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Volumn 15, Issue 2, 2013, Pages 140-145

Mesenchymal stromal cells: Misconceptions and evolving concepts

Author keywords

Adult stem cells; Marrow stromal cells; Mesenchymal stem cells; Multipotent mesenchymal stromal cells

Indexed keywords

5' NUCLEOTIDASE; ACTIVATED LEUKOCYTE CELL ADHESION MOLECULE; ADAPALENE; ALPHA1 INTEGRIN; BETA1 INTEGRIN; CD146 ANTIGEN; CD39 ANTIGEN; CD51 ANTIGEN; ENDOGLIN; FETAL ANTIGEN; HERMES ANTIGEN; NESTIN; PLATELET DERIVED GROWTH FACTOR BETA RECEPTOR; THY 1 ANTIGEN; VASCULAR CELL ADHESION MOLECULE 1;

EID: 84875458995     PISSN: 14653249     EISSN: 14772566     Source Type: Journal    
DOI: 10.1016/j.jcyt.2012.11.005     Document Type: Review
Times cited : (106)

References (50)
  • 1
    • 84967443930 scopus 로고    scopus 로고
    • Marrow stem
    • In: Polak J, Mantalaris S, Harding S, editors London: Imperial College Press
    • Phinney DG. Marrow stem. In: Polak J, Mantalaris S, Harding S, editors. Advances in tissue engineering. London: Imperial College Press; 2008. p. 95-122.
    • (2008) Advances in Tissue Engineering , pp. 95-122
    • Phinney, D.G.1
  • 2
    • 0032976690 scopus 로고    scopus 로고
    • Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta
    • Horwitz EM, Prockop DJ, Fitzpatrick LA, Koo WW, Gordon PL, Neel M, et al. Transplantability and therapeutic effects of bone marrow-derived mesenchymal cells in children with osteogenesis imperfecta. Nat Med. 1999;5:309-13.
    • (1999) Nat Med , vol.5 , pp. 309-313
    • Horwitz, E.M.1    Prockop, D.J.2    Fitzpatrick, L.A.3    Koo, W.W.4    Gordon, P.L.5    Neel, M.6
  • 3
    • 0033977382 scopus 로고    scopus 로고
    • Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy
    • Koc O, Gerson SL, Cooper BW, Dyhouse SM, Haynesworth SE, Caplan AI, et al. Rapid hematopoietic recovery after coinfusion of autologous-blood stem cells and culture-expanded marrow mesenchymal stem cells in advanced breast cancer patients receiving high-dose chemotherapy. J Clin Oncol. 2000;18:307-16.
    • (2000) J Clin Oncol , vol.18 , pp. 307-316
    • Koc, O.1    Gerson, S.L.2    Cooper, B.W.3    Dyhouse, S.M.4    Haynesworth, S.E.5    Caplan, A.I.6
  • 4
    • 0017119380 scopus 로고
    • Fibroblast precursors in normal and irradiated mouse hematopoietic organs
    • Friedenstein AJ, Gorskaja JF, Kulagina NN. Fibroblast precursors in normal and irradiated mouse hematopoietic organs. Exp Hematol. 1976;4:267-74.
    • (1976) Exp Hematol , vol.4 , pp. 267-274
    • Friedenstein, A.J.1    Gorskaja, J.F.2    Kulagina, N.N.3
  • 6
    • 0028102611 scopus 로고
    • The stro1 fraction of adult human bone marrow contains the osteogenic precursors
    • Gronthos S, Graves SE, Ohta S, Simmons PJ. The STRO1 fraction of adult human bone marrow contains the osteogenic precursors. Blood. 1994;84:4164-73.
    • (1994) Blood , vol.84 , pp. 4164-4173
    • Gronthos, S.1    Graves, S.E.2    Ohta, S.3    Simmons, P.J.4
  • 7
    • 0042306316 scopus 로고    scopus 로고
    • Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp
    • Shi S, Gronthos S. Perivascular niche of postnatal mesenchymal stem cells in human bone marrow and dental pulp. J Bone Min Res. 2003;18:694-704.
