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Volumn 70, Issue 16, 2010, Pages 6427-6436

Low-field magnetic resonance imaging to visualize chronic and cycling hypoxia in tumor-bearing mice

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BLOOD OXYGEN TENSION; BREATHING; CELL DENSITY; CONTROLLED STUDY; ELECTRON SPIN RESONANCE; HYPOXIA; IMMUNOHISTOCHEMISTRY; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; PERICYTE; PRIORITY JOURNAL; TUMOR MICROENVIRONMENT; TUMOR VOLUME; TUMOR XENOGRAFT; ADENOCARCINOMA; ANIMAL; C3H MOUSE; CANCER TRANSPLANTATION; CELL HYPOXIA; COLON TUMOR; FEMALE; HT 29 CELL LINE; HUMAN; METABOLISM; NUDE MOUSE; PATHOLOGY; PHYSIOLOGY; PRESSURE; PROCEDURES; SQUAMOUS CELL CARCINOMA; VASCULARIZATION; XENOGRAFT;

EID: 77955761645     PISSN: 00085472     EISSN: 15387445     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-10-1350     Document Type: Article
Times cited : (112)

References (50)
  • 1
    • 33947732977 scopus 로고    scopus 로고
    • Angiogenesis: An organizing principle for drug discovery?
    • Folkman J. Angiogenesis: an organizing principle for drug discovery? Nat Rev Drug Discov 2007;6:273-86.
    • (2007) Nat Rev Drug Discov , vol.6 , pp. 273-286
    • Folkman, J.1
  • 2
    • 35748970483 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: Targets for anti-angiogenesis and normalization
    • DOI 10.1016/j.mvr.2007.05.003, PII S002628620700060X, Therapeutic Applications of Angiogenesis and Anti-angiogenesis
    • Fukumura D, Jain RK. Tumor microvasculature and microenvironment: targets for anti-angiogenesis and normalization. Microvasc Res 2007;74:72-84. (Pubitemid 350051025)
    • (2007) Microvascular Research , vol.74 , Issue.2-3 , pp. 72-84
    • Fukumura, D.1    Jain, R.K.2
  • 3
    • 0023481357 scopus 로고
    • Transport of molecules across tumor vasculature
    • Jain RK. Transport of molecules across tumor vasculature. Cancer Metastasis Rev 1987;6:559-93.
    • (1987) Cancer Metastasis Rev , vol.6 , pp. 559-593
    • Jain, R.K.1
  • 4
    • 0033000313 scopus 로고    scopus 로고
    • 2 gradients in window chamber tumours: Impact on tumour hypoxia
    • 2 gradients in window chamber tumours: impact on tumour hypoxia. Br J Cancer 1999;79:1717-22.
    • (1999) Br J Cancer , vol.79 , pp. 1717-1722
    • Dewhirst, M.W.1    Ong, E.T.2    Braun, R.D.3
  • 5
    • 84966192535 scopus 로고
    • The histological structure of some human lung cancers and the possible implications for radiotherapy
    • Thomlinson RH, Gray LH. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br J Cancer 1955;9:539-49.
    • (1955) Br J Cancer , vol.9 , pp. 539-549
    • Thomlinson, R.H.1    Gray, L.H.2
  • 6
    • 0000168995 scopus 로고
    • A multicomponent x-ray survival curve for mouse lymphosarcoma cells irradiated in vivo
    • Powers WE, Tolmach LJ. A multicomponent x-ray survival curve for mouse lymphosarcoma cells irradiated in vivo. Nature 1963;197:710-1.
    • (1963) Nature , vol.197 , pp. 710-711
    • Powers, W.E.1    Tolmach, L.J.2
  • 7
    • 0023932431 scopus 로고
    • Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy
    • Gatenby RA, Kessler HB, Rosenblum JS, et al. Oxygen distribution in squamous cell carcinoma metastases and its relationship to outcome of radiation therapy. Int J Radiat Oncol Biol Phys 1988;14:831-8.
    • (1988) Int J Radiat Oncol Biol Phys , vol.14 , pp. 831-838
    • Gatenby, R.A.1    Kessler, H.B.2    Rosenblum, J.S.3
  • 8
    • 0029775242 scopus 로고    scopus 로고
    • Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix
    • Hockel M, Schlenger K, Aral B, et al. Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix. Cancer Res 1996;56:4509-15.
