Forensic investigation of K2, Spice, and "bath salt" commercial preparations: A three-year study of new designer drug products containing synthetic cannabinoid, stimulant, and hallucinogenic compounds

Forensic Science International

Volumn 233, Issue 1-3, 2013, Pages 416-422

  Seely, Kathryn A ^a   Patton, Amy L ^a   Moran, Cindy L ^b   Womack, Mary L ^b   Prather, Paul L ^c   Fantegrossi, William E ^c   Radominska Pandya, Anna ^c   Endres, Gregory W ^d   Channell, Kermit B ^b   Smith, Nathaniel H ^a   McCain, Keith R ^e   James, Laura P ^c,f   Moran, Jeffery H ^a,c  

^a ARKANSAS DEPARTMENT OF HEALTH   (United States)

^b Arkansas State Crime Laboratory   (United States)

^c UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^d Cayman Chemical Company   (United States)

^e UNIVERSITY OF ARKANSAS FOR MEDICAL SCIENCES   (United States)

^f ARKANSAS CHILDREN S HOSPITAL RESEARCH INSTITUTE   (United States)

Author keywords

Bath salts; Designer drug; Hallucinogen; K2; Stimulant; Synthetic cannabinoid

Indexed keywords

3 (1 NAPHTHOYL) 1 PENTYLINDOLE; 3,4 METHYLENEDIOXYMETHAMPHETAMINE; AM 2201; CANNABINOID; CANNABIS; CENTRAL STIMULANT AGENT; DESIGNER DRUG; JWH 122; JWH 210; METHAMPHETAMINE; METHYLENEDIOXYPYROVALERONE; METHYLONE; PENTEDRONE; PSYCHEDELIC AGENT; RECREATIONAL DRUG; UNCLASSIFIED DRUG; XLR 11;

ARTICLE; CHEMICAL STRUCTURE; DRUG ABUSE; DRUG CONTROL; DRUG DETERMINATION; FORENSIC IDENTIFICATION; PRIORITY JOURNAL; PUBLIC HEALTH PROBLEM; VALIDATION PROCESS;

BATH SALTS; DESIGNER DRUG; HALLUCINOGEN; K2; STIMULANT; SYNTHETIC CANNABINOID;

BENZODIOXOLES; CANNABINOIDS; CAPSULES; CENTRAL NERVOUS SYSTEM STIMULANTS; DESIGNER DRUGS; DRONABINOL; HALLUCINOGENS; HUMANS; INDOLES; METHAMPHETAMINE; METHYLAMINES; MOLECULAR STRUCTURE; NAPHTHALENES; PAPER; PENTANONES; POWDERS; PYRROLIDINES; SUBSTANCE-RELATED DISORDERS; TABLETS;

EID: 84887869784     PISSN: 03790738     EISSN: 18726283     Source Type: Journal    
DOI: 10.1016/j.forsciint.2013.10.002     Document Type: Article

References (30)