    • (2003) J Bone Min Res , vol.18 , pp. 694-704
    • Shi, S.1    Gronthos, S.2
  • 8
    • 21244460348 scopus 로고    scopus 로고
    • Perivascular cells expressing annexin a5 define a novel mesenchymal stem celllike population with the capacity to differentiate into multiple mesenchymal lineages
    • Brachvogel B, Moch H, Pausch F, Schlotzer-Schrehardt U, Hofmann C, von der Mark K, et al. Perivascular cells expressing annexin A5 define a novel mesenchymal stem celllike population with the capacity to differentiate into multiple mesenchymal lineages. Development. 2005;132:2657-68.
    • (2005) Development , vol.132 , pp. 2657-2668
    • Brachvogel, B.1    Moch, H.2    Pausch, F.3    Schlotzer-Schrehardt, U.4    Hofmann, C.5    Von Der Mark, K.6
  • 10
    • 42249092647 scopus 로고    scopus 로고
    • Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with cd146 perivascular cells and fibroblasts
    • Covas DT, Panepucci RA, Fontes AM, Silva WA Jr, Orellana MD, Freitas MC, et al. Multipotent mesenchymal stromal cells obtained from diverse human tissues share functional properties and gene-expression profile with CD146 perivascular cells and fibroblasts. Expt Hematol. 2008;36:642-54.
    • (2008) Expt Hematol , vol.36 , pp. 642-654
    • Covas, D.T.1    Panepucci, R.A.2    Fontes, A.M.3    Silva Jr., W.A.4    Orellana, M.D.5    Freitas, M.C.6
  • 11
    • 33745503987 scopus 로고    scopus 로고
    • Mesenchymal stem cells reside in virtually all post-natal organs and tissues
    • da Silva Meirelles L, Chagastelles PC, Nardi NB. Mesenchymal stem cells reside in virtually all post-natal organs and tissues. J Cell Sci. 2006;119:2204-13.
    • (2006) J Cell Sci , vol.119 , pp. 2204-2213
    • Da Silva Meirelles, L.1    Chagastelles, P.C.2    Nardi, N.B.3
  • 13
    • 80055059641 scopus 로고    scopus 로고
    • Pericytes resident inpostnatal skeletal muscle differentiate into muscle fibres and generate satellite cells
    • Dellavalle A, Maroli G, Covarello D, Azzoni E, Innocenzi A, Perani L, et al. Pericytes resident inpostnatal skeletal muscle differentiate into muscle fibres and generate satellite cells. Nat Comm. 2011;2:499.
    • (2011) Nat Comm , vol.2 , pp. 499
    • Dellavalle, A.1    Maroli, G.2    Covarello, D.3    Azzoni, E.4    Innocenzi, A.5    Perani, L.6
  • 14
    • 34250854663 scopus 로고    scopus 로고
    • Neuroepithelial cells supply an initial transient wave of msc differentiation
    • Takashima Y, Era T, Nakao K, Kondo S, Kasuga M, Smith AG, et al. Neuroepithelial cells supply an initial transient wave of MSC differentiation. Cell. 2007;129:1377-88.
    • (2007) Cell , vol.129 , pp. 1377-1388
    • Takashima, Y.1    Era, T.2    Nakao, K.3    Kondo, S.4    Kasuga, M.5    Smith, A.G.6
  • 16
    • 77955811853 scopus 로고    scopus 로고
    • Epithelial-mesenchymal transition-derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells
    • Battula VL, Evans KW, Hollier BG, Shi Y, Marini FC, Ayyanan A, et al. Epithelial-mesenchymal transition-derived cells exhibit multi-lineage differentiation potential similar to mesenchymal stem cells. Stem Cells. 2010;28:1435-45.
    • (2010) Stem Cells , vol.28 , pp. 1435-1445
    • Battula, V.L.1    Evans, K.W.2    Hollier, B.G.3    Shi, Y.4    Marini, F.C.5    Ayyanan, A.6
  • 17
    • 70350239862 scopus 로고    scopus 로고
    • Twist family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment
    • Isenmann S, Arthur A, Zannettino AC, Turner JL, Shi S, Glackin CA, et al. TWIST family of basic helix-loop-helix transcription factors mediate human mesenchymal stem cell growth and commitment. Stem Cells. 2009;27:2457-68.
    • (2009) Stem Cells , vol.27 , pp. 2457-2468
    • Isenmann, S.1    Arthur, A.2    Zannettino, A.C.3    Turner, J.L.4    Shi, S.5    Glackin, C.A.6
  • 18
    • 36249021493 scopus 로고    scopus 로고
    • Concise review: Mesenchymal stem/multipotent stromal cells: The state of transdifferentiation and modes of tissue repair - Current views
    • Phinney DG, Prockop DJ. Concise review: mesenchymal stem/multipotent stromal cells: the state of transdifferentiation and modes of tissue repair - current views. Stem Cells. 2007; 25:2896-902.
