The lectin pathway and its implications in coagulation, infections and auto-immunity

Current Opinion in Organ Transplantation

Volumn 16, Issue 1, 2011, Pages 21-27

  Degn, Søren E ^a   Jensenius, Jens C ^a   Bjerre, Mette ^b  

^a AARHUS UNIVERSITY   (Denmark)

^b AARHUS UNIVERSITY HOSPITAL   (Denmark)

Author keywords

coagulation; ficolin; infection; lectin pathway; mannan binding lectin; MAP 1; MAp44

Indexed keywords

FICOLIN; LECTIN; MANNOSE BINDING LECTIN; MICROTUBULE ASSOCIATED PROTEIN 1; SERINE PROTEINASE;

ADAPTIVE IMMUNITY; ARTICLE; AUTOIMMUNE DISEASE; AUTOIMMUNITY; BLOOD CLOTTING; CANCER PATIENT; CELLULAR IMMUNITY; GENE FUNCTION; HUMAN; INFECTION; INFLUENZA; ISCHEMIA; NONHUMAN; ORGAN TRANSPLANTATION; PREMATURITY; REPERFUSION INJURY;

ANIMALS; BLOOD COAGULATION; HUMANS; IMMUNITY, INNATE; INFECTION; LECTINS;

EID: 78751627719     PISSN: 10872418     EISSN: 15317013     Source Type: Journal    
DOI: 10.1097/MOT.0b013e32834253df     Document Type: Article

References (52)

