REST/NRSF-mediated intrinsic homeostasis protects neuronal networks from hyperexcitability

EMBO Journal

Volumn 32, Issue 22, 2013, Pages 2994-3007

  Pozzi, Davide ^a,b,d   Lignani, Gabriele ^a,c   Ferrea, Enrico ^a,e   Contestabile, Andrea ^a   Paonessa, Francesco ^a   D'Alessandro, Rosalba ^b   Lippiello, Pellegrino ^a   Boido, Davide ^b   Fassio, Anna ^a,c   Meldolesi, Jacopo ^b   Valtorta, Flavia ^b   Benfenati, Fabio ^a,c   Baldelli, Pietro ^a,c  

^a ISTITUTO ITALIANO DI TECNOLOGIA   (Italy)

^b VITA SALUTE SAN RAFFAELE UNIVERSITY   (Italy)

^c UNIVERSITY OF GENOA   (Italy)

^d HUMANITAS CLINICAL AND RESEARCH CENTER   (Italy)

^e GERMAN PRIMATE CENTER   (Germany)

Author keywords

4 aminopyridine; excitability; intrinsic homeostasis; Na channels; transcriptional repression

Indexed keywords

4 AMINOPYRIDINE; NEURON RESTRICTIVE SILENCER FACTOR; REPRESSOR ELEMENT 1 SILENCING TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR; UNCLASSIFIED DRUG; VOLTAGE GATED SODIUM CHANNEL;

ANIMAL CELL; ARTICLE; BRAIN CELL CULTURE; CELL ACTIVATION; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; ELECTRIC ACTIVITY; EMBRYO; GENE ACTIVATION; HIPPOCAMPAL NEURONAL CULTURE; HIPPOCAMPUS; HOMEOSTASIS; HYPERACTIVITY; MOUSE; NERVE CELL CULTURE; NERVE CELL EXCITABILITY; NERVE CELL NETWORK; NERVE CELL PLASTICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; SINGLE CELL ANALYSIS; SODIUM CURRENT;

4-AMINOPYRIDINE; ANIMALS; CELLS, CULTURED; HIPPOCAMPUS; HOMEOSTASIS; MICE; MICE, INBRED C57BL; NERVE NET; NEURONS; REPRESSOR PROTEINS;

EID: 84887824898     PISSN: 02614189     EISSN: 14602075     Source Type: Journal    
DOI: 10.1038/emboj.2013.231     Document Type: Article

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