메뉴 건너뛰기




Volumn 31, Issue 10, 2013, Pages 2033-2041

Concise review: Adult mesenchymal stromal cell therapy for inflammatory diseases: How well are we joining the dots?

Author keywords

Autoimmunity; Cell therapy; Clinical trials; Immunosuppression; Inflammation; Mesenchymal stem cells

Indexed keywords

BIOMEDICINE; BONE MARROW CELL; CELL CULTURE; CELL ISOLATION; CELL KINETICS; CLINICAL EFFECTIVENESS; CLINICAL TRIAL (TOPIC); GRAFT VERSUS HOST REACTION; HUMAN; IMMUNOMODULATION; IN VIVO STUDY; INFLAMMATORY DISEASE; MESENCHYMAL STEM CELL TRANSPLANTATION; NONHUMAN; REVIEW; RISK ASSESSMENT; TRANSLATIONAL RESEARCH; UNIVERSITY HOSPITAL;

EID: 84887896673     PISSN: 10665099     EISSN: None     Source Type: Journal    
DOI: 10.1002/stem.1452     Document Type: Review
Times cited : (125)

References (75)
  • 1
    • 0033515827 scopus 로고    scopus 로고
    • Multilineage potential of adult human mesenchymal stem cells
    • Pittenger MF, Mackay AM, Beck SC et al. Multilineage potential of adult human mesenchymal stem cells. Science 1999;284:143-147.
    • (1999) Science , vol.284 , pp. 143-147
    • Pittenger, M.F.1    Mackay, A.M.2    Beck, S.C.3
  • 2
    • 0034975453 scopus 로고    scopus 로고
    • Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century
    • Caplan AI, Bruder SP Mesenchymal stem cells: Building blocks for molecular medicine in the 21st century. Trend Mol Med 2001;7:259-264.
    • (2001) Trend Mol Med , vol.7 , pp. 259-264
    • Caplan, A.I.1    Bruder, S.P.2
  • 3
    • 58449135981 scopus 로고    scopus 로고
    • Why are MSCs therapeutic? New data: New insight
    • Caplan AI. Why are MSCs therapeutic? New data: New insight. J Pathol 2009;217:318-324.
    • (2009) J Pathol , vol.217 , pp. 318-324
    • Caplan, A.I.1
  • 4
    • 84872088799 scopus 로고    scopus 로고
    • The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine
    • Bianco P, Cao X, Frenette PS et al. The meaning, the sense and the significance: Translating the science of mesenchymal stem cells into medicine. Nat Med 2013;19:35-42.
    • (2013) Nat Med , vol.19 , pp. 35-42
    • Bianco, P.1    Cao, X.2    Frenette, P.S.3
  • 5
    • 84872139846 scopus 로고    scopus 로고
    • Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far?
    • Griffin MD, Ryan AE, Alagesan S et al. Anti-donor immune responses elicited by allogeneic mesenchymal stem cells: What have we learned so far? Immunol Cell Biol 2013;91:40-51.
    • (2013) Immunol Cell Biol , vol.91 , pp. 40-51
    • Griffin, M.D.1    Ryan, A.E.2    Alagesan, S.3
  • 6
    • 84860238652 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells and the innate immune system
    • Le Blanc K., Mougiakakos D. Multipotent mesenchymal stromal cells and the innate immune system. Nat Rev Immunol 2012;12:383-396.
    • (2012) Nat Rev Immunol , vol.12 , pp. 383-396
    • Le Blanc, K.1    Mougiakakos, D.2
  • 7
    • 84856973179 scopus 로고    scopus 로고
    • Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation
    • Prockop DJ, Youn Oh J. Mesenchymal stem/stromal cells (MSCs): Role as guardians of inflammation. Mol Ther 2012;20:14-20.
    • (2012) Mol Ther , vol.20 , pp. 14-20
    • Prockop, D.J.1    Youn Oh, J.2
  • 8
    • 78649895490 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal crohn's disease: Results of a phase I study
    • Duijvestein M, Vos ACW, Roelofs H et al. Autologous bone marrow-derived mesenchymal stromal cell treatment for refractory luminal Crohn's disease: Results of a phase I study. Gut 2010;59:1662-1669.