    • (1996) Cancer Res , vol.56 , pp. 4509-4515
    • Hockel, M.1    Schlenger, K.2    Aral, B.3
  • 9
    • 0032708195 scopus 로고    scopus 로고
    • Oxygenation of head and neck cancer: Changes during radiotherapy and impact on treatment outcome
    • Brizel DM, Dodge RK, Clough RW, Dewhirst MW. Oxygenation of head and neck cancer: changes during radiotherapy and impact on treatment outcome. Radiother Oncol 1999;53:113-7.
    • (1999) Radiother Oncol , vol.53 , pp. 113-117
    • Brizel, D.M.1    Dodge, R.K.2    Clough, R.W.3    Dewhirst, M.W.4
  • 10
    • 70549102512 scopus 로고    scopus 로고
    • Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress
    • Dewhirst MW. Relationships between cycling hypoxia, HIF-1, angiogenesis and oxidative stress. Radiat Res 2009;172:653-65.
    • (2009) Radiat Res , vol.172 , pp. 653-665
    • Dewhirst, M.W.1
  • 11
    • 0033405294 scopus 로고    scopus 로고
    • The hypoxic cell: A target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture
    • Brown JM. The hypoxic cell: a target for selective cancer therapy-eighteenth Bruce F. Cain Memorial Award lecture. Cancer Res 1999;59:5863-70.
    • (1999) Cancer Res , vol.59 , pp. 5863-5870
    • Brown, J.M.1
  • 12
    • 0034144552 scopus 로고    scopus 로고
    • Hypoxic cytotoxic agents: A new approach to cancer chemotherapy
    • Brown JM. Hypoxic cytotoxic agents: a new approach to cancer chemotherapy. Drug Resist Updat 2000;3:7-13.
    • (2000) Drug Resist Updat , vol.3 , pp. 7-13
    • Brown, J.M.1
  • 13
    • 0023107539 scopus 로고
    • Intermittent blood flow in a murine tumor: Radiobiological effects
    • Chaplin DJ, Olive PL, Durand RE. Intermittent blood flow in a murine tumor: radiobiological effects. Cancer Res 1987;47:597-601.
    • (1987) Cancer Res , vol.47 , pp. 597-601
    • Chaplin, D.J.1    Olive, P.L.2    Durand, R.E.3
  • 14
    • 0030476061 scopus 로고    scopus 로고
    • Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma
    • Kimura H, Braun RD, Ong ET, et al. Fluctuations in red cell flux in tumor microvessels can lead to transient hypoxia and reoxygenation in tumor parenchyma. Cancer Res 1996;56:5522-8.
    • (1996) Cancer Res , vol.56 , pp. 5522-5528
    • Kimura, H.1    Braun, R.D.2    Ong, E.T.3
  • 15
    • 0035893396 scopus 로고    scopus 로고
    • Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors
    • Cairns RA, Kalliomaki T, Hill RP. Acute (cyclic) hypoxia enhances spontaneous metastasis of KHT murine tumors. Cancer Res 2001;61:8903-8.
    • (2001) Cancer Res , vol.61 , pp. 8903-8908
    • Cairns, R.A.1    Kalliomaki, T.2    Hill, R.P.3
  • 16
    • 1542405875 scopus 로고    scopus 로고
    • Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma
    • Cairns RA, Hill RP. Acute hypoxia enhances spontaneous lymph node metastasis in an orthotopic murine model of human cervical carcinoma. Cancer Res 2004;64:2054-61.
    • (2004) Cancer Res , vol.64 , pp. 2054-2061
    • Cairns, R.A.1    Hill, R.P.2
  • 17
    • 0141988559 scopus 로고    scopus 로고
    • Molecular mechanisms of tumor invasion and metastasis: An integrated view
    • Cairns RA, Khokha R, Hill RP. Molecular mechanisms of tumor invasion and metastasis: an integrated view. Curr Mol Med 2003;3:659-71.
    • (2003) Curr Mol Med , vol.3 , pp. 659-671
    • Cairns, R.A.1    Khokha, R.2    Hill, R.P.3
  • 19
    • 4344707313 scopus 로고    scopus 로고
    • Quantifying transient hypoxia in human tumor xenografts by flow cytometry
    • Bennewith KL, Durand RE. Quantifying transient hypoxia in human tumor xenografts by flow cytometry. Cancer Res 2004;64:6183-9.
    • (2004) Cancer Res , vol.64 , pp. 6183-6189
    • Bennewith, K.L.1    Durand, R.E.2
  • 20
    • 0032835231 scopus 로고    scopus 로고
    • Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats
    • Braun RD, Lanzen JL, Dewhirst MW. Fourier analysis of fluctuations of oxygen tension and blood flow in R3230Ac tumors and muscle in rats. Am J Physiol 1999;277:H551-68.