    • (2007) Stem Cells , vol.25 , pp. 2896-2902
    • Phinney, D.G.1    Prockop, D.J.2
  • 19
    • 0035038659 scopus 로고    scopus 로고
    • The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain
    • Etchevers HC, Vincent C, Le Douarin NM, Couly GF. The cephalic neural crest provides pericytes and smooth muscle cells to all blood vessels of the face and forebrain. Development. 2001;128:1059-68.
    • (2001) Development , vol.128 , pp. 1059-1068
    • Etchevers, H.C.1    Vincent, C.2    Le Douarin, N.M.3    Couly, G.F.4
  • 21
    • 84934439681 scopus 로고    scopus 로고
    • Neural crest contribution to the cardiovascular system
    • Brown CB, Baldwin HS. Neural crest contribution to the cardiovascular system. Adv Exp Med Biol. 2006;589:134-54.
    • (2006) Adv Exp Med Biol , vol.589 , pp. 134-154
    • Brown, C.B.1    Baldwin, H.S.2
  • 22
    • 0036322290 scopus 로고    scopus 로고
    • Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies
    • Quirici N, Soligo D, Bossolasco P, Servida F, Lumini C, Deliliers GL. Isolation of bone marrow mesenchymal stem cells by anti-nerve growth factor receptor antibodies. Exp Hematol. 2002;30:783-91.
    • (2002) Exp Hematol , vol.30 , pp. 783-791
    • Quirici, N.1    Soligo, D.2    Bossolasco, P.3    Servida, F.4    Lumini, C.5    Deliliers, G.L.6
  • 23
    • 35348921682 scopus 로고    scopus 로고
    • Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment
    • Sacchetti B, Funari A, Michienzi S, Di Cesare S, Piersanti S, Saggio I, et al. Self-renewing osteoprogenitors in bone marrow sinusoids can organize a hematopoietic microenvironment. Cell. 2007;131:324-36.
    • (2007) Cell , vol.131 , pp. 324-336
    • Sacchetti, B.1    Funari, A.2    Michienzi, S.3    Di Cesare, S.4    Piersanti, S.5    Saggio, I.6
  • 24
    • 78751706417 scopus 로고    scopus 로고
    • Human bone marrow mesenchymal stem cells: A systematic reappraisal via the genostem experience
    • Charbord P, Livne E, Gross G, Haupl T, Neves NM, Marie P, et al. Human bone marrow mesenchymal stem cells: a systematic reappraisal via the genostem experience. Stem Cell Rev. 2011;7:32-42.
    • (2011) Stem Cell Rev , vol.7 , pp. 32-42
    • Charbord, P.1    Livne, E.2    Gross, G.3    Haupl, T.4    Neves, N.M.5    Marie, P.6
  • 25
    • 33747713246 scopus 로고    scopus 로고
    • Minimal criteria for defining multipotent mesenchymal stromal cells. The international society for cellular therapy position statement
    • Dominici M, Le Blanc K, Mueller I, Slaper-Cortenbach I, Marini F, Krause D, et al. Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy. 2006;8:315-7.
    • (2006) Cytotherapy , vol.8 , pp. 315-317
    • Dominici, M.1    Le Blanc, K.2    Mueller, I.3    Slaper-Cortenbach, I.4    Marini, F.5    Krause, D.6
  • 26
    • 0032748173 scopus 로고    scopus 로고
    • Propagation and senescence of human marrow stromal cells in culture: A simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate
    • Digirolamo CM, Stokes D, Colter D, Phinney DG, Class R, Prockop DJ. Propagation and senescence of human marrow stromal cells in culture: a simple colony-forming assay identifies samples with the greatest potential to propagate and differentiate. Br J Haematol. 1999;107:275-81.
    • (1999) Br J Haematol , vol.107 , pp. 275-281
    • Digirolamo, C.M.1    Stokes, D.2    Colter, D.3    Phinney, D.G.4    Class, R.5    Prockop, D.J.6
  • 27
    • 38349060190 scopus 로고    scopus 로고
    • Human multipotent stromal cells undergosharp transition from division to development in culture
    • Larson BL, Ylöstalo J, Prockop DJ. Human multipotent stromal cells undergosharp transition from division to development in culture. Stem Cells. 2008;26:193-201.