    • (2010) Gut , vol.59 , pp. 1662-1669
    • Duijvestein, M.1    Vos, A.C.W.2    Roelofs, H.3
  • 9
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study
    • Le Blanc K., Frassoni F, Ball L et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase II study. Lancet 2008;371:1579-1586.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3
  • 10
    • 77956620353 scopus 로고    scopus 로고
    • Pharma's developing interest in stem cells
    • McKernan R, McNeish J, Smith D. Pharma's developing interest in stem cells. Cell Stem Cell 2010;6:517-520.
    • (2010) Cell Stem Cell , vol.6 , pp. 517-520
    • McKernan, R.1    McNeish, J.2    Smith, D.3
  • 11
    • 84863338204 scopus 로고    scopus 로고
    • Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: A randomized controlled trial
    • Tan J, Wu W, Xu X et al. Induction therapy with autologous mesenchymal stem cells in living-related kidney transplants: A randomized controlled trial. JAMA 2012;307:1169-1177.
    • (2012) JAMA , vol.307 , pp. 1169-1177
    • Tan, J.1    Wu, W.2    Xu, X.3
  • 12
    • 79955853222 scopus 로고    scopus 로고
    • Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising crohn's disease
    • Ciccocioppo R, Bernardo ME, Sgarella A et al. Autologous bone marrow-derived mesenchymal stromal cells in the treatment of fistulising Crohn's disease. Gut 2011;60:788-798.
    • (2011) Gut , vol.60 , pp. 788-798
    • Ciccocioppo, R.1    Bernardo, M.E.2    Sgarella, A.3
  • 13
    • 84870887067 scopus 로고    scopus 로고
    • Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The poseidon randomized trial
    • Hare JM, Fishman JE, Gerstenblith G et al. Comparison of allogeneic vs autologous bone marrow-derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: The poseidon randomized trial. JAMA 2012;308:2369-2379.
    • (2012) JAMA , vol.308 , pp. 2369-2379
    • Hare, J.M.1    Fishman, J.E.2    Gerstenblith, G.3
  • 14
    • 84875458995 scopus 로고    scopus 로고
    • Mesenchymal stromal cells: Misconceptions and evolving concepts
    • Phinney DG, Sensebe L. Mesenchymal stromal cells: Misconceptions and evolving concepts. Cytotherapy 2013;15:140-145.
    • (2013) Cytotherapy , vol.15 , pp. 140-145
    • Phinney, D.G.1    Sensebe, L.2
  • 15
    • 77649194372 scopus 로고    scopus 로고
    • Challenges with advanced therapy medicinal products and how to meet them
    • The Committee for Advanced Therapies (CAT)
    • The Committee for Advanced Therapies (CAT). Challenges with advanced therapy medicinal products and how to meet them. Nat Rev Drug Discov 2010;9:195-201.
    • (2010) Nat Rev Drug Discov , vol.9 , pp. 195-201
  • 16
    • 84874217844 scopus 로고    scopus 로고
    • Cell therapy medicinal product regulatory framework in europe and its application for MSC based therapy development
    • Ancans J. Cell therapy medicinal product regulatory framework in Europe and its application for MSC based therapy development. Front Immunol 2012;3.
    • (2012) Front Immunol , vol.3
    • Ancans, J.1
  • 17
    • 70449701931 scopus 로고    scopus 로고
    • Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow
    • Morikawa S, Mabuchi Y, Kubota Y et al. Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med 2009;206:2483-2496.
    • (2009) J Exp Med , vol.206 , pp. 2483-2496
    • Morikawa, S.1    Mabuchi, Y.2    Kubota, Y.3
  • 18
    • 77957020167 scopus 로고    scopus 로고
    • The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche
    • Omatsu Y, Sugiyama T, Kohara H et al. The essential functions of adipo-osteogenic progenitors as the hematopoietic stem and progenitor cell niche. Immunity 2010;33:387-399.
    • (2010) Immunity , vol.33 , pp. 387-399
    • Omatsu, Y.1    Sugiyama, T.2    Kohara, H.3
  • 19
    • 77955646193 scopus 로고    scopus 로고
    • Mesenchymal and haematopoietic stem cells form a unique bone marrow niche
    • Mendez-Ferrer S., Michurina TV, Ferraro F et al. Mesenchymal and haematopoietic stem cells form a unique bone marrow niche. Nature 2010;466:829-834.
    • (2010) Nature , vol.466 , pp. 829-834
    • Mendez-Ferrer, S.1    Michurina, T.V.2    Ferraro, F.3
  • 20
    • 84856147560 scopus 로고    scopus 로고
    • Endothelial and perivascular cells maintain haematopoietic stem cells
    • Ding L, Saunders TL, Enikolopov G et al. Endothelial and perivascular cells maintain haematopoietic stem cells. Nature 2012;481:457-462.
