An investigation into the pharmacokinetics of 3-mercaptopropionic acid and development of a steady-state chemical seizure model using in vivo microdialysis and electrophysiological monitoring

Epilepsy Research

Volumn 74, Issue 2-3, 2007, Pages 116-125

  Crick, Eric W ^a   Osorio, Ivan ^b,c   Bhavaraju, Naresh C ^c   Linz, Thomas H ^d   Lunte, Craig E ^a  

^a UNIVERSITY OF KANSAS   (United States)

^b UNIVERSITY OF KANSAS MEDICAL CENTER   (United States)

^c Flint Hills Scientific LLC   (United States)

^d TRUMAN STATE UNIVERSITY   (United States)

Author keywords

3 Mercaptopropionic acid; Epilepsy; High performance liquid chromatography; Microdialysis; Pharmacokinetics; Seizure models

Indexed keywords

3 MERCAPTOPROPIONIC ACID; ANTICONVULSIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; CONTROLLED STUDY; CORPUS STRIATUM; DRUG ELIMINATION; ELECTROCHEMICAL DETECTION; ELECTROCORTICOGRAPHY; ELECTROPHYSIOLOGY; EPILEPTIC DISCHARGE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIPPOCAMPUS; IN VIVO STUDY; JUGULAR VEIN; LOADING DRUG DOSE; MALE; MICRODIALYSIS; MONITORING; NONHUMAN; PRIORITY JOURNAL; RAT; SEIZURE;

3-MERCAPTOPROPIONIC ACID; ANIMALS; AREA UNDER CURVE; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONVULSANTS; ELECTRODES, IMPLANTED; ELECTROENCEPHALOGRAPHY; HIPPOCAMPUS; MALE; MICRODIALYSIS; NEOSTRIATUM; NEUROTRANSMITTER AGENTS; RATS; RATS, WISTAR; SEIZURES;

EID: 34247523225     PISSN: 09201211     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.eplepsyres.2007.02.003     Document Type: Article

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