    • (2008) Stem Cells , vol.26 , pp. 193-201
    • Larson, B.L.1    Ylöstalo, J.2    Prockop, D.J.3
  • 28
    • 58149326737 scopus 로고    scopus 로고
    • Bone marrow stromal cells attenuate sepsis via prostaglandin e(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production
    • N-emeth K, Leelahavanichkul A, Yuen PS, Mayer B, Parmelee A, Doi K, et al. Bone marrow stromal cells attenuate sepsis via prostaglandin E(2)-dependent reprogramming of host macrophages to increase their interleukin-10 production. Nat Med. 2009;15:42-9.
    • (2009) Nat Med. , vol.15 , pp. 42-49
    • Nemeth, K.1    Leelahavanichkul, A.2    Yuen, P.S.3    Mayer, B.4    Parmelee, A.5    Doi, K.6
  • 29
    • 67649171661 scopus 로고    scopus 로고
    • Intravenous hmscs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein tsg-6
    • Lee RH, Pulin AA, Seo MJ, Kota DJ, Ylostalo J, Larson BL, et al. Intravenous hMSCs improve myocardial infarction in mice because cells embolized in lung are activated to secrete the anti-inflammatory protein TSG-6. Cell Stem Cell. 2009;5: 54-63.
    • (2009) Cell Stem Cell. , vol.5 , pp. 54-63
    • Lee, R.H.1    Pulin, A.A.2    Seo, M.J.3    Kota, D.J.4    Ylostalo, J.5    Larson, B.L.6
  • 30
    • 59449093151 scopus 로고    scopus 로고
    • Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against cd56 cd271 and mesenchymal stem cell antigen 1
    • Battula VL, Treml S, Bareiss PM, Gieseke F, Roelofs H, de Zwart P, et al. Isolation of functionally distinct mesenchymal stem cell subsets using antibodies against CD56, CD271, and mesenchymal stem cell antigen 1. Haematologica. 2009;94:173-84.
    • (2009) Haematologica , vol.94 , pp. 173-184
    • Battula, V.L.1    Treml, S.2    Bareiss, P.M.3    Gieseke, F.4    Roelofs, H.5    De Zwart, P.6
  • 31
    • 37549053263 scopus 로고    scopus 로고
    • Biochemical heterogeneity of mesenchymal stem cell populations: Clues to their therapeutic efficacy
    • Phinney DG. Biochemical heterogeneity of mesenchymal stem cell populations: clues to their therapeutic efficacy. Cell Cycle. 2007;6:2884-9.
    • (2007) Cell Cycle , vol.6 , pp. 2884-2889
    • Phinney, D.G.1
  • 32
    • 43049162965 scopus 로고    scopus 로고
    • Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts
    • Zhou S, Greenberger JS, Epperly MW, Goff JP, Adler C, Leboff MS, et al. Age-related intrinsic changes in human bone-marrow-derived mesenchymal stem cells and their differentiation to osteoblasts. Aging Cell. 2008;7:335-43.
    • (2008) Aging Cell , vol.7 , pp. 335-343
    • Zhou, S.1    Greenberger, J.S.2    Epperly, M.W.3    Goff, J.P.4    Adler, C.5    Leboff, M.S.6
  • 33
    • 0030702126 scopus 로고    scopus 로고
    • Aspiration to obtain osteoblast progenitor cells from human bone marrow: The influence of aspiration volume
    • Muschler GF, Boehm C, Easley K. Aspiration to obtain osteoblast progenitor cells from human bone marrow: the influence of aspiration volume. J Bone Joint Surg Am. 1997; 79:1699-709.
    • (1997) J Bone Joint Surg Am , vol.79 , pp. 1699-1709
    • Muschler, G.F.1    Boehm, C.2    Easley, K.3
  • 34
    • 38949186562 scopus 로고    scopus 로고
    • Mesenchymal stem cell preparations - Comparing apples and oranges
    • Wagner W, Ho AD. Mesenchymal stem cell preparations - comparing apples and oranges. Stem Cell Rev. 2007;3:239-48.
