Risk of infection and sepsis in severely injured patients related to single nucleotide polymorphisms in the lectin pathway

British Journal of Surgery

Volumn 100, Issue 13, 2013, Pages 1818-1826

  Bronkhorst, M W G A ^a   Lomax, M A Z ^a   Vossen, R H A M ^b   Bakker, J ^a   Patka, P ^a   Van Lieshout, E M M ^a  

^a ERASMUS MEDICAL CENTER   (Netherlands)

^b LEIDEN UNIVERSITY MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

FICOLIN; LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN; MASP2 PROTEIN, HUMAN; MBL2 PROTEIN, HUMAN;

ADULT; ARTICLE; BACTERIAL INFECTION; COMPLEMENT ACTIVATION; FEMALE; GENETICS; GENOTYPE; HUMAN; INJURY; INNATE IMMUNITY; MALE; MIDDLE AGED; PROSPECTIVE STUDY; RISK FACTOR; SEPSIS; SEPTIC SHOCK; SINGLE NUCLEOTIDE POLYMORPHISM; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME;

ADULT; BACTERIAL INFECTIONS; COMPLEMENT ACTIVATION; FEMALE; GENOTYPE; HUMANS; IMMUNITY, INNATE; LECTINS; MALE; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; PROSPECTIVE STUDIES; RISK FACTORS; SEPSIS; SHOCK, SEPTIC; SYSTEMIC INFLAMMATORY RESPONSE SYNDROME; WOUNDS AND INJURIES;

EID: 84887835802     PISSN: 00071323     EISSN: 13652168     Source Type: Journal    
DOI: 10.1002/bjs.9319     Document Type: Article

References (36)

