Nanoparticle mass transfer from lung airways to systemic regions-part ii: Multi-compartmental modeling

Journal of Biomechanical Engineering

Volumn 135, Issue 12, 2013, Pages

  Kolanjiyil, Arun V ^a   Kleinstreuer, Clement ^a,b  

^a North Carolina State University   (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

Author keywords

animal test data; human organs; model validations; multicompartment modeling; nanoparticle bio kinetics; temporal accumulations

Indexed keywords

ANIMAL TESTS; HUMAN ORGANS; MODEL VALIDATION; MULTI-COMPARTMENT MODELS; TEMPORAL ACCUMULATIONS;

BIOLOGICAL ORGANS; COMPUTER SIMULATION; DEPOSITION; MASS TRANSFER; NANOSTRUCTURED MATERIALS;

NANOPARTICLES;

NANOPARTICLE;

AIRWAY; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BLOOD FLOW; COMPUTER SIMULATION; HUMAN; LYMPHATIC SYSTEM; MASS; NONHUMAN; RAT; SIMULATOR; ANIMAL; ANTIBODY SPECIFICITY; BIOLOGICAL MODEL; BODY WEIGHT; HYDRODYNAMICS; INHALATION; LUNG; METABOLISM; PHYSIOLOGY; TISSUE DISTRIBUTION;

ANIMALS; BODY WEIGHT; HUMANS; HYDRODYNAMICS; INHALATION; LUNG; MODELS, BIOLOGICAL; NANOPARTICLES; ORGAN SPECIFICITY; RATS; TISSUE DISTRIBUTION;

EID: 84887849183     PISSN: 01480731     EISSN: 15288951     Source Type: Journal    
DOI: 10.1115/1.4025333     Document Type: Article

References (46)