    • (2007) Stem Cell Rev , vol.3 , pp. 239-248
    • Wagner, W.1    Ho, A.D.2
  • 35
    • 0034056758 scopus 로고    scopus 로고
    • Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model
    • Muraglia A, Cancedda R, Quarto R. Clonal mesenchymal progenitors from human bone marrow differentiate in vitro according to a hierarchical model. J Cell Sci. 2000;113: 1161-6.
    • (2000) J Cell Sci , vol.113 , pp. 1161-1166
    • Muraglia, A.1    Cancedda, R.2    Quarto, R.3
  • 36
    • 77950991204 scopus 로고    scopus 로고
    • In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment
    • Russell KC, Phinney DG, Lacey MR, Barrilleaux BL, Meyertholen KE, O'Connor KC. In vitro high-capacity assay to quantify the clonal heterogeneity in trilineage potential of mesenchymal stem cells reveals a complex hierarchy of lineage commitment. Stem Cells. 2010;28:788-98.
    • (2010) Stem Cells , vol.28 , pp. 788-798
    • Russell, K.C.1    Phinney, D.G.2    Lacey, M.R.3    Barrilleaux, B.L.4    Meyertholen, K.E.5    O'Connor, K.C.6
  • 37
    • 80053054005 scopus 로고    scopus 로고
    • Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency
    • Russell KC, Lacey MR, Gilliam JK, Tucker HA, Phinney DG, O'Connor KC. Clonal analysis of the proliferation potential of human bone marrow mesenchymal stem cells as a function of potency. Biotechnol Bioeng. 2011;108: 2716-26.
    • (2011) Biotechnol Bioeng , vol.108 , pp. 2716-2726
    • Russell, K.C.1    Lacey, M.R.2    Gilliam, J.K.3    Tucker, H.A.4    Phinney, D.G.5    O'Connor, K.C.6
  • 38
    • 74249099917 scopus 로고    scopus 로고
    • Characterization of human bone marrow stromal cell heterogeneity for skeletal regeneration strategies using a two-stage colony assay and computational modeling
    • Sengers BG, Dawson JI, Oreffo ROC. Characterization of human bone marrow stromal cell heterogeneity for skeletal regeneration strategies using a two-stage colony assay and computational modeling. Bone. 2010;46:496-503.
    • (2010) Bone , vol.46 , pp. 496-503
    • Sengers, B.G.1    Dawson, J.I.2    Oreffo, R.O.C.3
  • 39
    • 52049090350 scopus 로고    scopus 로고
    • Reversible commitment to differentiation by human multipotent stromal cells in singlecell- derived colonies
    • Ylöstalo J, Bazhanov N, Prockop DJ. Reversible commitment to differentiation by human multipotent stromal cells in singlecell- derived colonies. Exp Hematol. 2008;36:1390-402.
    • (2008) Exp Hematol , vol.36 , pp. 1390-1402
    • Ylöstalo, J.1    Bazhanov, N.2    Prockop, D.J.3
  • 40
    • 84871346956 scopus 로고    scopus 로고
    • Characterization of the optimal culture conditions for production of human mesenchymal stem cells
    • Sotiropoulou PA, Perez SA, Salagianni M, Baxevanis CN, Papamichail M. Characterization of the optimal culture conditions for production of human mesenchymal stem cells. Stem Cells. 2006;24:42-7.
    • (2006) Stem Cells , vol.24 , pp. 42-47
    • Sotiropoulou, P.A.1    Perez, S.A.2    Salagianni, M.3    Baxevanis, C.N.4    Papamichail, M.5
  • 41
    • 84934438320 scopus 로고    scopus 로고
    • Isolation of mesenchymal stem cells from murine bone marrow by immunodepletion
    • Phinney DG. Isolation of mesenchymal stem cells from murine bone marrow by immunodepletion. Methods Mol Biol. 2008;449:171-86.
    • (2008) Methods Mol Biol , vol.449 , pp. 171-186
    • Phinney, D.G.1
  • 42
    • 0029040101 scopus 로고
    • Developmental and tissue-specific regulation of mouse telomerase and telomere length
    • Prowse KR, Greider CW. Developmental and tissue-specific regulation of mouse telomerase and telomere length. Proc Natl Acad Sci U S A. 1995;92:4818-22.