    • (1999) Am J Physiol , vol.277
    • Braun, R.D.1    Lanzen, J.L.2    Dewhirst, M.W.3
  • 21
    • 4444292601 scopus 로고    scopus 로고
    • Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: A marker of tumour acute hypoxia?
    • Baudelet C, Ansiaux R, Jordan BF, et al. Physiological noise in murine solid tumours using T2*-weighted gradient-echo imaging: a marker of tumour acute hypoxia? Phys Med Biol 2004;49:3389-411.
    • (2004) Phys Med Biol , vol.49 , pp. 3389-3411
    • Baudelet, C.1    Ansiaux, R.2    Jordan, B.F.3
  • 22
    • 32844470756 scopus 로고    scopus 로고
    • The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors
    • Baudelet C, Cron GO, Ansiaux R, et al. The role of vessel maturation and vessel functionality in spontaneous fluctuations of T2*-weighted GRE signal within tumors. NMR Biomed 2006;19:69-76.
    • (2006) NMR Biomed , vol.19 , pp. 69-76
    • Baudelet, C.1    Cron, G.O.2    Ansiaux, R.3
  • 24
    • 70349655722 scopus 로고    scopus 로고
    • Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET
    • Wang K, Yorke E, Nehmeh SA, Humm JL, Ling CC. Modeling acute and chronic hypoxia using serial images of 18F-FMISO PET. Med Phys 2009;36:4400-8.
    • (2009) Med Phys , vol.36 , pp. 4400-4408
    • Wang, K.1    Yorke, E.2    Nehmeh, S.A.3    Humm, J.L.4    Ling, C.C.5
  • 25
    • 0029979794 scopus 로고    scopus 로고
    • The relationship between partial pressure of oxygen and perfusion in two murine tumors after X-ray irradiation: A combined gadopentetate dimeglumine dynamic magnetic resonance imaging and in vivo electron paramagnetic resonance oximetry study
    • Goda F, Bacic G, O'Hara JA, et al. The relationship between partial pressure of oxygen and perfusion in two murine tumors after X-ray irradiation: a combined gadopentetate dimeglumine dynamic magnetic resonance imaging and in vivo electron paramagnetic resonance oximetry study. Cancer Res 1996;56:3344-9.
    • (1996) Cancer Res , vol.56 , pp. 3344-3349
    • Goda, F.1    Bacic, G.2    O'Hara, J.A.3
  • 26
    • 0029033810 scopus 로고
    • Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation
    • Goda F, O'Hara JA, Rhodes ES, et al. Changes of oxygen tension in experimental tumors after a single dose of X-ray irradiation. Cancer Res 1995;55:2249-52.
    • (1995) Cancer Res , vol.55 , pp. 2249-2252
    • Goda, F.1    O'Hara, J.A.2    Rhodes, E.S.3
  • 27
    • 43049176328 scopus 로고    scopus 로고
    • Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas
    • Elas M, Bell R, Hleihel D, et al. Electron paramagnetic resonance oxygen image hypoxic fraction plus radiation dose strongly correlates with tumor cure in FSa fibrosarcomas. Int J Radiat Oncol Biol Phys 2008;71:542-9.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 542-549
    • Elas, M.1    Bell, R.2    Hleihel, D.3
  • 28
    • 19944426756 scopus 로고    scopus 로고
    • Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment
    • Ansiaux R, Baudelet C, Jordan BF, et al. Thalidomide radiosensitizes tumors through early changes in the tumor microenvironment. Clin Cancer Res 2005;11:743-50.
    • (2005) Clin Cancer Res , vol.11 , pp. 743-750
    • Ansiaux, R.1    Baudelet, C.2    Jordan, B.F.3
  • 29
    • 0037096740 scopus 로고    scopus 로고
    • Insulin increases the sensitivity of tumors to irradiation: Involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption
    • Jordan BF, Gregoire V, Demeure RJ, et al. Insulin increases the sensitivity of tumors to irradiation: involvement of an increase in tumor oxygenation mediated by a nitric oxide-dependent decrease of the tumor cells oxygen consumption. Cancer Res 2002;62:3555-61.
    • (2002) Cancer Res , vol.62 , pp. 3555-3561
    • Jordan, B.F.1    Gregoire, V.2    Demeure, R.J.3
  • 30
    • 0032112280 scopus 로고    scopus 로고
    • EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging
    • Ardenkjaer-Larsen JH, Laursen I, Leunbach I, et al. EPR and DNP properties of certain novel single electron contrast agents intended for oximetric imaging. J Magn Reson 1998;133:1-12.
