Development of a bio-mathematical model in rats to describe clearance, retention and translocation of inhaled nano particles throughout the body

Journal of Physics: Conference Series

Volumn 151, Issue , 2009, Pages

  MacCalman, L ^a   Tran, C L ^a   Kuempel, E ^b  

^a INSTITUTE OF OCCUPATIONAL MEDICINE   (United Kingdom)

^b NATIONAL INSTITUTE FOR OCCUPATIONAL SAFETY AND HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 65649135456     PISSN: 17426588     EISSN: 17426596     Source Type: Conference Proceeding    
DOI: 10.1088/1742-6596/151/1/012028     Document Type: Article

References (11)

1. Tran CL, Kuempel ED, Castranova V 2002 A rat lung model of exposure, dose, and response to inhaled silica Ann Occup Hyg. 46 (suppl. 1) 14-17
2. Tran CL, Graham M, Buchanan D 2001 A biomathematical model for rodent and human lung describing, exposure, dose, and response to inhaled silica (Institute of Occupational Medicine Technical Memorandum TM/01/01)
3. Brown, RP, Delp, MD, Lindstedt, SL, Rhomberg, LR and Beliles, RP 1997 Physiological parameter values for physiologically based pharmacokinetic models Toxicol Ind Health 13 (4) 407-484 (Pubitemid 27314117)
4. Luu, HMD, Hutter, JC and Bushar, HF 1997 Physiologically based pharmacokinetic model for 2, 4-toluenediamine leached from polyurethane foam-covered breast implants Environmental Health Perspectives 106 393-400
5. Kohn, MC and Melnick, RL 2000 The privileged access model of 1,3-Butadiene disposition Environmental Health Perspectives 108 (Suppl 5) 911-917
6. Kreyling, WG, Semmler-Behnke, M, Erbe, F, Mayer, P, Takenaka, S Schulz, H, Oberdörster, G and Ziesenis, A 2002 Translocation of ultrafine insoluble iridium particles from lung epithelium to extrapulmonary organs is size dependent but very low J Toxicol Environ Health, Part A 65 1513-1530 (Pubitemid 35217498)
7. Bernareggi, A and Rowland, M 1991 Physiologic modelling of cyclosporine kinetics in rat and man J Pharmaco Biopharm 19 21-50
8. Semmler, M, Seitz, J, Erbe, F, Mayer, P, Heyder, J, Oberdörster, G and Kreyling, WG 2004 Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, incluing transient translocation into secondary organs Inhal Toxicol 16 453-459 (Pubitemid 38685137)
9. Takenaka, S, Karg, E, Roth, C, Schultz, H, Ziesenis, A, Heinzmann, U, Schramel, P and Heyder, J 2001 Pulmonary and systemic distribution of inhaled ultrafine silver particles in rats Environ Health Perspect 109 (Suppl 4) 547-551 (Pubitemid 32834568)
10. Semmler-Behnke, M, Takenaka, S, Fertsch, S, Wenk, A, Seitz, J, Mayer, P, Oberdörster, G and Kreyling, WG 2007 Efficient elimination of inhaled nanoparticles from the alveolar region: evidence for interstitial uptake and subsequent reentrainment onto airways epithelium Environmental Health Perspectives 115 728-733 (Pubitemid 46785042)
11. CIIT and RIVM 2006 Multiple-path particle dosimetry model (MPPD V 2.0, 2002-2006) Research Triangle Park, NC: Centres for Health Research (CIIT) and The Netherlands: National Institute for Public Health and Environment (RIVM)