The polysaccharide inulin is characterized by an extensive series of periodic isoforms with varying biological actions

Glycobiology

Volumn 23, Issue 10, 2013, Pages 1164-1174

  Cooper, Peter D ^a,b,c,d   Barclay, Thomas G ^e   Ginic Markovic, Milena ^e   Petrovsky, Nikolai ^a,b  

^a VAXINE PTY LTD   (Australia)

^b The Australian National University   (Australia)

^c Australian National University   (Australia)

^d UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^e FLINDERS UNIVERSITY   (Australia)

Author keywords

Adjuvant; Carbohydrate; Inulin; Isoform; Vaccine

Indexed keywords

ALPHA INULIN 1; ALPHA INULIN 2; DELTA INULIN; EPSILON INULIN; GAMMA INULIN; INULIN; OMEGA INULIN; POLYSACCHARIDE; UNCLASSIFIED DRUG; ZETA INULIN;

ARTICLE; BIOLOGICAL ACTIVITY; CHEMICAL STRUCTURE; COMPLEMENT ACTIVATION; COVALENT BOND; DIFFERENTIAL SCANNING CALORIMETRY; FREEZING; GOOD MANUFACTURING PRACTICE; HIGH TEMPERATURE; MELTING POINT; POLYMERIZATION; PRECIPITATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE;

ADJUVANT; CARBOHYDRATE; INULIN; ISOFORM; VACCINE;

CHICORY; INULIN; ISOMERISM; PHASE TRANSITION; POLYMERIZATION; TRANSITION TEMPERATURE;

EID: 84887888030     PISSN: 09596658     EISSN: 14602423     Source Type: Journal    
DOI: 10.1093/glycob/cwt053     Document Type: Article

References (40)