    • (1998) J Magn Reson , vol.133 , pp. 1-12
    • Ardenkjaer-Larsen, J.H.1    Laursen, I.2    Leunbach, I.3
  • 31
    • 0037382342 scopus 로고    scopus 로고
    • Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): Methodology and comparison with blood oxygen level-dependent (BOLD) MRI
    • Elas M, Williams BB, Parasca A, et al. Quantitative tumor oxymetric images from 4D electron paramagnetic resonance imaging (EPRI): methodology and comparison with blood oxygen level-dependent (BOLD) MRI. Magn Reson Med 2003;49:682-91.
    • (2003) Magn Reson Med , vol.49 , pp. 682-691
    • Elas, M.1    Williams, B.B.2    Parasca, A.3
  • 33
    • 33845881112 scopus 로고    scopus 로고
    • Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with Oxylite oxygen measurements
    • Elas M, Ahn KH, Parasca A, et al. Electron paramagnetic resonance oxygen images correlate spatially and quantitatively with Oxylite oxygen measurements. Clin Cancer Res 2006;12:4209-17.
    • (2006) Clin Cancer Res , vol.12 , pp. 4209-4217
    • Elas, M.1    Ahn, K.H.2    Parasca, A.3
  • 34
    • 0020092785 scopus 로고
    • ESR studies of O2 uptake by Chinese hamster ovary cells during the cell cycle
    • Lai CS, Hopwood LE, Hyde JS, Lukiewicz S. ESR studies of O2 uptake by Chinese hamster ovary cells during the cell cycle. Proc Natl Acad Sci U S A 1982;79:1166-70.
    • (1982) Proc Natl Acad Sci U S A , vol.79 , pp. 1166-1170
    • Lai, C.S.1    Hopwood, L.E.2    Hyde, J.S.3    Lukiewicz, S.4
  • 35
    • 43049111741 scopus 로고    scopus 로고
    • Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice
    • Matsumoto S, Hyodo F, Subramanian S, et al. Low-field paramagnetic resonance imaging of tumor oxygenation and glycolytic activity in mice. J Clin Invest 2008;118:1965-73.
    • (2008) J Clin Invest , vol.118 , pp. 1965-1973
    • Matsumoto, S.1    Hyodo, F.2    Subramanian, S.3
  • 36
    • 34248363120 scopus 로고    scopus 로고
    • Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR
    • Devasahayam N, Subramanian S, Murugesan R, et al. Strategies for improved temporal and spectral resolution in in vivo oximetric imaging using time-domain EPR. Magn Reson Med 2007;57:776-83.
    • (2007) Magn Reson Med , vol.57 , pp. 776-783
    • Devasahayam, N.1    Subramanian, S.2    Murugesan, R.3
  • 37
    • 69249206633 scopus 로고    scopus 로고
    • Reconstruction for time-domain in vivo EPR three-dimensional multigradient oximetric imaging-a parallel processing perspective
    • Dharmaraj CD, Thadikonda K, Fletcher AR, et al. Reconstruction for time-domain in vivo EPR three-dimensional multigradient oximetric imaging-a parallel processing perspective. Int J Biomed Imaging 2009;2009:528639.
    • (2009) Int J Biomed Imaging , vol.2009 , pp. 528639
    • Dharmaraj, C.D.1    Thadikonda, K.2    Fletcher, A.R.3
  • 38
    • 0036324371 scopus 로고    scopus 로고
    • Single-point (constant-time) imaging in radiofrequency Fourier transform electron paramagnetic resonance
    • Subramanian S, Devasahayam N, Murugesan R, et al. Single-point (constant-time) imaging in radiofrequency Fourier transform electron paramagnetic resonance. Magn Reson Med 2002;48:370-9.
    • (2002) Magn Reson Med , vol.48 , pp. 370-379
    • Subramanian, S.1    Devasahayam, N.2    Murugesan, R.3
  • 39
    • 0033631855 scopus 로고    scopus 로고
    • Parallel coil resonators for time-domain radiofrequency electron paramagnetic resonance imaging of biological objects
    • Devasahayam N, Subramanian S, Murugesan R, et al. Parallel coil resonators for time-domain radiofrequency electron paramagnetic resonance imaging of biological objects. J Magn Reson 2000;142:168-76.
    • (2000) J Magn Reson , vol.142 , pp. 168-176
    • Devasahayam, N.1    Subramanian, S.2    Murugesan, R.3
  • 40
    • 62549145710 scopus 로고    scopus 로고
    • Pulsed EPR imaging of nitroxides in mice
    • Hyodo F, Matsumoto S, Devasahayam N, et al. Pulsed EPR imaging of nitroxides in mice. J Magn Reson 2009;197:181-5.