    • (2012) Nature , vol.481 , pp. 457-462
    • Ding, L.1    Saunders, T.L.2    Enikolopov, G.3
  • 21
    • 84874997081 scopus 로고    scopus 로고
    • CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance
    • Greenbaum A, Hsu Y-MS, Day RB et al. CXCL12 in early mesenchymal progenitors is required for haematopoietic stem-cell maintenance. Nature 2013;495:227-230.
    • (2013) Nature , vol.495 , pp. 227-230
    • Greenbaum, A.1    Hsu, Y.-M.S.2    Day, R.B.3
  • 22
    • 79959208871 scopus 로고    scopus 로고
    • Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow
    • Mourcin F, Breton C, Tellier J et al. Galectin-1-expressing stromal cells constitute a specific niche for pre-BII cell development in mouse bone marrow. Blood 2011;117:6552-6561.
    • (2011) Blood , vol.117 , pp. 6552-6561
    • Mourcin, F.1    Breton, C.2    Tellier, J.3
  • 23
    • 84863229757 scopus 로고    scopus 로고
    • Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration
    • Park D, Spencer JA, Koh Bong I et al. Endogenous bone marrow MSCs are dynamic, fate-restricted participants in bone maintenance and regeneration. Cell Stem Cell 2012;10:259-272.
    • (2012) Cell Stem Cell , vol.10 , pp. 259-272
    • Park, D.1    Spencer, J.A.2    Koh Bong, I.3
  • 24
    • 59449093151 scopus 로고    scopus 로고
    • Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1
    • Battula VL, Treml S, Bareiss PM et al. Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen-1. Haematologica 2009; 94:173-184.
    • (2009) Haematologica , vol.94 , pp. 173-184
    • Battula, V.L.1    Treml, S.2    Bareiss, P.M.3
  • 25
    • 84856506096 scopus 로고    scopus 로고
    • The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging
    • Maijenburg MW, Kleijer M, Vermeul K et al. The composition of the mesenchymal stromal cell compartment in human bone marrow changes during development and aging. Haematologica 2012;97:179-183.
    • (2012) Haematologica , vol.97 , pp. 179-183
    • Maijenburg, M.W.1    Kleijer, M.2    Vermeul, K.3
  • 26
    • 79955944297 scopus 로고    scopus 로고
    • CD146 expression on primary nonhe-matopoietic bone marrow stem cells is correlated with in situ localization
    • Tormin A, Li O, Brune JC et al. CD146 expression on primary nonhe-matopoietic bone marrow stem cells is correlated with in situ localization. Blood 2011;117:5067-5077.
    • (2011) Blood , vol.117 , pp. 5067-5077
    • Tormin, A.1    Li, O.2    Brune, J.C.3
  • 27
    • 50849139576 scopus 로고    scopus 로고
    • A perivascular origin for mesenchymal stem cells in multiple human organs
    • Crisan M, Yap S, Casteilla L et al. A perivascular origin for mesenchymal stem cells in multiple human organs. Cell Stem Cell 2008;3: 301-313.
    • (2008) Cell Stem Cell , vol.3 , pp. 301-313
    • Crisan, M.1    Yap, S.2    Casteilla, L.3
  • 28
    • 79961230399 scopus 로고    scopus 로고
    • Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises
    • Armulik A, Genové G, Betsholtz C. Pericytes: Developmental, physiological, and pathological perspectives, problems, and promises. Developmental Cell 2011;21:193-215.
    • (2011) Developmental Cell , vol.21 , pp. 193-215
    • Armulik, A.1    Genové, G.2    Betsholtz, C.3
  • 29
    • 79960464308 scopus 로고    scopus 로고
    • Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-ΚB signaling in resident macrophages
    • Choi H, Lee RH, Bazhanov N et al. Anti-inflammatory protein TSG-6 secreted by activated MSCs attenuates zymosan-induced mouse peritonitis by decreasing TLR2/NF-ΚB signaling in resident macrophages. Blood 2011;118:330-338.
    • (2011) Blood , vol.118 , pp. 330-338
    • Choi, H.1    Lee, R.H.2    Bazhanov, N.3
  • 30
    • 61849123247 scopus 로고    scopus 로고
    • Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25High forkhead box P3+ regulatory T cells
    • English K, Ryan JM, Tobin L et al. Cell contact, prostaglandin E2 and transforming growth factor beta 1 play non-redundant roles in human mesenchymal stem cell induction of CD4 + CD25High forkhead box P3+ regulatory T cells. Clin Exp Immunol 2009;156:149-160.