1. Oberdörster, G., 1988, "Lung Clearance of Inhaled Insoluble and Soluble Particles, " J. Aerosol Med., 1(4), pp. 289-330.
2. Kreyling, W., 1990, "Interspecies Comparison of Lung Clearance of "Insoluble" Particles, " J. Aerosol Med., 3(1), pp. 93-110.
3. Kreyling, W. G., Semmler, M., and Möller, W., 2004, "Dosimetry and Toxicology of Ultrafine Particles, " J. Aerosol Med., 17(2), pp. 140-152. (Pubitemid 38955674)
4. Geiser, M. and Kreyling, W. G., 2010, "Deposition and Biokinetics of Inhaled Nanoparticles, " Part. Fibre Toxicol, 7(2), pp. 1-17.
5. Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Lunts, A., Krey-ling, W., and Cox, C., 2002, "Extrapulmonary Translocation of Ultrafine Carbon Particles Following Whole-Body Inhalation Exposure of Rats, " J. Toxicol. Environ. Health, Part A, 65(20), pp. 1531-1543. (Pubitemid 35217499)
6. Geiser, M., Casaulta, M., Kupferschmid, B., Schulz, H., Semmler-Behnke, M., and Kreyling, W., 2008, "The Role of Macrophages in the Clearance of Inhaled Ultrafine Titanium Dioxide Particles." Am. J. Respir. Cell Mol. Biol., 38(3), pp. 371-376. (Pubitemid 351567707)
7. Brown, J. S., Zeman, K. L., and Bennett, W. D., 2002, "Ultrafine Particle Deposition and Clearance in the Healthy and Obstructed Lung, " Am. J. Respir. Crit. Care Med., 166(9), pp. 1240-1247. (Pubitemid 35222602)
8. Klepczynska-Nyström, A., Sanchez-Crespo, A., Andersson, M., Falk, R., Lun-din, A., Larsson, B., and Svartengren, M., 2012, "The Pulmonary Deposition and Retention of Indium-111 Labeled Ultrafine Carbon Particles in Healthy Individuals, " Inhalation Toxicol., 24(10), pp. 645-651.
9. Mills, N. L., Amin, N., Robinson, S. D., Anand, A., Davies, J., Patel, D., Jesus, M., Cassee, F. R., Boon, N. A., and MacNee, W., 2006, "Do Inhaled Carbon Nanoparticles Translocate Directly Into the Circulation in Humans?, " Am. J. Respir. Crit. Care Med., 173(4), pp. 426-431. (Pubitemid 43228331)
10. Möller, W., Felten, K., Sommerer, K., Scheuch, G., Meyer, G., Meyer, P., Häussinger, K., and Kreyling, W. G., 2008, "Deposition, Retention, and Trans-location of Ultrafine Particles From the Central Airways and Lung Periphery, " Am. J. Respir. Crit. Care Med., 177(4), pp. 426-432. (Pubitemid 351317586)
11. Nemmar, A., Hoet, P. H. M., Vanquickenborne, B., Dinsdale, D., Thomeer, M., Hoylaerts, M., Vanbilloen, H., Mortelmans, L., and Nemery, B., 2002, "Passage of Inhaled Particles Into the Blood Circulation in Humans, " Circulation, 105(4), pp. 411-414. (Pubitemid 34141694)
12. Roth, C., Scheuch, G., and Stahlhofen, W., 1993, "Clearance of the Human Lungs for Ultrafine Particles, " J. Aerosol Sci., 24(, 1), pp. S95-S96.
13. Semmler, M., Seitz, J., Erbe, F., Mayer, P., Heyder, J., Oberdörster, G., and Kreyling, W., 2004, "Long-Term Clearance Kinetics of Inhaled Ultrafine Insoluble Iridium Particles From the Rat Lung, Including Transient Translocation Into Secondary Organs, " Inhalation Toxicol., 16(6-7), pp. 453-459. (Pubitemid 38685137)
14. Semmler-Behnke, M., Takenaka, S., Fertsch, S., Wenk, A., Seitz, J., Mayer, P., Oberdörster, G., and Kreyling, W. G., 2007, "Efficient Elimination of Inhaled Nanoparticles From the Alveolar Region: Evidence for Interstitial Uptake and Subsequent Reentrainment Onto Airways Epithelium, " Environ. Health Per-spect., 115(5), pp. 728-733. (Pubitemid 46785042)
15. Takenaka, S., Karg, E., Kreyling, W., Lentner, B., Möller, W., Behnke-Semm-ler, M., Jennen, L., Walch, A., Michalke, B., and Schramel, P., 2006, "Distribution Pattern of Inhaled Ultrafine Gold Particles in the Rat Lung, " Inhalation Toxicol., 18(10), pp. 733-740.
16. Kreyling, W., Semmler, M., Erbe, F., Mayer, P., Takenaka, S., Schulz, H., Oberdörster, G., and Ziesenis, A., 2002, "Translocation of Ultrafine Insoluble Iridium Particles From Lung Epithelium to Extrapulmonary Organs is Size Dependent but Very Low, " J. Toxicol. Environ. Health, Part A, 65(20), pp. 1513-1530. (Pubitemid 35217498)
17. Ferin, J., Oberdörster, G., and Penney, D., 1992, "Pulmonary Retention of Ultrafine and Fine Particles in Rats." Am. J. Respir. Cell Mol. Biol., 6(5), pp. 535-542.
18. Elder, A., Gelein, R., Silva, V., Feikert, T., Opanashuk, L., Carter, J., Potter, R., Maynard, A., Ito, Y., and Finkelstein, J., 2006, "Translocation of Inhaled Ultra-fine Manganese Oxide Particles to the Central Nervous System, " Environ. Health Perspect., 114(8), pp. 1172-1178. (Pubitemid 44184673)
19. Oberdörster, G., Sharp, Z., Atudorei, V., Elder, A., Gelein, R., Kreyling, W., and Cox, C., 2004, "Translocation of Inhaled Ultrafine Particles to the Brain, " Inhalation Toxicol., 16(6-7), pp. 437-445. (Pubitemid 38685135)
20. Wang, J., Chen, C., Yu, H., Sun, J., Li, B., Li, Y., Gao, Y., He, W., Huang, Y., and Chai, Z., 2007, "Distribution of TiO 2 Particles in the Olfactory Bulb of Mice After Nasal Inhalation Using Microbeam SRXRF Mapping Techniques, " J. Radioanal. Nucl. Chem., 272(3), pp. 527-531. (Pubitemid 46686070)
21. Enderle, J. D. and Bronzino, J. D., 2011, Introduction to Biomedical Engineering, Academic, New York.