1. Pfeifer R, Tarkin IS, Rocos B, Pape HC,. Patterns of mortality and causes of death in polytrauma patients-has anything changed? Injury 2009; 40: 907-911.
2. Angus DC, Wax RS,. Epidemiology of sepsis: an update. Crit Care Med 2001; 29 (Suppl): S109-S116.
3. O'Keefe GE, Maier RV, Diehr P, Grossman D, Jurkovich GJ, Conrad D,. The complications of trauma and their associated costs in a level I trauma center. Arch Surg 1997; 132: 920-924.
4. Burk AM, Martin M, Flierl MA, Rittirsch D, Helm M, Lampl L, et al. Early complementopathy after multiple injuries in humans. Shock 2012; 37: 348-354.
5. Francis WR, Bodger OG, Pallister I,. Altered leucocyte progenitor profile in human bone marrow from patients with major trauma during the recovery phase. Br J Surg 2012; 99: 1591-1599.
6. Ganter MT, Brohi K, Cohen MJ, Shaffer LA, Walsh MC, Stahl GL, et al. Role of the alternative pathway in the early complement activation following major trauma. Shock 2007; 28: 29-34.
7. Manson J, Thiemermann C, Brohi K,. Trauma alarmins as activators of damage-induced inflammation. Br J Surg 2012; 99 (Suppl 1): 12-20.
8. Hildebrand F, Mommsen P, Frink M, van Griensven M, Krettek C,. Genetic predisposition for development of complications in multiple trauma patients. Shock 2011; 35: 440-448.
9. Dommett RM, Klein N, Turner MW,. Mannose-binding lectin in innate immunity: past, present and future. Tissue Antigens 2006; 68: 193-209.
10. Bronkhorst MW, Bouwman LH,. Mannose-Binding Lectin Deficiency. UpToDate: Waltham, 2011.
11. Sorensen R, Thiel S, Jensenius JC,. Mannan-binding-lectin-associated serine proteases, characteristics and disease associations. Springer Semin Immunopathol 2005; 27: 299-319.
12. Degn SE, Jensenius JC, Bjerre M,. The lectin pathway and its implications in coagulation, infections and auto-immunity. Curr Opin Organ Transplant 2011; 16: 21-27.
13. Skjoedt MO, Hummelshoj T, Palarasah Y, Honore C, Koch C, Skjodt K, et al. A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation. J Biol Chem 2010; 285: 8234-8243.
14. Stengaard-Pedersen K, Thiel S, Gadjeva M, Møller-Kristensen M, Sørensen R, Jensen LT, et al. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med 2003; 349: 554-560.
15. de Rooij BJ, van Hoek B, ten Hove WR, Roos A, Bouwman LH, Schaapherder AF, et al. Lectin complement pathway gene profile of donor and recipient determine the risk of bacterial infections after orthotopic liver transplantation. Hepatology 2010; 52: 1100-1110.
16. de Rooij BJ, van der Beek MT, van Hoek B, Vossen AC, Rogier Ten Hove W, Roos A et al. Mannose-binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation. J Hepatol 2011; 55: 800-807.
17. Meijvis SC, Herpers BL, Endeman H, de Jong B, van Hannen E, van Velzen-Blad H, et al. Mannose-binding lectin (MBL2) and ficolin-2 (FCN2) polymorphisms in patients on peritoneal dialysis with staphylococcal peritonitis. Nephrol Dial Transplant 2011; 26: 1042-1045.
18. Kilpatrick DC, Chalmers JD,. Human L-ficolin (ficolin-2) and its clinical significance. J Biomed Biotechnol 2012; 2012: 138797.
19. Garred P, Honoré C, Ma YJ, Rørvig S, Cowland J, Borregaard N, et al. The genetics of ficolins. J Innate Immun 2009; 2: 3-16.
20. Barber RC, Chang LY, Arnoldo BD, Purdue GF, Hunt JL, Horton JW, et al. Innate immunity SNPs are associated with risk for severe sepsis after burn injury. Clin Med Res 2006; 4: 250-255.
21. Henckaerts L, Nielsen KR, Steffensen R, Van Steen K, Mathieu C, Giulietti A, et al. Polymorphisms in innate immunity genes predispose to bacteremia and death in the medical intensive care unit. Crit Care Med 2009; 37: 192-201, e1-e3.
22. Siassi M, Hohenberger W, Riese J,. Mannan-binding lectin (MBL) serum levels and post-operative infections. Biochem Soc Trans 2003; 31: 774-775.
23. Baker SP, O'Neill B, Haddon W Jr, Long WB,. The injury severity score: a method for describing patients with multiple injuries and evaluating emergency care. J Trauma 1974; 14: 187-196.
24. Bone RC, Balk RA, Cerra FB, Dellinger RP, Fein AM, Knaus WA, et al. Definitions for sepsis and organ failure and guidelines for the use of innovative therapies in sepsis. The ACCP/SCCM Consensus Conference Committee. American College of Chest Physicians/Society of Critical Care Medicine. Chest 1992; 101: 1644-1655.
25. Vossen RH, van Duijn M, Daha MR, den Dunnen JT, Roos A,. High-throughput genotyping of mannose-binding lectin variants using high-resolution DNA-melting analysis. Hum Mutat 2010; 31: E1286-E1293.
26. Hellemann D, Larsson A, Madsen HO, Bonde J, Jarløv JO, Wiis J, et al. Heterozygosity of mannose-binding lectin (MBL2) genotypes predicts advantage (heterosis) in relation to fatal outcome in intensive care patients. Hum Mol Genet 2007; 16: 3071-3080.
27. Vengen IT, Madsen HO, Garred P, Platou C, Vatten L, Videm V,. Mannose-binding lectin deficiency is associated with myocardial infarction: the HUNT2 study in Norway. PLoS One 2012; 7: e42113.
28. Ojurongbe O, Ouf EA, Van Tong H, Toan NL, Song le H, Luz PR, et al. Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns. BMC Med Genet 2012; 13: 37.
29. Moller-Kristensen M, Ip WK, Shi L, Gowda LD, Hamblin MR, Thiel S, et al. Deficiency of mannose-binding lectin greatly increases susceptibility to postburn infection with Pseudomonas aeruginosa. J Immunol 2006; 176: 1769-1775.
30. Cedzynski M, Nuytinck L, Atkinson AP, St Swierzko A, Zeman K, Szemraj J, et al. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. Clin Exp Immunol 2007; 150: 99-104.
31. Haerynck F, Van Steen K, Cattaert T, Loeys B, Van Daele S, Schelstraete P, et al. Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients. Hum Immunol 2012; 73: 1175-1183.
32. Bang P, Laursen I, Thornberg K, Schierbeck J, Nielsen B, Valdimarsson H, et al. The pharmacokinetic profile of plasma-derived mannan-binding lectin in healthy adult volunteers and patients with Staphylococcus aureus septicaemia. Scand J Infect Dis 2008; 40: 44-48.
33. Frakking FN, Brouwer N, van de Wetering MD, Budde IK, Strengers PF, Huitema AD, et al. Safety and pharmacokinetics of plasma-derived mannose-binding lectin (MBL) substitution in children with chemotherapy-induced neutropaenia. Eur J Cancer 2009; 45: 505-512.
34. Brouwer N, Frakking FN, van de Wetering MD, van Houdt M, Hart M, Budde IK, et al. Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels. J Immunol 2009; 183: 3496-3504.
35. Laursen I., Mannan-binding lectin (MBL) production from human plasma. Biochem Soc Trans 2003; 31: 758-762.
36. Laursen I, Houen G, Højrup P, Brouwer N, Krogsøe LB, Blou L, et al. Second-generation nanofiltered plasma-derived mannan-binding lectin product: process and characteristics. Vox Sang 2007; 92: 338-350.