    • (2009) Clin Exp Immunol , vol.156 , pp. 149-160
    • English, K.1    Ryan, J.M.2    Tobin, L.3
  • 31
    • 78650827566 scopus 로고    scopus 로고
    • Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression
    • Ge W, Jiang J, Arp J et al. Regulatory T-cell generation and kidney allograft tolerance induced by mesenchymal stem cells associated with indoleamine 2,3-dioxygenase expression. Transplantation 2010;90: 1312-1320.
    • (2010) Transplantation , vol.90 , pp. 1312-1320
    • Ge, W.1    Jiang, J.2    Arp, J.3
  • 32
    • 79952042164 scopus 로고    scopus 로고
    • Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells
    • Kavanagh H, Mahon BP Allogeneic mesenchymal stem cells prevent allergic airway inflammation by inducing murine regulatory T cells. Allergy 2011;66:523-531.
    • (2011) Allergy , vol.66 , pp. 523-531
    • Kavanagh, H.1    Mahon, B.P.2
  • 33
    • 77950377767 scopus 로고    scopus 로고
    • Bone marrow stromal cells use TGF-ß to suppress allergic responses in a mouse model of ragweed-induced asthma
    • Nemeth K, Keane-Myers A, Brown JM et al. Bone marrow stromal cells use TGF-ß to suppress allergic responses in a mouse model of ragweed-induced asthma. PNAS 2010;107:5652-5657.
    • (2010) PNAS , vol.107 , pp. 5652-5657
    • Nemeth, K.1    Keane-Myers, A.2    Brown, J.M.3
  • 34
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogram-ming of host macrophages to increase their interleukin-10 production
    • Nemeth K, Leelahavanichkul A, Yuen PST et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E2-dependent reprogram-ming of host macrophages to increase their interleukin-10 production. Nat Med 2009;15:42-49.
    • (2009) Nat Med , vol.15 , pp. 42-49
    • Nemeth, K.1    Leelahavanichkul, A.2    Yuen, P.S.T.3
  • 35
    • 84860636948 scopus 로고    scopus 로고
    • Mesenchymal-stem-cell-induced immunoregulation involves fas-ligand-/fas-mediated T cell apoptosis
    • Akiyama K, Chen C, Wang D et al. Mesenchymal-stem-cell-induced immunoregulation involves fas-ligand-/fas-mediated T cell apoptosis. Cell Stem Cell 2012;10:544-555.
    • (2012) Cell Stem Cell , vol.10 , pp. 544-555
    • Akiyama, K.1    Chen, C.2    Wang, D.3
  • 36
    • 40749110247 scopus 로고    scopus 로고
    • Human mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the notch pathway
    • Li Y-P, Paczesny S., Lauret E et al. Human Mesenchymal stem cells license adult CD34+ hemopoietic progenitor cells to differentiate into regulatory dendritic cells through activation of the notch pathway. J Immunol 2008;180:1598-1608.
    • (2008) J Immunol , vol.180 , pp. 1598-1608
    • Li, Y.-P.1    Paczesny, S.2    Lauret, E.3
  • 37
    • 59449096601 scopus 로고    scopus 로고
    • Mesenchymal stem cells induce mature dendritic cells into a novel jagged-2-dependent regulatory dendritic cell population
    • Zhang B, Liu R, Shi D et al. Mesenchymal stem cells induce mature dendritic cells into a novel Jagged-2-dependent regulatory dendritic cell population. Blood 2009;113:46-57.
    • (2009) Blood , vol.113 , pp. 46-57
    • Zhang, B.1    Liu, R.2    Shi, D.3
  • 38
    • 79952724283 scopus 로고    scopus 로고
    • The bone marrow stem cell niche grows up: Mesenchymal stem cells and macrophages move
    • Ehninger A, Trumpp A. The bone marrow stem cell niche grows up: Mesenchymal stem cells and macrophages move in. J Exp Med 2011; 208:421-428.
    • (2011) J Exp Med , vol.208 , pp. 421-428
    • Ehninger, A.1    Trumpp, A.2
  • 39
    • 77956215701 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit human th17 cell differentiation and function and induce a T regulatory cell phenotype
    • Ghannam S, Pène J, Torcy-Moquet G et al. Mesenchymal stem cells inhibit human Th17 cell differentiation and function and induce a T regulatory cell phenotype. J Immunol 2010;185:302-312.