1. André I, Mazeau K, Tvaroska I, Putaux J-L, Winter WT, Taravel F, Chanzy H. 1996. Molecular and crystal structures of inulin from electron diffraction data. Macromolecules. 29: 4626-4635.
2. André I, Putaux J-L, Chanzy H, Taravel FR, Timmermans JW, de Wit D. 1996. Single crystals of inulin. Int J Biol Macromol. 18: 195-204.
3. Barclay T, Ginic-Markovic M, Cooper P.D., Petrovsky N. 2010. Inulin - A versatile polysaccharide with multiple pharmaceutical and food chemical uses. J Excipients Food Chem. 1: 1-24.
4. Barclay T, Ginic-Markovic M, Johnston M.R., Cooper PD, Petrovsky N. 2012. Analysis of the hydrolysis of inulin using real time H NMR spectroscopy. Carbohydr Res. 352: 117-125.
5. Cooper PD. 1985. Complement and cancer: Activation of the alternative pathway as a theoretical base for immunotherapy. In: Ray PK, editor. Advances in Immunology and Cancer Therapy Vol 1. New York, NY: Springer. p. 125-166.
6. Cooper PD. 1993. Solid-phase activators of the alternative pathway of complement and their use in vivo. In: Sim RB, editor. Activators and Inhibitors of Complement. Dordrecht, Netherlands: Kluwer Academic Publishers. p. 69-106.
7. Cooper PD, Carter M. 1986a. Anticomplementary action of polymorphic 'solubility forms' of particulate inulin. Mol Immunol. 23: 895-901.
8. Cooper PD, Carter M. 1986b. The anti-melanoma activity of inulin in mice. Mol Immunol. 23: 903-908.
9. Cooper PD, Masinello GR 1983. Protein A treatment of cancer: Activation of a serum component with trans-species anti-B16 melanoma activity. Int J Cancer. 32: 737-744.
10. Cooper PD, Petrovsky N. 2011. Delta inulin: A novel, immunologically- active, stable packing structure comprising βD-[2→1] poly(fructo-furanosyl) α-D-glucose polymers. Glycobiology. 21: 595-606.
11. Cooper PD, Sim RB 1984. Substances that can trigger activation of the alternative pathway of complement have anti-melanoma activity in mice. Int J Cancer. 33: 683-687.
12. Cooper PD, Steele EJ 1988. The adjuvanticity of gamma inulin. Immunol Cell Biol. 66: 345-352.
13. Cooper PD, Steele EJ 1991. Algammulin, a new vaccine adjuvant comprising gamma inulin particles containing alum: Preparation and in vitro properties. Vaccine. 9: 351-357.
14. Cooper PD, Turner R, McGovern J. 1991. Algammulin (gamma inulin/alum hybrid adjuvant) has greater adjuvanticity than alum for hepatitis B surface antigen in mice. Immunol Lett. 27: 131-134.
15. Cristillo AD, Ferrari MG, Hudacik L, Lewis B., Galmin L, Bowen B, Thompson D., Petrovsky N, Markham P, Pal R. 2011. Induction of mucosal and systemic antibody and T-cell responses following prime-boost immunization with novel adjuvanted human immunodeficiency virus-1-vaccine formulations. J Gen Virol. 92: 128-140.
16. Eckersley AM, Petrovsky N, Kinne J., Wernery R, Wernery U. 2011. Improving the dromedary antibody response: The hunt for the ideal camel adjuvant. J CamelPract Res. 18: 35-46.
17. Frazer IH, Tindle RW, Fernando GJP, Malcolm K, Herd K., McFadyn S, Cooper PD, Ward B. 1999. Safety and immunogenicity of HPV16 E7/Algammulin. In: Tindle RW, editor. Vaccines for Human Papillomavirus Infection and Anogenital Disease. New York, NY: RG Landes. p. 91-104.
18. Gordon DL, Sajkov D, Woodman R.J., Honda-Okubo Y, Cox MMJ, Heinzel S, Petrovsky N. 2012. Randomized clinical trial of immunogenicity and safety of a recombinant H1N1/2009 pandemic influenza vaccine containing Advax" polysaccharide adjuvant. Vaccine. 30: 5407-5416.
19. Gottlieb HE, Kotlyar V, Nudelman A. 1997. NMR chemical shifts of common laboratory solvents as trace impurities. J Org Chem. 62: 7512-7515.
20. Hébette C.L., Delcour JA, Koch MHJ, Booten K, Reynaers HL 2011. Crystallization and melting of inulin crystals. A small angle X-ray scattering approach (SAXS). Polimery. 56: 645-651.
21. Honda-Okubo Y., Saade F, Petrovsky N. 2012. Advax™, a polysaccharide adjuvant derived from delta inulin, provides improved influenza vaccine protection through broad-based enhancement of adaptive immune responses. Vaccine. 30: 5373-5381.
22. Katz JR, Weidinger A. 1931. Polymorphism of substances of high molecular weight. II. Amorphous and crystalline inulin. Recl Trav Chim Pays-Bas. 50: 1133-1137. Abstract only available.
23. Korbelik M, Cooper PD 2007. Potentiation of photodynamic therapy of cancer by complement: The effect of gamma-inulin. Br J Cancer. 96: 67-72.
24. + T cells and pre-exposure neutralizing antibody. J Virol. 87: 4395-4402.
25. Layton RC, Petrovsky N, Gigliotti A.P., Pollock Z., Knight J, Donart N, Pyles J., Harrod KS, Gao P, Koster F. 2011. Delta inulin polysaccharide adjuvant enhances the ability of split-virion H5N1 vaccine to protect against lethal challenge in ferrets. Vaccine. 29: 6242-6251.
26. Lobigs M, Pavy M, Hall R.A., Lobigs P., Cooper P, Komiya T, Toriniwa H., Petrovsky N. 2010. An inactivated Vero cell-grown Japanese encephalitis vaccine formulated with Advax, a novel inulin-based adjuvant, induces protective neutralizing antibody against homologous and heterologous flaviviruses. J Gen Virol. 91: 1407-1417.
27. Mano JF, Ribelles JLG, Alves NM, Sanchez MS 2005. Glass transition dynamics and structural relaxation of PLLA studied by DSC: Influence of crystal-linity. Polymer. 46: 8258-8265.
28. McDonald EJ. 1946. The polyfructosans and difructose anhydrides. Adv Carbohyd Chem. 2: 253-277.
29. Nezzal A, Aerts L, Verspaille M., Henderickx G, Redl A. 2009. Polymorphism of sorbitol. J Crystal Growth. 311: 3863-3870.
30. Perez S, Bertoft E. 2010. The molecular structures of starch components and their contribution to the architecture of starch granules: A comprehensive review. Starch. 62: 389-420.
31. Petrovsky N, Cooper PD 2011. Carbohydrate-based immune adjuvants. Expert Rev Vaccines. 10: 523-537.
32. Phelps CF. 1965. The physical properties of inulin solutions. Biochem J. 95: 41-47.
33. Ronkart SN, Deroanne C, Paquot M., Fougnies C, Blecker CS 2010. Impact of the crystallisation pathway of inulin on its mono-hydrate to hemi-hydrate thermal transition. Food Chem. 119: 317-322.
34. Ronkart SN, Deroanne C, Paquot M., Fougnies C, Lambrechts J-C, Blecker CS 2007. Characterization of the physical state of spray-dried inulin. Food Biophys. 2: 83-92.
35. Ronkart SN, Paquot M, Blecker C.S., Fougnies C., Doran L, Lambrechts J-C, Norberg B, Deroanne C. 2009. Impact of the crystallinity on the physical properties of inulin during water sorption. Food Biophys. 4: 49-58.
36. Saade F, Honda-Okubo Y, Trec S., Petrovsky N. 2013. A novel hepatitis B vaccine containing Advax, a polysaccharide adjuvant derived from delta inulin, induces robust humoral and cellular immunity with minimal reacto-genicity in preclinical testing. Vaccine. 31: 1999-2007.
37. Sarko A, Wu H-C. 1978. The crystal structure of A-, B- and C-polymorphs of amylose and starch. Starch. 30: 73-78.
38. Shamai K, Bianco-Peled H, Shimoni E. 2003. Polymorphism of resistant starch type III. Carbohydr Polymers. 54: 363-369.
39. Silva DG, Cooper PD, Petrovsky N. 2004. Inulin-derived adjuvants efficiently promote both Th1 and Th2 immune responses. Immunol Cell Biol. 82: 611-616.
40. Wunderlich B. 2006. The Application of MTDSC to Polymer Melting. In: Reading M, Hourston DJ, editors. Modulated Temperature Differential Scanning Calorimetry: Theoretical and Practical Applications in Polymer Characterisation. Dordrecht: Springer. p. 217-320.