22. ICRP, 1994, "Human Respiratory Tract Model for Radiological Protection, " Ann. ICRP, 24, pp. 1-3, Publication No. 66.
23. Tran, C., Jones, A., Cullen, R., and Donaldson, K., 1999, "Mathematical Modeling of the Retention and Clearance of Low-Toxicity Particles in the Lung, " Inhalation Toxicol., 11(12), pp. 1059-1076. (Pubitemid 30023322)
24. Kuempel, E. D., O'Flaherty, E. J., Stayner, L. T., Smith, R. J., Green, F., and Vallyathan, V., 2001, "A Biomathematical Model of Particle Clearance and Retention in the Lungs of Coal Miners." Regul. Toxicol. Pharmacol., 34(1), pp. 69-87. (Pubitemid 32831862)
25. MacCalman, L., Tran, C., and Kuempel, E., 2009, "Development of a Bio-Mathematical Model in Rats to Describe Clearance, Retention and Transloca-tion of Inhaled Nano Particles Throughout the Body, " J. Phys.: Conf. Ser., ed. 151, p. 012028.
26. Sturm, R., 2007, "A Computer Model for the Clearance of Insoluble Particles From the Tracheobronchial Tree of the Human Lung, " Comput. Biol. Med., 37(5), pp. 680-690. (Pubitemid 46400623)
27. Corley, R. A., Kabilan, S., Kuprat, A. P., Carson, J. P., Minard, K. R., Jacob, R. E., Timchalk, C., Glenny, R., Pipavath, S., and Cox, T., 2012, "Comparative Computational Modeling of Airflows and Vapor Dosimetry in the Respiratory Tracts of Rat, Monkey, and Human, " Toxicol. Sci., 128(2), pp. 500-516.
28. Schroeter, J. D., Kimbell, J. S., Gross, E. A., Willson, G. A., Dorman, D. C., Tan, Y., and Clewell, H. J. III, 2008, "Application of Physiological Computational Fluid Dynamics Models to Predict Interspecies Nasal Dosimetry of Inhaled Acrolein, " Inhalation Toxicol., 20(3), pp. 227-243. (Pubitemid 351323656)
29. Kolanjiyil, A. V. and Kleinstreuer, C., 2013, "Nanoparticle Mass Transfer From Lung Airways to Systemic Regions-Part I: Whole-Lung Aerosol Dynamics, " ASME J. Biomech. Eng., 135(12), p. 121003.
30. Kuempel, E. and Tran, C., 2002, "Comparison of Human Lung Dosimetry Models: Implications for Risk Assessment, " Ann. Occup. Hyg., 46(1), pp. 337-341.
31. Brown, J. S., Wilson, W. E., and Grant, L. D., 2005, "Dosimetric Comparisons of Particle Deposition and Retention in Rats and Humans, " Inhalation Toxicol., 17(7-8), pp. 355-385. (Pubitemid 40909584)
32. Kolanjiyil, A. V., 2013, "Deposited Nanomaterial Mass Transfer From Lung Airways to Systemic Regions, " M.S. thesis, North Carolina State University, Raleigh.
33. Zhu, M., Feng, W., Wang, Y., Wang, B., Wang, M., Ouyang, H., Zhao, Y., and Chai, Z., 2009, "Particokinetics and Extrapulmonary Translocation of Intratra-cheally Instilled Ferric Oxide Nanoparticles in Rats and the Potential Health Risk Assessment, " Toxicol. Sci., 107(2), pp. 342-351.
34. Hofmann, W. and Asgharian, B., 2003, "The Effect of Lung Structure on Muco-ciliary Clearance and Particle Retention in Human and Rat Lungs, " Toxicol. Sci., 73(2), pp. 448-456. (Pubitemid 36701747)
35. West, G. B., Brown, J. H., and Enquist, B. J., 1997, "A General Model for the Origin of Allometric Scaling Laws in Biology, " Science, 276(5309), pp. 122-126. (Pubitemid 27161259)
36. Hill, A. V., 1950, "The Dimensions of Animals and Their Muscular Dynamics, " Sci. Prog., 38(150), pp. 209-230.
37. Dedrick, R. L., 1973, "Animal Scale-Up, " J. Pharmacokinet. Pharmacodyn., 1(5), pp. 435-461.
38. Boxenbaum, H., 1982, "Interspecies Scaling, Allometry, Physiological Time, and the Ground Plan of Pharmacokinetics, " J. Pharmacokinet. Pharmacodyn., 10(2), pp. 201-227. (Pubitemid 12044187)
39. Mordenti, J., 1986, "Man Versus Beast: Pharmacokinetic Scaling in Mammals, " J. Pharm. Sci., 75(11), pp. 1028-1040. (Pubitemid 17216546)
40. Travis, C. C., White, R. K., and Ward, R. C., 1990, "Interspecies Extrapolation of Pharmacokinetics, " J. Theor. Biol., 142(3), pp. 285-304. (Pubitemid 20082897)
41. U.S. Environmental Protection Agency, 1992, "Draft Report: A Cross-Species Scaling Factor for Carcinogen Risk Assessment Based on Equivalence of mg/Kg3/4/Day: Notice, " Fed. Regist., 57, pp. 21152-24173.
42. Dedrick, R., Bischoff, K., and Zaharko, D., 1970, "Interspecies Correlation of Plasma Concentration History of Methotrexate (NSC-740), " Cancer Chemo-ther. Rep., 54(2), pp. 95-101.
43. Bailey, M., Kreyling, W., Andre, S., Batchelor, A., Collier, C., Drosselmeyer, E., Ferron, G., Foster, P., Haider, B., and Hodgson, A., 1989, "An Interspecies Comparison of the Lung Clearance of Inhaled Monodisperse Cobalt Oxide Particles-Part I: Objectives and Summary of Results, " J. Aerosol Sci., 20(2), pp. 169-188.
44. Kreyling, W., Hodgson, A., Guilmette, R., Scarlett, C., Badmin, A., and Stradling, G., 1998, "Interspecies Comparison of Lung Clearance Using Mono-disperse Terbium Oxide Particles, " Radiat. Prot. Dosimet., 79(1-4), pp. 241-243. (Pubitemid 28466939)
45. Tran, C. L., Graham, M., and Buchanan, D., 2001, "A Biomathematical Model for Rodent and Human Lung Describing Exposure, Dose, and Response to Inhaled Silica, " Iom Research Report No. TM 4.
46. Seaton, A., Godden, D., MacNee, W., and Donaldson, K., 1995, "Particulate Air Pollution and Acute Health Effects, " Lancet, 345(8943), pp. 176-178.