    • (2010) J Immunol , vol.185 , pp. 302-312
    • Ghannam, S.1    Pène, J.2    Torcy-Moquet, G.3
  • 40
    • 80053153051 scopus 로고    scopus 로고
    • Mesenchymal stem cell inhibition of T-helper 17 cell differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor
    • Duffy MM, Pindjakova J, Hanley SA et al. Mesenchymal stem cell inhibition of T-helper 17 cell differentiation is triggered by cell-cell contact and mediated by prostaglandin E2 via the EP4 receptor. Eur J Immunol 2011;41:2840-2851.
    • (2011) Eur J Immunol , vol.41 , pp. 2840-2851
    • Duffy, M.M.1    Pindjakova, J.2    Hanley, S.A.3
  • 41
    • 73249121388 scopus 로고    scopus 로고
    • Cell contact interaction between adipose-derived stromal cells and allo-activated T lymphocytes
    • Quaedackers ME, Baan CC, Weimar W et al. Cell contact interaction between adipose-derived stromal cells and allo-activated T lymphocytes. Eur J Immunol 2009;39:3436-3446.
    • (2009) Eur J Immunol , vol.39 , pp. 3436-3446
    • Quaedackers, M.E.1    Baan, C.C.2    Weimar, W.3
  • 42
    • 84865184497 scopus 로고    scopus 로고
    • Mesenchymal stem cells: A double-edged sword in regulating immune responses
    • Li W, Ren G, Huang Y et al. Mesenchymal stem cells: A double-edged sword in regulating immune responses. Cell Death Differ 2012; 19:1505-1513.
    • (2012) Cell Death Differ , vol.19 , pp. 1505-1513
    • Li, W.1    Ren, G.2    Huang, Y.3
  • 43
    • 37349075167 scopus 로고    scopus 로고
    • Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation
    • English K, Barry FP, Mahon BP Murine mesenchymal stem cells suppress dendritic cell migration, maturation and antigen presentation. Immunol Letters 2008;115:50-58.
    • (2008) Immunol Letters , vol.115 , pp. 50-58
    • English, K.1    Barry, F.P.2    Mahon, B.P.3
  • 44
    • 80054809361 scopus 로고    scopus 로고
    • Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells
    • Chiesa S, Morbelli S, Morando S et al. Mesenchymal stem cells impair in vivo T-cell priming by dendritic cells. PNAS 2011;108: 17384-17389.
    • (2011) PNAS , vol.108 , pp. 17384-17389
    • Chiesa, S.1    Morbelli, S.2    Morando, S.3
  • 45
    • 33746898242 scopus 로고    scopus 로고
    • Mesenchymal stem cells inhibit generation and function of both CD34 +-derived and monocyte-derived dendritic cells
    • Nauta AJ, Kruisselbrink AB, Lurvink E et al. Mesenchymal stem cells inhibit generation and function of both CD34 +-derived and monocyte-derived dendritic cells. J Immunol 2006;177:2080-2087.
    • (2006) J Immunol , vol.177 , pp. 2080-2087
    • Nauta, A.J.1    Kruisselbrink, A.B.2    Lurvink, E.3
  • 46
    • 84872159367 scopus 로고    scopus 로고
    • Cellular and molecular interactions of mesenchymal stem cells in innate immunity
    • Maria Spaggiari G., Moretta L. Cellular and molecular interactions of mesenchymal stem cells in innate immunity. Immunol Cell Biol 2013; 91:27-31.
    • (2013) Immunol Cell Biol , vol.91 , pp. 27-31
    • Maria Spaggiari, G.1    Moretta, L.2
  • 47
    • 84870244903 scopus 로고    scopus 로고
    • Immunomodulatory effect of mesenchymal stem cells on B cells
    • Franquesa M, Hoogduijn MJ, Bestard O et al. Immunomodulatory effect of mesenchymal stem cells on B cells. Front Immunol 2012;3.
    • (2012) Front Immunol , vol.3
    • Franquesa, M.1    Hoogduijn, M.J.2    Bestard, O.3
  • 48
    • 84870946957 scopus 로고    scopus 로고
    • MSCs, macrophages, and cancer: A dangerous menage-À-trois
    • Mantovani A. MSCs, Macrophages, and cancer: A dangerous menage-à-trois. Cell Stem Cell 2012;11:730-732.