1. Seely K.A., Lapoint J., Moran J.H., Fattore L. Spice drugs are more than harmless herbal blends: a review of the pharmacology and toxicology of synthetic cannabinoids. Prog. Neuropsychopharmacol. Biol. Psychiatry 2012, 39:234-243.
2. Johnston L.D., O'Malley P., Bachman J.G., Schulenberg J.E. Marijuana Use Continues to Rise Among U.S. Teens, While Alcohol Use Hits Historical Lows 2011, University of Michigan News Service, www.monitoringthefuture.org.
3. Vandrey R., Dunn K.E., Fry J.A., Girling E.R. A survey study to characterize use of Spice products (synthetic cannabinoids). Drug Alcohol Depend. 2012, 120:238-241.
4. AAPCC Synthetic Marijuana Data 2011.
5. Wehrman J. Fake Marijuana Spurs More than 4,500 Calls to U.S. Poison Centers 2011, AAPCC.
6. Drug Enforcement Administration DoJ Schedules of controlled substances: temporary placement of three synthetic cathinones in Schedule I. Final order. Fed. Regist. 2011, 76:65371-65375.
7. SDAPA (Synthetic Drug Abuse Prevention Act), Department of Justice, XI2012.
8. Controlled Substances Act of United States, 211970.
9. Atwood B.K., Huffman J., Straiker A., Mackie K. JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. Br. J. Pharmacol. 2010, 160:585-593.
10. Atwood B.K., Lee D., Straiker A., Widlanski T.S., Mackie K. CP47, 497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. Eur. J. Pharmacol. 2011, 659:139-145.
11. Howlett A.C., Barth F., Bonner T.I., Cabral G., Casellas P., Devane W.A., et al. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacol. Rev. 2002, 54:161-202.
12. Martin B.R., Jefferson R., Winckler R., Wiley J.L., Huffman J.W., Crocker P.J., et al. Manipulation of the tetrahydrocannabinol side chain delineates agonists, partial agonists, and antagonists. J. Pharmacol. Exp. Ther. 1999, 290:1065-1079.
13. Every-Palmer S. Synthetic cannabinoid JWH-018 and psychosis: an explorative study. Drug Alcohol Depend. 2011, 117:152-157.
14. Gunderson E.W., Haughey H.M., Ait-Daoud N., Joshi A.S., Hart C.L. Spice and K2 herbal highs: a case series and systematic review of the clinical effects and biopsychosocial implications of synthetic cannabinoid use in humans. Am. J. Addict. 2012, 21:320-326.
15. Lapoint J., James L.P., Moran C.L., Nelson L.S., Hoffman R.S., Moran J.H. Severe toxicity following synthetic cannabinoid ingestion. Clin. Toxicol. (Phila) 2011, 49:760-764.
16. Schneir A.B., Cullen J., Ly B.T. Spice girls: synthetic cannabinoid intoxication. J. Emerg. Med. 2010, 40:296-299.
17. Tomiyama K., Funada M. Cytotoxicity of synthetic cannabinoids found in Spice products: the role of cannabinoid receptors and the caspase cascade in the NG 108-15 cell line. Toxicol. Lett. 2011, 207:12-17.
18. Baumann M.H., Partilla J.S., Psychoactive Lehner K.R. bath salts: not so soothing. Eur. J. Pharmacol. 2013, 698:1-5.
19. Lehner K.R., Baumann M.H. Psychoactive 'bath salts': compounds, mechanisms, and toxicities. Neuropsychopharmacology 2013, 38:243-244.
20. Baumann M.H., Ayestas M.A., Partilla J.S., Sink J.R., Shulgin A.T., Daley P.F., et al. The designer methcathinone analogs, mephedrone and methylone, are substrates for monoamine transporters in brain tissue. Neuropsychopharmacology 2012, 37:1192-1203.
21. Baumann M.H., Partilla J.S., Lehner K.R., Thorndike E.B., Hoffman A.F., Holy M., et al. Powerful cocaine-like actions of 3,4-Methylenedioxypyrovalerone (MDPV), a principal constituent of psychoactive 'bath salts' products. Neuropsychopharmacology 2013, 38:552-562.
22. Brandt S.D., Tearavarich R., Dempster N., Cozzi N.V., Daley P.F. Synthesis and characterization of 5-methoxy-2-methyl-N,N-dialkylated tryptamines. Drug Test. Anal. 2012, 4:24-32.
23. Hill S.L., Thomas S.H. Clinical toxicology of newer recreational drugs. Clin. Toxicol. (Phila) 2011, 49:705-719.
24. Rose S.R., Poklis J.L., Poklis A. A case of 25I-NBOMe (25-I) intoxication: a new potent 5-HT2A agonist designer drug. Clin. Toxicol. (Phila) 2013, 51:174-177.
25. Bureau USC, Annual Estimates of the Resident Population: April 1, 2010 to July 1, 2012.
26. Denooz R., Vanheugen J.C., Frederich M., de Tullio P., Charlier C. Identification and structural elucidation of four cannabimimetic compounds (RCS-4, AM-2201, JWH-203 and JWH-210) in seized products. J. Anal. Toxicol. 2013, 37:56-63.
27. Dresen S., Ferreiros N., Putz M., Westphal F., Zimmermann R., Auwarter V. Monitoring of herbal mixtures potentially containing synthetic cannabinoids as psychoactive compounds. J. Mass Spectrom. 2010, 45:1186-1194.
28. Dunham S.J., Hooker P.D., Identification Hyde R.M. extraction and quantification of the synthetic cannabinoid JWH-018 from commercially available herbal marijuana alternatives. Forensic Sci. Int. 2012, 223:241-244.
29. O'Byrne P.M., Kavanagh P.V., McNamara S.M., Stokes S.M. Screening of stimulants including designer drugs in urine using a liquid chromatography tandem mass spectrometry system. J. Anal. Toxicol. 2013, 37:64-73.
30. Vircks K.E., Mulligan C.C. Rapid screening of synthetic cathinones as trace residues and in authentic seizures using a portable mass spectrometer equipped with desorption electrospray ionization. Rapid Commun. Mass Spectrom. 2012, 26:2665-2672.