1. Degn SE, Hansen AG, Steffensen R, et al. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J Immunol 2009; 183:7371-7378.
2. Skjoedt MO, Hummelshoj T, Palarasah Y, et al. A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation. J Biol Chem 2010; 285:8234-8243.
3. Takahashi M, Ishida Y, Iwaki D, et al. Essential role of mannose-binding lectinassociated serine protease-1 in activation of the complement factor D. J Exp Med 2010; 207:29-37.
4. Lynch NJ, Khan SU, Stover CM, et al. Composition of the lectin pathway of complement in Gallus gallus: absence of mannan-binding lectin-associated serine protease-1 in birds. J Immunol 2005; 174:4998-5006.
5. Degn SE, Jensen L, Gal P, et al. Biological variations of MASP-3 and MAp44, two splice products of the MASP1 gene involved in regulation of the complement system. J Immunol Methods 2010; 361:37-50.
6. Honore C, Rorvig S, Hummelshoj T, et al. Tethering of Ficolin-1 to cell surfaces through recognition of sialic acid by the fibrinogen-like domain. J Leukoc Biol 2010; 88:145-158.
7. Wittenborn T, Thiel S, Jensen L, et al. Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma. J Innate Immun 2010; 2:167-180.
8. Gout E, Garlatti V, Smith DF, et al. Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. J Biol Chem 2010; 285:6612-6622.
9. Inoshita H, Matsushita M, Koide S, et al. A novel measurement method for activation of the lectin complement pathway via both mannose-binding lectin (MBL) and L-ficolin. J Immunol Methods 2009; 349:9-17.
10. Selander B, Martensson U, Weintraub A, et al. Mannan-binding lectin activates C3 and the alternative complement pathway without involvement of C2. J Clin Invest 2006; 116:1425-1434.
11. Harboe M, Garred P, Karlstrom E, et al. The down-stream effects of mannan-induced lectin complement pathway activation depend quantitatively on alternative pathway amplification. Mol Immunol 2009; 47:373-380.
12. Degn SE, Thiel S, Jensenius JC. New perspectives on mannan-binding lectinmediated complement activation. Immunobiology 2007; 212:301-311.
13. Gulla KC, Gupta K, Krarup A, et al. Activation of mannan-binding lectinassociated serine proteases leads to generation of a fibrin clot. Immunology 2010; 129:482-495.
14. Krarup A, Wallis R, Presanis JS, et al. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS One 2007; 2:e623.
15. Dobo J, Harmat V, Beinrohr L, et al. MASP-1, a promiscuous complement protease: structure of its catalytic region reveals the basis of its broad specificity. J Immunol 2009; 183:1207-1214.
16. Endo Y, Nakazawa N, Iwaki D, et al. Interactions of ficolin and mannosebinding lectin with fibrinogen/fibrin augment the lectin complement pathway. J Innate Immun 2009; 2:33-42.
17. Takahashi K, Chang WC, Takahashi M, et al. Mannose-binding lectin and its associated proteases (MASPs) mediate coagulation and its deficiency is a risk factor in developing complications from infection, including disseminated intravascular coagulation. Immunobiology 2010 [Epub ahead of print].
18. Sprong T, Mollnes TE, Neeleman C, et al. Mannose-binding lectin is a critical factor in systemic complement activation during meningococcal septic shock. Clin Infect Dis 2009; 49:1380-1386.
19. Moller-Kristensen M, Thiel S, Jensenius JC. MBL polymorphisms and infectious diseases. In: Vasta GaAH, editor. Animal lectins: a functional view. Boca Raton, FL: CRC Press; 2008.
20. Steffensen R, Thiel S, Varming K, et al. Detection of structural gene mutations and promoter polymorphisms in the mannan-binding lectin (MBL) gene by polymerase chain reaction with sequence-specific primers. J Immunol Methods 2000; 241:33-42.
21. Garred P, Honore C, Ma YJ, et al. The genetics of ficolins. J Innate Immun 2009; 2:3-16.
22. Inaba S, Okochi K, Yae Y, et al. Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system. Fukuoka Igaku Zasshi 1990; 81: 284-291.
23. Munthe-Fog L, Hummelshoj T, Honore C, et al. Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency. N Engl J Med 2009; 360:2637-2644
24. Cestari Idos S, Krarup A, Sim RB, et al. Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi. Mol Immunol 2009; 47:426-437.
25. Evans-Osses I, Ansa-Addo EA, Inal JM, et al. Involvement of lectin pathway activation in the complement killing of Giardia intestinalis. Biochem Biophys Res Commun 2010; 395:382-386.
26. Carroll MV, Lack N, Sim E, et al. Multiple routes of complement activation by Mycobacterium bovis BCG. Mol Immunol 2009; 46:3367-3378.
27. Schlapbach LJ, Mattmann M, Thiel S, et al. Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis. Clin Infect Dis 2010; 51:153-162.
28. Schlapbach LJ, Kessler U, Thiel S, et al. M-ficolin in the neonatal period: associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis. Mol Immunol 2009; 46:2597-2603.
29. Swierzko AS, Atkinson AP, Cedzynski M, et al. Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. Mol Immunol 2009; 46:551-558.
30. Nisihara RM, Utiyama SR, Oliveira NP, et al. Mannan-binding lectin deficiency increases the risk of recurrent infections in children with Downs syndrome. Hum Immunol 2010; 71:63-66.
31. Cedzynski M, Atkinson AP, St Swierzko A, et al. L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. Mol Immunol 2009; 47:415-419.
32. Gonzalez SF, Lukacs-Kornek V, Kuligowski MP, et al. Capture of influenza by medullary dendritic cells via SIGN-R1 is essential for humoral immunity in draining lymph nodes. Nat Immunol 2010; 11:427-434.
33. Ruseva M, Kolev M, Dagnaes-Hansen F, et al. Mannan-binding lectin deficiency modulates the humoral immune response dependent on the genetic environment. Immunology 2009; 127:279-288.
34. Guttormsen HK, Stuart LM, Shi L, et al. Deficiency of mannose-binding lectin greatly increases antibody response in a mouse model of vaccination. Clin Immunol 2009; 130:264-271.
35. Liu Y, Endo Y, Iwaki D, et al. Human M-ficolin is a secretory protein that activates the lectin complement pathway. J Immunol 2005; 175:3150-3156.
36. Akaiwa M, Yae Y, Sugimoto R, et al. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/ alveolus and bile. J Histochem Cytochem 1999; 47:777-786.
37. Nakamura N, Nonaka M, Ma BY, et al. Characterization of the interaction between serum mannan-binding protein and nucleic acid ligands. J Leukoc Biol 2009; 86:737-748.
38. Miller C, Wilgenbusch S, Michaels M, et al. Molecular defects in the mannose binding lectin pathway in dermatological disease: case report and literature review. Clin Mol Allergy 2010; 8:6.
39. Messias-Reason IJ, Schafranski MD, Kremsner PG, et al. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. Clin Exp Immunol 2009; 157:395-399.
40. Monticielo OA, Chies JA, Mucenic T, et al. Mannose-binding lectin gene polymorphisms in Brazilian patients with systemic lupus erythematosus. Lupus 2010; 19:280-287.
41. Andersen T, Munthe-Fog L, Garred P, et al. Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus. J Rheumatol 2009; 36:757-759.
42. Troelsen LN, Garred P, Jacobsen S. Mortality and predictors of mortality in rheumatoid arthritis: a role for mannose-binding lectin? J Rheumatol 2010; 37:536-543.
43. Flyvbjerg A. Diabetic angiopathy, the complement system and the tumor necrosis factor superfamily. Nat Rev Endocrinol 2010; 6:94-101.
44. Fortpied J, Vertommen D, Van Schaftingen E. Binding of mannose-binding lectin to fructosamines: a potential link between hyperglycaemia and complement activation in diabetes. Diabetes Metab Res Rev 2010; 26:254-260.
45. Ilyas R, Wallis R, Soilleux EJ, et al. High glucose disrupts oligosaccharide recognition function via competitive inhibition: a potential mechanism for immune dysregulation in diabetes mellitus. Immunobiology 2010 [Epub ahead of print].
46. Potlukova E, Jiskra J, Freiberger T, et al. The production of mannan-binding lectin is dependent upon thyroid hormones regardless of the genotype: a cohort study of 95 patients with autoimmune thyroid disorders. Clin Immunol 2010; 136:123-129.
47. Riis AL, Hansen TK, Thiel S, et al. Thyroid hormone increases mannan-binding lectin levels. Eur J Endocrinol 2005; 153:643-649.
48. Schuffenecker I, Narod SA, Ezekowitz RA, et al. The gene for mannosebinding protein maps to chromosome 10 and is a marker for multiple endocrine neoplasia type 2. Cytogenet Cell Genet 1991; 56:99-102.
49. Sorensen CM, Hansen TK, Steffensen R, et al. Hormonal regulation of mannan-binding lectin synthesis in hepatocytes. Clin Exp Immunol 2006; 145:173-182.
50. Frakking FN, Brouwer N, van de Wetering MD, et al. Safety and pharmacokinetics of plasma-derived mannose-binding lectin (MBL) substitution in children with chemotherapy-induced neutropaenia. Eur J Cancer 2009; 45:505-512.
51. Brouwer N, Frakking FN, van de Wetering MD, et al. Mannose-binding lectin (MBL) substitution: recovery of opsonic function in vivo lags behind MBL serum levels. J Immunol 2009; 183:3496-3504.
52. Michelow IC, Dong M, Mungall BA, et al. A novel L-ficolin/mannose-binding lectin chimeric molecule with enhanced activity against Ebola virus. J Biol Chem 2010; 285:24729-24739.