    • (2012) Cell Stem Cell , vol.11 , pp. 730-732
    • Mantovani, A.1
  • 49
    • 48649088234 scopus 로고    scopus 로고
    • Concise review: Adult multipotent stromal cells and cancer: Risk or benefit?
    • Lazennec G, Jorgensen C. Concise Review: Adult multipotent stromal cells and cancer: Risk or benefit? Stem Cells 2008;26:1387-1394.
    • (2008) Stem Cells , vol.26 , pp. 1387-1394
    • Lazennec, G.1    Jorgensen, C.2
  • 50
    • 84866992169 scopus 로고    scopus 로고
    • Update on cancer related issues of mesenchymal stem cell-based therapies
    • Wang D, Wang S, Shi C. Update on cancer related issues of mesenchymal stem cell-based therapies. Curr Stem Cell Res Ther 2012;7: 370-380.
    • (2012) Curr Stem Cell Res Ther , vol.7 , pp. 370-380
    • Wang, D.1    Wang, S.2    Shi, C.3
  • 51
    • 84870929405 scopus 로고    scopus 로고
    • Preactivation of human MSCs with TNF - A enhances tumor-suppressive activity
    • Lee Ryang H., Yoon N, Reneau JC et al. Preactivation of human MSCs with TNF-a enhances tumor-suppressive activity. Cell Stem Cell 2012;11:825-835.
    • (2012) Cell Stem Cell , vol.11 , pp. 825-835
    • Lee Ryang, H.1    Yoon, N.2    Reneau, J.C.3
  • 52
    • 84870933589 scopus 로고    scopus 로고
    • CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFa
    • Ren G, Zhao X, Wang Y et al. CCR2-dependent recruitment of macrophages by tumor-educated mesenchymal stromal cells promotes tumor development and is mimicked by TNFa. Cell Stem Cell 2012;11:812-824.
    • (2012) Cell Stem Cell , vol.11 , pp. 812-824
    • Ren, G.1    Zhao, X.2    Wang, Y.3
  • 53
    • 84865412756 scopus 로고    scopus 로고
    • Immunogenicity of allogeneic mesenchymal stem cells
    • Schu S, Nosov M, O'Flynn L et al. Immunogenicity of allogeneic mesenchymal stem cells. J Cell Mol Med 2012;16:2094-2103.
    • (2012) J Cell Mol Med , vol.16 , pp. 2094-2103
    • Schu, S.1    Nosov, M.2    O'Flynn, L.3
  • 54
    • 78650686250 scopus 로고    scopus 로고
    • Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair
    • Huang X-P, Sun Z., Miyagi Y et al. Differentiation of allogeneic mesenchymal stem cells induces immunogenicity and limits their long-term benefits for myocardial repair. Circulation 2010;122:2419-2429.
    • (2010) Circulation , vol.122 , pp. 2419-2429
    • Huang, X.-P.1    Sun, Z.2    Miyagi, Y.3
  • 55
    • 84872914245 scopus 로고    scopus 로고
    • Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion
    • Eggenhofer E, Benseler V, Kroemer A et al. Mesenchymal stem cells are short-lived and do not migrate beyond the lungs after intravenous infusion. Front Immunol 2012;3.
    • (2012) Front Immunol , vol.3
    • Eggenhofer, E.1    Benseler, V.2    Kroemer, A.3
  • 56
    • 84874342825 scopus 로고    scopus 로고
    • Cell surface structures influence lung clearance rate of systemically infused mesenchymal stromal cells
    • Nystedt J, Anderson H, Tikkanen J et al. Cell surface structures influence lung clearance rate of systemically infused mesenchymal stromal cells. Stem Cells 2013;31:317-326.
    • (2013) Stem Cells , vol.31 , pp. 317-326
    • Nystedt, J.1    Anderson, H.2    Tikkanen, J.3
  • 57
    • 84880823501 scopus 로고    scopus 로고
    • Are cultured mesenchymal stromal cells an option for immunomodulation in transplantation?
    • Plock JA, Schnider JT, Schweizer R et al. Are cultured mesenchymal stromal cells an option for immunomodulation in transplantation? Front Immunol 2013;4.
    • (2013) Front Immunol , vol.4
    • Plock, J.A.1    Schnider, J.T.2    Schweizer, R.3
  • 58
    • 84859488945 scopus 로고    scopus 로고
    • Paracrine effects of mesenchymal stem cells enhance vascular regeneration in ischemic murine skin
    • Schlosser S, Dennler C, Schweizer R et al. Paracrine effects of mesenchymal stem cells enhance vascular regeneration in ischemic murine skin. Microvasc Res 2012;83:267-275.
