Meyre D, Boutin P, Tounian A, Deweirder M, Aout M, Jouret B, Heude B, Weill J, Tauber M, Tounian P, et al. Is glutamate decarboxylase 2 (GAD2) a genetic link between low birth weight and subsequent development of obesity in children?. J Clin Endocrinol Metab 2005, 90:2384-2390. 10.1210/jc.2004-1468, 15671113.
36. Maddox DM, Condie BG. Dynamic expression of a glutamate decarboxylase gene in multiple non-neural tissues during mouse development. BMC Dev Biol 2001, 1:1. 10.1186/1471-213X-1-1, 31335, 11178105.
37. Maemura K, Shiraishi N, Sakagami K, Kawakami K, Inoue T, Murano M, Watanabe M, Otsuki Y. Proliferative effects of gamma-aminobutyric acid on the gastric cancer cell line are associated with extracellular signal-regulated kinase 1/2 activation. J Gastroenterol Hepatol 2009, 24:688-696. 10.1111/j.1440-1746.2008.05687.x, 19032445.
38. Yamano Y, Uzawa K, Shinozuka K, Fushimi K, Ishigami T, Nomura H, Ogawara K, Shiiba M, Yokoe H, Tanzawa H. Hyaluronan-mediated motility: a target in oral squamous cell carcinoma. Int J Oncol 2008, 32:1001-1009.
39. Kruck S, Eyrich C, Scharpf M, Sievert KD, Fend F, Stenzl A, Bedke J. Impact of an altered Wnt1/β-catenin expression on clinicopathology and prognosis in clear cell renal cell carcinoma. Int J Mol Sci 2013, 14:10944-10957. 10.3390/ijms140610944, 3709711, 23708097.
40. Sawada G, Ueo H, Matsumura T, Uchi R, Ishibashi M, Mima K, Kurashige J, Takahashi Y, Akiyoshi S, Sudo T, et al. CHD8 is an independent prognostic indicator that regulates Wnt/β-catenin signaling and the cell cycle in gastric cancer. Oncol Rep 2013, 30:1137-1142.
41. Abd El-Rehim D, Ali MM. Aberrant expression of β-catenin in invasive ductal breast carcinomas. J Egypt Natl Canc Inst 2009, 21:185-195.
42. Usongo M, Li X, Farookhi R. Activation of the canonical WNT signaling pathway promotes ovarian surface epithelial proliferation without inducing β-catenin/Tcf-mediated reporter expression. Dev Dyn 2013, 242:291-300. 10.1002/dvdy.23919, 23239518.
43. Chen HJ, Hsu LS, Shia YT, Lin MW, Lin CM. The β-catenin/TCF complex as a novel target of resveratrol in the Wnt/β-catenin signaling pathway. Biochem Pharmacol 2012, 84:1143-1153. 10.1016/j.bcp.2012.08.011, 22935447.
44. Wang K, Li N, Yeung CH, Li JY, Wang HY, Cooper TG. Oncogenic Wnt/β-catenin signalling pathways in the cancer-resistant epididymis have implications for cancer research. Mol Hum Reprod 2013, 19:57-71. 10.1093/molehr/gas051, 23155044.
45. Lustig B, Jerchow B, Sachs M, Weiler S, Pietsch T, Karsten U, van de Wetering M, Clevers H, Schlag PM, Birchmeier W, et al. Negative feedback loop of Wnt signaling through upregulation of conductin/axin2 in colorectal and liver tumors. Mol Cell Biol 2002, 22:1184-1193. 10.1128/MCB.22.4.1184-1193.2002, 134640, 11809809.
46. Oshima T, Akaike M, Yoshihara K, Shiozawa M, Yamamoto N, Sato T, Yamada R, Fujii S, Rino Y, Kunisaki C, et al. Clinicopathological significance of the gene expression of matrix metalloproteinase-7, insulin-like growth factor-1, insulin-like growth factor-2 and insulin-like growth factor-1 receptor in patients with colorectal cancer: insulin-like growth factor-1 receptor gene expression is a useful predictor of liver metastasis from colorectal cancer. Oncol Rep 2008, 20:359-364.
47. Yamamoto H, Adachi Y, Itoh F, Iku S, Matsuno K, Kusano M, Arimura Y, Endo T, Hinoda Y, Hosokawa M, et al. Association of matrilysin expression with recurrence and poor prognosis in human esophageal squamous cell carcinoma. Cancer Res 1999, 59:3313-3316.
48. Mimori K, Yamashita K, Ohta M, Yoshinaga K, Ishikawa K, Ishii H, Utsunomiya T, Barnard GF, Inoue H, Mori M. Coexpression of matrix metalloproteinase-7 (MMP-7) and epidermal growth factor (EGF) receptor in colorectal cancer: an EGF receptor tyrosine kinase inhibitor is effective against MMP-7-expressing cancer cells. Clin Cancer Res 2004, 10:8243-8249. 10.1158/1078-0432.CCR-04-0849, 15623600.
49. Fanelli MF, Chinen LT, Begnami MD. The influence of transforming growth factor-α, cyclooxygenase-2, matrix metalloproteinase (MMP)-7, MMP-9 and CXCR4 proteins involved in epithelial-mesenchymal transition on overall survival of patients with gastric cancer. Histopathology 2012, 61:153-161. 10.1111/j.1365-2559.2011.04139.x, 22582975.
50. Barros SS, Henriques T, Pereira KM, de Medeiros AM, Galvão HC, Freitas RA. Immunohistochemical expression of matrix metalloproteinases in squamous cell carcinoma of the tongue and lower lip. Arch Oral Biol 2011, 56:752-760. 10.1016/j.archoralbio.2010.11.022, 21255765.