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 4818-4822
    • Prowse, K.R.1    Greider, C.W.2
  • 44
    • 84860517151 scopus 로고    scopus 로고
    • Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53 dependent mechanism: Implications for procurement methods that rely on long-term culture expansion of bone marrow
    • Boregowda S, Krishnappa V, Chambers J, LoGrasso PV, Lai W-T, Ortiz LA, et al. Atmospheric oxygen inhibits growth and differentiation of marrow-derived mouse mesenchymal stem cells via a p53 dependent mechanism: implications for procurement methods that rely on long-term culture expansion of bone marrow. Stem Cells. 2012;30: 975-87.
    • (2012) Stem Cells , vol.30 , pp. 975-987
    • Boregowda, S.1    Krishnappa, V.2    Chambers, J.3    LoGrasso, P.V.4    Lai, W.-T.5    Ortiz, L.A.6
  • 45
    • 33745494534 scopus 로고    scopus 로고
    • A crosstalk between myeloma cells and marrow stromal cells stimulates production of dkk1 and interleukin-6: A potential role in the development of lytic bone disease and tumor progression in multiple myeloma
    • Gunn WG, Conley A, Deininger L, Olson SD, Prockop DJ, Gregory CA. A crosstalk between myeloma cells and marrow stromal cells stimulates production of DKK1 and interleukin-6: a potential role in the development of lytic bone disease and tumor progression in multiple myeloma. Stem Cells. 2006;24: 986-91.
    • (2006) Stem Cells. , vol.24 , pp. 986-991
    • Gunn, W.G.1    Conley, A.2    Deininger, L.3    Olson, S.D.4    Prockop, D.J.5    Gregory, C.A.6
  • 46
    • 40849083276 scopus 로고    scopus 로고
    • Dkk1- induced inhibitionof wnt signaling in osteoblast differentiation is an underlying mechanism of boneloss in multiple myeloma
    • Qiang YW, Barlogie B, Rudikoff S, Shaughnessy JD Jr. Dkk1- induced inhibitionof Wnt signaling in osteoblast differentiation is an underlying mechanism of boneloss in multiple myeloma. Bone. 2008;42:669-80.
    • (2008) Bone , vol.42 , pp. 669-680
    • Qiang, Y.W.1    Barlogie, B.2    Rudikoff, S.3    Shaughnessy Jr., J.D.4
  • 47
    • 23944519424 scopus 로고    scopus 로고
    • Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing t-cell anergy
    • Zappia E, Casazza S, Pedemonte E, Benvenuto F, Bonanni I, Gerdoni E, et al. Mesenchymal stem cells ameliorate experimental autoimmune encephalomyelitis inducing T-cell anergy. Blood. 2005;106:1755-61.
    • (2005) Blood , vol.106 , pp. 1755-1761
    • Zappia, E.1    Casazza, S.2    Pedemonte, E.3    Benvenuto, F.4    Bonanni, I.5    Gerdoni, E.6
  • 48
    • 38649105374 scopus 로고    scopus 로고
    • Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide
    • Ren G, Zhang L, Zhao X, Xu G, Zhang Y, Roberts AI, et al. Mesenchymal stem cell-mediated immunosuppression occurs via concerted action of chemokines and nitric oxide. Cell Stem Cell. 2008;2:141-50.
    • (2008) Cell Stem Cell , vol.2 , pp. 141-150
    • Ren, G.1    Zhang, L.2    Zhao, X.3    Xu, G.4    Zhang, Y.5    Roberts, A.I.6
  • 49
    • 84856960632 scopus 로고    scopus 로고
    • Human msc suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander m2 macrophage differentiation
    • François M, Romieu-Mourez R, Li M, Galipeau J. Human MSC suppression correlates with cytokine induction of indoleamine 2,3-dioxygenase and bystander M2 macrophage differentiation. Mol Ther. 2012;20:187-95.
    • (2012) Mol Ther , vol.20 , pp. 187-195
    • François, M.1    Romieu-Mourez, R.2    Li, M.3    Galipeau, J.4
  • 50
    • 43049103438 scopus 로고    scopus 로고
    • Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: A phase ii study
    • Le Blanc K, Frassoni F, Ball L, Locatelli F, Roelofs H, Lewis I, et al. Mesenchymal stem cells for treatment of steroid-resistant, severe, acute graft-versus-host disease: a phase II study. Lancet. 2008;371:1579-86.
    • (2008) Lancet , vol.371 , pp. 1579-1586
    • Le Blanc, K.1    Frassoni, F.2    Ball, L.3    Locatelli, F.4    Roelofs, H.5    Lewis, I.6


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