    • (2012) Microvasc Res , vol.83 , pp. 267-275
    • Schlosser, S.1    Dennler, C.2    Schweizer, R.3
  • 59
    • 84861868459 scopus 로고    scopus 로고
    • Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat
    • Curley GF, Hayes M, Ansari B et al. Mesenchymal stem cells enhance recovery and repair following ventilator-induced lung injury in the rat. Thorax 2012;67:496-501.
    • (2012) Thorax , vol.67 , pp. 496-501
    • Curley, G.F.1    Hayes, M.2    Ansari, B.3
  • 60
    • 84870463737 scopus 로고    scopus 로고
    • Preconditioning enhances the paracrine effect of mesenchymal stem cells in preventing oxygen-induced neonatal lung injury in rats
    • Waszak P, Alphonse R, Vadivel A et al. Preconditioning enhances the paracrine effect of mesenchymal stem cells in preventing oxygen-induced neonatal lung injury in rats. Stem Cells Dev 2012;21:2789-2797.
    • (2012) Stem Cells Dev , vol.21 , pp. 2789-2797
    • Waszak, P.1    Alphonse, R.2    Vadivel, A.3
  • 61
    • 49249129381 scopus 로고    scopus 로고
    • The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury
    • Oh JY, Kim MK, Shin MS et al. The anti-inflammatory and anti-angiogenic role of mesenchymal stem cells in corneal wound healing following chemical injury. Stem Cells 2008;26:1047-1055.
    • (2008) Stem Cells , vol.26 , pp. 1047-1055
    • Oh, J.Y.1    Kim, M.K.2    Shin, M.S.3
  • 62
    • 80053284296 scopus 로고    scopus 로고
    • Action at a distance: Systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF - A stimulated gene/protein 6
    • Roddy GW, Oh JY, Lee RH et al. Action at a distance: Systemically administered adult stem/progenitor cells (MSCs) reduce inflammatory damage to the cornea without engraftment and primarily by secretion of TNF-a stimulated gene/protein 6. Stem Cells 2011;29: 1572-1579.
    • (2011) Stem Cells , vol.29 , pp. 1572-1579
    • Roddy, G.W.1    Oh, J.Y.2    Lee, R.H.3
  • 63
    • 0028881201 scopus 로고
    • Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use
    • Lazarus HM, Haynesworth SE, Gerson SL et al. Ex vivo expansion and subsequent infusion of human bone marrow-derived stromal progenitor cells (mesenchymal progenitor cells): Implications for therapeutic use. Bone Marrow Transplant 1995;16:557-564.
    • (1995) Bone Marrow Transplant , vol.16 , pp. 557-564
    • Lazarus, H.M.1    Haynesworth, S.E.2    Gerson, S.L.3
  • 64
    • 77954957825 scopus 로고    scopus 로고
    • Advancement of mesen-chymal stem cell therapy in solid organ transplantation (MISOT)
    • Hoogduijn MJ, Popp FC, Grohnert A et al. Advancement of mesen-chymal stem cell therapy in solid organ transplantation (MISOT). Transplantation 2010;90:124-126.
    • (2010) Transplantation , vol.90 , pp. 124-126
    • Hoogduijn, M.J.1    Popp, F.C.2    Grohnert, A.3
  • 65
    • 79956345519 scopus 로고    scopus 로고
    • Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia
    • See F, Seki T, Psaltis PJ et al. Therapeutic effects of human STRO-3-selected mesenchymal precursor cells and their soluble factors in experimental myocardial ischemia. J Cell Mol Med 2011;15:2117-2129.
    • (2011) J Cell Mol Med , vol.15 , pp. 2117-2129
    • See, F.1    Seki, T.2    Psaltis, P.J.3
  • 66
    • 84858668486 scopus 로고    scopus 로고
    • Single-platform quality control assay to quantify multipotential stromal cells in bone marrow aspirates prior to bulk manufacture or direct therapeutic use
    • Cuthbert R, Boxall SA, Tan HB et al. Single-platform quality control assay to quantify multipotential stromal cells in bone marrow aspirates prior to bulk manufacture or direct therapeutic use. Cytotherapy 2012; 14:431-440.