    • (2009) J Magn Reson , vol.197 , pp. 181-185
    • Hyodo, F.1    Matsumoto, S.2    Devasahayam, N.3
  • 41
    • 4744366351 scopus 로고    scopus 로고
    • Pharmacokinetics of a triarylmethyl-type paramagnetic spin probe used in EPR oximetry
    • Matsumoto K, English S, Yoo J, et al. Pharmacokinetics of a triarylmethyl-type paramagnetic spin probe used in EPR oximetry. Magn Reson Med 2004;52:885-92.
    • (2004) Magn Reson Med , vol.52 , pp. 885-892
    • Matsumoto, K.1    English, S.2    Yoo, J.3
  • 42
    • 70449408942 scopus 로고    scopus 로고
    • Estimation of tumor microvessel density by MRI using a blood pool contrast agent
    • Hyodo F, Chandramouli GV, Matsumoto S, et al. Estimation of tumor microvessel density by MRI using a blood pool contrast agent. Int J Oncol 2009;35:797-804.
    • (2009) Int J Oncol , vol.35 , pp. 797-804
    • Hyodo, F.1    Chandramouli, G.V.2    Matsumoto, S.3
  • 43
    • 0031008710 scopus 로고    scopus 로고
    • Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime
    • Azuma C, Raleigh JA, Thrall DE. Longevity of pimonidazole adducts in spontaneous canine tumors as an estimate of hypoxic cell lifetime. Radiat Res 1997;148:35-42.
    • (1997) Radiat Res , vol.148 , pp. 35-42
    • Azuma, C.1    Raleigh, J.A.2    Thrall, D.E.3
  • 44
    • 70449575832 scopus 로고    scopus 로고
    • Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI
    • Matsumoto S, Yasui H, Batra S, et al. Simultaneous imaging of tumor oxygenation and microvascular permeability using Overhauser enhanced MRI. Proc Natl Acad Sci U S A 2009;106:17898-903.
    • (2009) Proc Natl Acad Sci U S A , vol.106 , pp. 17898-17903
    • Matsumoto, S.1    Yasui, H.2    Batra, S.3
  • 45
    • 40949141801 scopus 로고    scopus 로고
    • Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide
    • Zhou Q, Guo P, Gallo JM. Impact of angiogenesis inhibition by sunitinib on tumor distribution of temozolomide. Clin Cancer Res 2008;14:1540-9.
    • (2008) Clin Cancer Res , vol.14 , pp. 1540-1549
    • Zhou, Q.1    Guo, P.2    Gallo, J.M.3
  • 47
    • 60549104814 scopus 로고    scopus 로고
    • Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model
    • Hendriksen EM, Span PN, Schuuring J, et al. Angiogenesis, hypoxia and VEGF expression during tumour growth in a human xenograft tumour model. Microvasc Res 2009;77:96-103.
    • (2009) Microvasc Res , vol.77 , pp. 96-103
    • Hendriksen, E.M.1    Span, P.N.2    Schuuring, J.3
  • 48
    • 20344391071 scopus 로고    scopus 로고
    • Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development
    • Sorg BS, Moeller BJ, Donovan O, Cao Y, Dewhirst MW. Hyperspectral imaging of hemoglobin saturation in tumor microvasculature and tumor hypoxia development. J Biomed Opt 2005;10:44004.
    • (2005) J Biomed Opt , vol.10 , pp. 44004
    • Sorg, B.S.1    Moeller, B.J.2    Donovan, O.3    Cao, Y.4    Dewhirst, M.W.5
  • 49
    • 39749194493 scopus 로고    scopus 로고
    • The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography
    • Lin Z, Mechalakos J, Nehmeh S, et al. The influence of changes in tumor hypoxia on dose-painting treatment plans based on 18F-FMISO positron emission tomography. Int J Radiat Oncol Biol Phys 2008;70:1219-28.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 1219-1228
    • Lin, Z.1    Mechalakos, J.2    Nehmeh, S.3
  • 50
    • 0036512446 scopus 로고    scopus 로고
    • Intensity-modulated radiotherapy
    • Leibel SA, Fuks Z, Zelefsky MJ, et al. Intensity-modulated radiotherapy. Cancer J 2002;8:164-76.
    • (2002) Cancer J , vol.8 , pp. 164-176
    • Leibel, S.A.1    Fuks, Z.2    Zelefsky, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.