    • (2012) Cytotherapy , vol.14 , pp. 431-440
    • Cuthbert, R.1    Boxall, S.A.2    Tan, H.B.3
  • 67
    • 84871297004 scopus 로고    scopus 로고
    • Characterization of bone marrow derived mesenchymal stem cells in suspension
    • Akiyama K, You YO, Yamaza T et al. Characterization of bone marrow derived mesenchymal stem cells in suspension. Stem Cell Res Ther 2012;3:40.
    • (2012) Stem Cell Res Ther , vol.3 , pp. 40
    • Akiyama, K.1    You, Y.O.2    Yamaza, T.3
  • 68
    • 84862900149 scopus 로고    scopus 로고
    • Are therapeutic human mesenchymal stromal cells compatible with human blood?
    • Moll G, Rasmusson-Duprez I, von Bahr L et al. Are therapeutic human mesenchymal stromal cells compatible with human blood? Stem Cells 2012;30:1565-1574.
    • (2012) Stem Cells , vol.30 , pp. 1565-1574
    • Moll, G.1    Rasmusson-Duprez, I.2    Von Bahr, L.3
  • 69
    • 84858080480 scopus 로고    scopus 로고
    • Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy
    • von Bahr L., Sundberg B, Lönnies L et al. Long-term complications, immunologic effects, and role of passage for outcome in mesenchymal stromal cell therapy. Biol Blood Marrow Transplant 2012;18:557-564.
    • (2012) Biol Blood Marrow Transplant , vol.18 , pp. 557-564
    • Von Bahr, L.1    Sundberg, B.2    Lönnies, L.3
  • 70
    • 84875468183 scopus 로고    scopus 로고
    • The mesenchymal stromal cells dilemma - Does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road?
    • Galipeau J. The mesenchymal stromal cells dilemma - does a negative phase III trial of random donor mesenchymal stromal cells in steroid-resistant graft-versus-host disease represent a death knell or a bump in the road? Cytotherapy 2013;15:2-8.
    • (2013) Cytotherapy , vol.15 , pp. 2-8
    • Galipeau, J.1
  • 71
    • 84862835586 scopus 로고    scopus 로고
    • Analysis of tissues following mes-enchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation
    • von Bahr L., Batsis I, Moll G et al. Analysis of tissues following mes-enchymal stromal cell therapy in humans indicates limited long-term engraftment and no ectopic tissue formation. Stem Cells 2012;30: 1575-1578.
    • (2012) Stem Cells , vol.30 , pp. 1575-1578
    • Von Bahr, L.1    Batsis, I.2    Moll, G.3
  • 72
    • 84863755249 scopus 로고    scopus 로고
    • Mesenchymal stromal cells for the treatment of graft-versus-host disease: Understanding the in vivo biological effect through patient immune monitoring
    • Dander E, Lucchini G, Vinci P et al. Mesenchymal stromal cells for the treatment of graft-versus-host disease: Understanding the in vivo biological effect through patient immune monitoring. Leukemia 2012; 26:1681-1684.
    • (2012) Leukemia , vol.26 , pp. 1681-1684
    • Dander, E.1    Lucchini, G.2    Vinci, P.3
  • 73
    • 84868523104 scopus 로고    scopus 로고
    • Mesenchymal stem cells are injured by complement after their contact with serum
    • Li Y, Lin F. Mesenchymal stem cells are injured by complement after their contact with serum. Blood 2012;120:3436-3443.
    • (2012) Blood , vol.120 , pp. 3436-3443
    • Li, Y.1    Lin, F.2
  • 74
    • 55049140192 scopus 로고    scopus 로고
    • Mesenchymal stem cells alter migratory property of T and dendritic cells to delay the development of murine lethal acute graft-versus-host disease
    • Li H, Guo Z, Jiang X et al. Mesenchymal stem cells alter migratory property of T and dendritic cells to delay the development of murine lethal acute graft-versus-host disease. Stem Cells 2008;26: 2531-2541.
    • (2008) Stem Cells , vol.26 , pp. 2531-2541
    • Li, H.1    Guo, Z.2    Jiang, X.3
  • 75
    • 79952624644 scopus 로고    scopus 로고
    • Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal™) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study
    • Prasad VK, Lucas KG, Kleiner GI et al. Efficacy and safety of ex vivo cultured adult human mesenchymal stem cells (Prochymal™) in pediatric patients with severe refractory acute graft-versus-host disease in a compassionate use study. Biol Blood Marrow Transplant 2011;17: 534-541.
    • (2011) Biol Blood Marrow Transplant , vol.17 , pp. 534-541
    • Prasad, V.K.1    Lucas, K.G.2    Kleiner, G.I.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.